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Advancing neuroscience through real-time processing of big data:Transition from open-loop to closed-loop paradigms

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Zoological Research 2024年第3期45卷 518-519页

作者： Yu-Fan Wang jiu-lin Du Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 200031China

The brain functions as a closed-loop system that continuously generates behavior in response to the external environment and adjusts actions based on the *** research methodologies in neuroscience,especially those employed in brain imaging experiments,have mainly adopted an open-loop paradigm(Grosenick et al.,2015).Functional neural circuits are analyzed offline and subsequently tested through manipulation of neuronal activities within specific regions or with genetic *** establishing a closed-loop research paradigm,functional ensembles can be detected and tested in real time with temporal *** functional ensembles,rather than brain regions or genetically labeled neural populations,serve as fundamental units of neural networks,offering valuable insights into the dissection of neural *** closed-loop research paradigm also enables the capture of high-dimensional activities of internal brain dynamics and precise elucidation of physiological processes such as learning,decision-making,and sleep.

关键词： neural loop Transition

Optimal control on special Euclidean group via natural gradient algorithm

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Science China(Information Sciences) 2016年第11期59卷 63-72页

作者： Chunhui LI Erchuan ZHANG lin jiu Huafei SUN School of Mathematics and Statistics Beijing Institute of Technology School of Mathematics and Statistics University of Western Australia Department of Mathematics Tulane University School of Mathematics and Statistics and Beijing Key Laboratory on MCAACI Beijing Institute of Technology

Considering the optimal control problem about the control system of the special Euclidean group whose output only depends on its input is meaningful in practical applications. The optimal control considered here is described as the output matrix is as close as possible to the target matrix by adjusting the system *** geodesic distance is adopted as the measure of the difference between the output matrix and the target matrix, and the trajectory of the control input obtained in the process is achieved. Furthermore, some numerical simulations are shown to illustrate our outcomes based on the natural gradient descent algorithm for optimizing the control system of the special Euclidean group.

关键词： system control natural gradient special Euclidean group geodesic distance numerical simulation

La2Zr2O7 and MgO co-doped composite Li-Garnet solid electrolyte

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Journal of Energy Chemistry 2020年第1期29卷 132-136,I0005页

作者： jiu lin linbin Wu Zhen Huang Xiaoxiong Xu Jiheng Liu Zhejiang Funlithium New Energy Technology Co. Ltd.

Various solid electrolytes,such as sulfides(10^-3-10^-2 S cm^-1)and oxides(10^-4–10^-3 S cm^-1)are explored and developed to solve the safety problems in commercial Li-ion batteries using liquid flammable *** Li anod... 详细信息

关键词： Li-Garnet Li7La3Zr2O12 Composite electrolyte High conductivity La2Zr2O7 MgO

Calcium-Mediated Mitochondrial Permeability Transition Involved in Hydrogen Peroxide-Induced Apoptosis in Tobacco Protoplasts

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Journal of Integrative Plant Biology 2006年第4期48卷 433-439页

作者： Yuan Wang jiu-Sheng lin Gen-Xuan Wang Key Laboratory of Arid Agroecology at Lanzhou University Ministry of Education Lanzhou 730000 China Department of Biochemisty and Plant Science Initiative George W. Beadle Center University of Nebraska-Lincoln Lincoln NE 68588 USA College of Life Sciences Zhejiang University Hangzhou 310027 China

In the present study, we focused on whether Intracellular free Ca^2＋（[Ca^2＋],） regulates the formation of mltochondrlal permeability transition pore （MPTP） In H2O2-induced apoptosis In tobacco protoplasts. It was shown that the decrease In mltochondrlal membrane potential （△ψm） preceded the appearance of H2O2-Induced apoptosls; pretreatment with the specific MPTP Inhibitor cyclosporine A, which also Inhibits Ca^2＋ cycling by the mitochondria, effectively retarded apoptosls and the decrease In △ψm. Apoptosls and decreased △ψm were exacerbated by CaCl2, whereas the plasma membrane voltage-dependent Ca^2＋ channel blocker lanthanum chloride （LaCl3） attentuated these responses. Chelation of extracellular Ca^2＋ with EGTA almost totally Inhibited apoptosls and the decrease In △ψmInduced by H2O2. The time-course of changes In [Ca^2＋]l In apoptosls was detected using the Ca^2＋ probe Fiuo-3 AM. These studies showed that [Ca^2＋]1 was Increased at the very early stage of H2O2-Induced apoptosls. The EGTA evidently Inhibited the Increase In [Ca^2＋]1 Induced by H=O=, whereas It was only partially Inhibited by LaCl3. The results suggest that H2O2 may elevate cytoplasmic free Ca^2＋ concentrations In tobacco protoplasts, which mainly results from the entry of extracellular Ca^2＋, to regulate mltochondrlal permeability transition. The signaling pathway of [Ca^2＋]1-medlated mltochondrlal permeability transition was associated with H2O2-Induced apoptosis In tobacco protoplaete.

关键词： apoptosis calcium hydrogen peroxide mitochondrial permeability transition pore programmed cell death tobacco protoplast.

Local non-equilibrium thermal fluctuation,internal noise and dissipation in gaseous heat conduction systems with high values of Prandtl number

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Chinese Chemical Letters 2011年第5期22卷 626-630页

作者： Feng lin jiu Li Luo Nan Rong Zhao Institute of Chemical Physics College of Chemistry. Sichuan Universitry Chengdu 610064 China

By means of a stochastic model suggested in this paper for the systems with local non-equilibrium excited thermal fluctuations, the famous Shannon entropy is extended to include the heat conduction processes controlled externally by boundary constraints of constant temperature gradients at two ***,using the description of master equation for the continuous Markov processes a balance equation of stochastic entropy production valid for one dimension gaseous heat conduction systems with high values of Prandtl number has been also *** on it,a general expression for both the stochastic entropy production and the entropy production of fluctuations have been further deduced by theΩ-*** this formalism,all kinds of stochastic contributions to the dissipation from the non-equilibrium thermal fluctuation and internal noise turn explicit.

关键词： Stochastic model of gaseous heat conduction Master equation of continuous stochastic processes Local non-equilibrium thermal fluctuation dissipation Entropy production of fluctuations

Chemical Composition,Anticancer,Anti-neuroinflammatory,and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia

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Chinese Journal of Integrative Medicine 2018年第3期24卷 207-212页

作者： lin Jing CAI Qiao-yan XU Wen lin jiu-mao PENG Jun Academy of Integrative Medicine Biomedical Research Center Fujian University of Traditional Chinese Medicine Fujian Key Laboratory of Integrative Medicine on Geriatrics Fujian University of Traditional Chinese Medicine Department of Pharmacology Fujian University of Traditional Chinese Medicine

Objective：To study the chemical composition,anticancer,anti-neuroinflammatory,and antioxidant activities of the essential oil of Patrinia scabiosaefolia（EO-PS）.Methods：Patrinia scabiosaefolia was analyzed by gas chromatography-mass *** human carcinoma cell lines,including SGC-7901,AGS,Hep G2,HT-29,HCT-8,5-FU/HCT-8,He La,and MDA-MB-231,were assessed by methylthiazolyldiphenyltetrazolium bromide（MTT） ***-neuroinflammatory activity was assessed by production of interleukin（IL）-1β and IL-6 induced by lipopolysaccharide in BV-2 cells（microglia from mice）.The antioxidant activity was evaluated with a 2,2-diphenyl-1-picrylhydrazyl（DPPH） scavenging ***：Forty-four components,representing 83.919% of the total oil,were identified in the *** major constituents were caryophyllene oxide（12.802%）,caryophyllene（6.909%）,α-caryophyllene（2.927%）,β-damascenone（3.435%）,calarene（5.621%）,and phenol（3.044%）.The MTT assay showed that the EO-PS exhibited significant dose-dependent growth inhibition in the 50–200 μg/m L dilution *** EO-PS exhibited a dose-dependent scavenging activity against the DPPH radical,with an half of maximal inhibitory concentration 1.455 mg/m ***：The EO-PS possesses a wide range of antitumor,anti-neuroinflammatory and antioxidant activities,suggesting that it may be a good candidate for further investigations of new bioactive substances.

关键词： Patrinia scabiosaefolia essential oil anti-neuroinflammatory anticancer antioxidant caryophyllene oxide

Structures of ceramics coatings on steel fabricated by hot-dipping and micro-arc oxidation

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中国有色金属学会会刊：英文版 2004年第Z1期14卷 170-172页

作者： SHEN De-jiu WANG Yu-lin GU Wei-chao XING Guang-zhong Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China Key Laboratory of Metastable Materials Science and TechnologyYanshan University Qinhuangdao 066004 China Key Laboratory of Metastable Materials Science and TechnologyYanshan University Qinhuangdao 066004 China Key Laboratory of Metastable Materials Science and TechnologyYanshan University Qinhuangdao 066004 China

Firstly, an aluminum coating was produced metallurgically on mild steel by hot-dipping, then an aluminum oxide coating was formed self-growingly from the aluminum coating by micro-arc oxidation treatment. The structures of the composite coatings were investigated by means of SEM, TEM and XRD. The results show that the composite coating consists of three layers which are Fe-Al alloy, aluminum coating and aluminum oxide orderly outward from the steel substrate. There are amorphous phases, k-Al2O3 and θ-Al2O3 mainly in the aluminum oxide.

关键词： hot dipping micro-arc oxidation ceramic coating

Longitudinal Quantitation of Tooth Displacement in Chinese Adolescents with Normal Occlusion

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Current Medical Science 2019年第2期39卷 317-324页

作者： Jie-ni ZHANG Xue-dong WANG jiu-xiang lin Department of Orthodontics Peking University School and Hospital of StomatologyBeijing 100081China

This longitudinal study aims to analyze the different modes of the maxillary and mandibular tooth displacement in subjects,who were aged 12.5-17.5 years(150-210 months),with untreated normal(Class I)*** lateral cephalograms for a set of 10 subjects(7 females and 3 males)at consecutive annual time points were selected and *** were analyzed on the basis of the superimpositions of serial tracings of lateral cephalograms on stable anterior cranial base,the anatomies of the maxillary and mandibular *** horizontal and vertical displacements of the first molar and incisor were assessed by *** local and the secondary tooth displacements with growth contributed to the total horizontal and vertical displacements of the molars and incisors of the *** the total tooth displacement,the horizontal growth of maxilla and mandible had the same contribution as the local tooth *** vertical maxillary growth played a smaller role than the local drift,and mandibular remodeling went in a reverse direction with the local tooth *** first molars moved more forward than the incisors in the upper and lower *** the upper and lower first molars showed forward *** analysis of tooth displacement may be utilized in making orthodontic treatment plan,including anchorage or torque control.

关键词： tooth movement growth evaluation cephalometries superimposition

A colorimetric chemosensor based on new water-soluble PODIPY dye for Hg^(2+) detection

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Chinese Chemical Letters 2015年第10期26卷 1241-1245页

作者： Xin-Dong Jiang Hai-Feng Yu jiu-Li Zhao Chang-Liang Sun Ying Xie lin-jiu Xiao College of Applied Chemistry Key Laboratory of Rare-Earth Chemistry and Applying Liaoning Province Shenyang University of Chemical Technology Center of Physical and Chemistry Test Shenyang University of Chemical Technology

The phosphorus-containing PODIPY 1 as a chemosensor can detect Hg^2＋ by a color change from pink to violet red without the use of any instrumentation. PODIPY 1 was selective to Hg^2＋ with a remarkable absorption change, and addition of other relevant metal ions caused almost no absorption change. The new PODIPY dye 1 was sensitive to various concentrations of Hg^2＋. The energy gap between the HOMO and LUMO of the metal complex 1–Hg^2＋ is smaller than that of chemosensor 1, which is in good agreement with the red shift in the absorption observed upon treatment of 1 with Hg^2＋. The 1-based test strips were easily fabricated and low-cost, useful in practical and efficient Hg^2＋test kits.

关键词： PODIPY Hg^2+ Colorimetric DFT Chemosensor