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Antibodies Against Annexin V and Prothrombin,Their Correlation with Other Anti-phospholipid Antibodies in Recurrent Pregnancy Loss

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Journal of Reproduction and Contraception 2005年第1期16卷 35-46页

作者： Zdenka Ulcova-Gallova Petr Mukensnabl Sarka Hadravska Vendula Kyselova jitka slechtova Zdenka Micanova Katerina Bibkova Miroslav Balvin Zdenek Rokyta Medical School and Faculty Hospital of Charles University Department of Obstetrics and Gynecology and Pathology Pilsen Czech Republic Department of Biology and Biochemistry of Fertilization Institute of Molecular Genetics Czech Academy of Sciences Prague Czech Republic Department of Haematology Pilsen Czech Republic Medical School and Faculty Hospital of Charles University Department of Obstetrics and Gynecology andPathology Pilsen Czech Republic

Objective To study the findings of serum antibodies against annexin V, prothrombin, ph-inositol, ph-acid, ph-ethanolamine, ph-serine, ph-glycerol, cardiolipin, and beta2-glycoprotein I and analyze the trophoblast annexin V receptors Methods Sera from 156patients aged 26-41 years with recurrent pregnancy loss （3-7 times） were investigated. Eighty-four fertile healthy women aged 24-38 years were included in a control group. ELISA methods were used for detecting a panel of sera anti-phospholipid antibodies. Immunolocalization of annexin V receptors in 143 trophoblast specimens of 156 patients was investigated by the immunofluorescence technique using Annexin V-FITC, Apoptosis and Annexin V-CY3 commercial kits. Results Positivity for anti-phospholipid antibodies mainly against ph-serine, ph- ethanolamine, and ph-inositol was found together in 80. 8%（126 out of 156 patients）, anti-prothrombin antibodies in 12% （18）, and anti-annexin V antibodies in 13. 5% （21） women. No significant levels of anti-phospholipid antibodies were found in 6 controls. Placenta immunohistopathology also exhibited some changes manifested by the presence of apoptotic and necrotic cells in trophoblast, and very few microthrombotization in some intervillous spaces. Conclusion Our detailed study demonstrated the prevalence of majority of antiphospholipid antibodies as a high risk factor for repeated reproductive failure. Very low microthrombosis in placentas could be explained by the changes of haemocoagulation properties out of uterus.

关键词： annexin V prothrombin anti-phospholipid antibodies trophoblast apoptosis recurrent pregnancy loss

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