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International Journal of Clean Coal and Energy 2016年第2期5卷 37-44页

作者： Eva Jiránková jitka mučková Petr Jadviščok Robert Vochta Vlastimil Molčák Martina Havlicová VSB-Technical University Ostrava Czech Republic Survey and Geology Manager OKD A.S. Mine Plant 2 Stonava Czech Republic

Mine Plant 2 is a part of the Ostrava-Karvina Coal District (OKD) that is located in the Czech part of the Upper Silesian Basin. The first coal was exhausted from Mine Plant 2 in 1968. The most used method of mining so far in this area has been strike longwall mining with controlled caving. Due to extensive changes in the surface, which occur as a consequence of deep mining by the method of longwall mining with controlled caving, it is not possible to use this method in densely populated areas. At the present time, therefore, the trial operation of a new mining method called room and pillar is carried out. The method was chosen with the aim to minimize subsidence and deformations of the surface. The room and pillar mining method has never been used before in the conditions of the OKR, therefore it is necessary to prove the real effect of mining by this method on the surface. For this purpose, a surface observation station was designed, consisting of 36 surface points. The position and height of all points of the observation station is determined in stages three times a year.

关键词： Surface Subsidence Room and Pillar Protective Pillar of the Shaft

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

黑死病与奥斯曼帝国的兴起(1347-1453)

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古代文明（中英文） 2025年第1期19卷 50-58,M0004,M0005页

作者：母仕洪西南大学历史文化学院、伊朗研究中心重庆400715

14世纪中叶以降,黑死病在东地中海地区反复暴发,对当地的国家造成严重冲击,尤其是使日渐衰微的拜占庭帝国遭受严重的人口衰减与社会瓦解。然而,此间征服事业方兴未艾的奥斯曼帝国不仅躲过黑死病致命侵袭,反而借助黑死病对敌对政权的摧... 详细信息

14世纪中叶以降,黑死病在东地中海地区反复暴发,对当地的国家造成严重冲击,尤其是使日渐衰微的拜占庭帝国遭受严重的人口衰减与社会瓦解。然而,此间征服事业方兴未艾的奥斯曼帝国不仅躲过黑死病致命侵袭,反而借助黑死病对敌对政权的摧残加速了对外扩张进程,实现了国力的持续提升。黑死病之所以对奥斯曼帝国与敌对政权的冲击效应大相径庭,主要缘于帝国位居内陆的地理位置、游牧社会组织形式以及相对有效的防疫举措。总之,黑死病肆虐对以拜占庭帝国为主的东地中海诸政权产生了严重负面效应,一定程度上为奥斯曼早期扩张铺平了道路,成为促进帝国兴起不可忽视的重要因素。

关键词：黑死病奥斯曼帝国拜占庭帝国瘟疫大流行

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Only mothers feed mature offspring in European Ceratina bees

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Insect Science 2021年第5期28卷 1468-1481页

作者： Michael Mikat jitka Waldhauserova Tereza Frankova Katerina Cermakova Vojtech Broz Simon Zeman Marcela Dokulilova Jakub Straka Department of Zoology Faculty of ScienceCharles UniversityPragueCzech Republic Jihlava Grammar School JihlavaCzech Republic Department of Ecology Faculty of ScienceCharles UniversityPragueCzech Republic

Parental care directed to adult offspring is uncommon in *** parental care has been documented in Xylocopinae bees(Hymenoptera:Apidae).Moreover,some Ceratina bees(Xylocopinae)are known to feed mature siblings,and feeding of mature siblings is achieved by dwarf eldest daughters when mothers *** daughters are intentionally malnourished by mothers and usually originate from the first brood ***,we examined the pattern of care prov ided to young adults in three small European carpenter bees:Ceratina(Ceratina)cucurbitina,C.(Euceratina)chalybea,and C.(E.)*** of nest departures and arrivals were performed to study foraging *** detected intensive foraging behavior of mothers in all three studied ***,we did not observe regular foraging bchavior of daughters in any *** experimental removal of mothers in *** led to the emigration of young adults and did not initiate foraging activity in *** conclude that the feeding of siblings does not occur in these species unlike in the American species *** detected female-biased sex ratios in the first brood cell in *** and *** offspring in the first brood cell was smaller than other female offspring only in *** results show that a female-biased sex ratio and the small size of daughters in the first brood cell do not provide sufficient ev idence for demonstrating the existence of an altruistic daughter and also that the pattern of maternal investment is not exclusively shaped by social interactions.

关键词： foraging trip Hymenoptera maternal care provisioning sociality Xylocopinae

Reconstruction of the mid-Devonian HP-HT metamorphic event in the Bohemian Massif(European Variscan belt)

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Geoscience Frontiers 2022年第3期13卷 177-195页

作者： Stephen Collett Karel Schulmann Piérig Deiller PavlaŠtípská Vít Peresty Marc Ulrich Yingde Jiang Luc de Hoÿm de Marien jitka Míková Centre for Lithospheric Research Czech Geological SurveyKlárov 311821 Praha 1Czech Republic Institut Terre et Environnement de Strasbourg UMR 7063 Universitéde Strasbourg—CNRS1 Rue Blessig67084 StrasbourgCedexFrance Institute of Petrology and Structural Geology Charles UniversityAlbertov 6Praha 212843Czech Republic State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Laboratories of the Czech Geological Survey Geologická615200 Praha 5Czech Republic

Mid-Devonian high-pressure(HP)and high-temperature(HT)metamorphism represents an enigmatic early phase in the evolution of the Variscan *** the Bohemian Massif this metamorphism is recorded mostly in allochthonous complexes with uncertain relationship to the major tectonic *** this regard,the MariánskéLázně Complex(MLC)is unique in its position at the base of its original upper plate(Teplá-Barrandian Zone).The MLC is composed of diverse,but predominantly mafic,magmatic-metamorphic rocks with late Ediacaran to mid-Devonian protolith ***-Devonian HP eclogite-facies metamorphism was swiftly followed by a HT granulite-facies overprint contemporaneous with the emplacement of magmatic rocks with apparent supra-subduction *** Hf in zircon isotopic measurements combined with a review of whole-rock isotopic and geochemical data reveals that the magmatic protoliths of the MLC,as well as in the upper plate Teplá-Barrandian Zone,developed above a relatively unaltered Neoproterozoic lithospheric *** remained coupled with this lithospheric mantle throughout a geological timeframe that encompasses separate Ediacaran and Cambrian age arc magmatism,protracted early Paleozoic rifting,and the earliest phases of the Variscan *** results are presented in the context of reconstructing the original architecture of the Variscan terranes up to and including the mid-Devonian HP-HT event.

关键词： Variscan Orogeny Avalonian-Cadomian Orogeny Eclogite Geochemistry Zircon Lu-Hf geochronology

Are genetically distinct lizard species able to hybridize？ A review

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Current Zoology 2015年第1期61卷 155-180页

作者： jitka JANCUCHOVA-LASkovA Eva LANDOVA Daniel FRYNTA Department of Zoology Faculty of Science Charles University Vini6n~t 7 CZ-128 44 Prague Czech Republic

Animal species are delimited by reproductive isolation mechanisms （RIMs）. Postzygotic RIMs are mainly products of genetic differences and thus their strength increases with elapsed divergence time. The relationship between postzygotic repro- ductive isolation and genetic divergence, however, differs considerably among major clades of vertebrates. We reviewed the available literature providing empirical evidence of natural and/or experimental hybridization between distinct species of lizards （squamates except snakes）. We found that hybridization events are widely distributed among nearly all major lizard clades. The majority of research focuses on parthenogenetic species and/or polyploid hybrids in families Lacertidae, Teiidae and Gekkonidae. Homoploid bisexual hybrids are mainly reported within Lacertidae and Iguania groups. As a proxy of genetic divergence of the hybridizing taxa we adopted nucleotide sequence distance （HKY85） of mitochondrial cyt b gene. The upper limit of genetic di- vergence was similar with regard to both parthenogenetic and bisexual hybrids. Maximum values of these distances between hy- bridizing species of lizards approached 18%-21%, which is comparable to or even exceeds the corresponding values reported for other principal clades of vertebrates. In spite of this, F1 hybrids are typically at least partially fertile in lizards and thus genetic introgression between highly divergent species is possible. The relationship between the genetic distance and hybrid fertility was not found [Current Zoology 61 （1）： 155-180, 2015].

关键词： Hybridization Introgression Fertility Viability Genetic divergence Lizards

Anticlockwise metamorphic paths at ca.890–790 Ma from the NE Baidrag block,Mongolia,indicate back-arc compression at the Rodinia periphery

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Geoscience Frontiers 2023年第2期14卷 154-181页

作者： PavlaŠtípská Vít Peresty Igor Soejono Karel Schulmann RCAndrew Kylander-Clark Carmen Aguilar Stephen Collett Martin Racek jitka Míková Otgonbaatar Dorjsuren Nikol Novotná Czech Geological Survey 11821 Praha 1Czech Republic Institute of Petrology and Structural Geology Charles University in PragueAlbertov 6Praha 212800Czech Republic Institut Terre et Environnement de Strasbourg UMR 7063 Universitéde Strasbourg-CNRS1 Rue Blessig67084 StrasbourgCedexFrance Department of Earth Science University of CaliforniaSanta BarbaraCA 93106United States Department of Mineralogy Petrology and Applied GeologyFaculty of Earth ScienceUniversity of Barcelona08028 BarcelonaSpain Institute of Geology Mongolian Academy of SciencesLabor Union StreetSonginokhairkhan DistrictUlaanbaatar 18080Mongolia

The processes leading to the assembly of the Rodinia supercontinent through Grenvillian collisional orogeny are relatively well *** contrast,accretionary orogenic processes occurring at the supercontinent periphery following Rodinia assembly are poorly *** fill this gap,we have identified metamorphic rocks in the Mongolia collage of the Central Asian Orogenic Belt,where numerous data testify for Meso-to Neoproterozoic magmatic *** tectono-metamorphic evolution of the periSiberian tract of the Central Asian Orogenic Belt is mainly characterized by the late Proterozoic–early Cambrian(Baikalian)***,we document here a Tonian age metamorphism at the northern part of the Precambrian Baidrag block,previously considered as a typical example of the Baikalian metamorphic *** study incorporates zircon and in-situ monazite geochronology linked to P-T modelling of Grt-Sil-Ky migmatite gneiss and Grt-St ***-Sil-Ky gneiss records initial burial to the sillimanite stability field at 720℃ and 6.0 kbar followed by further burial to the kyanite stability field at 750℃ and 9 kbar and decompression to 650℃ and 8 *** Grt-St schist records initial burial to the staurolite stability field at 620℃ and 6 kbar,followed by further burial to 590℃ and 8.5 *** monazite data yield a continuum of ^(207)Pb-corrected ^(238)U/^(206)Pb dates of ca.926–768 Ma in the Grt-Sil-Ky gneiss,and ca.937–754 Ma in the Grt-St *** on monazite textural positon,internal zoning,and REE patterns,the time of prograde burial to 6.0 kbar under a thermal gradient of 27–32℃/km is estimated at ca.890–853 *** is not clear whether such high-grade conditions prevailed until a phase of further burial under a geothermal gradient of 18–22℃/km dated at ca.835–815 *** late monazite recrystallization at ca.790 Ma is related to ***,monazite with dates of ca.568–515 Ma occur as whole grains or as rims with sharp boundaries on Tonian monaz

关键词： Central Asian Orogenic Belt Grenvillian-age metamorphism Monazite in-situ U-Pb dating Monazite REE composition Zircon U-Pb dating Thermodynamic modelling