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The role of histone modifications:from neurodevelopment to neurodiseases

Signal Transduction and Targeted Therapy 2022年第8期7卷 2710-2732页

作者： jisu park Kyubin Lee Kyunghwan Kim Sun-Ju Yi Department of Biological Sciences and Biotechnology Chungbuk National UniversityCheongjuChungbukRepublic of Korea

Epigenetic regulatory mechanisms,including DNA methylation,histone modification,chromatin remodeling,and microRNA expression,play critical roles in cell differentiation and organ development through spatial and temporal gene *** is a sophisticated and complex process by which neural stem cells differentiate into specialized brain cell types at specific times and regions of the brain.A growing body of evidence suggests that epigenetic mechanisms,such as histone modifications,allow the fine-tuning and coordination of spatiotemporal gene expressions during *** histone modifications contribute to the development of neurodegenerative and neuropsychiatric ***,recent progress in understanding histone modifications in regulating embryonic and adult neurogenesis is comprehensively *** histone modifications implicated in neurodegenerative and neuropsychiatric diseases are also covered,and future directions in this area are provided.

关键词： diseases specialized modification

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Neural Regeneration Research 2017年第10期12卷 1640-1647页

作者： jisu Hong Bo-yong park Hwan-ho Cho Hyunjin park Department of Electronic Electrical and Computer EngineeringSungkyunkwan UniversitySuwonKorea Center for Neuroscience Imaging Research(CNIR) Institute for Basic ScienceSuwonKorea School of Electronic and Electrical Engineering Sungkyunkwan UniversitySuwonKorea

Attention deficit and hyperactivity disorder（ADHD） is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and *** ADHD related symptoms are influenced by the complex interaction of brain networks which were under *** explored age-related brain network differences between ADHD patients and typically developing（TD） subjects using resting state f MRI（rs-f MRI） for three age groups of children,adolescents,and *** collected rs-f MRI data from 184 individuals（27 ADHD children and 31 TD children;32 ADHD adolescents and 32 TD adolescents;and 31 ADHD adults and 31 TD adults）.The Brainnetome Atlas was used to define nodes in the network *** compared three age groups of ADHD and TD subjects to identify the distinct regions that could explain age-related brain network differences based on degree centrality,a well-known measure of nodal *** left middle temporal gyrus showed significant interaction effects between disease status（i.e.,ADHD or TD） and age（i.e.,child,adolescent,or adult）（P 0.001）.Additional regions were identified at a relaxed threshold（P 0.05）.Many of the identified regions（the left inferior frontal gyrus,the left middle temporal gyrus,and the left insular gyrus） were related to cognitive *** results of our study suggest that aberrant development in cognitive brain regions might be associated with age-related brain network changes in ADHD *** findings contribute to better understand how brain function influences the symptoms of ADHD.

关键词： nerve regeneration attention deficit and hyperactivity disorder cognitive function connectivity resting-state f MRI Brainnetome Atlas whole brain analysis disease-aging interaction effect neuroscience neural regeneration

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Effect of Korean Magnolia obovata Extract on Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells

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Chinese Journal of Integrative Medicine 2020年第9期26卷 677-682页

作者： Hyunjhung Jhun Suji Baek Jinwoo Kim Kang-Pa Lee Hun-Young park Won-Hwan park Kiwon Lim jisu Kim Technical Assistance Center Korea Food Research InstituteJeonbuk(55365)Republic of Korea Department of Medical Science School of MedicineKonkuk UniversitySeoulRepublic of Korea Department of Bio-Science College of Natural ScienceDongguk UniversityGyeongbuk(38066)Republic of Korea Physical Activity&Performance Institute Konkuk UniversitySeoul(05029)Republic of Korea Department of Diagnostic College of Korean MedicineDongguk University GoyangGyeonggi-do(10326)Republic of Korea

Objective:To investigate the effects of Korean Magnolia obovata crude extract(KME)on plateletderived growth factor(PDGF)-BB-induced proliferation and migration of vascular smooth muscle cells(VSMCs).Methods:KME composition was analyzed by high-performance liquid chromatography(HPLC).VSMCs were isolated from the aorta of a Sprague-Dawley rat,incubated in serum free-Dulbecco's modified Eagle's medium in the presence or absence of KME(10,30,100,and 300(xg/mL),then further treated with PDGF-BB(10 ng/mL).VSMC proliferation was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and VSMC migration was determined using the Boyden chamber and scratch wound healing *** blot analysis was used to detect phosphorylation of extracellular signal-regulated protein kinases 1 and 2(p-ERK1/2),protein kinase B(p-Akt),and stress-activated protein kinase/c-Jun NH2-terminal kinase(p-SAPK/JNK).The antimigration and proliferation effects of KME were tested using aortic sprout ***:The HPLC analysis identified honokiol(0.45 mg/g)and magnolol(0.34 mg/g)as the major components of ***(30,100,and 300μg/m L)significantly decreased the proliferation and migration of PDGF-BB-stimulated(10 ng/mL)VSMCs and the PDGF-BB-induced phosphorylation of EKR1/2,Akt,and SAPK/JNK(P<0.05).Furthermore,PDGF-BBinduced VSMCs treated with 300μg/m L of KME showed reduction in aortic sprout ***:KME could inhibit abnormal proliferation and migration of VSMCs by down-regulating the phosphorylation of EKR1/2 and ***,KME might be a functional food for preventing vascular disorders.

关键词： extracellular signal-regulated protein kinases 1 and 2 Akt platelet-derived growth factor-BB smooth muscle cell functional food

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Human Rights and Social Stigma Review for Leprosy Patients in Korea

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Advances in Infectious Diseases 2021年第1期11卷 73-83页

作者： Seungshin Lee David Ahn Justin Kim Cathy park Kunmin Kim Alice Kim Chae Eun Kim jisu Shin Timothy Cho Jonathan Jo David park Tae Youn Kim Paul S. Chung School of Medicine University of California Irvine CA USA Youth with Talents Fairfax VA USA Fuzbien Technology Institute Rockville MD USA

Leprosy is a chronic disease caused by a low multiplying bacillus, Mycobacterium leprae, which primarily affects the skin and the extremities. Multidrug therapy (MDT) and Bacillus Calmette-Guérin (BCG) vaccinations are effective at treatment of the disease, but social misconceptions about the disease inhibit efficient health care for affected individuals. In South Korea, leprosy patients face social, economic, and political discrimination. Korean leprosy patients are isolated into Sorokdo island and face challenges such as difficulty receiving education and limited job opportunities. Leprosy cognitively, emotionally, and socially impacts patients’ lives, and represents a serious social inequality issue. To raise awareness, dispel myths about the disease, and to end patient discrimination that destroys families, we conducted case studies based on scientific journals. The paper specifically focuses on difficulties faced by Korean leprosy patients, and subsequent initiatives by the government to aid patients. To reach the WHO’s target of health and wellbeing for all by 2030, we need to educate the masses about leprosy and address relevant social inequality issues.

关键词： Leprosy Sorokdo

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小艾炷直接灸治疗慢性颈痛的量效关系研究

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中国针灸 2019年第7期39卷 734-738,754页

作者：卢璐傅俊媚冯福盈梁健宁纪素丽马瑞广州医科大学附属第五医院中医科广东广州510700 广东省中医院针灸科

目的:评价小艾炷直接灸治疗慢性颈痛的有效性,探索不同壮数的小艾炷直接灸治疗慢性颈痛的量效关系。方法:将120例慢性颈痛患者随机分为3壮组、5壮组、7壮组和假灸组,各30例,均选取风池、天柱、颈百劳、肩中俞、肩井,分别接受小艾炷直接... 详细信息

目的:评价小艾炷直接灸治疗慢性颈痛的有效性,探索不同壮数的小艾炷直接灸治疗慢性颈痛的量效关系。方法:将120例慢性颈痛患者随机分为3壮组、5壮组、7壮组和假灸组,各30例,均选取风池、天柱、颈百劳、肩中俞、肩井,分别接受小艾炷直接灸3壮、5壮、7壮及假艾灸的治疗。假灸组操作采用万花油将艾炷的下1/3(约1.5 mm)浸透。每周2次,共治疗10次。观察各组治疗前、治疗后和随访1个月的Northwickpark颈痛量表(NPQ)评分、McGill疼痛量表(MPQ)评分及局部压痛阈值(PPT),并评定各组治疗后及随访1个月的疗效。结果:治疗后和随访1个月,3壮组、5壮组及7壮组NPQ评分、MPQ评分均较治疗前降低(均P0.05)。治疗后和随访1个月,3壮组、5壮组及7壮组NPQ评分、MPQ评分均低于假灸组(均P0.05)。结论:不同壮数的小艾炷直接灸均可以有效缓解慢性颈痛,总体趋势为随着壮数增加而疗效提高。

关键词：慢性颈痛艾炷直接灸量效关系随机对照研究

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