检索结果-南通市图书馆

Relationship between HBV genotypes and anti-viral therapeutic efficacy of interferon-alpha

Hepatobiliary & Pancreatic diseases International 2007年第2期6卷 166-171页

作者： Ma, Jin-Chun Wang, lu-Wen Li, Xin-Jian Liao, Yong-Feng Hu, Xi-Ya Gong, Zuo-jiong Wuhan Univ Renmin Hosp Dept Infect Dis State Key Lab Virol Wuhan 430060 Peoples R China Huangshi Aikang Hosp Dept Infect Dis Huangshi 435000 Peoples R China

BACKGROUND: Much evidence demonstrates that the genotypes of hepatitis B virus (HBV) present differences in pathogenicity and outcomes owing to differences in genetic structure. This study aimed to investigate the influences of HBV genotypes on the anti-viral therapeutic efficacy of interferon-alpha (IFN-alpha) in chronic hepatitis B patients, and to determine the relationship between HBV genotypes and levels of viral replication or gene variations. METHODS: The chronic hepatitis B patients who were treated with IFN-alpha were selected randomly. Anti-viral therapeutic efficacy was monitored in these patients. The HBV genotypes were detected by PCR microplate hybridization ELISA. The levels of serum HBV-DNA were determined by fluorescence quantitative PCR. HBV gene variation at pre-C and basic core promoter (BCP) regions were assayed by gene chip technology. RESULTS: Genotypes B and C were predominant in 94 chronic hepatitis B patients. A, E and F genotypes were not found in these patients. The HBV-DNA levels of genotype C and mixed genotypes were significantly higher than those of genotype B. The response to IFN-alpha in patients with genotype B was markedly better than in those with genotypes C and D, and the complete response to IFN-alpha was only observed in genotype B. The response to IFN-alpha in patients with mixed genotypes was the least sensitive. The negative transition of HBeAg was correlated with variations in the HBV pre-C and BCP regions in patients with partial or no response to IFN-alpha. The variation rates of HBV pre-C and BCP regions were clearly higher in genotype C than in genotype B. CONCluSIONS: The results suggest that HBV genotype is correlated with the serum levels of HBV-DNA, HBV gene variations and therapeutic efficacy of IFN-alpha. The regular detection of HBV genotypes in the clinic will be of benefit for disease prognosis and planning of anti-viral therapeutic strategies.

关键词： hepatitis B virus genotype gene variation interferon-alpha anti-viral therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

增长目标设定能否驱动经济高质量发展

引用

经济学家 2022年第9期 39-48页

作者：莫龙炯张小鹿广东财经大学财政税务学院、广东地方公共财政研究中心清华大学创新发展研究院、社会科学学院经济学研究所

增长目标短期化能否驱动经济高质量发展是新时代亟需探讨的重要问题。从五大新发展理念视角构建地方经济高质量发展指标体系,运用广义矩估计(GMM)和工具变量法(IV)识别经济增长目标对经济高质量发展的影响,可以发现:政府设定增长目标拉... 详细信息

增长目标短期化能否驱动经济高质量发展是新时代亟需探讨的重要问题。从五大新发展理念视角构建地方经济高质量发展指标体系,运用广义矩估计(GMM)和工具变量法(IV)识别经济增长目标对经济高质量发展的影响,可以发现:政府设定增长目标拉动了短期经济增长率,但总体上对地方经济高质量发展没有显著驱动作用。经济增长目标和“层层加码”通过对科学技术支出、产业结构升级和城市绿色创新的挤出机制阻碍地方经济创新、协调和绿色发展。财政自主权和收入分权、支出分权通过调整地方政府财政资源、公共支出结构弱化了增长目标对经济高质量发展的抑制效应。本文为转变经济增长方式、完善符合高质量发展的政府目标治理体系提供了理论依据。

关键词：经济增长目标产业结构升级绿色创新高质量发展

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treatment of urethral strictures using lingual mucosas urethroplasty： experience of 92 cases

引用

Chinese Medical Journal 2010年第4期123卷 458-462页

作者： XU Yue-min FU Qiang SA Ying-long ZHANG jiong JIN Chong-rui SI Jie-min SONG lu-jie Department of Urology Sixth People's Hospital Shanghai Jiao Tong University Shanghai 200233 China

Background Urethroplasty of complex urethral stricture is a difficult procedure, and there is no widely accepted standard approach described in the published literature. We evaluated the efficacy and safety of urethroplasty using lingual mucosa grafts （LMGs） for the repair of urethral strictures. Methods Between August 2006 and April 2009, 92 cases of urethral strictures （length ranging from 2.5 cm to 18 cm, mean 6.5 cm） were treated using LMGs. Of the 92 patients, 38 with long-segment urethral strictures （9-18 cm） underwent dual LMG or LMG combined with foreskin flap or buccal mucosal graft urethroplasty. Results Follow-up was obtained for 3-33 months （mean 17.2 months） postoperatively. Complications occurred in 8 patients, including urinary fistulas in 4 patients; recurrent strictures developed in 4 patients at 3-4 months post-operatively. The remaining patients voided well postoperatively, with peak flows between 14.3 ml/s and 54.6 ml/s （mean 28.4 ml/s）. Conclusions The tongue is an excellent source of graft material for the repair of anterior mucosal strictures. Dual LMG substitution urethroplasty can successfully treat longer, more complex urethral strictures.

关键词： lingual mucosa urethral stricture urethroplasty

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A simple scoring system to predict early recurrence of Bismuth–Corlette type IV perihilar cholangiocarcinoma

引用

Gastroenterology Report 2019年第5期7卷 345-353,I0002页

作者： ding-Zhong Peng jiong lu Bei Li Hai-Jie Hu Xi-Wen Ye Xian-Ze Xiong Nan-Sheng Cheng Department of biliary surgery West China Hospital of Sichuan UniversityChengduSichuanP.R.China

Background:Early recurrence has been reported to be predictive of a poor prognosis for patients with perihilar cholangiocarcinoma(pCCA)after *** objective of our study was to construct a useful scoring system to predict early recurrence for Bismuth–Corlette type IV pCCA patients in clinic and to investigate the value of early recurrence in directing post-operative surveillance and adjuvant ***:In total,244 patients who underwent radical resection for type IV pCCA were *** on clinicopathological characteristics,perioperative details and survival outcomes were *** curves were generated using the Kaplan–Meier *** and multivariate logistic-regression models were used to identify factors associated with early ***:Twenty-one months was defined as the cutoff point to distinguish between early and late *** and multivariate analysis revealed that CA19-9 level>200 U/mL,R1 resection margin,higher N category and positive lymphovascular invasion were independent predictors of early *** scoring system was constructed *** early-recurrence rates of patients with scores of 0,1,2,3,4,and 5 were 23.9%,38.7%,60.0%,78.6%,83.4%,and 100%,*** therapy was significantly associated with higher overall survival rate for patients with early recurrence,but not for those with late *** in the early-recurrence group with scores2 had better prognoses after adjuvant ***:A simple scoring system using CA19-9 level,N category,resection margin and lymphovascular invasion status could predict early recurrence,and thus might direct post-operative surveillance and adjuvant therapy for patients with type IV pCCA.

关键词： early recurrence Bismuth–Corlette classification perihilar cholangiocarcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three-dimensional morphological characteristics measurement of ankle joint based on computed tomography image post-processing

引用

Chinese Medical Journal 2011年第23期124卷 3912-3918页

作者： CHEN Yan-xi lu Xiao-ling BI Gang YU Xiao HAO Yi-li ZHANG Kun ZOU Li-ling MEI jiong YU Guang-rong Department of Orthopaedics Tongji Hospital of Tongji University Shanghai 200065 China

As precise positioning of ankle radiography is not possible, quantitative measurement of all syndesmotic parameters on repeated ankle X-ray films may be of little value. The purpose of this study was to provide a set of scientific and objective evaluation criteria for assessing the quality of ankle fracture reduction accurately and reliably by an intelligent combining three-dimensional （3-D） computed tomography （CT） measurement model. Methods From June 2008 to March 2011, all the thin-slice CT images of 100 cases （50 males and 50 females） with normal ankle joint scanned by 16-slice spiral CT were collected. Two-dimensional （2-D） and 3-D images of ankle joints were generated by using multiple planar reconstruction （MPR） and surface shaded display （SSD） respectively. The relevant parameters about bone structures and their relationship were measured and analyzed based on 3-D topological narrow division technique and 3-D measurement techniques combining essential elements of point, line and surface. Results In this study, the mean distance from lateral malleolus tip to talocrural articular surface, the tip of medial malleolus anterior colliculus to talocrural articular surface and lateral malleolus tip to the tip of medial malleolus anterior colliculus were （22.83±1.12） mm, （12.84±1.09） mm, and （61.18±2.03） mm respectively in male group, and （20.16±1.00） mm, （10.30±1.05） mm and （53.00±1.40） mm respectively in female group. The above three parameters were correlated with gender, height and weight （P 〈0.05）. However, the mean perpendicular distance from lateral malleolus tip to the plane through the tip of medial malleolus anterior colliculus, the talocrural angle, later clear space, medial clear space, and the superior clear space were （9.93±0.29） mm, （10.01±0.38）°, （1.94±0.16） mm, （2.78±0.19） mm, and （3.14±0.15） mm respectively in 100 cases, were not significance correlated with gender, height and weight （P 〉0.05）. Conclusions This study could provide a certain amount o

关键词： ankle, computed tomography three-dimensional reconstruction morphological characteristics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

感染性胰腺坏死病人多重耐药菌感染危险因素分析

引用

中国实用外科杂志 2022年第4期42卷 412-416页

作者：卢炯地丁乙轩郑智曲元旭梅文通曹锋李非首都医科大学急性胰腺炎诊疗中心首都医科大学宣武医院普通外科北京100053

目的探讨影响感染性胰腺坏死(IPN)病人发生多重耐药菌(MDRB)感染的相关危险因素。方法回顾性分析2014-01-01至2020-12-31首都医科大学宣武医院普通外科收治的215例IPN病人的临床资料。根据病人有无MDRB感染,分为MDRB感染组(107例)和非M... 详细信息

目的探讨影响感染性胰腺坏死(IPN)病人发生多重耐药菌(MDRB)感染的相关危险因素。方法回顾性分析2014-01-01至2020-12-31首都医科大学宣武医院普通外科收治的215例IPN病人的临床资料。根据病人有无MDRB感染,分为MDRB感染组(107例)和非MDRB感染组(108例),比较两组病人的临床转归。结果MDRB感染组病人入院时CT严重指数(CTSI)评分[8(6~10)vs.6(4~8),P=0.001]和降钙素原(PCT)水平[(1.7±1.4)μg/L vs.(0.8±0.7)μg/L,P=0.001]高于非MDRB感染组病人。在临床治疗过程中,MDRB感染组病人更需要营养支持(80.4%vs.50.9%,P=0.001)、微创手术干预(88.8%vs.64.8%,P=0.001)等治疗措施。在临床转归方面,MDRB感染组病人更易发生术后并发症(23.4%vs.12.1%,P=0.029)和新发器官衰竭(11.2%vs.0.9%,P=0.002),导致重症监护室(ICU)住院时间[(30.1±28.7)d vs.(17.9±13.7)d,P=0.001]和总住院时间[(50.0±31.1)d vs.(29.0±21.5)d,P=0.001]延长。经多因素分析发现,合并胰腺外感染(OR=4.116,95%CI 1.381-12.271,P=0.011)、入院时PCT水平(OR=2.728,95%CI 1.502-4.954,P=0.001)、胰腺坏死程度(OR=2.728,95%CI 1.502-4.954,P=0.001)是影响IPN病人出现MDRB感染的独立危险因素。结论根据IPN病人是否出现胰腺外感染、胰腺坏死严重程度、入院时PCT水平可评估其发生MDRB感染的风险。

关键词：感染性胰腺坏死胰腺外感染病原菌多重耐药菌感染

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

毁灭与重生--基弗艺术中的火元素研究

引用

天津美术学院学报 2022年第2期 31-34页

作者：卢炯中国艺术研究院

在基弗作品中,对火元素的使用贯穿始终。他对火的描绘并非单单关注火本身,而是蕴含着神话中的毁灭与宗教中的重生双层隐喻。他将火元素与各种神话传说、宗教信仰、童年经历相结合,进而糅合成一种带有主观性的“德国精神”。同时,他的作... 详细信息

在基弗作品中,对火元素的使用贯穿始终。他对火的描绘并非单单关注火本身,而是蕴含着神话中的毁灭与宗教中的重生双层隐喻。他将火元素与各种神话传说、宗教信仰、童年经历相结合,进而糅合成一种带有主观性的“德国精神”。同时,他的作品通过历史史观与神话题材、表现主义与观念主义的结合,将宗教寓意转化成抽象的绘画语言,呈现出了其个体精神的创造力。

关键词：基弗火毁灭重生

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Cationic nanocarriers as potent adjuvants for recombinant S-RBD vaccine of SARS-CoV-2

引用

Signal Transduction and Targeted Therapy 2021年第1期6卷 8-10页

作者： Hong Lei Aqu Alu Jingyun Yang Cai He Weiqi Hong Zesheng Cheng Li Yang jiong Li Zhenling Wang Wei Wang Guangwen lu Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan University610041 SichuanChengduChina Emergency Department State Key Laboratory of BiotherapyWest China HospitalSichuan University610041 SichuanChengduChina

Dear Editor,The worldwide outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has urged the investigation of preventive ***,our team has developed a recombinant protein vaccine,targeting receptor binding domain(RBD)of the spike protein(S-RBD)of SARS-CoV-2,which could induce a potent antibody response and protect non-human primates from SARS-CoV-2 challenge.1 The recombinant RBD protein is proved as a potent antigen and a novel adjuvant is in demand for the effective stimulation of adaptive immunity.

关键词： adjuvant vaccine stimulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

引用

Cellular & Molecular Immunology 2022年第5期19卷 577-587页

作者： Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min luo Ziqi Zhang Tiangi lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang jiong Li Xiangrong Song lunzhi Dai Chong Chen Jia Geng Maling Gou lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao lu Xiaozhong Peng Xiawei Wei Laboratory of Aging Research and Cancer Drug Targeting State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.17Block 3Southern Renmin RoadChengduSichuan610041China National Kunming High-level Biosafety Primate Research Center Institute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeYunnanChina Westvac Biopharm Co. Ltd.No.618Fenghuang RoadShuangliu DistrictChengduSichuanChina division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control102629BeijingChina State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina

Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host *** to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse *** histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino *** acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S ***,histones enhance cell-cell ***,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse *** findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19.

关键词： COVID-19 SARS-CoV-2 neutrophil extracellular traps histones sialic acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting the number of visceral leishmaniasis cases in Kashgar, Xinjiang, China using the ARIMA-EGARCH model

引用

Asian Pacific Journal of Tropical Medicine 2020年第2期13卷 81-90页

作者： Hu-ling Li Rong-jiong Zheng Qiang Zheng Wei Jiang Xue-liang Zhang Wei-ming Wang Xing Feng Kai Wang Xiao-bo lu College of Public Health Xinjiang Medical UniversityUrumqi 830011P.R.China Department of Infectious diseases the first Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054P.R.China Xinjiang Center for disease Control and Prevention Urumqi830002P.R.China Department of Medical Engineering and Technology Xinjiang Medical UniversityUrumqi 830011P.R.China School of Mathematics Science Huaiyin Normal UniversityHuaian 223300 P.R.China

Objective:To forecast the visceral leishmaniasis cases using autoregress integrated moving average(ARIMA)and hybrid ARIMAEGARCH model,which offers a scientific basis to control visceral leishmaniasis spread in Kashgar Prefecture of Xinjiang,***:The data used in this paper are monthly visceral leishmaniasis cases in the Kashgar Prefecture of Xinjiang from 2004 to *** sample data between 2004 and 2015 were used for the estimation to choose the best model and the sample data in 2016 were used for the *** series of visceral leishmaniasis started on 1 January 2004 and ended on 31 December 2016,consisting of 1790 observations reported in Kashgar ***:For Xinjiang,the total number of reported cases were 2187,the male-to-female ratio of cases was 1:*** aged between 0 and 10 years accounted for 82.72%of all reported cases and the largest percentage of visceral leishmaniasis cases was detected among scattered children who accounted for 68.82%.The monthly incidences fitted by ARIMA(2,1,2)(1,1,1)12 model were consistent with the real data collected from 2004 to ***,the predicted cases failed to comply with the observed case number;we then attempted to establish a hybrid ARIMA-EGARCH model to fit visceral ***,the ARIMA(2,1,2)(1,1,1)12-EGARCH(1,1)model showed a good estimation when dealing with volatility clustering in the data ***:The combined model has been determined as the best prediction model with the root-mean-square error(RMSE)of 7.23%in the validation phase,which means that this model has high validity and rationality and can be used for short-term prediction of visceral leishmaniasis and could be applied to the prevention and control of the disease.

关键词： Visceral leishmaniasis ARIMA model Hybrid ARIMA-EGARCH Forecasting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：