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Characteristics of early gastric tumors with different differentiation and predictors of long-term outcomes after endoscopic submucosal dissection

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World Journal of Gastroenterology 2024年第14期30卷 1990-2005页

作者： Hong-Yi Zhu Jie Wu Yuan-Miao Zhang Fang-Lan Li Jin Yang Bin Qin jiong jiang Ning Zhu Meng-Yao Chen Bai-Cang Zou Department of Gastroenterology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Pathology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Gastroenterology Xianyang Hospital of Yan'an UniversityXianyang 712000Shaanxi ProvinceChina Department of Gastroenterology The First Hospital of Xi'anXi'an 710000Shaanxi ProvinceChina

BACKGROUND Gastric cancer is a common malignant tumor of the digestive tract,and endosco-pic submucosal dissection(ESD)is the preferred treatment for early-stage gastric *** analysis of the epidemiological characteristics of gastric mucosal tumors with different differentiation degrees and the influencing factors of long-term ESD efficacy may have certain significance for revealing the development of gastric cancer and *** To analyze the features of gastric mucosal tumors at different differentiation levels,and to explore the prognostic factors of *** We retrospectively studied 301 lesions in 285 patients at The Second Affiliated Hospital of Xi'an Jiaotong University from 2014 to 2021,according to the latest Japanese guidelines(sixth edition),and divided them into low-grade intrae-pithelial neoplasia(LGIN),high-grade intraepithelial neoplasia(HGIN),and computed tomography at 3,6 and 12 months after *** compared clinicopathologic characteristics,ESD efficacy,and complications with different degrees of differentiation,and analyzed the related factors associated with *** HGIN and differentiated carcinoma patients were significantly older compared with LGIN patients(P<0.001)and accounted for more 0-IIc(P<0.001),atrophic gastritis was common(P<0.001),and irregular microvascular patterns(IMVPs)and demarcation lines(DLs)were more obvious(P<0.001).There was more infiltration in the undifferentiated carcinoma tissue(P<0.001),more abnormal folds and poorer mucosal peristalsis(P<0.001),and more obvious IMVPs,irregular microsurface patterns and DLs(P<0.05)than in the LGIN and HGIN *** disease-free survival rates at 2,5,and 8 years after ESD were 95.0%,90.1%,and 86.9%,***-tiated lesions(HR 5.066),white moss(HR 7.187),incomplete resection(HR 3.658),and multiple primary cancers(HR 2.462)were significantly associated with poor *** Differentiations of gastric mucosal tumors have different epidemiological and

关键词： Gastric mucosal epithelial neoplasia Differentiated early gastric cancer Undifferentiated early gastric cancer Endoscopic submucosal dissection Long-term outcomes

2018~2022年临床科室大肠埃希菌检出分布及耐药情况分析

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海峡药学 2024年第4期36卷 59-63页

作者：江炯培何玥深圳市中西医结合医院广东深圳518104

目的了解医院近5年来临床样本中大肠埃希菌检出分布及耐药情况,为临床合理遴选抗菌药物提供参考。方法采用VITEK-COMPCAT细菌鉴定及药敏分析仪对医院2018年1月至2022年12月期间医院临床科室送检的9095份微生物样本(阳性标本)进行细菌... 详细信息

目的了解医院近5年来临床样本中大肠埃希菌检出分布及耐药情况,为临床合理遴选抗菌药物提供参考。方法采用VITEK-COMPCAT细菌鉴定及药敏分析仪对医院2018年1月至2022年12月期间医院临床科室送检的9095份微生物样本(阳性标本)进行细菌分离鉴定和药敏试验,并检测超广谱β-内酰胺酶(ESBLs),结合相关临床信息进行统计分析。结果所有标本共检出大肠埃希菌2073株,大肠埃希菌的检出率为22.79%(2073/9095),在检出的大肠埃希菌中共有701株产ESBLs,产酶率为33.80%(701/2073)。送检标本中,检出大肠埃希菌比例最高的是尿液标本34.15%(708/2073);送检临床科室中,检出大肠埃希菌比例最高的是胃肠外科32.66%(677/2073)。抗菌药物美罗培南敏感率为100.00%,替加环素敏感率为100.00%,阿米卡星敏感率为98.87%,头孢替坦敏感率为98.11%,哌拉西林/他唑巴坦敏感率为96.44%。结论大肠埃希菌在五年间的检出率呈现先上升后平稳下降趋势,产ESBLs的大肠埃希菌比例呈下降趋势,常用抗菌药物对大肠埃希菌保持较高的敏感率。

关键词：大肠埃希菌超广谱β-内酰胺酶(ESBLs) 耐药检出率分析条件致病菌

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结肠息肉内镜治疗术后艰难梭菌感染1例

中国感染与化疗杂志 2024年第3期24卷 341-343页

作者：王美史海涛姜炅曾虹沙素梅陈芬荣王燕刘欣西安交通大学第二附属医院消化内科西安710000 西安市第四医院

结肠息肉是结肠黏膜上的良性肿瘤样病变,内镜下套扎、电切等是目前临床上最常用的治疗技术,有操作简便、创伤小、完整切除率高等优点,但也存在出血、穿孔、感染等相关并发症。艰难梭菌(Clostridioides difficile)是定植于人类肠道内的... 详细信息

结肠息肉是结肠黏膜上的良性肿瘤样病变,内镜下套扎、电切等是目前临床上最常用的治疗技术,有操作简便、创伤小、完整切除率高等优点,但也存在出血、穿孔、感染等相关并发症。艰难梭菌(Clostridioides difficile)是定植于人类肠道内的厌氧性细菌,同时也是条件致病菌,通常发生在接受抗生素治疗的人群中。结肠息肉内镜治疗术会破坏肠道黏膜的完整性,为艰难梭菌更容易进入肠黏膜组织并引发感染提供可能。目前,结肠息肉内镜治疗术后合并艰难梭菌感染(CDI)病例少见报道。本文报道1例结肠息肉经内镜治疗术后出现艰难梭菌感染,并对其可能发病原因及内镜下表现进行分析,以期提高对该病的认识及重视。

关键词：结肠息肉内镜治疗术艰难梭菌感染

Decreased expression of gastrokine 1 in gastric mucosa of gastric cancer patients

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World Journal of Gastroenterology 2014年第44期20卷 16702-16706页

作者： Xiao-Yan Guo Lei Dong Bin Qin jiong jiang A-Meng Shi Department of Gastroenterology Second Affiliated Hospital of Xi’an Jiaotong University

AIM: To investigate the expression of gastrokine 1 (GKN1) in normal gastric mucosa, precancerous lesions and gastric cancer tissues, and to analyse its correlations with tumour site and pathological pattern.

关键词： Gastrokine 1 Gastric cancer Gastric mucosa Expression

Quick-scanning X-ray absorption fine structure beamline at SSRF

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Nuclear Science and Techniques 2024年第6期35卷 1-13页

作者： Yu Chen Qian Gao Zheng jiang jiong Li Shuo Zhang Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China

The layout and characteristics of the hard X-ray spectroscopy beamline(BL11B)at the Shanghai synchrotron radiation facility are described ***11B is a bending-magnet beamline dedicated to conventional and millisecond-scale quick-scanning X-ray absorption fine *** is equipped with a cylindrical collimating mirror,a double-crystal monochromator comprising Si(111)and Si(311),a channel-cut quick-scanning Si(111)monochromator,a toroidal focusing mirror,and a high harmonics rejection *** can provide 5-30 keV of X-rays with a photon flux of~5×10^(11)photons/s and an energy resolution of~1.31×10^(-4)at 10 *** performance of the beamline can satisfy the demands of users in the fields of catalysis,materials,and environmental *** paper presents an overview of the beamline design and a detailed description of its performance and capabilities.

关键词： Bending magnet beamline X-ray absorption fine structure Quick-scanning XAFS In situ Synchrotron radiation

Mechanical behavior of 2G NPR bolt anchored rock samples under static disturbance loading

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Journal of Mountain Science 2024年第7期21卷 2494-2516页

作者： WANG jiong jiang Jian WANG Siyu CHANG Yiwen LIU Peng HE Manchao CHENG Shuang State Key Laboratory for Tunnel Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China

The deep mining of coal resources is accompanied by severe environmental challenges and various potential engineering *** implementation of NPR(negative Poisson's ratio)bolts are capable of controlling large deformations in the surrounding rock *** paper focuses on studying the mechanical properties of the NPR bolt under static disturbance *** deep nonlinear mechanical experimental system was used to study the mechanical behavior of rock samples with different anchored types(unanchored/PR anchored/2G NPR anchored)under static disturbance *** whole process of rock samples was taken by high-speed camera to obtain the real-time failure characteristics under static disturbance *** the same time,the acoustic emission signal was collected to obtain the key characteristic parameters of acoustic emission such as acoustic emission count,energy,and *** deformation at the failure of the samples was calculated and analyzed by digital speckle *** findings indicate that the failure mode of rock is influenced by different types of *** peak failure strength of 2G NPR bolt anchored rock samples exhibits an increase of 6.5%when compared to the unanchored rock *** cumulative count and cumulative energy of acoustic emission exhibit a decrease of 62.16%and 62.90%,*** maximum deformation of bearing capacity exhibits an increase of 59.27%,while the failure time demonstrates a delay of 42.86%.The peak failure strength of the 2G NPR bolt anchored ones under static disturbance load exhibits an increase of 5.94%when compared to the rock anchored by PR(Poisson's ratio)*** cumulative count and cumulative energy of acoustic emission exhibit a decrease of 47.16%and 43.86%,*** maximum deformation of the bearing capacity exhibits an increase of 50.43%,and the failure time demonstrates a delay of 32%.After anchoring by 2G NPR bolt,anchoring support effectively reduces the risk of damage caused by s

关键词： Anchored rock samples Static disturbance load Acoustic emission characteristics Digital speckle Negative Poisson's ratio

Peptide tyrosine-tyrosine combined with its receptors exhibits an anti-cancer potential in pancreatic cancer MiaPaCa-2 cell

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Chinese Medical Journal 2014年第24期127卷 4235-4242页

作者： Li Hongxia Wang Zhixin Dong Lei jiang jiong Xu Xinsen Zhou Lei Wan Yong Department of Gastroenterology Department of Hepatobiliary Surgery the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine Xi'an Shaanxi 710061 China

Background Pancreatic cancer is a common malignant tumor of the digestive system. It is the fourth major cause of tumor-related death and its morbidity is increasing, and hence it is imperative to develop effective forms of therapy for pancreatic cancer. Peptide tyrosine-tyrosine （PYY） is an important gastrointestinal peptide hormone. According to previous literatures, PYY has been shown to inhibit tumor proliferation in cellular and animal models, but there has been limited research on the detailed mechanism of PYY in pancreatic cancer. This study was to observe the effects of PYY on pancreatic cancer cell and investigate the possible mechanism. Methods The expression of Y1, Y2, and Y5 receptors on pancreatic cancer cell lines were detected by reverse transcription quantitative polymerase chain reaction （RT-qPCR）. The cytotoxicity of PYY toward the MiaPaCa-2 cell was evaluated by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） assay; the cell morphology and structure changes were observed under inverted microscope and transmission electron microscope respectively. Apoptosis and cell cycle were evaluated by flow cytometry. The activity of caspase-3 was determined by activity assay kits and Western blotting. The expression of survivin, vascular endothelial growth factor （VEGF）, and cyclooxygenase-2 （COX-2） were determined by RT-qPCR and Western blotting. Results Expression of Y2 receptor is the most abundant PYY receptor on pancreatic cancer cell. PYY inhibited MiaPaCa-2 cell proliferation, blocked it in G0/G1 phase, increased the proportion of apoptosis cells and caspase-3 activity, and reduced the expression of survivin, VEGF, and COX-2. Conclusions PYY weakened the ability of the pancreatic MiaPaCa-2 cell viability through cell cycle blocking and apoptosis inducing. The inhibition effect of PYY may be mediated by the Y2 receptor. The increased caspase-3 activity and reduced expression of survivin, VEGF, and COX-2 may serve as a novel mechanism i

关键词： peptide tyrosine-tyrosine (PYY) pancreatic cancer MiaPaCa-2 cell anti-cancer

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包裹式加筋土挡墙的变形特性及影响因素研究

岩石力学与工程学报 2015年第A01期34卷 148-154页

作者：周健谢鑫波姜炯张姣同济大学地下建筑与工程系上海200092 同济大学岩土及地下工程教育部重点实验室上海200092 上海市政工程设计研究总院上海200092 上海城市管理职业技术学院土木工程与交通学院上海200432

通过离心模型试验和FLAC2D数值模拟,研究软土地基包裹式加筋土挡墙的变形特性及其影响因素。离心模型试验表明,包裹式加筋土挡墙工后的侧向变形较小,包裹式的加筋墙面起到了传统面板的作用。采用基于离心模型试验的FLAC2D数值模拟,通过... 详细信息

通过离心模型试验和FLAC2D数值模拟,研究软土地基包裹式加筋土挡墙的变形特性及其影响因素。离心模型试验表明,包裹式加筋土挡墙工后的侧向变形较小,包裹式的加筋墙面起到了传统面板的作用。采用基于离心模型试验的FLAC2D数值模拟,通过改变筋材的长度、布置间距(竖向)和刚度,探讨三者对挡墙变形特性的影响,结果表明,筋材的布置间距对挡墙变形的影响最显著,在实际工程中3个参数都应该控制在一定范围内。研究结果可为相关工程提供一定的参考及建议。

关键词：土力学软土地基离心模型试验 FLAC2D 包裹式加筋土挡墙变形特性筋材

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论《蜀山剑侠传》的超越生命观

西南师范大学学报（人文社会科学版） 2006年第2期32卷 70-75页

作者：孔庆东蒋炯毅北京大学中文系北京市100871

作为民国武侠小说北派五大家之一的还珠楼主,其作品代表了武侠小说中“奇幻仙侠派”的高峰。他的代表作《蜀山剑侠传》有丰富的思想文化内涵,其中蕴含的还珠楼主独特而系统化的生命观,是这部作品的重要意义所在。在对现实世界、生命形... 详细信息

作为民国武侠小说北派五大家之一的还珠楼主,其作品代表了武侠小说中“奇幻仙侠派”的高峰。他的代表作《蜀山剑侠传》有丰富的思想文化内涵,其中蕴含的还珠楼主独特而系统化的生命观,是这部作品的重要意义所在。在对现实世界、生命形态以及生命发展过程的观照中,都体现着还珠楼主超越性的生命观。这种观念,是中国传统文化的产物,同时又带有现代性,是武侠小说转向现代的体现。

关键词：《蜀山剑侠传》还珠楼主生命观超越