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High-performance formaldehyde prediction for indoor air quality assessment using time series deep learning

Building Simulation 2024年第3期17卷 415-429页

作者： Liu lu Xinyu Huang Xiaojun Zhou Junfei Guo Xiaohu Yang jinyue Yan School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’anChina Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina Future Energy Profile School of BusinessSocietyand EngineeringMälardalen UniversityVästeråsSweden

Indoor air pollution resulting from volatile organic compounds(VOCs),especially formaldehyde,is a significant health concern needed to predict indoor formaldehyde concentration(Cf)in green intelligent building *** study develops a thermal and wet coupling calculation model of porous fabric to account for the migration of formaldehyde molecules in indoor air and cotton,silk,and polyester fabric with heat flux in Harbin,Beijing,Xi’an,Shanghai,Guangzhou,and Kunming,*** time-by-time indoor dry-bulb temperature(T),relative humidity(RH),and Cf,obtained from verified simulations,were collated and used as input data for the long short-term memory(LSTM)of the deep learning model that predicts indoor multivariate time series Cf from the secondary source effects of indoor fabrics(adsorption and release of formaldehyde).The trained LSTM model can be used to predict multivariate time series Cf at other emission times and *** LSTM-based model also predicted Cf with mean absolute percentage error(MAPE),symmetric mean absolute percentage error(SMAPE),mean absolute error(MAE),mean square error(MSE),and root mean square error(RMSE)that fell within 10%,10%,0.5,0.5,and 0.8,*** addition,the characteristics of the input dataset,model parameters,the prediction accuracy of different indoor fabrics,and the uncertainty of the data set are *** results show that the prediction accuracy of single data set input is higher than that of temperature and humidity input,and the prediction accuracy of LSTM is better than recurrent neural network(RNN).The method’s feasibility was established,and the study provides theoretical support for guiding indoor air pollution control measures and ensuring human health and safety.

关键词： multivariate time series formaldehyde concentration deep learning heat-humidity coupling mass transfer secondary source effect

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Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1537-1553页

作者： Libin Pan Hang Yu Jie Fu Jiachun Hu Hui Xu Zhengwei Zhang Mengmeng Bu Xinyu Yang Haojian Zhang jinyue lu Jiandong Jiang Yan Wang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100050China Received 5 September 2022Revised 8 November

At present,clinical interventions for chronic kidney disease are very limited,and most patients rely on dialysis to sustain their lives for a long ***,studies on the gut—kidney axis have shown that the gut microbiota is a potentially effective target for correcting or controlling chronic kidney *** study showed that berberine,a natural drug with low oral availability,significantly ameliorated chronic kidney disease by altering the composition of the gut microbiota and inhibiting the production of gut-derived uremic toxins,including ***,berberine reduced the content of pcresol sulfate in plasma mainly by lowering the abundance of g_Clostridium_sensu_stricto_1 and inhibiting the tyrosine—p-cresol pathway of the intestinal ***,berberine increased the butyric acid producing bacteria and the butyric acid content in feces,while decreased the renal toxic trimethylamine *** findings suggest that berberine may be a therapeutic drug with significant potential to ameliorate chronic kidney disease through the gut—kidney axis.

关键词： Chronic kidney disease Gut microbiota Berberine Gut—kidney axis Clostridium p-Cresol Uremic toxins p-Cresol sulfate

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Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1024-1040页

作者： Hang Yu Hui Xu Xinyu Yang Zhengwei Zhang Jiachun Hu jinyue lu Jie Fu Mengmeng Bu Haojian Zhang Zhao Zhai Jingyue Wang Jiandong Jiang Yan Wang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing100050China

Specnuezhenide(SNZ)is among the main components of Fructus Ligustri lucidi,which has antiinflammation,anti-oxidation,and anti-tumor *** low bioavailability makes it difficult to explain the mechanism of pharmacological effect of *** this study,the role of the gut microbiota in the metabolism and pharmacokinetics characteristics of SNZ as well as the pharmacological meaning were *** can be rapidly metabolized by the gut microbiome,and two intestinal bacterial metabolites of SNZ,salidroside and tyrosol,were *** addition,carboxylesterase may be the main intestinal bacterial enzyme that mediates its *** the same time,no metabolism was found in the incubation system of SNZ with liver microsomes or liver homogenate,indicating that the gut microbiota is the main part involved in the metabolism of *** addition,pharmacokinetic studies showed that salidroside and tyrosol can be detected in plasma in the presence of gut ***,tumor development was inhibited in a colorectal tumor mice model administered orally with SNZ,which indicated that SNZ exhibited potential to inhibit tumor growth,and tissue distribution studies showed that salidroside and tyrosol could be distributed in tumor *** the same time,SNZ modulated the structure of gut microbiota and fungal group,which may be the mechanism governing the antitumoral activity of ***,SNZ stimulates the secretion of short-chain fatty acids by intestinal flora in vitro and in *** the future,targeting gut microbes and the interaction between natural products and gut microbes could lead to the discovery and development of new drugs.

关键词： Specnuezhenide Pharmacokinetics Tumor Gut microbiota Fungi Metabolism

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Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells

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Genes & Diseases 2024年第2期11卷 535-538页

作者： Xi Kong Peng lu jinyue Zhang Zheng Bao Chenghao Kuang Bingqing Xie Jianhua Peng Ning Ma Yong Jiang Shigang Yin Laboratory of Neurological Diseases and Brain Function The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Institute of Epigenetics and Brain Science Southwest Medical UniversityLuzhouSichuan 646000China Department of Neurosurgery The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Inflammation and Allergic Diseases Research Unit The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China

SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following *** is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal ***,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.

关键词： invasion homeostasis maintain

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Microstructure evolution from silicon core to surface in electronic-grade polycrystalline silicon

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Journal of Advanced Dielectrics 2024年第3期14卷 18-26页

作者： jinyue Peng Yuxuan Yang Yang Zhang Xinlu Xue Bochen lu Rong Qin Haijun Wu State Key Laboratory for Mechanical Behavior of Materials Electronic Materials Research Laboratory(Key Lab of Education Ministry)and School of Electronic and Information Engineering Xi’an Jiaotong University 710049 Xi’anChina Qinghai Xince Technology Co. Ltd.Huanghe Hydropower Development Co.Ltd.810007 XiningChina Instrumental Analysis Center Xi’an Jiaotong UniversityXi’anChina

Large-size electronic-grade polycrystalline silicon is an important material in the semiconductor industry with broad application ***,electronic-grade polycrystalline silicon has extremely high requirements for production technology and currently faces challenges such as carbon impurity breakdown,microstructure and composition nonuniformity and a lack of methods for preparing large-size mirror-like polycrystalline silicon *** paper innovatively uses physical methods such as wire cutting,mechanical grinding and ion thinning polishing to prepare large-size polycrystalline silicon samples that are clean,smooth,free from wear and have clear crystal *** material was characterized at both macroscopic and microscopic levels using metallographic microscopy,scanning electron microscopy(SEM)with backscattered electron diffraction(EBSD)techniques and scanning transmission electron microscopy(STEM).The crystal structure changes from single crystal silicon core to the surface of the bulk in the large-size polycrystalline silicon samples were revealed,providing a technical basis for optimizing and improving production processes.

关键词： Polysilicon silicon core matrix interface surface metallographic microscopy EBSD

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Microstructure of electronic-grade polycrystalline silicon core-matrix interface

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Journal of Advanced Dielectrics 2024年第3期14卷 11-17页

作者： Bochen lu Yuxuan Yang Yang Zhang Rong Qin Xinlu Xue jinyue Peng Haijun Wu State Key Laboratory for Mechanical Behavior of Materials Electronic Materials Research Laboratory(Key Lab of Education Ministry)and School of Electronic and Information Engineering Xi’an Jiaotong University 710049Xi’anP.R.China Qinghai Xince Technology Co. Ltd.Huanghe Hydropower Development Co.Ltd.810007XiningP.R.China Instrumental Analysis Center Xi’an Jiaotong University Xi’anP.R.China

This paper focuses on the problems encountered in the production process of electronic-grade polycrystalline *** points out that the characterization of electronic-grade polycrystalline silicon is mainly concentrated at the macroscopic scale,with relatively less research at the mesoscopic and microscopic ***,we utilize the method of physical polishing to obtain polysilicon characterization samples and then the paper utilizes metallographic microscopy,scanning electron microscopy-electron backscatter diffraction technology,and aberration-corrected transmission electron microscopy technology to observe and characterize the interface region between silicon core and matrix in the deposition process of electronic-grade polycrystalline silicon,providing a full-scale characterization of the interface morphology,grain structure,and orientation distribution from macro to ***,the paper illustrates the current uncertainties regarding polycrystalline silicon.

关键词： Polysilicon silicon core matrix interface metallographic microscopy EBSD

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基于无差拍电流预测控制的永磁同步电机谐波电流抑制策略

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电工技术学报 2022年第24期37卷 6345-6356页

作者：谷鑫鲁金月王志强金雪峰陈炜高效能电机系统智能设计与制造国家地方联合工程研究中心(天津工业大学) 天津300387

为解决永磁同步电机在运行过程中三相电流发生畸变、谐波含量高等问题,该文提出一种新的谐波电流抑制方法。首先分析了各次谐波电流在对应同步旋转坐标系下的表现形式,并在此基础之上设计了闭环谐波电流检测系统对谐波电流进行提取,最... 详细信息

为解决永磁同步电机在运行过程中三相电流发生畸变、谐波含量高等问题,该文提出一种新的谐波电流抑制方法。首先分析了各次谐波电流在对应同步旋转坐标系下的表现形式,并在此基础之上设计了闭环谐波电流检测系统对谐波电流进行提取,最后采用无差拍电流预测控制策略生成补偿电压用于抑制谐波电流。仿真与实验结果表明,该方法可以有效抑制谐波电流,提高电机三相电流的正弦度,并且具有计算简单、易于实现的特点。

关键词：永磁同步电机谐波电流谐波抑制同步旋转坐标系无差拍电流预测控制

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张力性刺激对人髓核细胞表达软骨层间蛋白的调控及机制

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中国脊柱脊髓杂志 2017年第2期27卷 169-174页

作者：何晋月孙靖路康周跃潘勇第三军医大学新桥医院骨科重庆市400038

目的:探索张力性刺激对人椎间盘髓核细胞分泌软骨层间蛋白(cartilage intermediate layer protein,CILP)的影响及其机制。方法:选取2016年6月在我院因创伤性骨折行L4/5椎间盘摘除及相邻椎体融合手术的1例38岁男性患者的髓核组织作为细... 详细信息

目的:探索张力性刺激对人椎间盘髓核细胞分泌软骨层间蛋白(cartilage intermediate layer protein,CILP)的影响及其机制。方法:选取2016年6月在我院因创伤性骨折行L4/5椎间盘摘除及相邻椎体融合手术的1例38岁男性患者的髓核组织作为细胞来源,术前MRI示该节段椎间盘组织改良Pfirrmann分级为Ⅱ级,分离培养其中的髓核细胞并传代至第3代,进行力学实验。使用Flexcell 5000系统通过电脑控制气压变化来使载有细胞的塑料膜发生形变,进而对膜载体上的细胞给予不同强度、时长的张力性力学加载。实验组分为4组,均以10%的拉伸量为刺激强度,给予不同时长(6h、12h、24h、48h)的刺激,空白对照组不给予任何刺激。利用RT-q PCR技术检测各组CILP的基因表达量,选出表达变化最为明显的一组,以该组的刺激时长为限,再将实验组分为3组,分别给予不同刺激强度(5%、10%、20%)的张力刺激,空白对照组不给予任何刺激,利用RTq PCR技术检测各组CILP的基因表达。选取相比较于对照组CILP增长效应最明显的力学强度和时长作为刺激条件,测定髓核细胞在该实验条件下smad3的磷酸化程度,并对髓核细胞预先给予smad3磷酸化的特异性抑制剂SIS3处理后再置于同一力学条件下,以RT-q PCR检测CILP的基因表达量,以此观察smad信号通路是否介导了张力性刺激对于髓核细胞CILP表达的调控。实验结果使用配对t检验以及单因素方差分析进行组间比较。结果:RT-q PCR结果显示,相较于空白对照组,不同刺激时长的10%张力性刺激均明显下调了CILP的表达,其中在刺激48h后对CILP的抑制效应达到最大(P0.05),10%的张力刺激48h明显降低CILP的表达(P<0.05),20%的张力刺激48h显著提高CILP表达量(P<0.05)且smad3的磷酸化水平相对于空白对照组明显增高;相对于只给予20%张力刺激的对照组,先给予SIS3预处理再给予相同力学刺激的实验组的CILP表达水平显著下调(P<0.05)。结论:张力性刺激调控髓核细胞的CILP表达,调控效应随着刺激时长和刺激强度的变化而不同;smad信号通路参与高强度的张力性刺激对CILP的上调效应。

关键词：髓核细胞软骨层间蛋白张力 Smad信号通路椎间盘退变

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无人机载多普勒分集前视合成孔径雷达成像方法

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电子与信息学报 2019年第12期41卷 2852-2858页

作者：孟智超卢景月谢朋飞张磊王虹现西安电子科技大学雷达信号处理国家重点实验室西安710071 中山大学电子与通信工程学院广州510275

前视合成孔径雷达(SAR)成像存在多普勒左右模糊的问题,需要利用空域资源进行解模糊处理。限于无人机(UAV)的载重与尺寸,接收阵列通常较小,解多普勒模糊的空域波束形成能力不足。此外,前视SAR回波方位多普勒梯度小、带宽窄,使得接收带宽... 详细信息

前视合成孔径雷达(SAR)成像存在多普勒左右模糊的问题,需要利用空域资源进行解模糊处理。限于无人机(UAV)的载重与尺寸,接收阵列通常较小,解多普勒模糊的空域波束形成能力不足。此外,前视SAR回波方位多普勒梯度小、带宽窄,使得接收带宽未被充分利用。基于以上问题,该文提出多普勒分集前视SAR成像方法。该算法在前视SAR成像技术的基础上,利用多普勒分集MIMO技术,将多普勒窄带前视回波调制于不同多普勒中心以达到充分利用多普勒接收带宽的目的。进而,可获得一个数倍于真实接收阵列孔径的虚拟接收阵列,极大地扩展了接收通道,有效地改善了前视SAR成像解多普勒左右模糊的性能。

关键词：前视SAR成像多输入多输出雷达多普勒分集自适应波束形成

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Acetylene hydrochlorination over supported ionic liquid phase(SILP)gold-based catalyst:Stabilization of cationic Au species via chemical activation of hydrogen chloride and corresponding mechanisms

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Chinese Journal of Catalysis 2021年第2期42卷 334-346页

作者： Jia Zhao Saisai Wang Bolin Wang Yuxue Yue Chunxiao Jin jinyue lu Zheng Fang Xiangxue Pang Feng Feng Lingling Guo Zhiyan Pan Xiaonian Li Industrial Catalysis Institute of Zhejiang University of Technology Hangzhou 310014ZhejiangChina Department of Environmental Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina

The activation of HCl by cationic Au in the presence of C2H2 is important for the construction of active Au sites and in acetylene ***,we report a strategy for activating HCl by the Au-based supported ionic liquid phase(Au–SILP)technology with the[N(CN)2^–]*** strategy enables HCl to accept electrons from[N(CN)2^–]anions in Au–[N(CN)2^–]complexes rather than from pure[Bmim][N(CN)2],leading to notable improvement in both the reaction path and the stability of the catalyst without changing the reaction triggered by acetylene ***,the induction period of the Au–SILP catalyst was shown to be absent in the reaction process due to the high Au(III)content in the Au(Ⅲ)/Au(Ⅰ)site and the high substrate diffusion rate in the ionic liquid *** work provides a facile method to improve the stability of Au-based catalysts for acetylene hydrochlorination.

关键词： Acetylene hydrochlorination Electron density Hydrogen chloride activation Stabilization mechanism Gold-based supported ionic liquid phase catalyst

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