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High-performance formaldehyde prediction for indoor air quality assessment using time series deep learning

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Building Simulation 2024年第3期17卷 415-429页

作者： Liu Lu Xinyu Huang Xiaojun Zhou Junfei Guo Xiaohu Yang jinyue Yan School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’anChina Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina Future Energy Profile School of BusinessSocietyand EngineeringMälardalen UniversityVästeråsSweden

Indoor air pollution resulting from volatile organic compounds(VOCs),especially formaldehyde,is a significant health concern needed to predict indoor formaldehyde concentration(Cf)in green intelligent building design.This study develops a thermal and wet coupling calculation model of porous fabric to account for the migration of formaldehyde molecules in indoor air and cotton,silk,and polyester fabric with heat flux in Harbin,Beijing,Xi’an,Shanghai,Guangzhou,and Kunming,China.The time-by-time indoor dry-bulb temperature(T),relative humidity(RH),and Cf,obtained from verified simulations,were collated and used as input data for the long short-term memory(LSTM)of the deep learning model that predicts indoor multivariate time series Cf from the secondary source effects of indoor fabrics(adsorption and release of formaldehyde).The trained LSTM model can be used to predict multivariate time series Cf at other emission times and locations.The LSTM-based model also predicted Cf with mean absolute percentage error(MAPE),symmetric mean absolute percentage error(SMAPE),mean absolute error(MAE),mean square error(MSE),and root mean square error(RMSE)that fell within 10%,10%,0.5,0.5,and 0.8,respectively.In addition,the characteristics of the input dataset,model parameters,the prediction accuracy of different indoor fabrics,and the uncertainty of the data set are analyzed.The results show that the prediction accuracy of single data set input is higher than that of temperature and humidity input,and the prediction accuracy of LSTM is better than recurrent neural network(RNN).The method’s feasibility was established,and the study provides theoretical support for guiding indoor air pollution control measures and ensuring human health and safety.

关键词： multivariate time series formaldehyde concentration deep learning heat-humidity coupling mass transfer secondary source effect

Diet and physical activity influence the composition of gut microbiota,benefit on Alzheimer's disease

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Food Science and Human Wellness 2024年第2期13卷 541-555页

作者： jinyue Zhou Min Tang Wanyi Li Rui Fang Chunlan Tang Qinwen Wang 无 School of Public Health Health Science CenterNingbo UniversityNingbo 315211China Department of Neurology Ningbo Rehabilitation HospitalNingbo 3151000China Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315100China Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Ningbo 315100China

Alzheimer's disease is a neurodegenerative disease with complex etiology.Gut microbiota influences the gutbrain axis,which may affect pathways related to the pathogenesis of Alzheimer's disease.Additionally,diet and physical activity are likely to affect the pathology of Alzheimer's disease as well as the gut microbiota.This demonstrates that it may be possible to prevent or halt the progression of Alzheimer's disease by regulating the gut microbiota using diet and physical activity strategies.Therefore,the present study reviews the association between these two interventions and gut microbiota in the human body.It also summarizes how these two interventions benefit Alzheimer's disease.Furthermore,the primary limitations of these two interventions are discussed and promising strategies are proposed,which may be beneficial to further study and develop the intervening measure for the progression of Alzheimer's disease.

关键词： Alzheimer’s disease Gut microbiota Brain-gut axis Diet Physical activity

Effects of alcohol on digestion,absorption and metabolism of sea cucumber saponins in healthy mice

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Food Science and Human Wellness 2024年第1期13卷 137-145页

作者： Wenxian Dang Rong Li jinyue Yang Changhu Xue Qingrong Huang Yuming Wang Tiantian Zhang College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Department of Food Science Rutgers State University New BrunswickNJ 08901USA

Sea cucumber saponins have attracted more attention in recent years due to biological activities.It is a popular practice to soak sea cucumber in Baijiu at home and being applied to industrial manufacturing in China.However,knowledge of the effect of alcohol on the absorption and metabolism of sea cucumber saponins is limited.The effects of alcohol on digestion,absorption and metabolism of sea cucumber saponins in BALB/c mice were investigated after gavage and tail intravenous injection.The results showed that the content of saponins in serum and liver was significantly higher under the influence of alcohol than that in the control group after oral administration.Alcohol promoted the absorption of sea cucumber saponins prototype as well as inhibited the process of saponins being transformed into deglycositic metabolites in the small intestine.Moreover,sea cucumber saponins remained in circulation for a long time and alcohol slowed down the clearance of sea cucumber saponins under the influence of alcohol after intravenous injection.This confirmed the feasibility of marinating sea cucumber in Baijiu to improve the efficacy of saponins and provides an important theoretical basis for the utilization of sea cucumber and the development of sea cucumber liquor.

关键词： Holothurin A Echinoside A Alcohol Absorption Metabolism

Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet

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Food Science and Human Wellness 2024年第2期13卷 649-658页

作者： Chengcheng Wang Xuefeng Duan Xiaoyue Li jinyue Yang Changhu Xue Teruyoshi Yanagita Tiantian Zhang Yuming Wang College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Laboratory of Nutrition Biochemistry Department of Applied Biochemistry and Food ScienceSaga UniversitySaga 840-8502Japan

Trimethylamine N-oxide(TMAO)is a risk factor of various chronic diseases,which was produced by metabolism from precursors to trimethylamine(TMA)in gut and the oxidation from TMA in liver.The TMA generation was influenced by diet,mainly due to the rich TMAO precursors in diet.However,it was still unclear that the effects of different proportion and source of macronutrients in different dietary pattern on the production process of TMAO.Here,the generation of TMA from precursors and TMAO from TMA was determined after single oral choline chloride and intraperitoneal injection TMA,respectively,in mice fed with carbohydrates,proteins and fats in different proportion and sources.The results suggested that the generation of TMAO was increased by low non-meat protein and high fat via enhancing the production of TMAO from TMA,and decreased by plant protein and refined sugar via reducing TMA production from precursors in gut and TMAO transformation from TMA in liver.The high fat and high sugar diets accelerating the development of atherosclerosis did not increase the production of TMAO,the risk factor for atherosclerosis,which indicated that the dietary compositions rather than the elevated TMAO level might be a more key risk factor for atherosclerosis.

关键词： Trimethylamine N-oxide(TMAO) Trimethylamine(TMA) Dietary composition Macronutrients Gut microbiota

Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells

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genes & Diseases 2024年第2期11卷 535-538页

作者： Xi Kong Peng Lu jinyue Zhang Zheng Bao Chenghao Kuang Bingqing Xie Jianhua Peng Ning Ma Yong Jiang Shigang Yin Laboratory of Neurological Diseases and Brain Function The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Institute of Epigenetics and Brain Science Southwest Medical UniversityLuzhouSichuan 646000China Department of Neurosurgery The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Inflammation and Allergic Diseases Research Unit The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China

SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following neuroinvasion.It is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal cells.Herein,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.

关键词： invasion homeostasis maintain

LncPheDB:a genome-wide lncRNAs regulated phenotypes database in plants

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aBIOTECH 2022年第3期3卷 169-177页

作者： Danjing Lou Fei Li jinyue ge Weiya Fan Ziran Liu Yanyan Wang Jingfen Huang Meng Xing Wenlong Guo Shizhuang Wang Weihua Qiao Zhenyun Han Qian Qian Qingwen Yang Xiaoming Zheng National Key Facility for Crop gene Resources and genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing100081China College of Life Science Shenyang Normal UniversityShenyang110034China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya572000China State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou310006China Agricultural genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen518120China International Rice Research Institute DAPO box 7777Metro ManilaThe Philippines

LncPheDB(https://***/)is a systematic resource of genome-wide long non-coding RNAs(lncRNAs)-phenotypes associations for multiple species.It was established to display the genome-wide lncRNA annotations,target genes prediction,variant-trait associations,gene-phenotype correlations,lncRNA-phenotype correlations,and the similar non-coding regions of the queried sequence in multiple species.LncPheDB sorted out a total of 203,391 lncRNA sequences,2000 phenotypes,and 120,271 variants of nine species(Zea mays L.,Gossypium barbadense L.,Triticum aestivum L.,Lycopersicon esculentum Mille,Oryza sativa L.,Hordeum vulgare L.,Sorghum bicolor L.,Glycine max L.,and Cucumis sativus L.).By exploring the relationship between lncRNAs and the genomic position of variants in genome-wide association analysis,a total of 68,862 lncRNAs were found to be related to the diversity of agronomic traits.More importantly,to facilitate the study of the functions of lncRNAs,we analyzed the possible target genes of lncRNAs,constructed a blast tool for performing similar fragmentation studies in all species,linked the pages of phenotypic studies related to lncRNAs that possess similar fragments and constructed their regulatory networks.In addition,LncPheDB also provides a user-friendly interface,a genome visualization platform,and multi-level and multi-modal convenient data search engine.We believe that LncPheDB plays a crucial role in mining lncRNA-related plant data.

关键词： LncRNA GWAS Phenotype SNP Plants

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某会展中心项目二期工程水系统设计优化分析

给水排水 2024年第5期50卷 84-88,94页

作者：施锦岳同济大学建筑设计研究院(集团)有限公司上海200092

给排水系统设计是大型会展工程设计的重点和难点之一,系统的优劣直接会影响会展后期运营、使用及维护。将某大型国际会展中心项目二期工程的给排水及消防系统,与一期系统进行对比,总结了大型会展项目在给排水及消防系统上的给排水系统... 详细信息

给排水系统设计是大型会展工程设计的重点和难点之一,系统的优劣直接会影响会展后期运营、使用及维护。将某大型国际会展中心项目二期工程的给排水及消防系统,与一期系统进行对比,总结了大型会展项目在给排水及消防系统上的给排水系统设计原则和思路,采用大空间消防炮灭火系统和地埋式消火栓对展厅进行保护,并设置成品展位箱作为布展接口。

关键词：大型会展室内消火栓自动洒水灭火系统固定消防水炮灭火系统

中国台湾“代理人”对美国国会的游说(2021~2023)——基于美国司法部档案的微观考察

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美国研究 2024年第3期38卷 85-106,6,7页

作者：郭金月中国国际问题研究院美国研究所

2021年1月至2023年1月,共有12家机构在美国司法部登记为中国台湾“代理人”并进行游说活动,其中多数与台渊源较深。台“代理人”围绕美国和中国台湾政要互动、经贸及防务、涉台立法、涉台舆论、新冠疫情及台谋求加入世界卫生组织等议题... 详细信息

2021年1月至2023年1月,共有12家机构在美国司法部登记为中国台湾“代理人”并进行游说活动,其中多数与台渊源较深。台“代理人”围绕美国和中国台湾政要互动、经贸及防务、涉台立法、涉台舆论、新冠疫情及台谋求加入世界卫生组织等议题对117届国会展开游说。相比众议员、非现任议员和共和党议员候选人,台“代理人”更倾向于为参议员、现任议员和民主党议员候选人捐款。台“代理人”的游说活动在议员拥有自主权的领域取得一定成效,但也受到美国联邦政府行政分支的考量、国际形势及游说机构工作效率等因素制约。

关键词：美国军事与外交中国台湾问题游说外国代理人 117届国会

genome-wide selection and introgression of Chinese rice varieties during breeding

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Journal of genetics and genomics 2022年第5期49卷 492-501页

作者： jinyue ge Junrui Wang Hongbo Pang Fei Li Danjing Lou Weiya Fan Ziran Liu Jiaqi Li Danting Li Baoxuan Nong Zongqiong Zhang Yanyan Wang Jingfen Huang Meng Xing Yamin Nie Xiaorong Xiao Fan Zhang Wensheng Wang Jianlong Xu Sung Ryul Kim Ajay Kohli Guoyou Ye Weihua Qiao Qingwen Yang Xiaoming Zheng National Key Facility for Crop gene Resources and genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Guangxi Key Laboratory for Polysaccharide Materials and Modifications School of Marine Sciences and BiotechnologyGuangxi University for NationalitiesNanningJiangsu 530006China College of Life Science Shenyang Normal UniversityShenyangJilin 110034China Liaoning Institute of Pomology YingkouLiaoning 115009China Rice Research Institute Guangxi Academy of Agricultural ScienceNanningGuangxi 530007China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanyaHainan 572000China International Rice Research Institute DAPO box 7777MetroManilaPhilippines Crop Biotech Institute&Department of genetic Engineering Kyung Hee UniversityYongin 446-701Republic of Korea

China is the largest rice-producing country,but the genomic landscape of rice diversity has not yet been clarified.In this study,we re-sequence 1070 rice varieties collected from China(400)and other regions in Asia(670).Among the six major rice groups(aus,indica-I,indica-II,aromatic,temperate japonica,and tropical japonica),almost all Chinese varieties belong to the indica-II or temperate japonica group.Most Chinese indica varieties belong to indica-II,which consists of two subgroups developed during different phases of rice breeding.The genomic segments underlying the differences between these subgroups span36.32 Mb.The Chinese japonica rice varieties fall into the temperate japonica group,consisting of two subgroups based on their geographical distribution.The genomic segments underlying the differences between these subgroups span 27.69 Mb.These differentiated segments in the Chinese indica varieties span 45 genes with nonsynonymous mutations that are closely related to variations in plant height and grain width.Fifty-four genes with nonsynonymous mutations are associated with the differences in heading date between the two Chinese japonica subgroups.These findings provide new insights into rice diversity in China that will facilitate the molecular breeding.

关键词： Rice genome selection Introgression Agronomic traits Breeding