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Science China(Life Sciences) 2024年第4期67卷 839-842页

作者： jinyuan Tao Zijie Pan Wenwen Kong Beixin Mo Xuemei chen Yu Yu Guangdong Provincial Key Laboratory for Plant Epigenetics Longhua Bioindustry and Innovation Research InstituteCollege of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China School of Life Sciences Peking-Tsinghua Joint Center for Life SciencesPeking UniversityBeijing 100871China

Dear Editor,The process of anther development is generally conserved across plant species(Ma,2005).Many protein-coding genes and noncoding RNAs have been identified to participate in early anther development in Arabidopsis(Walbot and Egger,2016).mi R319 is one of the most ancient and conserved mi RNA families in land plants(Chávez Montes et al.,2014).

关键词： Arabidopsis miR319 ancient

An alternative approach to improve the compatibility of PCE in cement paste blend with coal gangue powder

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Waste Disposal and Sustainable Energy 2024年第1期6卷 139-150页

作者： Zonglin Xie Yuxuan Li Dahui Sun Yi Tian jinyuan Hu Qiang Yuan Zheng chen School of Civil Engineering Central South UniversityChangshaChina China Railway NO.9 Group CO. LTDShenyangChina National Engineering Research Center for High-Speed Railway Construction Technology ChangshaChina Guangxi Key Laboratory of Disaster Prevention and Engineering Safety Guangxi UniversityNanningChina

Coal gangue(CG)is an environmental waste that faces an urgent demand for disposal in China.The utilization of CG in construction materials has broad application prospects and gained increasing interest.However,the poor compatibility of polycarboxylate superplasticizer(PCE)with CG powder hinders its efficiency in a wide range of applications.Here,this paper attempts to improve the compatibility of PCE with CG powder in cement paste based on the regulation of aggregation and the adsorption behavior of PCE.Dynamic light scattering(DLS)and fluorescence spectroscopy tests were carried out to understand the improved mechanism.The results indicated that the addition of CG powder increases the ionic strengths of the cement liquid phase,which makes PCE tend to aggregate at a lower concentration compared with no CG powder introduction.Adding(CH_(3)COO)_(2)Cu is beneficial for enhancing the workability of cement paste by reducing PCE aggregation while maintaining the compressive strength of cement specimens.Therefore,(CH_(3)COO)_(2)Cu extra addition can be regarded as an effective and sustainable way to improve the workability of cement paste with CG powder.

关键词： Coal gangue powder Polycarboxylate superplasticizer Compatibility Aggregation

Exosomal circular RNAs inglioma:coexistenceof opportunitiesand challenges forapplication

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Chinese Medical Journal 2022年第13期135卷 1528-1530页

作者： Xiaoyong chen jinyuan chen Yue chen Honghai You Yuanxiang Lin Zanyi Wu Dezhi Kang chenyu Ding Department of Neurosurgery Neurosurgical Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Department of Ophthalmology The First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina The Graduate School of Fujian Medical University FuzhouFujianChina Fujian Provincial Key Laboratory of Precision Medicine for Cancer The First Affiliated HospitalFujan Medical UniversityFuzhouFujianChina Key Laboratory of Radiation Biology of Fujian Higher Education Instions The First Affiliated HospitalFujian Medical UniversitFuzhouFujianChina Fujian Provincial Insttutes of Brain Disorders and Brain Sciences FuzhouFujianChina Fujian Provincial Clinical Research Center for Neurological Diseases FuzhouFujianChina.

Glioma is the most common primary tumor in the central nervous system.With the help of intercellular communication,glioma cells have the ability to survive in the tumor microenvironment(TME)and make it more suitable.

关键词： glioma tumor circular

设计思维创新:发展演化、过程机制与实践原则

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科研管理 2024年第5期45卷 43-55页

作者：陶金元陈劲北京联合大学管理学院北京100101 清华大学经济管理学院北京100084 清华大学技术创新研究中心北京100084

对复杂问题高效求解并达成创新性解决方案是组织打造核心竞争力的关键,这必然要以科学规范的方法论作为依据。设计思维创新致力于问题导向的创新而不断发展演化,但因其分散的实践而呈现出碎片化和经验化特征。系统梳理设计思维创新的发... 详细信息

对复杂问题高效求解并达成创新性解决方案是组织打造核心竞争力的关键,这必然要以科学规范的方法论作为依据。设计思维创新致力于问题导向的创新而不断发展演化,但因其分散的实践而呈现出碎片化和经验化特征。系统梳理设计思维创新的发展脉络,夯实其哲学基础并深入阐释理论框架、过程机制和实践原则,对推进理论发展和提高创新绩效具有重要意义。本文通过文献可视化对比分析刻画了设计思维理论研究的趋势、重点及其脉络关系,进而遵循辩证唯物主义方法论的内涵结构和因果过程逻辑构建了设计思维创新的分析框架,并结合重点文献就其核心要素及过程机制进行了系统剖析。研究发现:(1)设计思维创新致力于复杂问题的求解并因实践需要而发展演化;(2)设计思维创新秉承人本主义的价值导向和实用主义的效果逻辑;(3)设计思维创新强调非线性迭代机制、综合性实践工具和跨学科领域的系统融合;(4)适用于整体创新流程和主题环节的实践原则为设计思维创新效率提供保障。本研究为推动问题导向的创新提供了系统的理论依据和丰富的工具方法,有助于组织提升创新绩效和打造核心竞争力;研究结论为在发挥制度优势基础上推动中国式创新理论发展和加速中国创新发展战略提供了参考借鉴。

关键词：设计思维创新方法论核心理念过程机制实践原则

Simultaneously realizing thermal andelectromagnetic cloaking by multi-physicalnull medium

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Opto-Electronic Science 2024年第2期3卷 45-59页

作者： Yichao Liu Xiaomin Ma Kun Chao Fei Sun Zihao chen jinyuan Shan Hanchuan chen Gang Zhao Shaojie chen Key Lab of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi ProvinceCollege of Electronic Information and Optical EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Simultaneously manipulating multiple physical fields plays an important role in the increasingly complex integrated systems,aerospace equipment,biochemical productions,etc.For on-chip systems with high integration level,the precise and efficient control of the propagation of electromagnetic waves and heat fluxes simultaneously is particularly important.In this study,we propose a graphical designing method(i.e.,thermal-electromagnetic surface transformation)based on thermal-electromagnetic null medium to simultaneously control the propagation of electromagnetic waves and thermal fields according to the pre-designed paths.A thermal-electromagnetic cloak,which can create a cloaking effect on both electromagnetic waves and thermal fields simultaneously,is designed by thermal-electromagnetic surface transformation and verified by both numerical simulations and experimental measurements.The thermal-electromagnetic surface transformation proposed in this study provides a new methodology for simultaneous controlling on electromagnetic and temperature fields,and may have significant applications in improving thermal-electromagnetic compatibility problem,protecting of thermal-electromagnetic sensitive components,and improving efficiency of energy usage for complex onchip systems.

关键词： transformation optics multi-physical cloak null medium

Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： jinyuan Wang Jinlu Zhang Shicheng Yu Hongyan Li Shaohong chen Jingting Luo Haibo Wang Yuxia Guan Haihan Zhang Shiyi Yin Huili Wang Heping Li Junle Liu Jingyuan Zhu Qiong Yang Ying Sha Chuan Zhang Yuhang Yang Xuan Yang Xifang Zhang Xiuli Zhao Likun Wang Liping Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available treatment.Here,we report the results of the first-in-human clinical trial(NCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 days.This open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/8-hCYP4V2.Overall,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were observed.Compared with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the treatment.We conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline

Characterization of SH3GLB1 in the Checkfor auditory system and its potential role in updates mitophagy

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Genes & Diseases 2024年第4期11卷 61-64页

作者： Xue Gao Weiqian Wang Jincao Xu Shasha Huang Kun Yang jinyuan Yang Yijin chen Guojian Wang Mingyu Han Zhendong Wang Dongyang Kang Yongyi Yuan Pu Dai College of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijing 100853China National Clinical Research Center for Otolaryngologic Diseases State Key Lab of Hearing ScienceMinistry of EducationBeijing 100853China Beijing Key Lab of Hearing Impairment Prevention and Treatment Chinese PLA Medical SchoolBeijing 100853China Department of Otolaryngology PLA Rocket Force Characteristic Medical CenterBeijing 100088China

Mitochondria energize the inner ear to maintain the cochlear potential createdbythe striavascularis,assist the motility of outer hair cells,perform synaptic processes,and maintain the spontaneous and sound-driven discharges of the spiral ganglion neurons(SGNs).Mitophagy deficiencies induce the accumulation of damaged organelles and mitochondria in cells and are a primary cause of drug-induced hearing loss.

关键词： auditory maintain potential

Preparation and properties of hollow fibre nanofiltration membrane with continuous coffee-ring structure

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 351-362页

作者： Xiuzhen Wei Xufeng Xu Yi chen Qian Zhang Lu Liu Ruiyuan Yang jinyuan chen Bosheng Lv College of Environment Zhejiang University of TechnologyHangzhou 310014China Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Hangzhou 310014China

Polyamide(PA)hollow fibre composite nanofiltration(NF)membranes with a coffee-ring structure and beneficial properties were prepared by adding graphene oxide(GO)into the interfacial polymerization process.The presentation of the coffee-ring structure was attributed to the heterogeneous,finely dispersed multiphase reaction system and the“coffee-stain”effect of the GO solution.When the piperazine concentration was 0.4 wt-%,the trimesoyl chloride concentration was 0.3 wt-%,and the GO concentration was 0.025 wt-%,the prepared NF membranes showed the best separation properties.The permeate flux was 76 L·m^(−2)·h^(−1),and the rejection rate for MgSO4 was 98.6%at 0.4 MPa.Scanning electron microscopy,atomic force microscopy,and attenuated total reflectance-Fourier transform infrared spectroscopy were used to characterize the chemical structure and morphology of the PA/GO NF membrane.The results showed that GO was successfully entrapped into the PA functional layer.Under neutral operating conditions,the PA/GO membrane showed typical negatively charged NF membrane separation characteristics,and the rejection rate decreased in the order of Na2SO_(4)>MgSO_(4)>MgCl_(2)>NaCl.The PA/GO NF membrane showed better antifouling performance than the PA membrane.

关键词： GO PA interfacial polymerization hollow fibre NF membrane

参建通道经济能促进欠发达地区对外开放吗--来自西部陆海新通道的经验证据

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国际贸易问题 2024年第1期 105-121页

作者：陈万灵陈金源温可仪广东外语外贸大学经济贸易学院

高质量共建西部陆海新通道是加快构建“双循环”新发展格局,引领西部欠发达地区对外开放的重要举措。本文以是否参建西部陆海新通道为分组依据,在充分识别异质性处理效应的基础上构建多期双重差分模型,对欠发达地区参建通道经济的对外... 详细信息

高质量共建西部陆海新通道是加快构建“双循环”新发展格局,引领西部欠发达地区对外开放的重要举措。本文以是否参建西部陆海新通道为分组依据,在充分识别异质性处理效应的基础上构建多期双重差分模型,对欠发达地区参建通道经济的对外开放效应展开经验分析。研究发现:参建通道经济持续带动了欠发达地区的对外开放,促进贸易开放与投资开放上涨6.8%与1.6%,但该效应存在显著的时空异质性;参建通道经济通过改善交通基础设施“硬联通”建设,优化资源要素配置与弥补欠发达地区不利的开放初始条件推动对外开放,但未能带动民心文化等“软联通”建设;西部陆海新通道成为服务国家战略的国际开放大通道,推动欠发达地区与“一带一路”倡议的开放联动,中新(重庆)战略性互联互通示范项目开放特色显著,但开放不均衡的难题亟待解决。本研究对高质量建设西部陆海新通道,促进中国更高水平的向西开放具有重要意义。

关键词：西部陆海新通道对外开放通道经济 “一带一路”倡议

国际贸易通道建设与中国向西开放--来自西部陆海新通道的经验证据

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南方经济 2024年第3期 101-120页

作者：汪田姣陈金源温可仪华南师范大学经济与管理学院、广东省国际经贸发展中心 510080 广东外语外贸大学经济贸易学院

向西融入共建“一带一路”,开辟国际贸易新通道是新时期中国高水平对外开放的重要命题。文章基于2010—2022年中国31个省份层面的面板数据,以西部陆海新通道建设为准自然实验,采用多期双重差分法系统研究国际贸易新通道建设对中国“向... 详细信息

向西融入共建“一带一路”,开辟国际贸易新通道是新时期中国高水平对外开放的重要命题。文章基于2010—2022年中国31个省份层面的面板数据,以西部陆海新通道建设为准自然实验,采用多期双重差分法系统研究国际贸易新通道建设对中国“向西开放”的影响效应与作用机制。研究发现,西部陆海新通道建设显著促进了中国“向西开放”,政策效应集中于主通道区域与沿海地区,且主要促进了中国与发展中国家、“一带一路”国家与RCEP国家的向西出口开放水平。西部陆海新通道建设主要通过传统基础设施、数字基础设施完善带来的的贸易成本节约效应与市场资源的整合效应带动中国“向西开放”。拓展研究表明,西部陆海新通道的“向西开放”效应存在可持续与可推广性质,其出口溢出效应主要来源于周边地区合作共建的贸易创造而非贸易转移。文章为中国开辟更多“向西开放”国际贸易新通道,规避中美贸易摩擦、全球价值链低端锁定等“向东开放”传统问题提供经验证据,为推进高水平对外开放提供政策启示。

关键词：国际贸易通道西部陆海新通道向西开放“一带一路”倡议