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Energy and Parameter Analysis of SOFC System for Hydrogen Production from Methane Steam Reforming

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Journal of Thermal Science 2022年第6期31卷 2088-2110页

作者： DENG Meilong liu jinyi ZHANG Xiaosong LI Jinsong FU Lirong School of Mechanics and Electronics Engineering Hainan UniversityHaikou 570228China

In this paper, an integrated system of solid oxide fuel cell(SOFC) and methane steam reforming for hydrogen production is proposed. The mathematical model of the coupled integrated system is studied by COMSOL and Aspen software, and the energy analysis of the integrated system is carried out. The system recovers and reuses the waste heat of the SOFC stack through the heat exchanger, which can realize the cascade efficient use of energy. By adjusting the different reforming temperatures, steam-to-carbon ratio and SOFC operating temperature of methane steam reforming to produce hydrogen, the parameters that have a greater impact on the system are studied. The research results show that as the steam-to-carbon ratio and reformer operating temperature increase, the net output power and efficiency of the system increase. When the fuel cell operating temperature is 800℃, the output power and efficiency of the system reach the maximum values of 899.93 W and 52.52%, respectively. Increasing the operating temperature of SOFC helps to improve the efficiency of fuel cells, but the efficiency of the integrated system of methane steam reforming hydrogen production and SOFC first increases and then decreases. This system can realize the direct coupling between the SOFC reactor subsystem and the methane steam reforming hydrogen production system under optimized conditions, which has reference significance for the actual operating conditions of the coupled system.

关键词： SOFC methane steam reformer hydrogen mathematical model system optimization

3-O-Acetyl-11-keto-β-boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma

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Acta Pharmaceutica Sinica B 2020年第2期10卷 301-312页

作者： Wan Li Liwen Ren Xiangjin Zheng Jinyi Liu Jinhua Wang Tengfei Ji Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

Glioblastoma is the most common and aggressive primary tumor in the central nervous system,accounting for 12%-15%of all brain tumors.3-O-Acetyl-11-keto-β-boswellic acid(AKBA),one of the most active ingredients of gum resin from Boswellia carteri Birdw.,was reported to inhibit the growth of glioblastoma cells and subcutaneous glioblastoma.However,whether AKBA has antitumor effects on orthotopic glioblastoma and the underlying mechanisms are still unclear.An orthotopic mouse model was used to evaluate the anti-glioblastoma effects of AKBA.The effects of AKBA on tumor growth were evaluated using MRI.The effects on the alteration of metabolic landscape were detected by MALDIMSI.The underlying mechanisms of autophagy reducing by AKBA treatment were determined by immunoblotting and immunofluorescence,respectively.Transmission electron microscope was used to check morphology of cells treated by AKBA.Our results showed that AKBA(100 mg/kg)significantly inhibited the growth of orthotopic U87-MG gliomas.Results from MALDI-MSI showed that AKBA improved the metabolic profile of mice with glioblastoma,while immunoblot assays revealed that AKBA suppressed the expression of ATG5,p62,LC3 B,p-ERK/ERK,and P53,and increased the ratio of p-mTOR/mTOR.Taken together,these results suggested that the antitumor effects of AKBA were related to the normalization of aberrant metabolism in the glioblastoma and the inhibition of autophagy.AKBA could be a promising chemotherapy drug for glioblastoma.

关键词： Glioblastoma AKBA MALDI-MSI Phospholipids Autophagy

Tumorigenic bacteria in colorectal cancer:mechanisms and treatments

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Cancer Biology & Medicine 2022年第2期19卷 147-162页

作者： Sha Li Jinyi Liu Xiangjin Zheng Liwen Ren Yihui Yang Wan Li Weiqi Fu Jinhua Wang Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

Colorectal cancer(CRC)is the third most common and the second most fatal cancer.In recent years,more attention has been directed toward the role of gut microbiota in the initiation and development of CRC.Some bacterial species,such as Fusobacterium nucleatum,Escherichia coli,Bacteroides fragilis,Enterococcus faecalis,and Salmonella sp.have been associated with CRC,based upon sequencing studies in CRC patients and functional studies in cell culture and animal models.These bacteria can cause host DNA damage by genotoxic substances,including colibactin secreted by pks+Escherichia coli,B.fragilis toxin(BFT)produced by Bacteroides fragilis,and typhoid toxin(TT)from Salmonella.These bacteria can also indirectly promote CRC by influencing host-signaling pathways,such as E-cadherin/β-catenin,TLR4/MYD88/NF-κB,and SMO/RAS/p38 MAPK.Moreover,some of these bacteria can contribute to CRC progression by helping tumor cells to evade the immune response by suppressing immune cell function,creating a proinflammatory environment,or influencing the autophagy process.Treatments with the classical antibacterial drugs,metronidazole or erythromycin,the antibacterial active ingredients,M13@Ag(electrostatically assembled from inorganic silver nanoparticles and the protein capsid of bacteriophage M13),berberine,and zerumbone,were found to inhibit tumorigenic bacteria to different degrees.In this review,we described progress in elucidating the tumorigenic mechanisms of several CRC-associated bacteria,as well as progress in developing effective antibacterial therapies.Specific bacteria have been shown to be active in the oncogenesis and progression of CRC,and some antibacterial compounds have shown therapeutic potential in bacteria-induced CRC.These bacteria may be useful as biomarkers or therapeutic targets for CRC.

关键词： Colorectal cancer microbiota tumorigenic mechanism genotoxicity cancer pathways tumor immunity

MELK is an oncogenic kinase essential for metastasis,mitotic progression,and programmed death in lung carcinoma

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Signal Transduction and Targeted Therapy 2021年第1期6卷 83-94页

作者： Qin Tang Wan Li Xiangjin Zheng Liwen Ren Jinyi Liu Sha Li Jinhua Wang Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines BeijingChina Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical College100050 BeijingChina

Lung cancer is the fastest growth rate of morbidity and mortality in nearly a decade,and remains difficult to treat.Furthermore,the molecular mechanisms underlying its development are still unclear.In this study,bioinformatics analysis showed that MELK was highly expressed in lung cancer and negatively correlated to the survival of lung adenocarcinoma(LUAD).Immunohistochemistry analysis of LUAD patient tissues revealed there were a high level of MELK expression in LUAD.Knockdown of MELK expression inhibits the migration and invasion of LUAD cells,which may be mediated by Twist1,Slug,MMP7,and N-catenin.Overexpression of MELK promoted the growth of LUAD cells in medium,3D Matrigel,and nude mice.Inhibition of MELK by OTSSP167 arrested cycle of LUAD cells at G2/M phase via PLK1-CDC25C-CDK1 pathway,and triggered apoptosis-mediated pyroptosis.Together,these data indicate that MELK is critical for metastasis,mitotic progression,and programmed death of LUAD and may be a promising therapeutic target for LUAD.

关键词： metastasis PLK1 lung

Optimization of CNC Turning Machining Parameters Based on Bp-DWMOPSO Algorithm

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Computers, Materials & Continua 2023年第10期77卷 223-244页

作者： Jiang Li Jiutao Zhao Qinhui liu Laizheng Zhu jinyi Guo Weijiu Zhang College of Mechanical and Electrical Engineering Harbin Engineering UniversityHarbin150001China

Cutting parameters have a significant impact on the machining effect.In order to reduce the machining time and improve the machining quality,this paper proposes an optimization algorithm based on Bp neural networkImproved Multi-Objective Particle Swarm(Bp-DWMOPSO).Firstly,this paper analyzes the existing problems in the traditional multi-objective particle swarm algorithm.Secondly,the Bp neural network model and the dynamic weight multi-objective particle swarm algorithm model are established.Finally,the Bp-DWMOPSO algorithm is designed based on the established models.In order to verify the effectiveness of the algorithm,this paper obtains the required data through equal probability orthogonal experiments on a typical Computer Numerical Control(CNC)turning machining case and uses the Bp-DWMOPSO algorithm for optimization.The experimental results show that the Cutting speed is 69.4 mm/min,the Feed speed is 0.05 mm/r,and the Depth of cut is 0.5 mm.The results show that the Bp-DWMOPSO algorithm can find the cutting parameters with a higher material removal rate and lower spindle load while ensuring the machining quality.This method provides a new idea for the optimization of turning machining parameters.

关键词： Machining parameters Bp neural network Multiple Objective Particle Swarm Optimization Bp-DWMOPSO algorithm

Ganglioside GD3 synthase(GD3S),a novel cancer drug target

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Acta Pharmaceutica Sinica B 2018年第5期8卷 713-720页

作者： Jinyi Liu Xiangjin Zheng Xiaocong Pang Li Li Jinhua Wang Cui Yang Guanhua Du Ethnic Drug Screening & Pharmacology Center Key Laboratory of Chemistry in Ethnic Medicinal Resources State Ethnic Affairs Commission & Ministry of Education Yunnan Minzu University Key Laboratory of Drug Target Research and Drug Screen Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College

Gangliosides are a class of important glycosphingolipids containing sialic acid that are widely distributed on the outer surface of cells and are abundantly distributed in brain tissue. Disialoganglioside with three glycosyl groups(GD3) and disialoganglioside with two glycosyl groups(GD2) are markedly increased in pathological conditions such as cancers and neurodegenerative diseases. GD3 and GD2 were found to play important roles in cancers by mediating cell proliferation, migration, invasion, adhesion,angiogenesis and in preventing immunosuppression of tumors. GD3 synthase(GD3S) is the regulatory enzyme of GD3 and GD2 synthesis, and is important in tumorigenesis and the development of cancers.The study of GD3S as a drug target may be of great significance for the discovery of new drugs for cancer treatment. This review will describe the gangliosides and their roles in physiological and pathological conditions; the roles of GD3 and GD2 in cancers; the expression, functions and mechanisms of GD3S,and its potential as a drug target in cancers.

关键词： Ganglioside GD3 GD2 GD3S Drug target Cancer treatment

Graphene oxide as a photocatalytic nuclease mimicking nanozyme for DNA cleavage

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Nano Research 2020年第2期13卷 455-460页

作者： jinyi Zhang Shihong Wu Lingzi Ma Peng Wu Juewen liu Department of Chemistry Waterloo Institute for NanotechnologyWaterlooOntarioN2L 3G1Canada State Key Laboratory of Hydraulics and Mountain River Engineering Analytical&Testing CenterSichuan UniversityChengdu 610064China

Developing nanomaterial-based enzyme mimics for DNA cleavage is an interesting challenge and it has many potential applications.Single-layered graphene oxide(GO)is an excellent platform for DNA adsorption.In addition,GO has been employed for photosensitized generation of reactive oxygen species(ROS).Herein,we demonstrate that GO sheets could cleave DNA as anuclease mimicking nanozyme in the presence of UV or blue light.For various DNA sequences and lengths,well-defined product bands were observed along with photobleaching of the fluorophore label on the DNA.Different from previously reported GO cleavage of DNA,our method did not require metal ions such as Cu^2+.Fluorescence spectroscopy suggested a high adsorption affinity between GO and DNA.For comparison,although zero-dimensional fluorescent carbon dots(C-dots)had higher photosensitivity ir terms of producing ROS,their cleavage activity was much lower and only smeared cleavage products were observed,indicatingthat the ROS acted on the DNA in solution.Based on the results,GO behaved like a classic heterogeneous catalyst following substrate adsorption,reaction,and product desorption steps.This simple strategy may help in the design of new nanozymes by introducing light.

关键词： graphene oxide photocatalysis nuclease mimicking nanozyme DNA cleavage

Wheat-RegNet:An encyclopedia of common wheat hierarchical regulatory networks

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Molecular Plant 2023年第2期16卷 318-321页

作者： Tengfei Tang Shilong Tian Haoyu Wang Xiaotong Lv Yilin Xie Jinyi Liu Meiyue Wang Fei Zhao Wenli Zhang Hao Li Yijing Zhang State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesCollege of AgricultureHenan UniversityKaifengHenan 457004China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of Sciences300 Fenglin RoadShanghai 200032China University of the Chinese Academy of Sciences Beijing 100049China State Key Laboratory for Crop Genetics and Germplasm Enhancement CICMCPNanjing Agricultural UniversityNo.1 WeigangNanjingJiangsu 210095 China State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and DevelopmentDepartment of BiochemistryInstitute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China China Center of Industrial Culture Collection(CICC) China National Research Institute of Food and Fermentation IndustriesBeijing 100015China

Dear Editor,Common wheat(Triticum aestivum,2n=6×=42,AABBDD)is the staple crop worldwide.Elucidating the gene regulatory network provides essential information for mechanism studies and targeted manipulation of gene activity for breeding.However,it is a challenging task given the extremely large(16 Gb)and complicated allohexaploid genome of common wheat.Integrating multi-omics data is a compelling approach to construct the hierarchical regulatory network.

关键词： aestivum Wheat hierarchical

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3465-3480页

作者： Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Department of Pharmacology Capital Medical UniversityBeijing 100069China

Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely.

关键词： SW33 GBM G2/M phase Apoptosis Autophagy mTOR Anti-inflammation Safety