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不同郁闭度福建柏林下天然更新研究

林业勘察设计 2005年第1期25卷 17-18页

作者：林金叶福建省洋口国有林场，353211

福建柏是我省主要用材造林树种之一,其幼树具有一定的耐荫性.文章探讨人工福建柏纯林林下更新与林分郁闭度之间的关系及相互作用,并提出促进福建柏林下天然更新的对策.

关键词：天然更新福建柏林下林分郁闭度造林树种相互作用耐荫性用材幼树纯林

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数字出版时代编辑流程再造原因分析

农业图书情报学刊 2018年第3期30卷 134-136页

作者：院金谒严秀丽林静新疆农业科学院<农村科技>编辑部新疆乌鲁木齐830091

数字出版时代已经来临,传统编辑流程已不能适应时代发展需求,改变传统编辑流程,实现编辑流程再造是传统出版单位的必然选择。文章在分析中国数字出版现状的基础上,详细阐述了在数字出版时代编辑流程再造势在必行的内部因素和外部因素,... 详细信息

数字出版时代已经来临,传统编辑流程已不能适应时代发展需求,改变传统编辑流程,实现编辑流程再造是传统出版单位的必然选择。文章在分析中国数字出版现状的基础上,详细阐述了在数字出版时代编辑流程再造势在必行的内部因素和外部因素,以期为传统出版单位转型提供参考。

关键词：数字出版编辑流程再造外部因素内部因素

非综合征型聋患者及家庭成员耳聋基因MYO15A检测及其产前诊断意义

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听力学及言语疾病杂志 2018年第4期26卷 366-371页

作者：柴福赵海亮李胜林晋业魏建芳邱书奇深圳市龙岗区耳鼻咽喉医院深圳市耳鼻咽喉研究所深圳市耳鼻咽喉重点实验室深圳518172

目的分析2例汉族非综合征型聋(nonsyndromic sensorineural hearingloss,NSHL)患者及家庭成员中耳聋基因MYO15A的突变位点,探讨MYO15A基因检测用于产前诊断的可行性。方法采集2例汉族非综合征型感音神经性聋患儿(均为男性,年龄分别为2岁... 详细信息

目的分析2例汉族非综合征型聋(nonsyndromic sensorineural hearingloss,NSHL)患者及家庭成员中耳聋基因MYO15A的突变位点,探讨MYO15A基因检测用于产前诊断的可行性。方法采集2例汉族非综合征型感音神经性聋患儿(均为男性,年龄分别为2岁8个月和3岁6个月)及两个家庭(编号为NSHL-01和NSHL-02)成员血样并记录临床资料。应用芯片捕获高通量测序(targeted genomic capturing and next-generation sequencing,targeted DNA-Hiseq)对2例NSHL患儿进行127个耳聋基因检测,获得变异序列后,针对所检出变异序列对家庭成员和健康对照个体的MYO15A基因序列进行变异验证分析,确定致病性突变后,使用sanger测序法对NSHL-02家庭中的高危胎儿进行孕中期产前诊断。结果在NSHL-01家庭的患儿中检测出MYO15A基因复合杂合突变,即:内含子18亚区c.5134-1G>A(p.-)杂合突变和外显子20亚区c.5324A>C(***1775Pro)杂合突变,本地收集的200例正常测序样本中无关于此SNP的频率信息;患儿的父亲携带c.5134-1G>A杂合突变,而患儿的母亲携带c.5324A>C杂合突变。在NSHL-02家庭的患儿检出MYO15A基因复合杂合突变,第二外显子c.374delG(Arg125ArgfsX319)杂合突变和外显子56亚区c.9358C>T(***3120Ter)杂合突变,本地收集的200例正常测序样本中无关于此SNP的频率信息;患儿的父亲携带c.9358C>T杂合突变,而患儿的母亲携带c.374delG杂合突变;该家庭高危胎儿携带c.9358C>T杂合突变,不携带c.374delG杂合突变,出生后表型正常。结论 MYO15A基因内含子18亚区c.5134-1G>A杂合突变和外显子20c.5324A>C杂合突变,及第二外显子c.374delG杂合突变和外显子56亚区c.9358C>T杂合突变是2个NSHL家庭的致病原因,芯片捕获高通量测序及数据分析技术可对2个NSHL家庭进行有效的基因诊断,结合sanger技术可进行产前诊断。

关键词：非综合征型感音神经性聋 MYO15A基因产前诊断

Hybrid quantum private communication with continuous-variable and discrete-variable signals

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Science China(Physics,Mechanics & Astronomy) 2015年第2期58卷 14-20页

作者： LIU WeiQi PENG jinye WANG Chao CAO ZhengWen HUANG Duan lin DaKai HUANG Peng ZENG GuiHua College of Information Science and Technology Northwest University State Key Laboratory of Advanced Optical Communication Systems and Networks and Center of Quantum Information Sensing and ProcessingShanghai Jiaotong University

The quantum key distribution(QKD) has been entering the practical application era. Subsequently, hybrid quantum private communication with discrete-variable signals, continuous-variable signals, and classic optical signals becomes inevitable in the practical scenario. In this paper, we experimentally investigated the mutual effects between the discrete-variable QKD(DVQKD) and the continuous-variable QKD(CVQKD) via a fiber channel. The experimental results show that the DVQKD will be influenced by the continuous-variable quantum signals and classic optical signals, while the CVQKD is not sensitive to the discrete-variable quantum signals.

关键词： hybrid quantum private communication Gaussian-modulated CVQKD protocol BB84 protocol mutual influences

Hierarchical inhibition of mTORC1 by glucose starvation-triggered AXIN lysosomal translocation and by AMPK

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Life Metabolism 2023年第3期2卷 19-32页

作者： Mengqi Li Xiaoyan Wei jinye Xiong Jin-Wei Feng Chen-Song Zhang Sheng-Cai lin State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamenFujian 361102China

When glucose is replete,mammalian/mechanistic target of rapamycin complex 1(mTORC1)is active and anchored to the lysosomal surface via the two GTPases,Ras-related GTPase(RAG)and Ras homolog enriched in brain(Rheb),which are regulated by Ragulator and tuberous sclerosis complex 2(TSC2),*** glucose is low,aldolase senses low fructose-1,6-bisphosphate level and promotes the translocation of AXIN−liver kinase B1(LKB1)to the lysosomal surface,which leads to the activation of AMP-activated protein kinase(AMPK)and the inhibition of RAGs,sundering mTORC1 from the lysosome and causing its *** can also inactivate mTORC1 by phosphorylating Raptor and ***,the hierarchy of AXIN-and AMPK-mediated inhibition of mTORC1 remains poorly ***,we show that AXIN translocation does not require AMPK expression or *** glucose starvation conditions,knockout of AXIN extended the half-life of mTORC1 inhibition from 15 to 60 min,whereas knockout of AMPK only extended it to 30 ***(constitutively active RAGB)almost entirely blocked the lysosomal dissociation and inhibition of mTORC1 under glucose starvation,but it did not inhibit AMPK,indicating that under these conditions,it is AXIN lysosomal translocation that inhibits mTORC1,and it does so via inhibition of RAGs.5-aminoimidazole-4-carboxamide ribonucleoside(AICAR),a mimetic of AMP,which activates both cytosolic AMPK and lysosomal AMPK,fully inhibited mTORC1 even when it is stably anchored to the lysosome by RAGBGTP,whereas glucose starvation mildly inhibited such anchored ***,we demonstrate that the lysosomal translocation of AXIN plays a primary role in glucose starvation-triggered inhibition of mTORC1 by inhibiting RAGs,and that AMPK activity inhibits mTORC1 through phosphorylating Raptor and TSC2,especially under severe stress.

关键词： mTORC1 glucose sensing AMPK

Endogenous repair theory enriches construction strategies for orthopaedic biomaterials:a narrative review

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Biomaterials Translational 2021年第4期2卷 343-360页

作者： Yizhong Peng jinye Li Hui lin Shuo Tian Sheng Liu Feifei Pu Lei Zhao Kaige Ma Xiangcheng Qing Zengwu Shao Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

The development of tissue engineering has led to new strategies for mitigating clinical problems;however,the design of the tissue engineering materials remains a *** limited sources and inadequate function,potential risk of microbial or pathogen contamination,and high cost of cell expansion impair the efficacy and limit the application of exogenous cells in tissue ***,endogenous cells in native tissues have been reported to be capable of spontaneous repair of the damaged *** cells exhibit remarkable plasticity,and thus can differentiate or be reprogrammed to alter their phenotype and function after *** a comprehensive review,we found that the plasticity of these cells plays a major role in establishing the cell source in the mechanism involved in tissue *** engineering materials that focus on assisting and promoting the natural self-repair function of endogenous cells may break through the limitations of exogenous seed cells and further expand the applications of tissue engineering materials in tissue *** review discusses the effects of endogenous cells,especially stem cells,on injured tissue repairing,and highlights the potential utilisation of endogenous repair in orthopaedic biomaterial constructions for bone,cartilage,and intervertebral disc regeneration.

关键词： biomaterials cell plasticity endogenous repair stem cells tissue engineering

Study on the influencing factors of adsorption rate of high voltage electrostatic spray system

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Study on the influencing factors of adsorption rate of high ...

Decellularized Disc Hydrogels for hBMSCs tissue-specific differentiation and tissue regeneration

第40届中国控制会议

作者： lin Zhen Liang Shengkai Xie jinye Pan Jiazhen Institute of Technology Sanya University of Sanya

The traditional plant protection spray operation in China is mainly manual, and the spraying method of spraying liquid is widely used. The spraying method is serious, the utilization rate of pesticide is poor, the work efficiency is low, and the labor intensity of operators is large. The effect of ordinary spray on plants is not good. Electrostatic spraying technology improves the existing pesticide use, improves the efficiency of use and reduces environmental pollution. Electrostatic spray also has efficiency problems. It is found that spray parameters have great influence on droplet deposition. In this paper, the parameters combination of electrostatic spray precision spraying is studied. The principle and characteristics of electrostatic spray are *** deposition rate and charge to mass ratio of electrostatic spray under different voltage, water pressure parameters and the ratio of charge to mass are compared with experimental results. The experimental results show that when the spray pressure is 0.60 MPa, the best performance is for the 10 collocation and optimization of electrostatic spray in practical application.

关键词： Electrostatic spraying Precision spraying Deposition rate Charge to mass ratio

来源： cnki会议评论

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Bioactive Materials 2021年第10期6卷 3541-3556页

作者： Yizhong Peng Xiangcheng Qing Hui lin Donghua Huang jinye Li Shuo Tian Sheng Liu Xiao Lv Kaige Ma Rui Li Zilong Rao Ying Bai Songfeng Chen Ming Lei Daping Quan Zengwu Shao Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Musculoskeletal Tumor Center Department of OrthopedicsThe Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina School of Chemistry Sun Yat-sen UniversityGuangzhou510127China School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou510127China Department of Orthopaedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou City450052China

Tissue specificity,a key factor in the decellularized tissue matrix(DTM),has shown bioactive functionalities in tuning cell fate-e.g.,the differentiation of mesenchymal stem ***,cell fate is also determined by the living microenvironment,including material composition and spatial ***,two neighboring tissues within intervertebral discs,the nucleus pulposus(NP)and annulus fibrosus(AF),were carefully processed into DTM hydrogels(abbreviated DNP-G and DAF-G,respectively)to determine the tissue-specific effects on stem cell fate,such as specific components and different culturing methods,as well as in vivo *** differences in their protein compositions were identified by proteomic ***,the fate of human bone marrow mesenchymal stem cells(hBMSCs)also responds to both culturing methods and ***,hBMSCs cultured with DNP-G(3D)differentiated into NP-like cells,while hBMSCs cultured with DAF-G(2D)underwent AF-like differentiation,indicating a close correlation with the native microenvironments of NP and AF cells,***,we found that the integrin-mediated RhoA/LATS/YAP1 signaling pathway was activated in DAF-G(2D)-induced AF-specific ***,the activation of YAP1 determined the tendency of NP-or AF-specific differentiation and played opposite regulatory ***,DNP-G and DAF-G specifically promoted tissue regeneration in NP degeneration and AF defect rat models,*** conclusion,DNP-G and DAF-G can specifically determine the fate of stem cells through the integrin-mediated RhoA/LATS/YAP1 signaling pathway,and this tissue specificity is both compositional and spatial,supporting the utilization of tissue-specific DTM in advanced treatments of intervertebral disc degeneration.

关键词： Tissue specificity Decellularized tissue matrix Intervertebral disc Differentiation YAP1

不同温度作用下砂岩微观结构变化与演化规律实验研究

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岩石力学与工程学报 2024年第3期43卷 600-610页

作者：王刚郑金叶刘义鑫辛林山东科技大学矿山灾害预防控制国家重点实验室培育基地山东青岛266590 山东科技大学安全与环境工程学院山东青岛266590

深部煤层的高地应力以及地下气化过程中产生的高温热应力的共同作用会对岩石造成损伤,破坏煤层围岩的稳定性。采用扫描电子显微镜、X射线衍射、CT扫描等实验手段对砂岩试样不同温度(25℃,200℃,400℃,600℃,800℃,1000℃)下微观结构及... 详细信息

深部煤层的高地应力以及地下气化过程中产生的高温热应力的共同作用会对岩石造成损伤,破坏煤层围岩的稳定性。采用扫描电子显微镜、X射线衍射、CT扫描等实验手段对砂岩试样不同温度(25℃,200℃,400℃,600℃,800℃,1000℃)下微观结构及矿物成分变化情况进行研究。结果表明:温度变化对砂岩的微细观结构具有重要影响。砂岩的孔隙率整体上随温度的升高而增大,1000℃的砂岩孔隙率最大,25℃的砂岩孔隙率最小。砂岩不同孔径的孔隙数量总体上随温度的升高而减少,但1000℃砂岩的微孔数量最多,25℃砂岩其他孔径的孔隙数量最多。加热后砂岩开始产生微裂纹,当温度超过600℃时,试件产生的微裂纹的数量明显增加,微裂纹长度、宽度及密度随着温度的升高进一步扩展。试件的矿物成分衍射强度及矿物的含量随温度的变化各不相同,超过600℃时各类矿物成分衍射强度变化发生转折,超过400℃时,砂岩内部矿物成分发生物理化学反应,晶体之间发生转化,随温度的升高,石英矿物含量逐渐增加,长石矿物逐渐减少;试件表观形态变化的临界温度为400℃。

关键词：岩石力学砂岩热损伤微细观结构矿物成分孔隙结构