检索结果-南通市图书馆

Chinese Chemical Letters 2024年第4期35卷 382-388页

作者： Shiyu Hou Maolin Sun Liming Cao Chaoming Liang Jiaxin Yang Xinggui Zhou jinxing ye Ruihua Cheng School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Pharmacy East China University of Science and TechnologyShanghai 200237China

Microchannels enable the fast and efficient mixing of multiphase *** this study, a millimeter-scale three-dimensional(3D) circular cyclone-type microreactor was designed for the *** flow characteristics and mixing intensity were simulated by computational fluid dynamics simulations at a flow rate range of 12–96 m L/min using a water/ethyl acetate *** the 3D variable-diameter structure,the microreactor induced paired opposite vortices and abruptly changed the local pressure to achieve a stable turbulent effect within the theoretical range of laminar *** injection simulations indicated that sufficient mixing units successfully promote fluid ***-coupling experiments showed a segregation index of X_S= 0.00,039 within a residence time of 9 *** experiments on the nbutanol/succinic acid/water system showed that the 3D circular cyclone-type microreactor achieved 100%extraction efficiency(E) in 4.25 s, and the overall volume mass transfer coefficient(K_La) reached 0.05–1.5s^(-1) in 12–96 m L/*** isolated yield of the phase transfer alkylation and oxidation reactions in the 3D circular cyclone-type microreactor achieved 99% within 36 s, which was superior to the coil microreactor and batch reactor.

关键词： Microfluidics Passive microreactor CFD simulation Extraction Liquid-liquid biphase reaction

A sequential continuous flow synthesis and purification process of calcium dibutyryladenosine cyclophosphate

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 402-406页

作者： Liming Cao Maolin Sun Chaoming Liang Lei Yang Yueyue Ma Ruihua Cheng Yanxiong Ke Wei Yu jinxing ye Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China Shanghai No.1 Biochemical& Pharmaceutical Co. Ltd.Shanghai 200080China

Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular *** traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable ***,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was *** acylation reaction was completed in a continuous coil reactor at 160℃ in 20 *** the high toxic solvent pyridine was replaced by ***,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer *** with the membrane phase separators,the residence time of the purification step was 30 *** isolated yield of this sequential continuous process was 92%with 99%purity.

关键词： Flow chemistry Calcium dibutyryladenosine cyclophosphate Continuous flow synthesis In-line purification 3D circular cyclone-type micromixer chip

Two-step continuous flow process of sodium tanshinone ⅡA sulfonate using a 3D circular cyclone-type microreactor

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第1期35卷 290-294页

作者： Maolin Sun Chaoming Liang Liming Cao Yaguo Wang Jiasheng Yang Shiyu Hou Wei Yu Yueyue Ma Ruihua Cheng jinxing ye School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Pharmacy East China University of Science and TechnologyShanghai 200237China School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China Shanghai No.1 Biochemical&Pharmaceutical Co. Ltd.Shanghai 200080China

A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate(STS).Our approach was inspired by the well-established and industrially applied batch synthetic route for STS *** constructed a telescoped two-step continuous flow *** involved a continuous tanshinone IIA sulfonation and in-line salt *** the setup,we constructed a 3D circular cyclone-type microreactor using femtosecond laser *** to the 68%yield for 2 h in batch,the two-step continuous flow had an STS yield of 90%,achieved for a total residence time of<3.0 min under optimal *** proposed continuous flow method vastly simplified the operation and improved procedural safety,while significantly reducing the required acid content and wastewater production.

关键词： Continuous flow Sodium tanshinone IIA sulfonate Cardiovascular Microreactor Green chemistry

Micro/nano flow chemistry by Beyond Limits Manufacturing

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第5期35卷 3-12页

作者： Peiwen Liu Fang Zhao Jing Zhang Yunpeng Bai jinxing ye Bo Bao Xinggui Zhou Li Zhang Changlu Zhou Xinhai Yu Peng Zuo Jianye Xia Lian Cen Yangyang Yang Guoyue Shi Lin Xu Weiping Zhu Yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for BiomanufacturingEast China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

In September 2018,we proposed the cutting-edge concept of“Beyond Limits Manufacturing”(BLM).BLM technology is based on the three-dimensional inner engraving or precise outer engraving of ultra-fast laser,to invent micro/nano scale flow chips or devices,which makes it possible for the microform,integration,economy,safety,high efficiency,green and intelligence of research,development and manufacturing process,so as to realize transformational manufacturing in the era of Industry *** this paper,we reviewed the representative results we made in the field of micro/nano flow chemistry during the implementation of the BLM major project(December 2019 to August 2023),and discussed its application prospects in micro/nano flow chemistry.

关键词： Beyond Limits Manufacturing Flow chemistry Pharmaceutical manufacturing Microreactor

在线全文

学校读者我要写书评

暂无评论

制药工程专业导论课程的教学探索与实践

高等药学教育研究 2024年第1期 21-26页

作者：郑俊霞赵肃清卢宇靖叶金星丁金龙广东工业大学生物医药学院广东广州510006

制药工程专业导论是面向制药工程专业新生的第一门专业基础课,是后继专业课的先导课程,对加深学生的专业认知度、培养学生对专业学习的兴趣及主动性具有重要意义。文章以广东工业大学制药工程专业为例,探讨了专业导论课程的重要性,并对... 详细信息

制药工程专业导论是面向制药工程专业新生的第一门专业基础课,是后继专业课的先导课程,对加深学生的专业认知度、培养学生对专业学习的兴趣及主动性具有重要意义。文章以广东工业大学制药工程专业为例,探讨了专业导论课程的重要性,并对课程的教学内容、教学方法以及考核方式进行了探索和实践,旨在更好地提高制药专业导论的教学效果,从而达到课程的教学目标。

关键词：制药工程专业导论教学探索与实践教学内容教学方法考核方式

Achieving exceptionally high strength and rapid degradation rate of Mg-Er-Ni alloy by strengthening with lamellar γ' and bulk LPSO phases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第1期168卷 88-102页

作者： Chaoneng Dai Jingfeng Wang Yuanlang Pan Kai Ma Yinhong Peng ye Wang Danqian Wang Chunhua Ran jinxing Wang Yanlong Ma College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing 400044China College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054China

As-extruded Mg-Er-Ni alloys with different volume fractions of long-period stacking ordered(LPSO)phase and density of lamellar γ' phase were prepared,and the microstructure,mechanical,and degradation properties were *** the bulk LPSO phase and the lamellar γ' phase,and controlling the dynamic recrystallization processes during deformation by adjusting the volume fraction of LPSO and the density of the γ' phase,a synergistic increase in strength and degradation rate can be *** the one hand,the increase in corrosion rate was related to the increased volume fraction of the bulk LPSO phase and the densities of the lamellar γ' phase,which provide more galvanic ***,high densities of the lamellar γ' phase can provide more corrosion interface by inhibiting the recrystallization process to refine dynamic recrystallized(DRXed)grains during the hot *** the other hand,the ultimate tensile strength(UTS)and tensile yield strength(TYS)of the Mg-Er-Ni alloy increased from 345 and 265 MPa to 514 MPa and 358 MPa,respectively,which was mainly attributed to grain boundary and texture strengthening,bulk LPSO phase and lamellar γ' phase ***,Mg^(-1)4Er-4Ni alloy,which contains the highest volume fraction bulk LPSO phase and the densities of lamellar γ' phase,re-alized a synergistic enhancement of strength and degradation *** UTS,TYS,and degradation rate of Mg^(-1)4Er-4Ni were 514 MPa,358 MPa,and 142.5 mg cm^(-2)h^(-1)(3 wt%KCl solution at 93◦C),*** research provides new insight into developing Mg alloys with high strength and degradation rates for fracturing tool materials in the application of oil and gas exploitation in harsh environments.

关键词： Mg-Er-Ni alloy Lamellarγ'and bulk LPSO phases Rapid degradation rate High strength Mechanical and corrosion mechanism

Remote regioselective organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethyl isatin ketimines with cyclic 2,4-dienones

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第2期31卷 377-380页

作者： Chuncheng Zou Yuanyuan Han Chuikun Zeng Tony YZhang jinxing ye Gonghua Song Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationEast China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Chemistry Biology East China University of Science and TechnologyShanghai 200237China

An organocatalytic asymmetric [3+2] cycloaddition of trifluoromethyl-containing azomethine ylides with cyclic 2,4-dienones was *** process enables efficient incorporation of CF3 groups into functionalized spiro [pyrro... 详细信息

关键词： Organocatalysis Spiro oxindole skeleton [3+2]cycloaddition Cyclic 2,4-dienones CF3 group

在线全文

学校读者我要写书评

暂无评论

关于印花糊料流变性的测定

丝绸 2000年第5期37卷 34-35页

作者：叶金兴浙江工程学院浙江杭州310033

流变特性是印花糊料一个重要的性能 ,直线方程logη=logK +QlogD因粘度和剪切速率的对数之间存在极好的相关性 ,而能正确描述所有印花糊料的这一特性 ,PVI值为这直线方程中斜率的反对数而更为清晰方便地表示这一特性。上述方程作图时 ,... 详细信息

流变特性是印花糊料一个重要的性能 ,直线方程logη=logK +QlogD因粘度和剪切速率的对数之间存在极好的相关性 ,而能正确描述所有印花糊料的这一特性 ,PVI值为这直线方程中斜率的反对数而更为清晰方便地表示这一特性。上述方程作图时 ,粘度和剪切速率应采用双对数坐标 ,粘度测定时要注意因存在结构粘度而出现剪切变稀现象所引起的粘度波动。

关键词：印花糊料流变性方程 PVI值测定粘度

波勒式双季铵盐两亲物在蚕丝酸性染料染色中的作用

在线全文

学校读者我要写书评

暂无评论

丝绸 2000年第6期37卷 18-19页

作者：叶金兴浙江工程学院浙江杭州310033

蚕丝用酸性染料染色时 ,加入波勒式双季胺盐电解质 ,可增加蚕丝纤维对染料的吸附量。

关键词：蚕丝酸性染料染色双季铵盐促染作用

手性磷酸控制的不对称碳氢芳基化反应合成平面手性二茂铁化合物

在线全文

学校读者我要写书评

暂无评论

有机化学 2016年第4期36卷 752-759页

作者：张松陆俊筑叶金星段伟良华东理工大学药学院制药工程与过程化学研究中心上海200237 中国科学院上海有机化学研究所金属有机化学国家重点实验室上海200032

报道了钯催化的分子内不对称C—H键芳基化反应.以简单易得的二茂铁羰基化合物为底物,Pd(CH_3CN)_4(OTf)_2为催化剂,使用手性磷酸作为唯一手性源,Buchwald类型联苯单膦配体,甲苯作溶剂,100℃进行反应,得到一系列二茂铁化合物,ee值最高可... 详细信息

报道了钯催化的分子内不对称C—H键芳基化反应.以简单易得的二茂铁羰基化合物为底物,Pd(CH_3CN)_4(OTf)_2为催化剂,使用手性磷酸作为唯一手性源,Buchwald类型联苯单膦配体,甲苯作溶剂,100℃进行反应,得到一系列二茂铁化合物,ee值最高可达83%.该反应为合成平面手性二茂铁化合物提供了一种新途径.

关键词：钯催化 C—H键活化不对称催化手性磷酸二茂铁