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Virus-Encoded microRNAs: Future Therapeutic Targets?

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Cellular & Molecular Immunology 2006年第6期3卷 411-419页

作者： Peng Qi jinxiang han Yanqin Lu Chuanxi Wang Fanfeng Bu Shandong Medicinal Biotechnology Center Shandong Academy of Medical Science Key laboratory of Ministry of Health for Biotech-Drug Jinan 250062 China School of Medicine Shandong University Jinan 250012 China

The discovery of microRNAs （miRNAs） is a remarkable breakthrough in the field of molecular genetics, as miRNAs are key actors which regulate gene expression in diverse cellular processes from unicellular yeast to human. The recent discovery of virus-encoded miRNAs indicates that viruses also use this fundamental mode of gene regulation. Research into viral miRNAs function demonstrates that some miRNAs play an important role in regulating both the viral life cycle and the interaction between viruses and their hosts. The first in vivo ＂antagomir＂ study provides an exciting first step towards miRNA therapy, and the potential for ultimately designing molecular medicines based on the modulation of miRNAs seems good.

关键词： microRNA gene expression anti-miRNA oligonucleotide therapeutic target antivirus

TXNDC5 synergizes with HSC70 to exacerbate the inflammatory phenotype of synovial fibroblasts in rheumatoid arthritis through NF-κB signaling

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Cellular & Molecular Immunology 2018年第7期15卷 685-696页

作者： Lin Wang Hongyan Dong Guanhua Song Rui Zhang Jihong Pan jinxiang han Department of Biochemistry and Molecular Biology Shandong University School of MedicineJinanShandongChina Research Center for Medicinal Biotechnology Key Laboratory for Rare and Uncommon Diseases of Shandong ProvinceShandong Academy of Medical SciencesJinanShandongChina Department of Pathology Linyi People's HospitalLinyiChina Institute of Basic Medicine Shandong Academy of Medical SciencesJinanShandongChina

The upregulated expression of thioredoxin domain-containing protein 5(TXNDC5)is associated with rheumatoid arthritis in patients and model ***,the underlying mechanism by which TXNDC5 influences the pathological activation of rheumatoid arthritis synovial fibroblasts(RASFs)remains *** this study,we show that TXNDC5 expression in RASFs and their cytokine production are significantly upregulated in response to LPS,TNF-αand IL-6,but suppressed by transfection with ***5 is further validated as the direct target of NF-κB ***,TXNDC5 directly interacts with heat shock cognate 70 protein(HSC70)to sequester it in the cytoplasm,and HSC70 silencing exerts the same effects as TXNDC5 on the biological activity of RASFs(for example,decreased cell viability,invasion and cytokine production).Furthermore,HSC70 activates NF-κB signaling by destabilizing IκBβprotein in the absence of LPS or facilitating its nuclear translocation in the presence of ***,TXNDC5 can also regulate the activity of NF-κB signaling in a HSC70-IκBβ-dependent *** together,by linking HSC70 and NF-κB signaling,TXNDC5 plays a pro-inflammatory role in RASFs,highlighting a potential approach to treat RA by blocking the TXNDC5/HSC70 interaction.

关键词： cytokine inflammation rheumatoid arthritis synovial fibroblast TXNDC5

Recent progress of traditional Chinese medical science based on theory of biophoton

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Frontiers of Optoelectronics 2014年第1期7卷 28-36页

作者： Xiuxiu WANG Jinzhao HUANG jinxiang han Meina YANG Jingxiang PANG Xiaolei ZHAO School of Physics and Technology University of Jinan Jinan 250022 China Shandong Medicinal Biotechnology Center Key Laboratory for Biotech-Drugs of the Ministry of Health Jinan 250062 China

With the development of biophotonics, bio- photon detection technology has been appropriately used. In this paper, the main features and fundamental concep- tions of biophotonics were introduced basically. Then the coherence theory of biophoton emission was reviewed. Furthermore, based on this coherence concept, the quantum theory of traditional Chinese medicine （TCM） and properties of Chinese medicinal herbs were presented. To show the nature of biophoton emission in living systems and clarify its basic detection mechanism, high sensitive detection system which allows non-invasive and non-destructive （or less） recording was finally presented.

关键词： biophoton traditional Chinese medicine(TCM) syndrome meridian Chinese herbs detectiontechnology

Spectral analysis of laser-induced ultraweak delayed luminescence from plants

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Spectral analysis of laser-induced ultraweak delayed lumines...

第四届泛环渤海生物化学与分子生物学会学术交流会

作者： Xiuxiu Wang jinxiang han Shandong Medicinal Biotechnology Center Key Laboratory for Biotech-Drugs of the Ministry of HealthShandong Academy of Medical Sciences

At present it is generally accepted that all living organisms exhibit ultraweak photon emission(biophoton emission),within the spectral region at least from 200 to 800 *** photon emission includes spontaneously photon emission and delayed *** researches showed that laser-induced ultraweak delayed luminescence decay kinetics of plant samples can give some significant

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Formation and development of the coherence of biophotons

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Formation and development of the coherence of biophotons

第八届全国医学生物化学与分子生物学第五届全国临床应用生...

作者： Xiaolei Zhao jinxiang han Shandong Medical Biotechnology Center Key Laboratory for Biotech-Drugs of Ministry of Health University of Ji'nan-Shandong Academy of Medical Sciences School of Medicine and Life Sciences

the ultra-weak light emission(UPE) is a general phenomenon of living systems,exists in a variety of animals,plants,algae and microbial systems,and is a inherent function of ***,the generation mechanism of UPE has many kinds of statement *** recent years,along with the continuously going deep into of the research of UPE,the biophoton coherence theory proposed by Popp is recognized by more and more *** paper reviews the research progress of UPE since 1923,detailed introduces the background and process of proposing the biophoton coherence theory,summarizes some important evidences which support the coherence of biophoton,outlines that,as a common phenomenon in the biological,the researches of UPE not only have great scientific significance in the life science field,but also have extensive application value in medicine,agriculture,food and environmental *** the same time,this paper prospects the important role played by UPE in the modernzation of traditional Chinese medicine theory.

关键词： Biophoton coherence theory Traditional Chinese Medicine theory quantum Traditional Chinese Medicine

Research Development of MicroRNA in Cell Differentiation

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Research Development of MicroRNA in Cell Differentiation

泛环渤海地区九省市生物化学与分子生物学会——2011年学术交流会

作者： Luan Jing Cui Yazhou han jinxiang Shandong Medicinal Biotechnology Centre Key Laboratory for Biotech-Drugs Ministry of Health Key Laboratory for Rare&Uncommon Diseases of Shandong ProvinceShandong Academy of Medical Sciences

MicroRNAs(miRNAs) are an abundant class of noncoding small(～22 nucleotides) RNAs which emerge as key regulators of diverse biological and pathological processes,including cell differentiation. They could regulate biological processes by binding to mRNA 3’-untranslated region(UTR) sequences to attenuate translation and then control the genetic expression.A great deal of researches indicate that when the expression levels of some miRNAs change,the differentiation of some cells will be abnormal,resulting some related ***,the alteration of the expression levels of certain miRNAs may be curative for special *** paper makes a review of the researches of miRNAs associated with cell differentiation.

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Development of a novel method to harvest multipotent Mesenchymal stem/progenitor cells by three-dimensional scaffold material from spatium intermusculare

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Development of a novel method to harvest multipotent Mesench...

华东六省一市生物化学与分子生物学会2010年学术交流会

作者： Xiaoyun Wu Shili Wang jinxiang han Shandong Medicinal Biotechnology Center Shandong Academy of Medical Sciences

Background Mesenchymal stem/progenitor stem cells(MSCs)are an importam candidate cell type for cell-based tissue engineering and regenerative ***,the methods to harvest MSCs are via bone marrow aspiration and tissue biopsy digestion(muscle,adipose).These methods are either the highly invasive donation procedure,low yield(cell frequency)(*** bone marrow)or tissue damage,a limited differentiation capability(*** tissue biopsy).The

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MicroRNAs:important mediators of ossification

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MicroRNAs:important mediators of ossification

华东六省一市生物化学与分子生物学学会-2011年学术交流会

作者： Ziqiang Wang Yanqin Lu jinxiang han Shandong Medicinal Biotechnology Center

MicroRNAs(miRNAs)are a class of small noncoding RNAs that principally function in the spatiotemporal regulation of protein translation by binding the 3’-untranslated region of target mRNAs,leading to mRNA degradation or translational *** of genome-wide miRNA microarray demonstrates that a single miRNA can repress expression of hundreds of genes,and emerging evidences suggest miRNAs affect

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The founction of matrix vesicle in calcification

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The founction of matrix vesicle in calcification

第三届泛环渤海（七省二市）生物化学与分子生物学会——2012年学术交流会

作者： Xiaoying Zhou Yazhou Cui Xiaoyan Zhou jinxiang han Shandong Academy of Medical Sciences Shandong Medical Biotechnological CenterKey Laboratory for Rare Disease Re-search of Shandong Provinceand Key Laboratory for Biotech Drugs of the Ministry of Health

During the process of matrix vesicle(MV) - mediated initiation of mineralisation, chondrocytes and osteoblasts mineralise the extracellular matrix by promoting the seeding of basic calcium phosphate crystals of hydroxyapalite(HA) along the collagen *** MVs perform specialized roles in initiating matrix mineralization,include regulating the Pi/PPi ratio in the intra - and extracellular fluid,managing mineral nucleation,controlling calcium and Pi ion homeostasis,and interacting with the surrounding ECM to direct HA localisation and *** MVs possess protein and lipid machinery that is essential to carry out these functions,and they are highly enriched in certain mineralisation - relevant proteins,enzymes, receptors,transporters,regulators,lipids and *** of the MV proteins can affect Pi/PPi homeostasis,HA crystal initiation in the MVs,or crystal propagation along the extracellular collagen fibrils,resulting in hypomineralisation,hypermineralisation,or ectopic ossification at various *** findings from single and multiple gene knockouts of TNSALP,NPP1,ANK,PHOSPHO1,PiT1/2,and Annexin A5 are reviewed.

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