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Study on pharmacokinetics and tissue distribution of the isocorydine derivative (AICD) in rats by HPLC-DAD method

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Acta Pharmaceutica Sinica B 2015年第3期5卷 238-245页

作者： Yali Chen Qian Yan Mei Zhong Quanyi Zhao Junxi liu Duolong Di jinxia liu Institute of Medicinal Chemistry School of PharmacyLanzhou University Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of Sciences Institute of Biology Gansu Academy of Sciences

A simple and effective high-performance liquid chromatography with diode-array detection method coupled with a liquid liquid extraction pretreatment has been developed for determining the pharmacokinetics and tissue distribution of a novel structurally modified derivative (8-acetamino-isocorydine) of isocorydine. According to the in vivo experiments data calculations by DAS 2.0 software, a two compartment metabolic model was suitable for describing the pharmacokinetic of 8-acetaminoiso-corydine in rats. 8-Acetamino-isocorydine was absorbed well after oral administration, and the absolute bioavailability was 76.5%. The half-life of 8-acetamino-isocorydine after intravenous and oral administration was 2.2 h and 2.0 h, respectively. In Oro, 8-acetamino-isocorydine was highly distributed in the lungs, kidney and liver; however, relatively little entered the brain, suggesting that 8-acetaminoisocorydine could not easily pass through the blood brain bather. Our work describes the first characterization of the pharmacokinetic parameters and tissue distribution of 8-acetamino-isocorydine. The acquired data will provide useful infonnation for the in vivo pharmacology of 8-acetaminoisocorydine, and can he applied to new drug research. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia IMedica, Chinese Academy of 'Medical Sciences. Production and hosting by Elsevier B.V.

关键词： Alkaloids Pharmacokinetics Tissue distribution High-performance liquid chromatography with didode-array detection 8-Acetaminao-isocorydine

Research on Deformation, Texture and Properties of IF Steel in Multiple Rolling Technology

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Journal of Materials Science & Technology 2003年第2期19卷 183-184页

作者： jinxia LI, Xianghua liu and Guodong WANGState Key Lab. of Rolling and Automation, Northeastern University, Shenyang 110004, China Lab. of Rolling and Automat. Northeastern Univ. Shenyang 110004 China

The relationships among the deformation, texture and deep drawing properties of IF steel were investigated. By adopting double cold rolling (DCR) technology, the deep drawing property has been developed evidently. With the aid of orientation distribution function (ODF) analysis, it was found that he main reason for good property is the counterbalance in intensity of the ideal texture component {111} and {111} .

关键词： Texture Double cold rolling r-value Deformation.

Novel thermal expansion of lead titanate

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Rare Metals 2003年第4期22卷 294-297页

作者： XING Xianran, DENG jinxia, CHEN Jun and liu GuirongDepartment of Physical Chemistry, University of Science & Technology Beijing, Beijing 100083, China Department of Physical Chemistry University of Science & Technology Beijing 北京 100083

Lattice parameters of lead titanate were precisely re-determined in thetemperature range of-150-950 deg C by high precision XRPD measurements. It was clarified that therewas no any evidence for a new phase transition at low tempera-lures. Tetragonal distortion straindecreases with temperature increasing. A novel thermal expansion was observed, positive thermalexpansion from -150 deg C to room temperature (RT) and above 490 deg C, and the negative thermalexpansion in the temperature range of RT-490 deg C. A big jump of thermal expansion coefficient isattributed to the tetragonal-cubic phase transition. A rationalization for the negative thermalexpansion of PbTiO_3 is due to the decrease of anion-anion repulsion as polyhedra become moreregular at heating. The mechanisms of positive and negative thermal expansions were elucidated asthe same nature in the homogenous tetragonal phase at present case.

关键词： metallurgical physical chemistry thermal expansion X-ray powder diffraction(XRPD) lead titanate phase transition

Advances in Application of PCR Amplification in Etiologic Diagnosis

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Medicinal Plant 2021年第4期12卷 89-92页

作者： Sixi YANG Ran LI jinxia liu Pathogenic Biology Experimental Center Chengde Medical CollegeChengde 067000China

In recent years,with the rapid development of molecular biology diagnostic technology,many new polymerase chain reaction(PCR)technologies with high specificity and good sensitivity have gradually been *** expanding the range of detection methods,these technologies inevitably have some ***,in clinical pathogen diagnosis,medical personnel should choose the detection method according to the detection purpose and pathogen *** this paper,the basic principle,application scope,advantages and disadvantages and development of various emerging PCR diagnostic techniques are respectively described in order to provide a theoretical reference for the selection of pathogenic biological diagnostic techniques in the clinical practice.

关键词： New PCR PCR amplification technology Pathogen detection Evaluation

Thermal expansion of lattice parameter of (powder) silicon up to 1473 K

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Rare Metals 2004年第4期23卷 364-367页

作者： XINGXianran CHENJun DENGjinxia liuGuirong DepartmentofPhysicalChemistry UniversityofScienceandTechnologyBeijingBeijing100083China

The XRPD (X-ray powder diffxactometry) patterns of silicon powder with a unit cell structure of diamond were determined from 298 to 1473 K. Lattice parameters of Si linearly increase with temperature. The thermal shifts of the positions of all reflection peaks are linearly correlated with the temperature. The coefficients of the intrinsic linear thermal expansion and volumetric thermal expansion were determined as 3.87×10-6/K and 1.16×10-5/K respectively. It indicates that Si is still a suitable standard in the XRPD method at high temperatures.

关键词： metallurgical physical chemistry thermal expansion high temperature X-ray powder diffraction (HTXRPD) silicon.

Analysis of The Impact of Excellent Event Management on the Safety of Patients and Clinical Caregivers

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Journal of Clinical and Nursing Research 2024年第4期8卷 169-173页

作者： Linlin He Junwei Guo jinxia liu PKUCare Zibo Hospital Zibo 255000Shandong ProvinceChina

Objective: To investigate the impact of excellent event management in improving patient safety and nursing staff care satisfaction. Methods: The study was analyzed by retrospective comparison, and routine management from January 2022 to December 2022 was set as the control group, and excellent event management from January 2023 to January 2024 was set as the study group. The differences in nursing outcomes between both groups were compared. Results: The rate of adverse events in the study group (0.61%) was lower than that in the control group (0.96%), and the rate of excellent events in the study group (2.57%) was higher than that in the control group (0.97%) (P < 0.05). Meanwhile, the satisfaction level of nursing safety in the study group reached 98.81%, which was much higher than in the control group (92.21%) (P < 0.05). Conclusion: Nursing excellent event management had a positive impact on improving patient care safety satisfaction, reducing the rate of adverse events, and increasing the rate of reporting excellent events.

关键词： Excellent events Quality of care Impact Safety management

Establishment of an Improved Loop-mediated Isothermal Amplification Technique for Visual Detection of Brucella

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Medicinal Plant 2022年第2期13卷 18-20,36页

作者： Sixi YANG Kexin ZHANG jinxia liu Experimental Center of Pathogenic Biology Chengde Medical University Chengde 067000 China

[Objectives]Loop-mediated isothermal amplification(LAMP)was developed and optimized for rapid and specific diagnosis of Brucella infection.[Methods]The conserved sequence of the brucellosis standard strain Omp25 gene fragment was selected,primers needed in the loop-mediated isothermal amplification system were designed,and nucleic acid of the standard strain was ***,reaction system,reaction conditions and stain types were repeatedly optimized to establish an improved LAMP detection kit for *** tests were performed on blood samples from clinically confirmed cases and their sensitivity and specificity were ***,the detection technology and kit were applied to the detection and screening of suspected *** in pastoral ***,SPSS21.0 was used to evaluate the consistency of LAMP and Q-PCR.[Results]LAMP system was optimized,and the optimal final concentrations of MgSO_(4) and betaine were 8 and 0.8 mmol/L,*** sensitivity and specificity of the modified LAMP technique were verified by using human blood samples with confirmed *** LAMP specific test,there was no nonspecific amplification,indicating good *** the LAMP sensitivity test,the minimum detection line for ***,***,and *** was 10 copies/μL,which was an order of magnitude higher than that for *** consistency between modified LAMP and Q-PCR was *** established Brucella LAMP kit was used to detect the blood samples of 200 sheep suspected to be infected with *** LAMP kit detected 42 positive samples,with a positive rate of 21%and a detection sensitivity of 100%.Negative specimens were detected in 158 cases,with a specificity of 100%.There were 41 negative samples detected by PCR,with a positive rate of 20.5%.The detection specificity was consistent with that of LAMP kit.[Conclusions]The modified LAMP for Brucella has been successfully *** technology is characterized by good sens

关键词： Brucella Loop-mediated isothermal amplification Omp25 Diagnostic kit Development

Wood cellulose films regenerated from NaOH/urea aqueous solution and treated by hot pressing for food packaging application

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Food Bioscience 2022年第6期50卷 1824-1831页

作者： Kehao Huang Anne Maltais jinxia liu Yixiang Wang Department of Food Science and Agricultural Chemistry McGill UniversitySte Anne de BellevueQuebecH9X 3V9Canada Institut de Technologie des Emballages et du Génie Alimentaire (ITEGA) MontréalQuébecH1N 1C1Canada Department of Civil Engineering McGill UniversityMontrealQuebecH3A 0C3Canada

Cellulose films made from‘green’solvent provide the possibility to mitigate environmental pollution caused by non-degradable plastic ***,regenerated cellulose films were prepared from five wood pulps in NaOH/urea aqueous solution,dried either at ambient conditions or by hot pressing,and tested as biodegradable packaging *** results revealed that different wood origins did not cause much difference in the structure of cellulose ***,hot-pressing could not only efficiently remove water from wet films,but also significantly improve the tensile strength and water vapor barrier property of regenerated *** RC-P-HP film had the tensile strength of 85.00±3.26 MPa,Young's modulus of 6.45±0.36 GPa,and water vapor permeability of 3.59±0.14×10−7 gm−1h−1Pa−1,and exhibited the similar capacity as the commercial plastic wrap during the preservation of cherry tomatoes for up to 16 ***,this study demonstrates a feasible strategy to fabricate wood cellulose films for biodegradable food packaging.

关键词： Wood pulps Cellulose films Regeneration Hot pressing Food packaging

Structure and Property of AgLaY Alloy

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Rare Metals 2001年第3期20卷 192-196页

作者： jinxia Li, Yongtao liu, Zhenzhong Tai 1) The State Key Lab of Rolling and Automation, Northastern University, Shenyang 110004, China 2) Maerial & Metallurgical College, Northeastern University, Shenyang 110004, China 3) Shenyang ASTRON Mining Ltd. Corp., 东北大学轧制技术与连轧自动化国家重点实验室辽宁沈阳 110004 东北大学辽宁沈阳 110004 Shenyang ASTRON Mining Ltd 辽宁沈阳 110003

The structure of RE-Ag alloy was observed and analyzed using electron probe. The property changes of the alloy containing two rare earth elements AgLaY during cold forming and the high temperature softening-resistance during annealing were studied using Vickers hardness tester. The distribution and action of the rare earth elements in Ag-alloy were also analyzed. Experimental results show that AgLaY alloy has more remarkable work-hardening effect than AgLa and pure silver, and it also has better thermal-resistance. The effects of RE elements, La and Y, on the properties of Ag-alloy are attributable to their symbiotic distribution and complementary function. Because of the common properties of La and Y as RE elements, they have the completely similar distribution in Ag-alloy. At the same time, La and Y make full use of complementary role in the alloy since they belong to different periods in periodic table and have differences in atomic structure and properties.

关键词： rare earth element RE-Ag alloy heat-resistance structure and property complementarity