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Asymmetrically ligated single atomic nickel sites for efficient hydrogen peroxide electrosynthesis

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Nano Research 2024年第3期17卷 1094-1100页

作者： Xusheng Cheng jinwen Hu Wenzhe Shang Jingya Guo Cuncun Xin Songlin zhang Suchan Song Wei Liu Yantao Shi State Key laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsSchool of ChemistryDalian University of TechnologyDalian 116024China

Atomic transition-metal-nitrogen-carbon electrocatalysts hold great promise as alternatives to benchmark Pt in the oxygen reduction reaction.The pristine metal centers with quasi square-planar D_(4h) configuration,however,still suffer from unfavorable energetics and thereby strong activity/selectivity trade-off during the catalytic process.Here we present a ligand-field engineering of single-atom Ni-N-C catalysts to boost the sluggish kinetics via rationally constructing prototypical asymmetrically ligated Ni-N_(3)O_(1) sites.The as-obtained Ni-supported multi-walled carbon nanotubes with molten salt-treated(defined as Ni/CNS)catalyst delivered an excellent H_(2)O_(2) selectivity(>90%)within a wide potential window(0.2–0.7 V vs.reversible hydrogen electrode(RHE))and robust stability(for 10 h)in alkaline medium.Combined electron paramagnetic resonance and theoretical analysis rationalize this finding and demonstrate that the broken symmetry facilitates the electron transfer of a σ* to O–O orbital as compared to the Ni-N_(4) counterpart,playing an indispensable role in efficient O_(2) activation.

关键词： broken D4h single nickel sites oxygen reduction H_(2)O_(2)production

Stability analysis of longwall top-coal caving face in extra-thick coal seams based on an innovative numerical hydraulic support model

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International Journal of Mining Science and Technology 2024年第4期34卷 491-505页

作者： Jun Guo Wenbo Huang Guorui Feng jinwen Bai Lirong Li Zi Wang Luyang Yu Xiaoze Wen Jie zhang Wenming Feng College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Shanxi Province for Mine Rock Strata Control and Disaster Prevention Taiyuan University of TechnologyTaiyuan 030024China Shanxi Coking Coal Group Co. Ltd.Taiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China

The relationship between support and surrounding rock is of great significance to the control of surrounding rock in mining process.In view of the fact that most of the existing numerical simulation methods construct virtual elements and stress servo control to approximately replace the hydraulic support problem,this paper establishes a new numerical model of hydraulic support with the same working characteristics as the actual hydraulic support by integrating numerical simulation software Rhino,Griddle and FLAC3D,which can realize the simulation of different working conditions.Based on this model,the influence mechanism of the supporting strength of hydraulic support on surrounding rock stress regulation and coal stability in front of the top coal caving face in extra thick coal seam were researched.Firstly,under different support intensity,the abutment pressure of the bearing coal and the coal in front of it presents the “three-stage”evolution characteristics.The influence range of support intensity is 15%–30%.Secondly,1.5 MPa is the upper limit of impact that the support strength can have on the front coal failure area.Thirdly,within a displacement range of 2.76 m from the coal wall,a support strength of1.5 MPa provides optimal control of the horizontal displacement of the coal.

关键词： Extremely thick coal seam Fully mechanized top coal caving Support strength Support-surrounding rock interaction

Detection of polycyclic aromatic hydrocarbons using a high performance-single particle aerosol mass spectrometer

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Journal of Environmental Sciences 2023年第2期124卷 806-822页

作者： Yao zhang Chenglei Pei jinwen zhang Chunlei Cheng Xiufeng Lian Mubai Chen Bo Huang Zhong Fu Zhen Zhou Mei Li Institute of Mass Spectrometry and Atmospheric Environment Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air pollutionJinan UniversityGuangzhou 510632China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Guangzhou 510632China Guangzhou Environmental Monitoring Center Guangzhou 510030China Guangzhou Hexin Analytical Instrument Company Limited Guangzhou 510530China

The real-time detection of the mixing states of polycyclic aromatic hydrocarbons(PAHs)and nitro-PAHs in ambient particles is of great significance for analyzing the source,aging process,and health effects of PAHs and nitro-PAHs;yet there is still few effective technology to achieve this type of detection.In this study,11 types of PAH and nitro-PAH standard sampleswere analyzed using a high performance-single particle aerosolmass spectrometer(HP-SPAMS)in lab studies.The identification principles‘parent ions’and‘mass-to-charge(m/z)=77’of each compound were obtained in this study.It was found that different laser energies did not affect the identification of the parent ions.The comparative experiments of ambient atmospheric particles,cooking and biomass burning emitted particles with and without the addition of PAHs were conducted and ruled out the interferences from primary and secondary organics on the identification of PAHs.Besides,the reliability of the characteristic ions extraction method was evaluated through the comparative study of similarity algorithm and deep learning algorithm.In addition,the real PAH-containing particles from vehicle exhaust emissions and ambient particles were also analyzed.This study improves the ability of single particle mass spectrometry technology to detect PAHs and nitro-PAHs,and HP-SPAMS was superior to SPAMS for detecting single particles containing PAHs and nitro-PAHs.This study provides support for subsequent ambient observations to identify the characteristic spectrum of single particles containing PAHs and nitro-PAHs.

关键词： Single particle Polycyclic aromatic hydrocarbons Identification principles Mass spectrometry Aerosol

Foldable Units and Wing Expansion of the Oakleaf Butterfly During Eclosion

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Journal of Bionic Engineering 2022年第3期19卷 724-736页

作者： jinwen zhang Xiaoming Chen Qin Lu Jinguo Liu Xiaofei Ling Weiwei Wang Pengfei Liu Hang Chen Research Institute of Resource Insects Chinese Academy of ForestryKunming650224China Nanjing Forestry University Nanjing210037China Robotics Laboratory of Chinese Academy of Sciences Shenyang Institute of Automation(SIA)Liaoning110169China

Eclosion is a rapid process of morphological changes in insects,especially for the wings of butterflies.The orange oakleaf butterfly(Kallima inachus)transits from pupae to adults with a 9.3 fold instant increase in the surface area of their wings.To explore the mechanism for the rapid morphological changes in butterfly wings,we analyzed changes in microstructures in the wings of K.inachus.We found that there were lots of micron-sized foldable units in the wings at the pupal stage.The foldable units could provide as much as 31.35 times of increase in wing surface area.During eclosion,foldable units were flattened sequentially and resulted in a rapid increase in wing surface areas.The unfolding process was regulated by the structures and layouts of wing veins.Based on our observation,foldable units play important roles in both deformation and stretching of wings.The foldable units of microstructures may provide mimics for simulating entities of large-deformational bionic structures with practical application.

关键词： Eclosion Foldable units Reserve surface area Wing spreading power

Luteolin promotes neuronogenesis in hippocampus of chronic unpredictable mild stress rats and primary hippocampus of fetal rats

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Journal of Traditional Chinese Medicine 2024年第4期 670-679页

作者： LIU Tongtong zhang Xi YANG Hui LIN Xiaoyuan LIU Jian zhang Xiuli GUO Dongwei ZHAO Hongqing ZOU Manshu LEI Chang LONG Hongping LUO Yan XIANG Yun GE jinwen WANG Yuhong MENG Pan Institute of Innovation and Applied Research in Chinese Medicine Hunan University of Chinese Medicine the Second People's Hospital of Hunan Province The First Affiliated Hospital Hunan University of Chinese Medicine Hunan Academy of Chinese Medicine

OBJECTIVE: To investigate the effects of luteolin on chronic unpredictable mild stress(CUMS)-induced depressive rats and corticosterone(CORT)-induced depressive primary hippocampal neurons, and to elucidate the mechanism behind the action.METHODS: The antidepressant mechanism of luteolin was studied by using CUMS rat model and primary hippocampal neurons in fetal rats. In vivo, novelty suppressed feeding, open-field and sucrose preference tests as well as Morris water maze were evaluated. The content of brain derived neurotrophic factor(BDNF), 5-hydroxytryptamine(5-HT), norepinephrine(NE), and dopamine(DA) in serum were detected by enzyme-linked immunosorbent assay. The mechanisms of luteolin were explored based on neurotrophin and hippocampal neurogenesis, and proliferation. Survival of the septotemporal axis in hippocampus was assayed using the 5-bromo-2-deoxyuridine(BrdU), the expression of BDNF,neurotrophin-3(NT-3), and nerve growth factor(NGF) in hippocampus dentate gyrus region were measured by Western-blotting. In vitro, BDNF, NT-3, tropomyosin receptor kinase B(TrkB), and phosphorylated cyclic adenosine monophosphate responsive element binding protein(p-CREB) were detected through the high content analysis(HCA) to investigate neurotrophin and apoptosis.RESULTS: Induction of CUMS in rats induced depressive symptoms, while luteolin significantly enhanced sucrose consumption, decreased feeding latency, increased locomotor activity, escape latency, distance of target quadrant and regulated the content of depressive-like biomarkers. Histology analysis revealed that luteolin increased the abundance of new born neurons that had been labeled with BrdU, BrdU + neuronal nuclear antigen,and BrdU + doublecortin in septo-temporal axis of S2(mid-septal) and T3(mid-temporal). Moreover,expression of BDNF, NT-3, and NGF increased significantly in the septo-temporal axis of S2 and T3. HCA showed increased expression of BDNF, NT-3, TrkB and p-CREB in primary hippocampal neurons. CONCLUSION: The results provided direct evide

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Exploratory clinical study of chidamide,an oral subtype-selective histone deacetylase inhibitor,in combination with exemestane in hormone receptor-positive advanced breast cancer

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Chinese Journal of Cancer Research 2018年第6期30卷 605-612页

作者： Qingyuan zhang Tao Wang Cuizhi Geng Yue zhang jinwen zhang Zhiqiang Ning Zefei Jiang Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China Department of Breast Cancer the 307th hospital of Chinese People's Liberation ArmyBeijing 100071China The Fourth Hospital of Hebei Medical University Shijiazhuang 050011China Shenzhen Chipscreen Biosciences Shenzhen 518057China

Objective: The recurrence or progression under endocrine therapy in hormone receptor-positive(HR+)advanced breast cancer(ABC) remained a critical clinical challenge.Chidamide is an oral subtype-selective histone deacetylase(HDAC) inhibitor with multiple functions in tumor growth inhibition and microenvironment modulation via epigenetic reprogramming.The purpose of this study was to evaluate the safety,pharmacokinetics(PK),and preliminary efficacy of chidamide in combination with exemestane in HR+ ABC patients.Methods: Eligible patients were postmenopausal women with HR+ ABC recurrent or progressed to at least one endocrine therapy.Blood samples were obtained in the run-in period and the first day of combination treatment for PK analysis.In combination treatment,patients were given exemestane 25mg daily and chidamide 30mg twice a week(BIW) until progression of disease or intolerable toxicities.A treatment cycle was defined as 4 weeks.Safety,PK parameters,and preliminary efficacy were evaluated.Results: A total of 20 patients were enrolled between July and December,2015.The median number of treatments cycle was 5.2(20.8 weeks) with 2 patients still on treatment at the data cut-off date of October,2017.The treatment-related adverse events(AE) ≥ grade 3 in more than 2 patients were neutropenia(35%),thrombocytopenia(30%),and leucopenia(20%).The plasma exposure of exemestane was consistent in the presence or absence of chidamide.A slight increase in chidamide exposure was noted in the presence of exemestane,probably due to the inter-and intra-patient variations.The best response in 16 evaluable patients was assessed by Response Evaluation Criteria in Solid Tumors(RECIST),including 4 patients with partial response,10 patients with stable disease.The median progression-free survival(PFS) was 7.6 months.Conclusions: The combination of chidamide with exemestane was generally well tolerated with promising preliminary efficacy in HR+ ABC patients.The overall results from this study encourage further pivotal trial in this pat

关键词： Advanced breast cancer hormone receptor-positive chidamide exemestane

基于黄芩汤治疗结直肠癌作用机制的网络药理学和分子对接分析

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吉林大学学报（医学版） 2024年第1期50卷 208-220页

作者：陈霭莹姜靖雯张慧广州中医药大学附属海南中医院海南海口570100 海南省中医院肿瘤科海南海口570100

目的:通过网络药理学和分子对接技术分析黄芩汤治疗结直肠癌(CRC)的潜在作用靶点,阐明其相关分子机制。方法:基于中药系统药理学数据库与分析平台(TCMSP)构建黄芩汤活性成分和作用靶点数据集,通过GeneCards、人类在线孟德尔遗传(OMIM)... 详细信息

目的:通过网络药理学和分子对接技术分析黄芩汤治疗结直肠癌(CRC)的潜在作用靶点,阐明其相关分子机制。方法:基于中药系统药理学数据库与分析平台(TCMSP)构建黄芩汤活性成分和作用靶点数据集,通过GeneCards、人类在线孟德尔遗传(OMIM)、药物遗传学和药物基因组学知识库(PharmGKB)等数据库构建CRC疾病相关靶点数据集。利用R软件、Cytoscape软件和STRING数据库构建药物-疾病靶点交集、黄芩汤中药复方调控网络和蛋白-蛋白互作(PPI)网络。利用R软件和Metascape平台进行基因本体论(GO)功能富集分析和京都基因与基因组百科全书(KEGG)信号通路富集分析。采用AutoDock和PyMol软件进行分子对接验证,评估配受体结合情况。结果:筛选黄芩汤有效活性成分136个,黄芩汤治疗CRC的潜在靶点242个,核心靶点18个,基于信号通路分析获得CRC密切相关核心关键靶点5个,分别为蛋白激酶B1 (AKT1)、丝裂原活化蛋白激酶3 (MAPK3)、原癌基因FOS、肿瘤蛋白P53 (TP53)和原癌基因MYC。GO功能富集分析,主要参与多种细胞应激反应的生物过程。KEGG信号通路富集分析,潜在靶点在癌症通路高度富集;进一步对CRC核心靶点进行KEGG信号通路富集分析,主要涉及内分泌抵抗、细胞凋亡和表皮生长因子受体-酪氨酸激酶抑制剂(EGFR-TKI)抵抗等通路。分子对接验证,黄芩汤活性成分槲皮素、山柰酚、汉黄芩素、7-甲氧基-2-甲基异黄酮和柚皮素与AKT1、MAPK3、FOS、TP53及MYC均对接稳定,其中槲皮素与AKT1结合性最好。结论:黄芩汤活性成分可多靶点和多通路治疗CRC,核心配受体槲皮素和AKT1可能通过调控磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B (AKT)和哺乳动物雷帕霉素靶蛋白(mTOR)信号通路影响细胞增殖、分化和凋亡进程,发挥治疗CRC作用。

关键词：黄芩汤网络药理学分子对接结直肠肿瘤槲皮素

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绝对进步与相对成长:一个学校效能评估框架

上海教育科研 2024年第3期 21-29页

作者：卢瑶罗靳雯张青根华中科技大学教育科学研究院 430074 美国加州大学洛杉矶分校教育与信息研究学院 90095

增值(VA)评价和学生成长百分等级(SGPs)评价均以学生的成长评估学校效能,但二者的评估理念、统计技术、评估结果又有明显不同。为此,基于绝对进步理念下的VA与相对成长理念下的SGPs构建为评估学校效能的新框架“VA-SGPs”。在新框架指导... 详细信息

增值(VA)评价和学生成长百分等级(SGPs)评价均以学生的成长评估学校效能,但二者的评估理念、统计技术、评估结果又有明显不同。为此,基于绝对进步理念下的VA与相对成长理念下的SGPs构建为评估学校效能的新框架“VA-SGPs”。在新框架指导下,基于中国教育追踪调查数据,采用OLS、HLM、SGPs模型研究发现:在学业成绩方面,超过70%学校在两种评估理念下的学校效能排名相差较大,且带给学生绝对进步较大的学校可能是带给学生相对成长较低的学校;在认知能力方面,超过40%学校在两种评估理念下的学校效能排名相差较大,认知能力上的高效能学校在学业成绩上可能是低效能学校。这说明新框架下的双维评估结果具有互补性,即双维评估理念具有发现非传统意义上“好学校”的潜力。

关键词：学校效能 VAM SGPs模型好学校

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经颅随机噪声刺激的研究进展

中国生物医学工程学报 2024年第2期43卷 227-239页

作者：邹惠茹张治国黄淦李琳玲梁臻张力魏晋文深圳大学生物医学部生物医学工程学院广东深圳518060 广东省医学信息检测与超声成像重点实验室广东深圳518060 哈尔滨工业大学(深圳)计算机科学与技术学院广东深圳518055 鹏城实验室广东深圳518055

经颅随机噪声刺激(tRNS)是一种利用随机噪声电流调控大脑神经元活动的技术,其通过随机共振等机制影响大脑活动和认知行为,在神经科学和神经病理学等领域展示出较为突出的调控效果,得到越来越多的关注和应用。综述经颅随机噪声刺激的生... 详细信息

经颅随机噪声刺激(tRNS)是一种利用随机噪声电流调控大脑神经元活动的技术,其通过随机共振等机制影响大脑活动和认知行为,在神经科学和神经病理学等领域展示出较为突出的调控效果,得到越来越多的关注和应用。综述经颅随机噪声刺激的生理效应和实施方法,以及在知觉、运动、学习和记忆以及脑疾病康复等方面的应用,总结相关研究现状和发展趋势。

关键词：经颅随机噪声刺激知觉运动学习和记忆