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Detection of polycyclic aromatic hydrocarbons using a high performance-single particle aerosol mass spectrometer

Journal of Environmental Sciences 2023年第2期124卷 806-822页

作者： Yao zhang Chenglei Pei jinwen zhang Chunlei Cheng Xiufeng Lian Mubai Chen Bo Huang Zhong Fu Zhen Zhou Mei Li Institute of Mass Spectrometry and Atmospheric Environment Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air pollutionJinan UniversityGuangzhou 510632China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Guangzhou 510632China Guangzhou Environmental Monitoring Center Guangzhou 510030China Guangzhou Hexin Analytical Instrument Company Limited Guangzhou 510530China

The real-time detection of the mixing states of polycyclic aromatic hydrocarbons(PAHs)and nitro-PAHs in ambient particles is of great significance for analyzing the source,aging process,and health effects of PAHs and nitro-PAHs;yet there is still few effective technology to achieve this type of detection.In this study,11 types of PAH and nitro-PAH standard sampleswere analyzed using a high performance-single particle aerosolmass spectrometer(HP-SPAMS)in lab studies.The identification principles‘parent ions’and‘mass-to-charge(m/z)=77’of each compound were obtained in this study.It was found that different laser energies did not affect the identification of the parent ions.The comparative experiments of ambient atmospheric particles,cooking and biomass burning emitted particles with and without the addition of PAHs were conducted and ruled out the interferences from primary and secondary organics on the identification of PAHs.Besides,the reliability of the characteristic ions extraction method was evaluated through the comparative study of similarity algorithm and deep learning algorithm.In addition,the real PAH-containing particles from vehicle exhaust emissions and ambient particles were also analyzed.This study improves the ability of single particle mass spectrometry technology to detect PAHs and nitro-PAHs,and HP-SPAMS was superior to SPAMS for detecting single particles containing PAHs and nitro-PAHs.This study provides support for subsequent ambient observations to identify the characteristic spectrum of single particles containing PAHs and nitro-PAHs.

关键词： Single particle Polycyclic aromatic hydrocarbons Identification principles Mass spectrometry Aerosol

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Foldable Units and Wing Expansion of the Oakleaf Butterfly During Eclosion

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Journal of Bionic Engineering 2022年第3期19卷 724-736页

作者： jinwen zhang Xiaoming Chen Qin Lu Jinguo Liu Xiaofei Ling Weiwei Wang Pengfei Liu Hang Chen Research Institute of Resource Insects Chinese Academy of ForestryKunming650224China Nanjing Forestry University Nanjing210037China Robotics Laboratory of Chinese Academy of Sciences Shenyang Institute of Automation(SIA)Liaoning110169China

Eclosion is a rapid process of morphological changes in insects,especially for the wings of butterflies.The orange oakleaf butterfly(Kallima inachus)transits from pupae to adults with a 9.3 fold instant increase in the surface area of their wings.To explore the mechanism for the rapid morphological changes in butterfly wings,we analyzed changes in microstructures in the wings of K.inachus.We found that there were lots of micron-sized foldable units in the wings at the pupal stage.The foldable units could provide as much as 31.35 times of increase in wing surface area.During eclosion,foldable units were flattened sequentially and resulted in a rapid increase in wing surface areas.The unfolding process was regulated by the structures and layouts of wing veins.Based on our observation,foldable units play important roles in both deformation and stretching of wings.The foldable units of microstructures may provide mimics for simulating entities of large-deformational bionic structures with practical application.

关键词： Eclosion Foldable units Reserve surface area Wing spreading power

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Exploratory clinical study of chidamide,an oral subtype-selective histone deacetylase inhibitor,in combination with exemestane in hormone receptor-positive advanced breast cancer

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Chinese Journal of Cancer Research 2018年第6期30卷 605-612页

作者： Qingyuan zhang Tao Wang Cuizhi Geng Yue zhang jinwen zhang Zhiqiang Ning Zefei Jiang Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China Department of Breast Cancer the 307th hospital of Chinese People's Liberation ArmyBeijing 100071China The Fourth Hospital of Hebei Medical University Shijiazhuang 050011China Shenzhen Chipscreen Biosciences Shenzhen 518057China

Objective: The recurrence or progression under endocrine therapy in hormone receptor-positive(HR+)advanced breast cancer(ABC) remained a critical clinical challenge.Chidamide is an oral subtype-selective histone deacetylase(HDAC) inhibitor with multiple functions in tumor growth inhibition and microenvironment modulation via epigenetic reprogramming.The purpose of this study was to evaluate the safety,pharmacokinetics(PK),and preliminary efficacy of chidamide in combination with exemestane in HR+ ABC patients.Methods: Eligible patients were postmenopausal women with HR+ ABC recurrent or progressed to at least one endocrine therapy.Blood samples were obtained in the run-in period and the first day of combination treatment for PK analysis.In combination treatment,patients were given exemestane 25mg daily and chidamide 30mg twice a week(BIW) until progression of disease or intolerable toxicities.A treatment cycle was defined as 4 weeks.Safety,PK parameters,and preliminary efficacy were evaluated.Results: A total of 20 patients were enrolled between July and December,2015.The median number of treatments cycle was 5.2(20.8 weeks) with 2 patients still on treatment at the data cut-off date of October,2017.The treatment-related adverse events(AE) ≥ grade 3 in more than 2 patients were neutropenia(35%),thrombocytopenia(30%),and leucopenia(20%).The plasma exposure of exemestane was consistent in the presence or absence of chidamide.A slight increase in chidamide exposure was noted in the presence of exemestane,probably due to the inter-and intra-patient variations.The best response in 16 evaluable patients was assessed by Response Evaluation Criteria in Solid Tumors(RECIST),including 4 patients with partial response,10 patients with stable disease.The median progression-free survival(PFS) was 7.6 months.Conclusions: The combination of chidamide with exemestane was generally well tolerated with promising preliminary efficacy in HR+ ABC patients.The overall results from this study encourage further pivotal trial in this pat

关键词： Advanced breast cancer hormone receptor-positive chidamide exemestane

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中外信息公开标准比较研究

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图书馆学研究 2024年第6期 39-49页

作者：霍亮张锦文郝杰张婷婷天津师范大学管理学院北京市西城区图书馆

信息公开标准对提升我国信息公开质量有着至关重要的作用。为了更好地完善我国信息公开标准化工作,有必要与发达国家进行对比研究。运用定量和定性方法对国外5个发达国家和我国信息公开相关标准在基本情况与制定过程方面进行对比。研究... 详细信息

信息公开标准对提升我国信息公开质量有着至关重要的作用。为了更好地完善我国信息公开标准化工作,有必要与发达国家进行对比研究。运用定量和定性方法对国外5个发达国家和我国信息公开相关标准在基本情况与制定过程方面进行对比。研究发现:我国信息公开标准体量略胜于国外;与国外标准相比,我国更注重政府信息公开的发展,对具体领域信息公开规范较少,对行业、企业的信息公开标准数量相对较少,管理要求内容宽泛。据此提出优化我国信息公开标准工作的建议。

关键词：文献计量标准文献内容对比信息公开

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Identification of Common Maize Diseases and Their Prevention and Control Methods

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Agricultural Biotechnology 2022年第2期11卷 38-42,47页

作者： Xiaochun HUANG Huihui CAO Ruihuan DU Yajing WANG Shuhong zhang Liwu HAO Yanpo YAO Chaohui LI jinwen zhang Tangshan Food and Drug Comprehensive Testing Center Tangshan 063000China Hebei Agricultural Products Quality and Safety Testing Innovation Center Tangshan 063000China Tangshan Institute of Functional Agricultural Product Industrial Technology Tangshan 063000China

Agriculture is the basic industry of China's economic development,and maize is an important part of the agricultural economy.With the increase of global environmental warming and industrial pollution,as well as the adjustment of agricultural planting structure and the transformation of farming and cultivation methods in China,the breeding of maize varieties has been accelerated,and the planting area has increased rapidly,resulting in the condition that the occurrence of maize diseases and pests has been increasing.The damage of some minor diseases continued to increase nationwide or in local areas,and rose to major diseases,and some new diseases appeared in production,posing a threat to the safe production of maize.This paper summarized the occurrence status of important maize diseases in China,and put forward corresponding prevention and control countermeasures.

关键词： Maize Disease control Maize yield Pests and diseases Control measures

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How does the improved DB mode degrade the complex integrity of infrastructure mega-projects？ Evidence from the Hong Kong-Zhuhai-Macao Bridge project in China

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Frontiers of Engineering Management 2018年第1期5卷 40-51页

作者： jinwen zhang Yumin QIU School of Management and Engineering Nanjing University Nanjing 210093 China Hong Kong-Zhuhai-Macao Bridge Authority Zhuhai 519060 China

Complex integrity is one of the main characteristics of infrastructure mega-projects(IMPs). Cost,technology, risk, duration, environmental impact, and other uncertain complexities are interrelated and constitute a challenging and complex management problem. At present, there is no unified understanding of or solutions to these complex integrity problems. This study analyzes the complex integrity of the island-tunnel subproject of the Hong Kong-Zhuhai-Macao Bridge(HZMB) project and proposes an improved design-build(DB) mode in which the owner provides a preliminary design and has the right to form and manage consortium. This improved DB mode creatively degrades the special complexities that arise from multiple dimensions. On this basis, it is an efficacious way to grasp the main contradictions, integrate the effective resources, and degrade the complex integrity in multiple dimensions and at multiple levels so as to effectively deal with the complexity management of IMPs.

关键词： Hong Kong-Zhuhai-Macao Bridge project island-tunnel subproject complex integrity complexity degradation the general contracting mode of design-build the design-build consortium

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基于触觉交互界面的虚拟现实警务训练系统

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测控技术 2024年第4期43卷 83-88,94页

作者：张金文张伟宋爱国内蒙古警察职业学院公安管理系内蒙古呼和浩特010050 南京浩伟智能科技有限公司研发中心江苏南京210049 东南大学仪器科学与工程学院江苏南京210096

虚拟现实凭借着其高沉浸感的体验,在警务仿真培训中有着广泛应用,由于商用虚拟现实系统多关注视觉反馈,难以使用标准的手控器为警务培训提供逼真的触觉交互体验。触觉交互界面基于多功能的离散单点触控交互系统,可实现虚拟现实中的道具... 详细信息

虚拟现实凭借着其高沉浸感的体验,在警务仿真培训中有着广泛应用,由于商用虚拟现实系统多关注视觉反馈,难以使用标准的手控器为警务培训提供逼真的触觉交互体验。触觉交互界面基于多功能的离散单点触控交互系统,可实现虚拟现实中的道具操作直接交互,针对虚拟训练中的警务场景,该系统能够识别用户所选道具,并响应用户的交互动作,以提高虚拟现实系统的交互真实性。该系统使用HTC Vive追踪器对用户进行运动捕捉,以生成人体骨架驱动虚拟代理。同时,使用单片机获取并处理用户的道具选择信息及用户与道具的交互信息,再通过蓝牙通信传输至上位机。硬件设计采用STM32F103系列中的C8T6最小系统板,相关功能通过软件Keil5编程实现。实验验证了系统的正确性和可行性,能够提供多样的物理触觉代理,增强了虚拟环境中的交互体验。该系统为虚拟现实交互技术提供了新的思路和方向,具有很好的应用前景。

关键词：虚拟现实触觉输入装置触觉传感器人机交互多道具识别

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疏浚吹填泥沙静态间歇沉降行为及其稳态宏观评价标准

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岩土工程学报 2024年第3期46卷 549-557页

作者：鲍树峰董志良莫海鸿周睿博张劲文广州交通大学(筹)/广州航海学院土木与工程管理学院广东广州510725 广东省近海基础设施绿色建造与智能运维重点实验室广东广州510725 中交四航工程研究院有限公司广东广州510230 中交集团交通基础工程环保与安全重点实验室广东广州510230 华南理工大学土木与交通学院广东广州510641 中交四航局港湾工程设计院有限公司广东广州510220

关于疏浚吹填泥沙的静态间歇沉降行为与机理及其稳态宏观评价标准,目前暂未深入研究。这是当今疏浚吹填泥沙地基采用真空过滤排水固结技术进行处理时无法科学判断最佳启动时间的主要原因之一。鉴于此,先对疏浚吹填泥沙的静态间歇沉降行... 详细信息

关于疏浚吹填泥沙的静态间歇沉降行为与机理及其稳态宏观评价标准,目前暂未深入研究。这是当今疏浚吹填泥沙地基采用真空过滤排水固结技术进行处理时无法科学判断最佳启动时间的主要原因之一。鉴于此,先对疏浚吹填泥沙的静态间歇沉降行为进行理论研究,建立了颗粒悬浮液的沉降速度与平均孔隙比的理论关系式。然后,获取典型工程现场的疏浚吹填泥沙,配制典型浓度试样,开展静态间歇沉降模型试验研究。研究结果表明:(1)黏粒(d<0.005mm)含量是影响疏浚吹填泥沙静态间歇沉降行为与机理的关键因素之一;(2)颗粒通量最大值Gmax往往出现在试验难以测出的非常低的浓度条件下,且黏粒含量越高,越难通过试验方式测得;(3)对于黏粒含量为40%~60%的疏浚吹填泥沙,建议将“平均孔隙比累计变化率为60%~75%”作为静态间歇沉降稳定状态的宏观评价标准。

关键词：疏浚吹填泥沙静态间歇沉降行为稳态评价标准

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Changes in Plasma Levels of Vasoactive Factors in Patients Undergoing Abdominal Surgery

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Surgical Science 2014年第9期5卷 389-396页

作者： jinwen zhang Meng Li Feng zhang Department of Vascular Surgery the Second Hospital of Hebei Medical University Shijiazhuang China

Background: To investigate the changes in plasma levels of endothelin (ET), nitric oxide (NO), prostacyclin (PGI2) and thromboxane A2 (TXA2) in patients undergoing abdominal operation. Materials and Methods: Thirty cases of abdominal surgery (14 males, 16 females;mean age 48 ± 11 years, ranging from 24 to 70) were prospectively recruited: Twenty-four cases of cholelithiasis and cholecystitis, 2 cases of peptic ulcer and 4 cases of portal vein hypertension. At five different time points (1-3 days after hospitalization (T1), at surgery beginning, after anesthesia (T2) and at the first (T3), third (T4) and fifth day (T5) after surgery), plasma levels of ET-1, NO2-, NO3-,?6-keto-PGF1α and thromboxane B2 (TXB2), the latter two being stable metabolites of PGI2 and TXA2 respectively, were measured. Results: ET-1 levels increased significantly after anesthesia and surgery (T1 = 69.2 ± 10.7 vs. T2 = 82.4 ± 14.7 vs. T3 = 96.6 ± 22.8 pg/ml, p 2 levels before surgery were significantly lower than that after (T2 = 67.5 ± 52.7 vs. T3 = 157.6 ± 21.8 pg/ml, p < 0.05). Pre-surgery NO levels were significantly higher than that after surgery (T1 = 2575 ± 50 vs. T2 = 1922 ± 44 vs. T3 = 1692 ± 39 ng/ml, p < 0.05 for T1 vs. T2 and T3). Pre-surgery levels of 6-keto-PGI1α were significantly higher than that after anesthesia and surgery (T1 = 180.5 ± 17.8 vs. T2 = 132.1 ± 32.6 vs. T3 = 110.9 ± 31.9 pg/ml, p < 0.05 for T1 vs. T2 and T3). Conclusions: Level of vasoconstrictive factors (ET and TXA2) increased significantly after surgery, while vasodilatory factors (NO and PGI2) decreased significantly after operation. Imbalance in vasoactive factors encourages hypercoagulability and then may play a role in the pathobiology of post-surgery complications, such as deep venous thrombosis (DVT).

关键词： Prostacyclin Endothelin Thromboxane A2 Nitric Oxide Deep Venous Thrombosis Thrombotic State

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Construction management and technical innovation of the main project of Hong Kong–Zhuhai–Macao Bridge

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Frontiers of Engineering Management 2018年第1期5卷 128-132页

作者： Yongling ZHU jinwen zhang Xinglin GAO Hong Kong Zhuhai Macao Bridge Authority zhuhai 519060 China

Design Units:CCCC Highway Consultants Co.,Ltd.;China Zhongtie Major Bridge Reconnaissance&Design Institute Co.,Ltd.Construction Units:China Communications Construction Company Limited Consortium;China

关键词： Macao Bridge Zhuhai

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