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Polarized condensates confer row identity of hair cell stereocilia

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Journal of Molecular Cell Biology 2022年第7期14卷 78-79页

作者： Yingdong Shi Lin Lin Chao Wang jinwei zhu Department of Neurology the First Affiliated Hospital of USTCMinistry of Education Key Laboratory for Cellular DynamicsBiomedical Sciences and Health Laboratory of Anhui ProvinceSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China

Sound waves are converted into electric signals by hair bundles(also known as stereocilia)in the cochlear hair ***,a cluster of actin protrusions at the apical surface of hair cells,are organized into rows of graded height(Figure 1).Mechanical force induced by sound waves leads to stereocilia deflection towards the tallest row and subsequent activation of mechanoelectrical transducer channels at the tips of the shorter rows,thus achieving mechanoelectrical transduction(Gillespie and Muller,2009).Such a staircase-like architecture is essential for auditory perception as manifested by severe deafness caused by genetic mutations that disrupt stereocilia morphology(Barr-Gillespie,2015).However,little is known about how this planar asymmetry of stereocilia is achieved.

关键词： electrical Figure shorter

Mechanism of the Selective Catalytic Reduction of NOx with NH3 over W-Doped Fe/TiO2 Catalyst

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Chemical Research in Chinese Universities 2014年第6期30卷 1005-1010页

作者： SHU Yun WANG Hongchang zhu jinwei ZHANG Fan Research Center of Air Pollution Control Technology Chinese Research Academy of Environmental Sciences Beijing 100012 P. R. China

The W-doped Fe/TiO2 catalyst prepared by an impregnation method exhibited a good NH3-selective cata- lytic reduction（SCR） activity and N2 selectivity with broad operation temperature window. The interaction between Fe and W could increase the amount of surface chemisorbed oxygen, and thus enhances the low temperature SCR activity by facilitating the fast SCR of 2NH3＋NO＋NO2 →2N2＋3H2O. The NH3-SCR reaction mechanism over the W-Fe/TiO2 was fully investigated via in situ diffuse reflectance infrared Fourier transform spectroscopy（in situ DRIFTS）. In the low temperature range（〈250 ℃）, the reactive surface species were mainly coordinated NH3, ionic NH~ and adsorbed NO2 species, and the SCR mainly followed the Langmuir-Hinshelwood mechanism, during which the adsorbed NO2 species became the important active sites. In the high temperature range（〉250 ℃）, the reactive surface species were mainly NH2, and the SCR mainly followed the Eley-Rideal mechanism, during which the for- mation of NH2NO intermediate species after H-abstraction of NH3 was the rate-determining step.

关键词： Selective catalytic reduction Iron Tungsten Reaction mechanism

Active oxygen species and oxidation mechanism over Ce-doped LaMn_(0.8)Ni_(0.2)O_(3)/hierarchical ZSM-5 in pentanal oxidation

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Journal of Rare Earths 2021年第9期39卷 1062-1072页

作者： Jian Li Yingjie Shi Xiaoheng Fu Yun Shu Jiayu Huang jinwei zhu Gang Tian Jingnan Hu Research Center of Air Pollution Control Technology Chinese Research Academy of Environmental SciencesBeijing 100012China School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China

Hierarchical ZSM-5(HZ)molecular sieves based on fly ash were synthesized using a method combining water heat treatment with step-by-step *** coupling catalysts between La_(1-x)Ce_(x)Mn_(0.8)-Ni_(0.2)O_(3)(x≤0.5)perovskites and HZ were prepared through the impregnation method,which were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),high-resolution transmission electron microscopy(HRTEM),N_(2)adsorption,X-ray photoelectron spectroscopy(XPS),NH3-temperature programmed desoprtion(NH3-TPD),H_(2)-temperature programmed reduction(H_(2)-TPR)and O_(2)-TPD techniques and investigated regarding pentanal oxidation at 120-390℃to explore the effects of Ce doping on the catalytic activity and the active oxygen species of the coupling catalysts,meanwhile,the reaction mechanism and pathway of pentanal oxidation were also *** results reveal that Ce substitution at La sites can change the electronic interactions between all the elements and promote the electronic transfer among La,Ce,Ni,Mn and HZ,influencing directly the physicochemical characteristics of the ***,the amount and transfer ability of surface adsorbed oxygen(O_(2)-and O-)regarded as the reactive oxygen species and the low temperature reducibility are the main influence factors in pentanal ***,La_(0.8)Ce_(0.2)Mn_(0.8)Ni_(0.2)O_(3)/HZ exhibits the best catalytic activity and deep oxidation capacity as well as a better water resistance due to its larger amount of surface adsorbed oxygen species and higher low temperature ***’s more,appropriate Ce substitution can significantly enhance the amount of O_(2)-ions,which can distinctly enhance the catalytic activity of the catalyst,and moderate acid strength and appropriate acid amount can also facilitate the improvement of the pentanal oxidation *** is found that there is a synergic catalytic effect between surface acidity and redox ability of the *** to the in s

关键词： Hierarchical ZSM-5 molecular sieve Catalytic oxidation Active oxygen species Perovskite Ce doping Rare earths

Insight into the effect of surface carboxyl and amino groups on the adsorption of titanium dioxide for acid red G

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Frontiers of Chemical Science and Engineering 2021年第5期15卷 1147-1157页

作者： Wenlong Zhang Xuyang Zhao Lin Zhang jinwei zhu Shanshan Li Ping Hu Jiangtao Feng Wei Yan Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an710049China Shaanxi Electrical Equipment Institution Xi’an710025China Shaanxi Polytechnic Institute Xianyang712000China

In this study,TiO_(2)functionalized with organic groups were prepared to study the effect of carboxyl and amino groups on the adsorption behavior of TiO_(2)for the removal of acid red G(ARG)as an anionic dye from aqueous ***_(2)was successfully modified with carboxyl and amino groups by using the hydrolysis method with oxalic acid(OAD,with two carboxyl groups),ethylenediamine(EDA,with two amino groups)and DL-alanine(DLA,with one carboxyl group and one amino group)at low temperature(65℃)and labeled as OAD-TiO_(2),EDA-TiO_(2)and DLA-TiO_(2),*** ARG uptake by the functionalized TiO_(2)samples was largely dependent on the functional *** interaction between ARG and the functional organic groups on the TiO_(2)samples plays an important role in the adsorption process,which leads to the excellent adsorption performance(higher capacity and faster adsorption rate)of the functionalized TiO_(2)samples than that of P25(commercial TiO_(2)without modification).Furthermore,there is no obvious loss of the adsorption capacity for the functionalized TiO_(2)even after 5 adsorption-desorption cycles,which indicated the good reusability of the modified TiO_(2)samples for anionic dye removal from aqueous solution.

关键词： amino group carboxylic group titanium dioxide ARG adsorption

Comprehensive Characterization of the Integrin Family Across 32 Cancer Types

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GENOMICS PROTEOMICS & BIOINFORMATICS 2024年第4期22卷 qzae035页

作者： Zou, Cheng zhu, jinwei Xiong, Jiangling Tian, Yu Peng, Yousong Cheung, Edwin Zhang, Dingxiao Hunan Univ Sch Biomed Sci Hunan Key Lab Anim Models & Mol Med Changsha 410082 Peoples R China Hunan Univ Coll Biol Changsha 410082 Peoples R China Univ Macau Fac Hlth Sci Zhuhai Macau 999078 Macau Peoples R China

Integrin genes are widely involved in tumorigenesis. Yet, a comprehensive characterization of integrin family members and their interactome at the pan-cancer level is lacking. Here, we systematically analyzed integrin family in approximately 10,000 tumors across 32 cancer types. Globally, integrins represent a frequently altered and misexpressed pathway, with alteration and dysregulation overall being protumorigenic. Expression dysregulation, better than mutational landscape, of integrin family successfully identifies a subgroup of aggressive tumors with a high level of proliferation and stemness. The results reveal that several molecular mechanisms collectively regulate integrin expression in a context-dependent manner. For potential clinical usage, we constructed a weighted scoring system, integrinScore, to measure integrin signaling patterns in individual tumors. Remarkably, integrinScore was consistently correlated with predefined molecular subtypes in multiple cancers, with integrinScore-high tumors being more aggressive. Importantly, integrinScore was cancer-dependent and closely associated with proliferation, stemness, tumor microenvironment, metastasis, and immune signatures. IntegrinScore also predicted patients' response to immunotherapy. By mining drug databases, we unraveled an array of compounds that may modulate integrin signaling. Finally, we built a user-friendly database, Pan-cancer Integrin Explorer (PIExplorer;http://***/PIExplorer), to facilitate researchers to explore integrin-related knowledge. Collectively, we provide a comprehensive characterization of integrins across cancers and offer gene-specific and cancer-specific rationales for developing integrin-targeted therapy. Graphical abstract

关键词： Integrin Pan-cancer Tumor microenvironment Immunotherapy Transcriptional regulation

Structure and function of the guanylate kinase-like domain of the MAGUK family scaffold proteins

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Frontiers of physics 2012年第5期7卷 379-396页

作者： jinwei zhu Yuan SHANG Jia CHEN Mingjie ZHANG Division of Life Science State Key Laboratory of Molecular Neuroscience Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China Institute for AdvanCed Study Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China

Membrane associated guanylate kinases （MAGUKs） are a family of scaffold proteins that play essential roles in organ development, cell-cell communication, cell polarity establishment and maintenance, and cellular signal transduction. Every member of the MAGUK family contains a guanylate kinase-like （GK） domain, which has evolved from the enzyme catalyzing GMP to GDP conversion to become a protein-protein interaction module with no enzymatic activity. Mutations of MAGUKs are linked to a number of human diseases, including autism and hereditary deafness. In this review, we summarize the structural basis governing cellular function of various members of the MAGUKs. In particular, we focus on recent discoveries of MAGUK GKs as specific phospho-protein interaction modules, and discuss functional implications and connections to human diseases of such regulated MAGUK GK/target interactions.

关键词： MAGUK GK domain phospho-protein interaction module synapse neuronal disease

SO_2/Hg removal from flue gas by dry FGD

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International Journal of Mining Science and Technology 2012年第1期22卷 107-110页

作者： Wang Fan Wang Hongmei Zhang Fan zhu jinwei Tian Gang Liu Yu Mao Jixian Chinese Research Academy of Environmental Sciences Beijing 100012China

To study the mechanism of SO2 and Hg removal from flue gas, an experimental packed bed reactor was designed to simulate the dry FGD, where a mixture of lime and fly ash in ratio 1：3 w/w was used as the S02 and Hg sorbent, and steam at temperature of 100 ℃ was applied for activation of the sorbent, while the activation time set to 20 rain. The experimental factors including the SO2/Hg sorbent characteristics, 50% breakthrough time for SO2/Hg removal, sorbent packed bed depth and reaction temperature were investigated. The experimental results show that after steam activation, the BET specific surface area and specific pore volume increased from 37.8 to 45.5 m^2/g and from 0.42 to 0.51 cm^3/g, respectively. With activation of the sorbent by steam, the 50% breakthrough times of SO2 and Hg removal increased from 34 to 42 rain and from 23 to 45 rain, respectively. When the packed bed depth was increased from 5 to 25 ram. the 50% breakthrough times for Hg and S02 removal increased from 12 to 52 rain and from 6 to 47 rain, respectively. With the increase of the reaction temperature, the 50% breakthrough of SO2/Hg removal decreased accordingly. Steam activation can efficiently improve SO2/Hg removal simultaneously.

关键词： SO2 removal Hg removal Dry FGD Sorbent activation

An unexpected MAGUK GK target recognition mode revealed by the interaction between DLG and KIF13B

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An unexpected MAGUK GK target recognition mode revealed by t...

第五届中国结构生物学学术讨论会

作者： jinwei zhu Yuan Shang Rongguang Zhang Mingjie Zhang National Center for Protein Science Shanghai Institute of Biochemistry and Cell BiologyShanghai Institutes of Biological Sciences Chinese Academy of Sciences Division of Life Science State Key Laboratory of Molecular Neuroscience Hong Kong University of Science and Technology Center of Systems Biology and Human Health School of Science and Institute for Advanced Study Hong Kong University of Science and Technology

The master scaffold proteins membrane-associated guanylate kinases（MAGUKs） share a signature guanylate kinase（GK） domain, which is evolved from a nucleotide kinase into a protein binding module. Despite of diverse functional roles in cell polarity control and synaptic signaling, the only known action mode of MAGUK GK is via a phosphorylation-dependent binding to short peptides from target proteins. Here we discover that DLG4 GK binds to an unphosphorylated and autonomously folded domain within the tail cargo binding region of a kinesin motor KIF13 B with exquisite specificity and high affinity. The structure of the DLG4 GK in complex with its binding domain of KIF13 B reveals the molecular mechanism governing this novel mode of target recognition by the GK domain, providing insights into DLG/KIF13 B complex-mediated regulations of diverse cellular processes including mitotic spindle orientation and cell polarity establishment and maintenance. We further provide evidence that such phosphorylation-independent target binding is another general property of GK domains, and thus expanding the action mechanisms of the MAGUK family proteins.

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来源： cnki会议评论

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基于数据挖掘的中医药数据预处理方法

计算机工程 2006年第15期32卷 280-282,F0003页

作者：朱金伟鞠时光辛燕江苏大学计算机学院镇江212013

中药文化的地区差异带来了中医药数据的众多不确定性,为解决基于数据挖掘的新药研制决策支持系统的数据问题,提出了一套规范原始中医药数据的处理方法。应用了数据归约技术、聚类的方法、模糊集理论改进了中医药数据的质量,使得在预处... 详细信息

中药文化的地区差异带来了中医药数据的众多不确定性,为解决基于数据挖掘的新药研制决策支持系统的数据问题,提出了一套规范原始中医药数据的处理方法。应用了数据归约技术、聚类的方法、模糊集理论改进了中医药数据的质量,使得在预处理后的中药方剂数据库中成功挖掘出重要规则,为研制中药新药提供了有力的决策支持。

关键词：数据预处理数据挖掘数据归约模糊集隶属函数