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A ballistocardiogram measurement system for home monitoring:design,performance,and evaluation

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Chinese Science Bulletin 2014年第23期59卷 2909-2917页

作者： Xinrong Cao Jie Wang Xianwen Zhang jintian tang Institute of Medical Physics and Engineering Tsinghua University

We present a ballistocardiogram(BCG)measurement system for obtaining the BCG *** performance of the BCG measurement system was tested,including the dynamic response frequency of the platform(32 Hz with a 75 kg load),and the signal to noise ratio of the system(minimum 23 dB).Factors that could influence BCG recording during measurement were investigated by collecting data from 48 healthy subjects(28 males and 20females).The basic features of the BCG signal,such as the amplitude and time interval,were extracted,and differences by gender were analyzed.A correlation between the IJ amplitude(amplitude difference between I-and J-peak)and the respiration phase was found(R2=0.49).The BCG signals for both sitting(SiBCG)and standing(StBCG)postures were obtained using this *** showed that the StBCG amplitudes were larger than those of SiBCG but there was no significant difference in the time *** robustness of our system was verified,and its potential for non-invasive cardiac activity monitoring was demonstrated.

关键词：冲击测量系统性能评价信号传送设计监控家庭时间间隔卡介苗

Local adaptive segmentation algorithm for 3-D medical image based on robust feature statistics

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Science China(Information Sciences) 2014年第10期57卷 158-169页

作者： ZHUO ZiHan ZHAI WeiMing LI Xin LIU LingLing tang jintian Key Laboratory Particle & Radiation Imaging Ministry of Education Department of Engineering PhysicsTsinghua University State Key Laboratory of Intelligent Technology and Systems National Laboratory for Information Science and Technology Department of Computer Science and Technology Tsinghua University Department of Medical Imaging Tianjin Medical University

Medical image segmentation is of pivotal importance in computer-aided clinical diagnosis. Many factors, including noises, bias field effect, local volume effect, as well as tissue movement may affect the medical image, thus causing blurring or uneven characteristics when forming a picture. Such quality defects will inevitably impair the gray-scale difference between adjacent tissues and lead to insufficient segmentation or even leakage during tissue or organ segmentation. In the present investigation, a local adaptive segmentation algorithm for 3-D medical image based on robust feature statistics(LARFS) was proposed. By combining segmentation algorithm principles for traditional region growing(RG) and robust feature statistics(RFS), the location and neighborhood image information of input seed point can be comprehensively analyzed by *** show that, for different segmentation objects, under controlling the input parameter of growing factor within certain range, LARFS segmentation algorithm can adapt well to the regional geometric shape. And because the robust feature statistics is applied in the contour evolution process, LARFS algorithm is not sensitive to noises and not easily influenced by image contrast and object topology. Hence, the leakage and excessive segmentation effects are ameliorated with a smooth edge, and the accuracy can be controlled within the effective error range.

关键词： medical image adaptive segmentation region growing robust feature statistics contour evolution

In vivo assessment of hepatotoxicity,nephrotoxicity and biodistribution using 3-aminopropyltriethoxysilane-coated magnetic nanoparticles(APTS-MNPs) in ICR mice

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Chinese Science Bulletin 2014年第16期59卷 1800-1808页

作者： Xiaowen Wang Jieying Zhang Xin Yang Zhenghai tang Yanwen Hu Benke Chen jintian tang Institute of Neurological Disorders Yuquan HospitalTsinghua University Department of Biological Pharmaceuticals Beijing University of Chinese Medicine Key Laboratory of Particle & Radiation Imaging Tsinghua UniversityMinistry of Education

The biocompatibility and biodistribution of magnetic nanoparticles(MNPs)in vivo are essential to ensure their safely clinical *** have studied these aspects with our 3-aminopropyltriethoxysilanecoated magnetic nanoparticles(APTS-MNPs)formulation,which can be used as magnetic induction hyperthermia *** in tissue iron levels were analyzed after intraperitoneal injection of APTS-MNPs to ICR *** and kidney functions were ***,liver,spleen,lung,kidney,testis,and brain were sectioned for pathological *** of iron in various body tissues changed with time but greater fraction of the injected iron localized in the liver and spleen than in other *** showed an increase in AST and LDH following APTS-MNPs *** analyses of selected tissues showed no obvious abnormal *** conclusion,APTS-MNPs did not cause continuing changes in the liver and kidney function and thus can be safely used for in vivo application.

关键词：磁性纳米粒子 ICR小鼠生物分布肝毒性 MNP 肾毒性乙氧基氨丙基

CHARACTERIZATION　OF　VELOCITY　SINGULARITY　AND　SUPPRESSION　OF　NOISE

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中国有色金属学会会刊：英文版 1994年第4期4卷 7-9页

作者： Song,Shougen tang,jintian(Department of Geology, Central South University of Technology,Changsha 410083)

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ＣＨＡＲＡＣＴＥＲＩＺＡＴＩＯＮＯＦＶＥＬＯＣＩＴＹＳＩＮＧＵＬＡＲＩＴＹＡＮＤＳＵＰＰＲＥＳＳＩＯＮＯＦＮＯＩＳＥ￥Ｓｏｎｇ，ＳｈｏｕｇｅｎＴａｎｇ，Ｊｉｎｔｉａｎ（ＤｅｐａｒｔｍｅｎｔｏｆＧｅｏｌｏｇｙ，ＣｅｎｔｒａｌＳｏｕｔｈＵｎｉｖｅｒｓｉｔ...

关键词： imaging characterization of singularity noise multiscale

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Preparation and Performance of Collagen Modified Polyester Used as Implantable Artificial Hair

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Journal of Donghua University(English Edition) 2018年第1期35卷 38-42页

作者： CHEN Ying YU Jinze tang jintian Department of Material Science and Engineering Beijing Key Laboratory of Clothing Materials R&D and AssessmentBeijing Institute of Fashion TechnologyBeijing 100029China Institute of Medical Physics and Engineering Department of Engineering PhysicsTsinghua UniversityBeijing 100084China College of Textile and Fashion Qingdao UniversityQingdao 266071China

The implantable artificial hair was prepared by grafting collagen on the surface of poly(ethylene terephthalate)(PET)to improve its *** acid(AAc)was used to modify the surface properties of PET firstly,and then collagen was grafted on the PET-AAc *** concentration of collagen solution was discussed to graft more collagen on PET *** were well characterized by scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FTIR)and X-ray photoelectron spectroscopy(XPS).SEM indicated that collagen with about 3.07μm thickness was coated on PET surface when the concentration of collagen solution was 1.0 mg/m *** and XPS showed AAc and collagen were both on the surface of PET *** optimized concentration of collagen solution was 1.0 mg/m L,resulting in the most grafting density of 3.46μg/cm^(2).It can be concluded that a large amount of collagen is coated on PET surface.

关键词： collagen acrylic acid(AAc) polycethylene terephthalate(PET) grafting density implantable artificial hair

Pullulan Acetate Coated Magnetite Nanoparticles for Hyper-Thermia:Preparation,Characterization and In Vitro Experiments

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Nano Research 2010年第1期3卷 23-31页

作者： Fuping Gao Yuanyuan Cai Jing Zhou Xiaoxue Xie Weiwei Ouyang Yuhui Zhang Xufei Wang Xiaodong Zhang Xiaowen Wang Lingyun Zhao jintian tang Key Laboratory of Particle&Radiation Imaging Ministry of EducationInstitute of Medical Physics and EngineeringDepartment of Engineering PhysicsTsinghua UniversityBeijing 100084China Department of Biopharmaceutics Beijing University of Traditional Chinese MedicineBeijing 100102China Department of Oncology Xiangya Hospital of Central South UniversityChangsha 410008China

Amphipathic polymer pullulan acetate (PA)-coated magnetic nanoparticles were prepared and characterized by various physicochemical means. The cytotoxicity and cellular uptake of the magnetic nanoparticles were examined. The hyperthermic effect of the magnetic nanoparticles on tumor cells was evaluated. Transmission electron microscopy (TEM) showed that the PA coated magnetic nanoparticles (PAMNs) had spherical morphology. Dynamic light scattering (DLS) showed that the size distribution of PAMNs was unimodal,with an average diameter of 25.8 nm ± 6.1 nm. The presence of the adsorbed layer of PA on the magnetite surface was confirmed by Fourier transform infrared (FTIR) spectroscopy. Magnetic measurements revealed that the saturation magnetization of the PAMNs reached 51.9 emu/g and the nanoparticles were superparamagnetic. Thermogravimetric analysis (TGA) showed that the Fe_(3)O_(4) particles constituted 75 wt% of the PAMNs. The PAMNs had good heating properties in an alternating magnetic field. Cytotoxicity assay showed that PAMNs exhibited no significant cytotoxicity against L929 cells. TEM results showed that a large number of PAMNs were internalized into KB cells. PAMNs have good hyperthermia effect on KB cells in vitro by magnetic field induced hyperthermia. These novel magnetic nanoparticles have great potential as magnetic hyperthermia mediators.

关键词： Magnetic nanoparticles pullulan acetate hyperthermia cytotoxicity cellular uptake

A novel and effective hyperthermia method for Schistosomiasis japonica prevention and treatment

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Science Bulletin 2015年第16期60卷 1461-1464页

作者： Huixia Yang Tao tang Pei He Youren Zhang Le Xie Guangqi Liu Li Li Weichao Kong Jingdingsha Li Ruiting Liu Yukun Li Junjian Hu Xiaowen Wang Liya Li Guanghong Xiang Geoffrey Gobert Yuesheng Li jintian tang The Yuquan Hospital Tsinghua University Laboratory of Innovative Medical Technology Department of Engineering Physics Tsinghua University The WHO Collaborating Centre for Research and Control of Schistosomiasis on Lake Region Hunan Institute of Parasitic Diseases Department of Pharmaceutics Beijing University of Chinese Medicine Graduate School Hunan University of Chinese Medicine School of Measuring and Optical Engineering Nanchang Hangkong University Department of Oncology Xiangya Hospital Central South University Department of Medical Oncology China-Japan Friendship Hospital Queensland Institute of Medical Research Clinic for Vascular and Endovascular Surgery University Clinic of Muenster

The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 % （37 ℃, 5 min） to 0 （49℃, 10 min） with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy （P 〈 0.05）. Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45-49℃ for 5 min within 8 h of infection, worm reduction rate （WRR） reached 74 %-83 % （P 〈 0.01）. The sensitivity of adult schistosoma to heat was also investigated using microwave intraperitoneal hyperthermia （thermal dosages 42-43℃, 20 min）. The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel （PZQ）-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus, hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage.

关键词： Hyperthermia Schistosomiasis japonica Praziquantel (PZQ) Cercariae

miR-30靶向调控Zeb2相关通路抑制胆囊癌细胞EMT进程

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中国比较医学杂志 2022年第9期32卷 69-75页

作者：唐津天唐润娟新疆维吾尔自治区肿瘤医院肝胆胰外科乌鲁木齐830000 新疆医科大学第二附属医院康复科乌鲁木齐830000

目的本研究旨在探讨小RNA-30(miR-30)在胆囊癌(GBC)上皮间充质转化(EMT)进程中的作用和潜在机制。方法 qRT-PCR用于检测胆囊上皮细胞和癌细胞系miR-30相对表达水平;过表达miR-30后采用MTT、平板克隆实验用于检测细胞增殖能力;细胞划痕... 详细信息

目的本研究旨在探讨小RNA-30(miR-30)在胆囊癌(GBC)上皮间充质转化(EMT)进程中的作用和潜在机制。方法 qRT-PCR用于检测胆囊上皮细胞和癌细胞系miR-30相对表达水平;过表达miR-30后采用MTT、平板克隆实验用于检测细胞增殖能力;细胞划痕实验和Transwell小室试验分别评估细胞迁移和侵袭能力;Western blot用于评估细胞EMT相关蛋白(E-cadherin、N-cadherin和Vimentin)和EMT相关转录因子(Snail、Slug和Zeb2)的表达水平。拯救实验用于探索miR-30与Zeb2的靶向调控关系。结果 miR-30在2个代表性GBC细胞系(GBC-SD和NOZ)中明显下调(P<0.05)。过表达miR-30会抑制GBC-SD细胞增殖、克隆形成、细胞迁移、细胞侵袭和EMT过程(P<0.05),而过表达Zeb2可以逆转miR-30导致的EMT抑制作用(P<0.05)。结论 miR-30通过靶向Zeb2减弱GBC细胞的EMT进展,表明miR-30是一种肿瘤抑制因子,可作为GBC的新型潜在分子治疗靶点。

关键词：胆囊癌 miR-30 Zeb2 EMT

矢车菊素-3-O-葡萄糖苷保护RAW264.7细胞免受过氧化氢诱导的氧化损伤

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食品科学 2021年第13期42卷 103-113页

作者：薛宏坤谭佳琪李倩唐劲天清华大学工程物理系粒子与辐射成像教育部重点实验室北京100084 北京大学前沿交叉学科研究院北京100080

本研究旨在探究矢车菊素-3-O-葡萄糖苷(cyanidin-3-O-glucoside,C3G)对H2O2诱导RAW264.7细胞氧化损伤的保护作用及其机制。通过噻唑蓝法测定C3G和过氧化氢分别对RAW264.7细胞存活率的影响;采用酶联免疫吸附测定法检测细胞内超氧化物歧化... 详细信息

本研究旨在探究矢车菊素-3-O-葡萄糖苷(cyanidin-3-O-glucoside,C3G)对H2O2诱导RAW264.7细胞氧化损伤的保护作用及其机制。通过噻唑蓝法测定C3G和过氧化氢分别对RAW264.7细胞存活率的影响;采用酶联免疫吸附测定法检测细胞内超氧化物歧化酶(superoxide dismutase,SOD)和谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)活力以及一氧化氮(nitric oxide,NO)和丙二醛(malondialdehyde,MDA)水平;利用2’,7’-二氯荧光素二乙酸酯活性氧荧光探针检测细胞内活性氧(reactive oxygen species,ROS)水平;通过逆转录定量聚合酶链式反应和Western blot法分别测定相关mRNA和蛋白表达水平。结果表明,C3G(6.25~25.00μmol/L)能显著抑制H2O2诱导RAW264.7细胞活性降低(P<0.05)。C3G显著降低H2O2诱导RAW264.7细胞内ROS过表达、MDA水平和NO释放(P<0.05),显著增加SOD和GSH-Px活力(P<0.05)。此外,与空白对照相比,400μmol/L H2O2处理组中,蛋白激酶Mst1/2和Kelch样环氧氯丙烷相关蛋白Keap1的mRNA及蛋白相对表达水平显著上调(P<0.05),而细胞中核因子E2相关因子和下游抗氧化酶HO-1的mRNA及蛋白相对表达水平显著下调(P<0.05);而采用C3G干预RAW264.7细胞,上述相关mRNA及蛋白的相对表达水平被逆转。结论:C3G对H2O2诱导RAW264.7细胞氧化损伤保护作用,可能与激活Mst/Nrf2信号通路和提高抗氧化酶活性有关。

关键词：矢车菊素-3-O-葡萄糖苷 RAW264.7细胞氧化损伤 Mst/Nrf2信号通路