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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第3期14卷 247-252页

作者： Sitthichai IAMSAARD Thawatchai PRABSATTROO Wannisa SUKHORUM Supaporn MUCHIMAPURA Panee SRISAARD Nongnut UABUNDIT Wipawee THUKHAMMEE jintanaporn wattanathorn Department of Anatomy Faculty of MedicineKhon Kaen University Integrative Complementary Alternative Medicine Research and Development Group Faculty of MedicineKhon Kaen University Department of Physiology Faculty of MedicineKhon Kaen University

Objective:To investigate the effect of Anethum graveolens(AG) extracts on the mounting frequency,histology of testis and epididymis,and sperm ***:Male rats induced by cold immobilization before treating with vehicle or AG extracts [50,150,and 450 mg/kg body weight(BW)] via gastric tube for consecutive 1,7,and 14 d were examined for mounting frequency,testicular phosphorylation level by immunoblotting,sperm concentration,sperm acrosome reaction,and histological structures of testis and epididymis,***:AG(50 mg/kg BW) significantly increased the mounting frequency on Days 1 and 7 compared to the control ***,rat testis treated with 50 mg/kg BW AG showed high levels of phosphorylated proteins as compared with the control *** histological analyses,AG extract did not affect the sperm concentration,acrosome reaction,and histological structures of testis and ***:AG extract enhances the aphrodisiac activity and is not harmful to sperm and male reproductive organs.

关键词： Anethum graveolens Linn. (dill) Mounting frequency Testicular phosphorylation Sperm acrosome reaction

Antidepressant and cognitive activities of intranasal piperine-encapsulated liposomes

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Advances in Bioscience and Biotechnology 2011年第2期2卷 108-116页

作者： Aroonsri Priprem Pennapa Chonpathompikunlert Saengrawee Sutthiparinyanont jintanaporn wattanathorn Faculty of Pharmaceutical Sciences Khon Kaen University Department of Physiology (Neuroscience Graduate Program) Faculty of Medicine Khon Kaen University School of Pharmaceutical Sciences University of Phayao

Antidepressant and cognitive effects of piperine -encapsulated liposomes (PL) were investigated in male Wistar rats. Oral piperine (5 mg/kg body weight/day) and intranasal PL (7.2 μg/day) were randomly assigned to daily administer for 14 days to rats which were subjected to forced swimming, Mor-ris water maze and spontaneous motor behavior tests. PL significantly exhibited anti-depression like activity and cognitive enhancing effects, in comparison to the control groups after the first dose (p < 0.01) and the effects could be maintained throughout the period of study. Quantitative analysis of the brain homogenates by HPLC indicated that piperine, delivered either orally or nasally, distributed to the hippocampus at a higher extent than the cortex and that the time to peak concentration of nasal PL was shorter than for the oral piperine. Intranasal PL was, thus, potential in delivery of piperine, at a low dose, to exert its an-tidepressant and cognitive enhancing activities.

关键词： Piperine Liposome Anti-Depression Activity Cognitive Enhancement Effect Intranasal Route

Moringa oleifera extract enhances sexual performance in stressed rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第3期16卷 179-190页

作者： Thawatchai PRABSATTROO jintanaporn wattanathorn Sitthichai IAMSAARD Pichet SOMSAPT Opass SRITRAGOOL Wipawee THUKHUMMEE Supaporn MUCHIMAPURA Graduate School and Department of Physiology (Neuroscience Program) Faculty of MedicineKhon Kaen University Integrative Complementary and Alternative Medicine Research and Development Center Khon Kaen University Department of Physiology Faculty of MedicineKhon Kaen University Department of Anatomy Faculty of MedicineKhon Kaen University Division of Nuclear Medicine Department of RadiologyFaculty of MedicineKhon Kaen University

Aphrodisiacs are required to improve male sexual function under stressful conditions. Due to the effects of oxidative stress and dopamine on male sexual function, we hypothesized that Monnga oleifera leaves might improve male sexual dysfunction induced by stress. Therefore, the effects on various factors playing important roles in male sexual behavior, such as antioxidant effects, the suppression of monoamine and phosphodiesterase type 5 （PDE-5） activities, serum testosterone and corticosterone levels, and histomorphological changes in the testes, of a hy- droethanolic extract of M. oleifera leaves were investigated. Various doses of extract including 10, 50, and 250 mg/kg body weight （BW） were given orally to male Wistar rats before exposure to 12 h-immobilization stress for 7 d. The results demonstrated that the extract showed both antioxidant and monoamine oxidase type B （MAO-B） suppression activities. At 7 d of treatment, the low dose of extract improved sexual performance in stress-exposed rats by de- creasing intromission latency and increasing intromission frequency. It also suppressed PDE-5 activity, decreased serum corticosterone level, but increased serum testosterone, numbers of interstitial cells of Leydig and spermatozoa. The increased numbers of interstitial cells of Leydig and spermatozoa might have been due to the antioxidant effect of the extract. The increased sexual performance during the intromission phase might have been due to the suppression of MAO-B and PDE-5 activities and increased testosterone. Therefore, M. oleifera is a potential aphrodisiac, but further research concerning the precise underlying mechanisms is still needed.

关键词： Moringa oleifera Sexual behaviors Stress

The Effect of Pineapple Juice on the Spatial memory,Lipid Peroxidation and Scavenger Enzymes Activities

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The Effect of Pineapple Juice on the Spatial memory,Lipid Pe...

Tomato, a Potential Yin Food, Protects against Stroke

第14届国际自由基学术大会

作者： Patsarawan Petch-nui Supaporn Muchimapura jintanaporn wattanathorn Department of Physiology and Graduate School Department of Physiology Faculty of Medicine Khon Kaen University Thailand 40002

＜正＞Oxidative stress plays an important role in many pathological conditions including neuropsychological disorders. Consumption of food containing high antioxidant was reported to improve oxidative stress disturban...

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Chinese Medicine 2012年第3期3卷 144-150页

作者： jintanaporn wattanathorn Wipawee Thukham-mee Supaporn Muchimapura Terdthai Tong-Un Panakaporn Wannanon Department of Physiology Faculty of Medicine Khon Kaen University Khon Kaen Thailand

Backgroud: Ischemic stroke is one of the challenge strategies nowadays due to the limitation of therapeutic efficacy. Yin deficiency and oxidative stress have been implicated in the mechanism of brain damage induced by cerebral ischemia. Therefore, we aimed to investigate whether tomato, a “Yang food” possessing antioxidant, may ameliorate brain damage in focal cerebral ischemia induced by right middle cerebral artery occlusion. Methods: Male rats were orally given tomato pomace (contained total phenolic compound 413.07 ± 34.45 mg of gallic acid equivalent/mg) at doses of 2, 19 and 50 mg/kg at a period of 2 weeks before and 3 weeks after the occlusion of right middle cerebral artery. Then, they were determined the brain ischemic volume and neurological score. Moreover, the markers of oxidative stress including malondialdehyde level and the activities of superoxide dismutase, catalase and glutathione peroxidase in hippocampus, striatum and cerebral cortex were also determined. Result: The results showed that tomato pomace could mitigate brain damage and neurological impairment. The neuroprotective mechanism might occur partly via the decreased oxidative stress. Conclusion: Tomato may provide health benefit for those who are risk for stroke. However, further researches are required.

关键词： Tomato Lycopersicon Escalentum Focal Cerebral Ischemia Brain Damage

Phenolic contents and antioxidant capacities of Thai-Makham Pom(Phyllanthus emblica L.)aqueous extracts

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第4期15卷 405-408页

作者： Sitthichai IAMSAARD Supatcharee ARUN Jaturon BURAWAT Wannisa SUKHORUM jintanaporn wattanathorn Somsak NUALKAEW Bungorn SRIPANIDKULCHAI Department of Anatomy Faculty of MedicineKhon Kaen University Center for Research and Development of Herbal Health Products Faculty of Pharmaceutical SciencesKhon Kaen University Integrative Complementary Alternative Medicine Research and Development Group Faculty of MedicineKhon Kaen University Department of Pharmaceutical Sciences Faculty of PharmacyMahasarakham University

This study was aimed at determining the amount of the total phenolic contents （TPCs） and to evaluate the antioxidant activities of different extracts （leaves, branches, and barks） of Phyllanthus emblica （PE） L.,

关键词：余甘子总酚含量抗氧化能力传统药用植物

中国和东盟国家常用传统药物治疗糖尿病及其并发症药理作用的研究进展

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中草药 2021年第4期52卷 1165-1176页

作者：李意春郝二伟刘婧曦杜正彩白钢张铁军 wattanathorn jintanaporn Sirisaard Panee Tang Pei-ling 侯小涛邓家刚刘昌孝广西中医药大学药学院广西中药药效研究重点实验室广西中医药科学实验中心广西南宁530000 广西中医药大学中国-东盟传统医学研究国际合作联合实验室广西南宁530200 南开大学药物化学生物学国家重点实验室天津300000 天津药物研究院天津300462 孔敬大学人类高性能与健康促进研究所泰国孔敬40002 泰国清迈大学药学院生药学和制药技术系泰国清迈50200 马来西亚拉曼大学学院应用科学学院生物科学系马来西亚吉隆坡53300

糖尿病是一种由于体内胰岛素绝对或相对分泌不足而引起的以糖代谢紊乱为主的全身性疾病,严重威胁人类的身心健康,而中国和东盟地区更是糖尿病高发地区,患病人数居全球第1位。通过查阅《中国-东盟传统药物志》,中国和东盟国家用于治疗糖... 详细信息

糖尿病是一种由于体内胰岛素绝对或相对分泌不足而引起的以糖代谢紊乱为主的全身性疾病,严重威胁人类的身心健康,而中国和东盟地区更是糖尿病高发地区,患病人数居全球第1位。通过查阅《中国-东盟传统药物志》,中国和东盟国家用于治疗糖尿病、消渴症的传统药物有81种,其中在中国和东盟国家中应用较为广泛且研究较为深入的有25种。利用中国知网、维普、Pubmed等数据库系统地查阅和整理国内外关于25种传统药物治疗糖尿病及其并发症的相关文献,对25种药物降血糖药理作用及其作用机制进行综述,传统药物改善糖尿病及其并发症的作用机制主要是通过抑制炎症及过氧化反应,调节糖脂,改善胰岛素抵抗,提高胰岛素敏感性,修复胰岛细胞,促进胰岛素分泌等途径,可为开发安全、有效的降糖药以及加强中国和东盟国家进一步的研究合作提供有益的参考。

关键词：中国-东盟传统药物糖尿病并发症药理作用作用机制

中国-东盟传统药用植物抗呼吸道常见病毒研究进展

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中成药 2022年第11期44卷 3579-3587页

作者：杜正彩郝二伟韦棪婷陈晓璐 jintanaporn wattanathorn Tang Pei Ling Justin Jang Hann Chu 白钢刘昌孝侯小涛邓家刚广西中药药效研究重点实验室广西农作物废弃物功能成分研究协同创新中心广西南宁530200 广西中医药大学广西中医药科学实验中心广西南宁530200 广西中医药大学中国-东盟传统药物研究国际合作联合实验室广西南宁530200 广西中医药大学药学院广西南宁530200 孔敬大学人类高性能与健康促进研究所泰国孔敬40002 马来西亚拉曼大学学院应用科学学院生物科学系马来西亚吉隆坡53300 新加坡国立大学微生物与免疫学系分子RNA病毒学与抗病毒策略实验室新加坡肯特岗117597 南开大学药物化学生物学国家重点实验室天津300000 天津药物研究院新药评价研究中心现代中药研究中心天津300193

呼吸道病毒感染是全球范围内人类发病和死亡的主要原因之一,其致死率在所有传染病中居于首位。天然药用植物具有多成分、多靶点及多途径协同发挥抗病毒作用的特点,在抗呼吸道病毒新药开发方面具有极大的潜力。本文从《中国-东盟传统药... 详细信息

呼吸道病毒感染是全球范围内人类发病和死亡的主要原因之一,其致死率在所有传染病中居于首位。天然药用植物具有多成分、多靶点及多途径协同发挥抗病毒作用的特点,在抗呼吸道病毒新药开发方面具有极大的潜力。本文从《中国-东盟传统药物志》中350种药物进行筛选,对具有抗呼吸道病毒的药物以抗病毒种类数、化学成分、作用机制等进行分类统计,并对其抗呼吸道病毒感染的作用机制和物质基础进行阐述和分析,旨在从中国-东盟传统药用植物中筛选出抗呼吸道常见病毒的活性成分,以期为后续新药研发及临床治疗提供参考。

关键词：中国-东盟传统药用植物呼吸道病毒感染作用机制

Carry forward advantages of traditional medicines in prevention and control of outbreak of COVID-19 pandemic

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Chinese Herbal Medicines 2020年第3期12卷 207-213页

作者： Jia-gang Deng Xiao-tao Hou Tie-jun Zhang Gang Bai Er-wei Hao Justin Jang Hann Chu jintanaporn wattanathorn Panee Sirisa-ard Ch'ng Soo Ee John Low Chang-xiao Liu China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research Guangxi University of Chinese MedicineNanning 530200China Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica Guangxi University of Chinese MedicineNanning 530200China State Key Laboratory of Drug Delivery and Pharmacokinetics Tianjin Institute of Pharmceutical ResearchTianjin 300462China State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300353China Laboratory of Molecular RNA Virology and Antiviral Strategies Department of Microbiology and ImmunologyNational University of SingaporeKent Ridge 117597Singapore Research Institute for Human High Performance and Health Promotion Khon Kaen UniversityKhon Kaen 40002Thailand Department of Pharmacognosy and Pharmaceutical Technology Faculty of Pharmacy.University of Chiang MaiChiang Mai 50200Thailand GAIQ Test Innovation(Malaysia)Service Center Selangor 40150Malaysia Bioalpha international Sdn.Bhd. Selangor 43000Malaysia

Members of the China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research used the video conference platform to exchange and discuss the advantages of traditional medicine through the form of score exchange and report,and research and develop the amount and issues of the therapeutic COVID-19 products of *** paper mainly reviews the achievements of the implementation of the epidemic prevention and control plan,advances of scientific basic studies on SARS-CoV-2,analysis and screening of potential targets and pathways of antiviral compounds based on network pharmacology and development of antiviral food dual-use *** authors believe that the declaration of the(10+3)special meeting of national leaders on epidemic prevention and control should raise the medical and pharmaceutical issues of common *** is the responsibility of our joint laboratory members to accelerate the development of traditional medicine research and *** the authors believe that this exchange will certainly promote the development of the cause of cooperation.

关键词： COVID-19 pandemic international cooperation prevention and control research and development traditional medicines

Antioxidant activity and protective effect of Clitoria ternatea flower extract on testicular damage induced by ketoconazole in rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第6期15卷 548-555页

作者： Sitthichai IAMSAARD Jaturon BURAWAT Pipatpong KANLA Supatcharee ARUN Wannisa SUKHORUM Bungorn SRIPANIDKULCHAI Nongnut UABUNDIT jintanaporn WATTATHORN Wiphawi HIPKAEO Duriya FONGMOON Hisatake KONDO Department of Anatomy and Integrative Complementary Alternative Medicine Research and Development Group Faculty of Medicine Khon Kaen University Center for Research and Development of Herbal Health Products Faculty of Pharmaceutical SciencesKhon Kaen University Department of Medical Services Lampang Cancer Hospital Ministry of Public health

Background： Ketoconazole （KET）, an antifungal drug, has adverse effects on the male reproductive system. Pre-treatments with antioxidant plant against testicular damage induced by KET are required. The flowers of Clitoria tematea （CT） are proven to have hepatoprotective potential. However, the protective effect on KET-induced testicular damage has not been reported. Objective： To investigate the protective effect of CT flower extracts with antioxidant activity on male reproductive parameters including sperm concentration, serum testosterone level, histopathology of the testis, and testicular tyrosine phosphorylation levels in rats induced with KET. Methods： The antioxidant activity of CT flower extracts was determined using 2,2-diphenyl-1-picrylhydrazyl （DPPH） and ferric reducing antioxidant power （FRAP） assays. Male rats were treated with CT flower extracts （10, 50, or 100 mg/kg BW） or distilled water via a gastric tube for 28 d （preventive period： Days 1-21） and induced by KET （100 mg/kg BW） via intraperitoneal injection for 7 d （induction period： Days 22-28）. After the experiment, all animals were examined for the weights of the testis, epididymis plus vas deferens and seminal vesicle, serum testosterone levels, sperm concentration, histological structures and diameter of testis, and testicular tyrosine phosphorylation levels by immunoblotting. Results： The CT flower extracts had capabilities for DPPH scavenging and high reducing power. At 100 mg/kg BW, the extract had no toxic effects on the male reproductive system. Significantly, in CT＋KET groups, CT flower extracts （50 and 100 mg/kg BW） alleviated the reduction of reproductive organ weight parameters, testosterone levels, and sperm concentration. In addition, CT flower extracts gave protection from testicular damage in KET-induced rats. Moreover, in the CT100＋KET group, CT flower extracts significantly enhanced the expression of a testicular 50-kDa tyrosine phosphorylated protein compared with that of other

关键词： Cfitoria tematea (CT) flower extracts Antioxidant activity Ketoconazole (KET) Testicular damage Testicular tyrosine phosphorylation