检索结果-南通市图书馆

Dibutyl phthalate disrupts[Ca^(2+)]_(i),reactive oxygen species,[pH]_(i),protein kinases and mitochondrial activity,impairing sperm function

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2025年第5期151卷 68-78页

作者： Seung Hyun park Myung Chan Gye Department of Life Science and Institute for Natural Sciences Hanyang UniversitySeoul 04763Republic of Korea

To explore the mechanism of sperm dysfunction caused by dibutyl phthalate(DBP),the effects of DBP on intracellular[Ca^(2+)]and[pH],reactive oxygen species(ROS),lipid peroxidation(LPO),mitochondrial permeability transition pore(mPTP)opening,mitochondrial membrane potential(MMP),adenosine triphosphate(ATP)levels,phosphorylation of protein kinase A(PKA)substrate proteins and phosphotyrosine(p-Tyr)proteins,sperm motility,spontaneous acrosome reaction,and tail bending were examined in mouse *** 100μg/mL,DBP significantly increased tail bending and[Ca^(2+)]***,DBP showed biphasic effects on[pH]*** at 10–100μg/mL significantly decreased sperm ***,Ca^(2+)ionophore A23187 decreased[pH]_(i)sperm motility,suggesting that DBP-induced excessive[Ca^(2+)]_(i)decreased sperm *** significantly increased ROS and *** at 100μg/mL significantly decreased mPTP closing,MMP,and ATP levels in spermatozoa,as did H2O2,indicative of ROS-mediatedmitochondrial dysfunction caused by *** as well as H2O2 increased p-Tyr sperm proteins and phosphorylated PKA substrate sperm *** at 1–10μg/mL significantly increased the spontaneous acrosome reaction,suggesting that DBP can activate sperm ***,DBP showed a biphasic effect on intracellular signaling in *** concentrations relevant to seminal ortho-phthalate levels,DBP activates[pH]i,protein tyrosine kinases and PKA via physiological levels of ROS generation,potentiating sperm *** at high doses excessively raises[Ca^(2+)]_(i)and ROS and disrupts[pH]i,impairing the mitochondrial function,tail structural integrity,and sperm motility.

关键词： Dibutyl phthalate Reactive oxygen species(ROS) [Ca^(2+)]_(i) [pH]_(i) Mitochondria Protein kinases Sperm

Effect of preprocessing on performances of machine learning-based mineral composition analysis on gas hydrate sediments, Ulleung Basin, East Sea

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2025年第1期22卷 151-162页

作者： Hongkeun Jin Ju Young park Sun Young park Byeong-Kook Son Baehyun Min Kyungbook Lee Department of Geoenvironmental Sciences Kongju National University Tunnel & Underground Facility Division ESCO Consultant & Engineers Company Yellow Sea Institute of Geoenvironmental Sciences Petroleum and Marine Research Division Korea Institute of Geoscience and Mineral Resources Department of Climate and Energy Systems Engineering Ewha Womans University Center for Climate/Environment Change Prediction Research Ewha Womans University

Gas hydrate(GH) is an unconventional resource estimated at 1000-120,000 trillion *** on GH is ongoing to determine its geological and flow characteristics for commercial production. After two large-scale drilling expeditions to study the GH-bearing zone in the Ulleung Basin, the mineral composition of 488 sediment samples was analyzed using X-ray diffraction(XRD). Because the analysis is costly and dependent on experts, a machine learning model was developed to predict the mineral composition using XRD intensity profiles as input data. However, the model's performance was limited because of improper preprocessing of the intensity profile. Because preprocessing was applied to each feature, the intensity trend was not preserved even though this factor is the most important when analyzing mineral composition. In this study, the profile was preprocessed for each sample using minmax scaling because relative intensity is critical for mineral analysis. For 49 test data among the 488data, the convolutional neural network(CNN) model improved the average absolute error and coefficient of determination by 41% and 46%, respectively, than those of CNN model with feature-based preprocessing. This study confirms that combining preprocessing for each sample with CNN is the most efficient approach for analyzing XRD data. The developed model can be used for the compositional analysis of sediment samples from the Ulleung Basin and the Korea Plateau. In addition, the overall procedure can be applied to any XRD data of sediments worldwide.

关键词： Sample-based preprocessing X-ray diffraction (XRD) Machine learning Mineral composition Gas hydrate (GH) Ulleung basin

Prominent cycling reversibility and kinetics enabled by CaTiO_(3) protective layer on Zn metal for aqueous Zn-ion batteries

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo park Jong-Seong Bae Taehyun park Il Tae Kim Jaehyun Hur School of Chemical Biologicaland Battery EngineeringGachon UniversitySeongnamGyeonggi 13120Republic of Korea Busan Center Korea Basic Science InstituteBusan 46742Republic of Korea

Aqueous Zn-ion batteries (AZIBs) have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction (HER) from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO_(3)(CTO) protective layer on Zn(CTO@Zn) as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant (εr=180) and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn^(2+)ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential (~68 m V) for 1500 h at 1 mA cm^(-2)/0.5 mA h cm^(-2),excelling bare ***,when paired with the V_(2)O_(5)-C cathode,the CTO@Zn//V_(2)O_(5)-C full battery delivers 148.4 mA h g^(-1)(based on the mass of the cathode) after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： CaTiO_(3) Artificial layer Dielectric constant Znmetal anode Zinc aqueous battery

Advancing depth perception in spatial computing with binocular metalenses

在线全文

学校读者我要写书评

暂无评论

Opto-Electronic Advances 2025年第1期8卷 1-3页

作者： Junkyeong park Gyeongtae Kim Junsuk Rho Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Electrical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea

Spatial computing and augmented reality are advancing rapidly,with the goal of seamlessly blending virtual and physical ***,traditional depth-sensing systems are bulky and energy-intensive,limiting their use in wearable *** overcome this,recent research by *** et *** a compact binocular metalens-based depth perception system that integrates efficient edge detection through an advanced neural *** system enables accurate,realtime depth mapping even in complex environments,enhancing potential applications in augmented reality,robotics,and autonomous systems.

关键词： metasurface metalens deep learning depth perception edge detection

The H∞ Robust Stability and Performance Conditions for Uncertain Robot Manipulators

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 270-272页

作者： Geun Il Song Hae Yeon park Jung Hoon Kim the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Institute for Convergence Research and Education in Advanced Technology Yonsei University

Dear Editor,H∞This letter develops a new framework for the robust stability and performance conditions as well as the relevant controller synthesis with respect to uncertain robot *** often exist model uncertainties between the nominal model and the real robot manipulator and disturbances. Hence, dealing with their effects plays a crucial role in leading to high tracking performances, as discussed in [1]–[5].

关键词： Robot applications

Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO KYUNG park MINSUK KWON MINAE AN JUNG YONG HONG JOON OH park SUNG HEE LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

Scalable Ir‑Doped NiFe_(2)O_(4)/TiO_(2) Heterojunction Anode for Decentralized Saline Wastewater Treatment and H_(2) Production

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 1-18页

作者： Sukhwa Hong Jiseon Kim Jaebeom park Sunmi Im Michael R.Hoffmann Kangwoo Cho Division of Environmental Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 790−784Korea Linde Laboratory California Institute of TechnologyPasadenaCA 91125USA Institute for Convergence Research and Education in Advanced Technology(I‑CREATE) Yonsei University International CampusIncheon 21983Republic of Korea

Wastewater electrolysis cells(WECs)for decentralized wastewater treatment/reuse coupled with H_(2) production can reduce the carbon footprint associated with transportation of water,waste,and energy *** study reports Ir-doped NiFe_(2)O_(4)(NFI,~5 at%Ir)spinel layer with TiO_(2) overlayer(NFI/TiO_(2)),as a scalable heterojunction anode for direct electrolysis of wastewater with circumneutral pH in a single-compartment *** dilute(0.1 M)NaCl solutions,the NFI/TiO_(2) marks superior activity and selectivity for chlorine evolution reaction,outperforming the benchmark IrO_(2).Robust operation in near-neutral pH was *** including operando X-ray absorption spectroscopy unveiled crucial roles of TiO_(2) which serves both as the primary site for Cl−chemisorption and a protective layer for NFI as an ohmic *** electrolysis of NH4+-laden synthetic wastewater demonstrated that NFI/TiO_(2)not only achieves quasi-stoichiometric NH_(4)^(+)-to-N_(2)conversion,but also enhances H_(2)generation efficiency with minimal competing reactions such as reduction of dissolved oxygen and reactive *** scaled-up WEC with NFI/TiO_(2)was demonstrated for electrolysis of toilet wastewater.

关键词： Wastewater electrolysis cell Ir-doped NiFe_(2)O_(4) Reactive chlorine species Decentralized H_(2)production On-site wastewater treatment

Gut–brain axis and environmental factors in parkinson's disease:bidirectional link between disease onset and progression

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第12期20卷 3416-3429页

作者： Soo Jung park Kyung Won Kim Eun Jeong Lee Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Life Science and Multidisciplinary Genome Institute Hallym UniversityChuncheonSouth Korea

parkinson's disease has long been considered a disorder that primarily affects the brain,as it is defined by the dopaminergic neurodegeneration in the substantia nigra and the brain accumulation of Lewy bodies containingα-synuclein *** recent decades,however,accumulating research has revealed that parkinson's disease also involves the gut and uncovered an intimate and important bidirectional link between the brain and the gut,called the“gut–brain axis.”Numerous clinical studies demonstrate that gut dysfunction frequently precedes motor symptoms in parkinson's disease patients,with findings including impaired intestinal permeability,heightened inflammation,and distinct gut microbiome profiles and ***,α-synuclein deposition has been consistently observed in the gut of parkinson's disease patients,suggesting a potential role in disease ***,individuals with vagotomy have a reduced parkinson's disease *** these observations,researchers have hypothesized thatα-synuclein accumulation may initiate in the gut and subsequently propagate to the central dopaminergic neurons through the gut–brain axis,leading to parkinson's *** review comprehensively examines the gut's involvement in parkinson's disease,focusing on the concept of a gut-origin for the *** also examine the interplay between altered gut-related factors and the accumulation of pathologicalα-synuclein in the gut of parkinson's disease *** the accessibility of the gut to both dietary and pharmacological interventions,targeting gut-localizedα-synuclein represents a promising avenue for developing effective parkinson's disease therapies.

关键词： gut inflammation gut microbiome gut-brain axis micro/nano-plastics parkinson’s disease α-synuclein

Film-Cooling Performance with Various Hole Length to Diameter Ratios for Cylindrical and Laidback Fan-Shaped Holes with an Inlet Groove

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2025年第02期 607-625页

作者： park Jisu KIM Jun-Hee KANG Changwoo Department of Mechanical Engineering Jeonbuk National University Research Institute of Industrial Science & Technology 187-12 Geumho-ro Laboratory for Renewable Energy and Sector Coupling Jeonbuk National University

The influence of the hole length-to-diameter ratio on film-cooling performance is numerically investigated for a cylindrical hole and laidback fan-shaped hole with an inlet *** analysis of film-cooling is conducted by solving three-dimensional Reynolds-averaged Navier-Stokes equations(RANS)with a Realizable k-ε turbulence *** and triangular grooves are applied to the inlet of cylindrical and laidback fan-shaped *** ratio of the hole length(L) to the diameter(D),i.e.,L/D,is varied between 6-12 at blowing ratios(M) of 0.5 to 1.5 for the cylindrical hole and 0.5 to 3.0 for the laidback fan-shaped *** cylindrical holes with an inlet groove,the film-cooling effectiveness decreases as the L/D increases,regardless of the blowing ***,in the case of laidback fan-shaped holes,the cooling performance with the length-to-diameter ratios shows different tendencies for each blowing *** low blowing ratios(M=1.0),relatively high effects were observed with more than 5% increases in the effectiveness at L/D=10 and 12 compared to that of L/D=***,the performance is maximized at L/D=8 under high-blowing-ratio conditions(M=3.0).The cooling efficiency is enhanced up to 148% for square grooves and 124% for triangle grooves compared to those of L/D=6.

关键词：