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Non-small cell lung carcinoma(NSCLC):Implications on molecular pathology and advances in early diagnostics and therapeutics

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Genes & Diseases 2023年第3期10卷 960-989页

作者： Hafiza Padinharayil jinsu varghese Mithun Chacko John Golgodu Krishnamurthy Rajanikant Cornelia M.Wilson Minnatallah Al-Yozbaki Kaviyarasi Renu Saikat Dewanjee Rupa Sanyal Abhijit Dey Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Abilash Valsala Gopalakrishnan Alex George Jubilee Centre for Medical Research Jubilee Mission Medical College and Research InstituteThrissurKerala 680005India PG&Research Department of Zoology St.Thomas CollegeKozhencheryPathanamthittaKerala 689641India Department of Medical Oncology Jubilee Mission Medical College and Research InstituteThrissurKerala 680005India School of Biotechnology National Institute of TechnologyCalicutKerala 673601India Canterbury Christ Church University Natural Applied SciencesLife Sciences Industry Liaison LabDiscovery ParkSandwich CT139FFUnited Kingdom Centre of Molecular Medicine and Diagnostics(COMManD) Department of BiochemistrySaveetha Dental College&HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiTamil Nadu 600077India Department of Pharmaceutical Technology Jadavpur UniversityKolkataWest Bengal 700032India Department of Botany Bhairab Ganguly CollegeFeeder RoadBelghoriaKolkataWest Bengal 700056India Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Department of Biomedical Sciences School of Bio-Sciences and TechnologyVellore Institute of Technology(VIT)VelloreTamil Nadu 632014India

Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) provides the foundation for therapeutic advances by promoting molecular targeted and immunotherapies and ensuring accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention, diagnosis, and management, supporting health-care interventions. Global cancer mortality projections from 2016 to 2060 show that cancer will overtake ischemic heart diseases (IHD) as the leading cause of death (18.9 million) immediately after 2030, surpassing non-small cell lung cancer (NSCLC), which accounts for 85 percent of lung cancers. The clinical stage at the diagnosis is the main prognostic factor in NSCLC therapies. Advanced early diagnostic methods are essential as the initial stages of cancer show reduced mortality compared to the advanced stages. Sophisticated approaches to proper histological classification and NSCLC management have improved clinical efficiency. Although immune checkpoint inhibitors (ICIs) and targeted molecular therapies have refined the therapeutic management of late-stage NSCLC, the specificity and sensitivity of cancer biomarkers should be improved by focusing on prospective studies, followed by their use as therapeutic tools. The liquid biopsy candidates such as circulating tumor cells (CTCs), circulating cell-free tumor DNA (cfDNA), tumor educated platelets (TEP), and extracellular vesicles (EVs) possess cancer-derived biomolecules and aid in tracing: driver mutations leading to cancer, acquired resistance caused by various generations of therapeutic agents, refractory disease, prognosis, and surveillance.

关键词： Biomarker Clinical trial Epidemiology Histology Liquid biopsy NSCLC Targeted therapy

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Near infrared emissions from both high efficient quantum cutting (173%) and nearly-pure-color upconversion in NaY(WO_(4))_(2):Er^(3+)/Yb^(3+) with thermal management capability for silicon-based solar cells

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Light(Science & Applications) 2024年第1期13卷 113-126页

作者： Duan Gao Baojiu Chen Xuezhu Sha Yuhang Zhang Xin Chen Li Wang Xizhen Zhang jinsu Zhang Yongze Cao Yichao Wang Lei Li Xiangping Li Sai Xu Hongquan Yu Lihong Cheng School of Science Dalian Maritime UniversityDalian 116026 LiaoningChina

Raising photoelectric conversion efficiency and enhancing heat management are two critical concerns for siliconbased solar *** this work,efficient Yb^(3+) infrared emissions from both quantum cutting and upconversion were demonstrated by adjusting Er^(3+) and Yb^(3+) concentrations,and thermo-manage-applicable temperature sensing based on the luminescence intensity ratio of two super-low thermal quenching levels was discovered in an Er^(3+)/Yb^(3+) codoped tungstate *** quantum cutting mechanism was clearly decrypted as a two-step energy transfer process from Er^(3+) to Yb^(3+).The two-step energy transfer efficiencies,the radiative and nonradiative transition rates of all interested 4 f levels of Er^(3+) in NaY(WO_(4))_(2) were confirmed in the framework of Föster-Dexter theory,Judd-Ofelt theory,and energy gap law,and based on these obtained efficiencies and rates the quantum cutting efficiency was furthermore determined to be as high as 173%in NaY(WO_(4))_(2):5 mol%Er^(3+)/50 mol%Yb^(3+) *** and nearly pure infrared upconversion emission of Yb3+under 1550 nm excitation was achieved in Er^(3+)/Yb^(3+)co-doped NaY(WO_(4))_(2) by adjusting Yb^(3+) doping *** Yb^(3+) induced infrared upconversion emission enhancement was attributed to the efficient energy transfer ^(4)I_(11/2)(Er^(3+))+^(2)F_(7/2)(Yb^(3+))→^(4)I_(15/2)(Er^(3+))+^(2)F_(5/2)(Yb^(3+))and large nonradiative relaxation rate of ^(4)I_(9/2).Analysis on the temperature sensing indicated that the NaY(WO_(4))_(2):Er^(3+)/Yb^(3+)serves well the solar cells as thermos-managing ***,it was confirmed that the fluorescence thermal quenching of ^(2)H_(11/2)/^(4)S_(3/2) was caused by the nonradiative relaxation of ^(4)S_(3/2).All the obtained results suggest that NaY(WO_(4))_(2):Er^(3+)/Yb^(3+) is an excellent material for silicon-based solar cells to improve photoelectric conversion efficiency and thermal management.

关键词： quantum thermal relaxation

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Botulinum toxin type A for treating chronic low back pain:A double blinded randomized control study

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World Journal of Methodology 2024年第3期14卷 119-125页

作者： Mantu Jain Shahnawaz Khan Paulson varghese Sujit Kumar Tripathy Manaswini Mangaraj Department of Orthopaedics All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Biochemistry All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia

BACKGROUND Low back pain(LBP)is a prevalent issue that orthopedic surgeons frequently address in the outpatient *** can arise from various causes,with stiffness in the paraspinal muscles being a notable *** administration of Botulinum toxin type A(BoNT-A)has been found to alleviate back pain by relaxing these stiff *** BoNT-A is approved for use in numerous conditions,a limited number of randomized clinical trials(RCTs)validate its efficacy specifically for treating *** To study the safety and the efficacy of BoNT-A in minimizing pain and improving functional outcomes in patients of chronic LBP(CLBP).METHODS In this RCT,adults aged 18-60 years with mechanical LBP persisting for at least six months were *** were allocated to either the Drug group,receiving 200 Ipsen Units(2 mL)of BoNT-A,or the Control group,which received a 2 mL *** a 2-month follow-up period,both groups were assessed using the Visual Analog Scale(VAS)for pain intensity and the Oswestry Disability Index(ODI)for disability at the start and conclusion of the study.A decrease in pain by 50%was deemed clinically *** The study followed 40 patients for two months,with 20 in each group.A clinically significant reduction in pain was observed in 36 *** was a statistically significant decrease in both VAS and ODI scores in the groups at the end of two ***,when comparing the mean score changes,only the reduction in ODI scores(15 in the placebo group vs 16.5 in the drug group,clinically insignificant)was statistically significant(P=0.012),whereas the change in mean VAS scores was not significant(P=0.45).CONCLUSION The study concludes that BoNT-A does not offer a short-term advantage over placebo in reducing pain or improving LBP scores in CLBP patients.

关键词： Botulinum toxin type A Chronic low back pain Randomized control study Double-blinded Pain management Therapeutic efficacy

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基于产学研融合的“控制性详细规划”课程教学改革研究

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科技资讯 2024年第8期22卷 224-228页

作者：曹风晓杨晋苏福建理工大学建筑与城乡规划学院福建福州350118

“控制性详细规划”课程是城乡规划专业核心课程。通过反思“控制性详细规划”课程在“新工科”建设阶段面临的挑战和教学实践过程中存在的问题。从注重联合教学、强调真题实做、增加专业讲座、邀请行业专家课后评图和联动科研输出5个... 详细信息

“控制性详细规划”课程是城乡规划专业核心课程。通过反思“控制性详细规划”课程在“新工科”建设阶段面临的挑战和教学实践过程中存在的问题。从注重联合教学、强调真题实做、增加专业讲座、邀请行业专家课后评图和联动科研输出5个方面出发,提出五维一体“控制性详细规划”教学改革思路,建立校企资源融合的联合实践平台、研发学校与企业良好合作的实践教学模式,形成“平台+模式”的双保障体系。构建产学研融合的教学体系,形成复合式系统教学改革与实践方案,以期激发学生的学习能动性与创新能力。

关键词：产学研融合控制性详细规划教学改革五维一体平台+模式

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基于内聚力单元的石拱桥数值模拟

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低温建筑技术 2024年第1期46卷 37-41页

作者：邹金粟王柏生浙江大学土木工程系杭州310058

古石拱桥一般由块石砌筑而成,材料有明显的非匀质性,且古石拱桥在长期荷载作用下很容易产生累计变形改变拱圈几何形状,进而影响其结构受力,采用传统整体式有限元模型很难准确模拟古石拱桥的受力性能。因此,为精确模拟古石拱桥实际受力状... 详细信息

古石拱桥一般由块石砌筑而成,材料有明显的非匀质性,且古石拱桥在长期荷载作用下很容易产生累计变形改变拱圈几何形状,进而影响其结构受力,采用传统整体式有限元模型很难准确模拟古石拱桥的受力性能。因此,为精确模拟古石拱桥实际受力状态,分析承载力影响因素,采用参数化建模的方法建立两相数值模型,用内聚力单元模拟材料非线性,并通过自编程序引入初始缺陷。分析了几何参数及材料参数对拱桥承载能力和破坏模式的影响。结果表明几何参数与材料参数显著影响结构的承载能力和破坏模式,为石拱桥的设计及修复、加固工作提供依据。

关键词：石拱桥初始缺陷两相数值模型内聚力单元

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Privacy-Enhanced Data Deduplication Computational Intelligence Technique for Secure Healthcare Applications

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Computers, Materials & Continua 2022年第2期70卷 4169-4184页

作者： jinsu Kim Sungwook Ryu Namje Park Department of Convergence Information Security Graduate SchoolJeju National University63294Korea Master’s Program in Future Strategy Korea Advanced Institute of Science and Technology34141Korea Department of Computer Education Teachers CollegeJeju National University63294Korea

A significant number of cloud storage environments are already implementing deduplication *** to the nature of the cloud environment,a storage server capable of accommodating large-capacity storage is *** storage capacity increases,additional storage solutions are *** leveraging deduplication,you can fundamentally solve the cost ***,deduplication poses privacy concerns due to the structure *** this paper,we point out the privacy infringement problemand propose a new deduplication technique to solve *** the proposed technique,since the user’s map structure and files are not stored on the server,the file uploader list cannot be obtained through the server’s meta-information analysis,so the user’s privacy is *** addition,the personal identification number(PIN)can be used to solve the file ownership problemand provides advantages such as safety against insider breaches and sniffing *** proposed mechanism required an additional time of approximately 100 ms to add a IDRef to distinguish user-file during typical deduplication,and for smaller file sizes,the time required for additional operations is similar to the operation time,but relatively less time as the file’s capacity grows.

关键词： Computational intelligence cloud multimedia data deduplication

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免疫佐剂及自佐剂递送系统研究进展

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药学进展 2024年第6期48卷 421-436页

作者：王晋苏董婧雯黄莹范一诺张琦岩周占威孙敏捷中国药科大学药学院药剂系

佐剂是防治疾病疫苗的重要组分，可增强机体对抗原的特异性免疫应答，显著提高免疫反应的强度、广度和持久性，在传染病防治及肿瘤治疗方面起重要作用。目前基于免疫学与药剂学的发展，传统佐剂暴露出生物毒性强、系统暴露量高及免疫刺... 详细信息

佐剂是防治疾病疫苗的重要组分，可增强机体对抗原的特异性免疫应答，显著提高免疫反应的强度、广度和持久性，在传染病防治及肿瘤治疗方面起重要作用。目前基于免疫学与药剂学的发展，传统佐剂暴露出生物毒性强、系统暴露量高及免疫刺激活性机制不明等问题。开发免疫佐剂递送系统正成为生物制品免疫治疗的研究热点。简介已批准上市佐剂的组成与免疫激活机制，分析具备佐剂效应的疫苗递送系统的开发优势，重点综述基于脂质体、病毒样颗粒、有机合成材料、天然生物材料以及无机纳米材料的新型佐剂平台的研究进展，以期为开发安全、有效的新型疫苗佐剂材料和佐剂平台提供参考。

关键词：佐剂免疫疗法递送系统抗感染抗肿瘤

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Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan varghese Carmen Behrens Tina McDowell Luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning Le Natalie I Vokes Chao Cheng John V.Heymach Don L.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

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社区环境对居民健康的综合影响机制研究

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城市建筑 2024年第4期21卷 97-102页

作者：曹风晓林恒毅张祖坤余波杨晋苏福建理工大学建筑与城乡规划学院

保障居民健康是《“十四五”国民健康规划》的重要原则之一,社区环境对居民健康的主动式干预已成为研究热点。为探究社区建成环境、自然环境和社会环境对居民健康的综合影响,构建社区环境、居民健康行为和居民健康三者之间的结构方程模... 详细信息

保障居民健康是《“十四五”国民健康规划》的重要原则之一,社区环境对居民健康的主动式干预已成为研究热点。为探究社区建成环境、自然环境和社会环境对居民健康的综合影响,构建社区环境、居民健康行为和居民健康三者之间的结构方程模型,文章以福州市10个社区为例,在对社区居民问卷调查的基础上进行结构方程验证。研究表明:(1)公交出行便利度与建成环境的相关性最强,绿化环境美观度对自然环境的影响最大,邻里熟络度对社区环境的影响最大,每日步行出行时间对居民健康行为的影响最大,安全感对居民健康的影响最大;(2)居民健康行为对居民健康具有显著的正向影响;社区环境对居民健康有直接的正向影响,其中社区社会环境对居民健康的影响最大;社区环境还可以通过居民健康行为间接影响居民健康。

关键词：社区环境社区居民健康居民健康行为综合影响机制

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Sepsis during short bowel syndrome hospitalizations:Identifying trends,disparities,and clinical outcomes in the United States

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 26-36页

作者： Dushyant Singh Dahiya Jennifer Wachala Shantanu Solanki Dhanshree Solanki Asim Kichloo Samantha Holcomb Uvesh Mansuri Khwaja Saad Haq Hassam Ali Manesh Kumar Gangwani Yash R Shah Teresa varghese Hafiz Muzaffar Akbar Khan Simon Peter Horslen Thomas D Schiano Syed-Mohammed Jafri Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Internal Medicine Samaritan Medical CenterWatertownNY 13601United States Division of Gastroenterology Hepatology&Nutrition The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Medicine Institute for Foreign Medical Graduate EducationHoustonTX 77030United States Department of Internal Medicine MedStar Harbor HospitalBaltimoreMD 21225United States Department of Internal Medicine WellStar Spalding Regional HospitalGriffinGA 30224United States Division of Gastroenterology Hepatology and NutritionEast Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Gastroenterology and Hepatology University of Arkansas for Medical SciencesLittle RockAR 72205United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology SUNY Upstate Medical UniversitySyracuseNY 13210United States Department of Pediatrics School of Medicine and UPMC Children’s Hospital of PittsburghUniversity of PittsburghPittsburghPA 15219United States Division of Liver Diseases Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Gastroenterology and Hepatology Henry Ford HospitalDetroitMI 48202United States

BACKGROUND Short bowel syndrome(SBS)hospitalizations are often complicated with *** is a significant paucity of data on adult SBS hospitalizations in the United States and across the *** To assess trends and outcomes of SBS hospitalizations complicated by sepsis in the United *** The National Inpatient Sample was utilized to identify all adult SBS hospitalizations between *** study cohort was further divided based on the presence or absence of *** were identified,and hospitalization characteristics and clinical outcomes were *** of mortality for SBS hospitalizations complicated with sepsis were *** Of 247097 SBS hospitalizations,21.7%were complicated by *** SBS hospitalizations had a rising trend of hospitalizations from 20.8%in 2005 to 23.5%in 2014(P trend<0.0001).Compared to non-septic SBS hospitalizations,septic SBS hospitalizations had a higher proportion of males(32.8%vs 29.3%,P<0.0001),patients in the 35-49(45.9%vs 42.5%,P<0.0001)and 50-64(32.1%vs 31.1%,P<0.0001)age groups,and ethnic minorities,i.e.,Blacks(12.4%vs 11.3%,P<0.0001)and Hispanics(6.7%vs 5.5%,P<0.0001).Furthermore,septic SBS hospitalizations had a higher proportion of patients with intestinal transplantation(0.33%vs 0.22%,P<0.0001),inpatient mortality(8.5%vs 1.4%,P<0.0001),and mean length of stay(16.1 d vs 7.7 d,P<0.0001)compared to the non-sepsis cohort.A younger age,female gender,White race,and presence of comorbidities such as anemia and depression were identified to be independent predictors of inpatient mortality for septic SBS *** Septic SBS hospitalizations had a rising trend between 2005-2014 and were associated with higher inpatient mortality compared to non-septic SBS hospitalizations.

关键词： Short bowel syndrome Sepsis Outcomes Mortality Trends

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