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环烷基稠油火驱开发中焦炭生成规律及物理化学特征

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特种油气藏 2024年第3期31卷 136-142页

作者：陈登亚游红娟陈昂郭文轩陈龙王旭生郭勇中国石油新疆油田分公司新疆克拉玛依834000 中国科学院兰州化学物理研究所甘肃兰州730000

为明确环烷基稠油在火驱过程中生成焦炭的规律和石油焦炭基本性质,应用动态气流氧化原油装置,开展了环烷基稠油注空气燃烧生成焦炭过程的研究,并对生成的石油焦炭进行了组成和结构表征。研究表明:环烷基稠油在250~300℃开始生成焦炭,随... 详细信息

为明确环烷基稠油在火驱过程中生成焦炭的规律和石油焦炭基本性质,应用动态气流氧化原油装置,开展了环烷基稠油注空气燃烧生成焦炭过程的研究,并对生成的石油焦炭进行了组成和结构表征。研究表明:环烷基稠油在250~300℃开始生成焦炭,随着反应温度升高,焦炭产率逐渐增加,温度达到450℃时,焦炭产率最高,为10.8%;温度为500~600℃时,焦炭的燃烧反应加剧,焦炭收率降至4.6%。电镜观察焦炭为0.05~1.00μm碳层叠加的致密片层结构,以400℃为分界点可以将焦炭分为2类。300~350℃生成焦炭的h/C为0.78~0.82,为含有大量烷基链的氧化焦炭;400℃时裂解反应加剧,稠油成焦过程由加氧反应为主转变为裂解反应为主;400~600℃生成焦炭的h/C为0.33~0.47,为芳香度和石墨化程度更高的裂解焦炭。该研究对环烷基稠油火驱开发点火及火线控制具有一定指导意义。

关键词：火驱原位燃烧焦炭低温氧化高温氧化环烷基物理化学特征

Development of a new method for analyzing free aluminum ions(Al^(3+)) in seafood using hPLC-ICP-MS

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Chinese Science Bulletin 2013年第35期58卷 4437-4442页

作者： Shang DeRong ZhAO YanFang ZhAI YuXiu NING jinsong DING haiYan ShENG XiaoFeng Yellow Sea Fishery Research Institute Chinese Academy of Fishery Sciences

This paper presents a novel method for simultaneous online examination of free aluminum ions(Al3+)in seafood,using solidphase extraction and high-performance liquid chromatography online with inductively coupled plasma mass spectrometry(SPEhPLC-ICP-MS),without post-column *** optimum conditions for chromatographic separation of Al3+were achieved using an IonPac CS5A analytical column with an IonPac CG5A guard *** mobile phase consisted of 0.040 mol/L LiOh,0.0060 mol/L 2,6-pyridinedicarboxylic acid,and 0.090 mol/L Ch3COOh(ph 4.7).The free Al3+ions in seafood were extracted by shaking with the mobile phase at 70°C for 2 *** was conducted using an Oasis MCX,3cc/60 mg,30μm column,which was activated and equilibrated with 2 mL of methanol and 4 mL of deionized water before ***(0.075 mol/L,2 mL)was used to wash inorganic Al from the SPE *** standard recoveries of Al3+were all above 89%and the relative standard deviations were all below 5%.The proposed method was successfully used for the examination of Al3+in seafood samples,and the results were similar to those obtained using the static equilibrium method.

关键词：铝离子游离海鲜电感耦合等离子体质谱法 IonPac 高效液相色谱相对标准偏差固相萃取

右美托咪定复合艾司氯胺酮对腹腔镜胃减容手术患者术后恢复质量的影响

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临床麻醉学杂志 2024年第8期40卷 836-841页

作者：陈丽莉樊金燕张传武孟振昂王光磊徐州医科大学附属医院麻醉科 221000

目的探讨右美托咪定复合艾司氯胺酮对腹腔镜胃减容手术患者术后恢复质量的影响。方法选择择期行腹腔镜胃减容手术患者136例,男41例,女95例,年龄18~64岁,BMI 30~45 kg/m^(2),ASAⅡ或Ⅲ级。将患者随机分为四组:右美托咪定复合艾司氯胺酮组... 详细信息

目的探讨右美托咪定复合艾司氯胺酮对腹腔镜胃减容手术患者术后恢复质量的影响。方法选择择期行腹腔镜胃减容手术患者136例,男41例,女95例,年龄18~64岁,BMI 30~45 kg/m^(2),ASAⅡ或Ⅲ级。将患者随机分为四组:右美托咪定复合艾司氯胺酮组(DE组)、艾司氯胺酮组(E组)、右美托咪定组(D组)和对照组(C组),每组34例。麻醉诱导前10 min,DE组和D组泵注右美托咪定0.5μg/kg,随后以0.4μg·kg^(-1)·h^(-1)持续泵注至手术结束前40 min。麻醉诱导时,DE组和E组给予艾司氯胺酮0.5 mg/kg负荷剂量,随后以0.1 mg·kg^(-1)·h^(-1)持续泵注至手术结束前40 min,C组在相同时点给予等容量生理盐水。记录术前24 h和术后24 h 40项恢复质量(QoR-40)评分。记录术中丙泊酚和瑞芬太尼用量、术后24 h内地佐辛用量、术后拔管时间、术后首次下床活动时间和术后首次肛门排气时间。记录拔管即刻、术后2、6、12、24 h静息时VAS疼痛评分。记录术后恶心呕吐、躁动、低氧血症和肺炎等不良反应发生情况。结果与C组比较,DE组、E组和D组术后24 h QoR-40评分明显升高(Ph内地佐辛用量明显减少,术后首次下床活动时间和术后首次肛门排气时间明显缩短(Ph静息时VAS疼痛评分明显降低(Ph静息时VAS疼痛评分明显降低(Ph QoR-40评分明显升高,术中丙泊酚用量明显减少,术后2、6、12 h静息时VAS疼痛评分明显降低(Ph QoR-40评分明显升高,术中丙泊酚用量明显减少,术后2、6 h静息时VAS疼痛评分明显降低(Ph静息时VAS疼痛评分和不良反应发生率差异均无统计学意义。结论右美托咪定复合艾司氯胺酮可减轻腹腔镜胃减容手术患者术后疼痛,提高术后恢复质量,促进快速康复。

关键词：右美托咪定艾司氯胺酮腹腔镜胃减容手术恢复质量肥胖

微氧生化-生物接触氧化法对癸二酸废水的处理特性研究

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工业水处理 2024年第4期44卷 147-154页

作者：徐军史新星王开春李坤刘冠董自斌曲昂中蓝连海设计研究院有限公司江苏连云港222004 江苏省环保微生物菌剂工程技术研究中心江苏连云港222004 江苏省环境保护高氨氮与高盐废水生化处理工程技术中心江苏连云港222004

癸二酸废水属于典型难降解工业废水,废水处理难度大,且富含的高硫酸盐极易被还原为硫化氢释放,导致环境污染。采用微氧生化-生物接触氧化工艺处理癸二酸废水,考察其对难降解工业废水的处理特性。结果表明,当进水负荷逐渐趋于稳定,在进水... 详细信息

癸二酸废水属于典型难降解工业废水,废水处理难度大,且富含的高硫酸盐极易被还原为硫化氢释放,导致环境污染。采用微氧生化-生物接触氧化工艺处理癸二酸废水,考察其对难降解工业废水的处理特性。结果表明,当进水负荷逐渐趋于稳定,在进水COD 4500~5500 mg/L、挥发酚150~200 mg/L的情况下,经微氧生化-生物接触氧化工艺处理后,出水CODh2S。在微氧段构建及启动阶段,伴随着DO升高,出水浊度不断降低;当整体工艺连续稳定运行时,系统除浊率保持在70%~90%之间,表明整体工艺对降低出水浊度有很好的效果。系统中MLSS 6000~8000 mg/L,SVI 100~150 mL/g,表明系统中污泥沉降性较好。系统运行稳定性评价表明系统具有较强的抗负荷冲击能力和耐盐度变化能力,可广泛应用于难降解工业废水的治理中。

关键词：癸二酸废水微氧生化生物接触氧化硫化物抗负荷冲击耐盐度变化

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EZh2-, ChD4-, and IDh-linked epigenetic perturbation and its association with survival in glioma patients

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Journal of Molecular Cell Biology 2017年第6期9卷 477-488页

作者： Le Zhang Ying Liu Mengning Wang Zhenhai Wu Na Li jinsong Zhang Chuanwei Yang College of Computer Science Sichuan University Chengdu China College of Computer and Information Science Southwest University Chongqing China The Vivian Smith Department of Neurosurgery Center for Stem Cell and Regenerative Medicine The University of Texas Health Science Center at Houston Houston TX USA harvard Stem Cell Institute Harvard University Cambridge MA USA Department of neurosurgery ShouGuang People's Hospital Shandong China Pharmacological & Physiological Science School of Medicine Saint Louis University St. Louis MO USA Breast Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Systems Biology The University of Texas MD Anderson Cancer Center Houston TX USA

GUoma is a complex disease with limited treatment options. Recent advances have identified isocitrate dehydrogenase （IDh） mutations in up to 80% lower grade gUomas （LGG） and in 76% secondary gUoblastomas （GBM）. IDh mutations are also seen in 10%-20% of acute myeloid leukemia （AML）. In AML, it was determined that mutations of IDh and other genes involving epigenetic regulations are early events, emerging in the pre-leukemic stem cells （pre-LSCs） stage, whereas mutations in genes propa- gating oncogenic signal are late events in leukemia. IDh mutations are also early events in gUoma, occurring before TP53 mutation, 1p/19q deletion, etc. Despite these advances in gUoma research, studies into other molecular alterations have lagged considerably. In this study, we analyzed currently available databases. We identified EZh2, KMT2C, and ChD# as important genes in glioma in addition to the known gene IDh1/2. We also showed that genomic alterations of PIK3CA, CDKN2A, CDK#, FIPIL1, or FUBP1 collaborate with IDh mutations to negatively affect patients＇ survival in LGG. In LGG patients with TP53 mutations or IDh1/2 mutations, additional genomic alterations of EZh2, KMC2C, and ChD4 individually or in combination were associated with a markedly decreased disease-free survival than patients without such alterations. Alterations of EZh2, KMT2C, and ChD4, at gen- etic level or protein level could perturb epigenetic program, leading to malignant transformation in glioma. By reviewing current literature on both AML and gUoma and performing bioinformatics analysis on available datasets, we developed a hypothetical model on the tumorigenesis from premaUgnant stem cells to gUoma.

关键词： glioma epigenetics bioinformatics prognosis gene mutation

Oxidative damage of primary cultured hippocampal neurons Does androgen have an antagonistic effect?

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Neural Regeneration Research 2010年第5期5卷 358-363页

作者： Zhaohui Li Zhiping Cai huixian Cui jinsong Zhu Sha Li Guosheng Xie Lei Xue Department of Neurosurgery Second Affiliated Hospital of Hebei Medical University Shijiazhuang 050000 Hebei Province China Department of human Anatomy Hebei Medical University Shijiazhuang 050017 Hebei Province China Department of Anatomy Hebei University Basic Medical College Baoding 071000 Hebei Province China

BACKGROUND： Evidence illustrates that androgen has a neuroprotective role. however, whether androgen also has the protective effect on hippocampal neurons during free radical mediated injury remains unclear. OBJECTIVE： To investigate the neuroprotective effect of androgen on hippocampal neurons during free radical damage. DESIGN, TIME AND SETTING： A controlled in vitro experiment was performed at the Department of human Anatomy, Cell Culture Lab, and Neuroendocrinology Lab, Basic Medical School, hebei Medical University from February to June 2009. MATERIALS： Testosterone was provided by Tianjin Jinyao Amino Acid Company, China. METhODS： Primary cultured neurons from 24 Sprague Dawley rats were randomly assigned into four groups： control, h202, testosterone, and testosterone （pre-added） plus h2O2 groups. MAIN OUTCOME MEASURES： The positive cell ratio of microtubule associated protein-Ⅱ and neuron specific enolase was determined by immunocytochemistry. Neuronal morphology was observed by hematoxylin-eosin staining and Nissl staining. Cell vitality and viability were determined using an inverted phase contrast microscope. The content of nitric oxide synthase, malondialdehyde, and superoxide dismutase were measured with a spectrophotometer. RESULTS： As compared with the control group, cell vitality and viability, and superoxide dismutase level were significantly decreased in the h202 group （P 〈 0.05）, while nitric oxide synthase and malondialdehyde levels were significantly increased （P 〈 0.05）. Neuronal vitality and viability as well as superoxide dismutase level in the testosterone plus h2O2 group were significantly greater than in the h2O2 group （P 〈 0.05）, and nitric oxide synthase and malondialdehyde levels were significantly less than in the h2O2 group （P〈 0.05）. CONCLUSION： Androgen partially reversed h2O2-induced neuronal damage and protected neurons.

关键词： androgen primary cultured hippocampal neuron free radical nitric oxide synthase superoxide dismutase malondialdehyde oxidative damage

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.h.Bu F.M.Cai h.Cai J.J.Cao Q.h.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen h.Chen h.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen h.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.h.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.h.Guo A.Guskov K.L.han L.han M.han X.Q.hao J.B.he S.Q.he X.G.he Y.L.he Z.B.he Z.X.heng B.L.hou T.J.hou Y.R.hou C.Y.hu h.M.hu K.hu R.J.hu W.h.hu X.h.hu Y.C.hu J.hua G.S.h.ang J.S.h.ang M.h.ang Q.Y.h.ang W.Q.h.ang X.T.h.ang X.J.h.ang Y.B.h.ang Y.S.h.ang N.hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia h.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao h.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.h.Li C.Li D.Y.Li F.Li G.Li G.Li h.B.Li h.Li h.N.Li h.J.Li h.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.h.Li S.Li T.Li W.J.Li X.Li X.h.Li X.Q.Li X.h.Li Y.Li Y.Y.Li Z.J.Li h.Liang J.h.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu h.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.h.Luo h.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer h.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China hangzhou Institute for Advanced Study UCASHangzhou 310024China hebei Normal University Shijiazhuang 050024China hebei University Baoding 071002China hefei University of Technology Hefei 230601China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China high Energy Physics Center Chung-Ang UniversitySeoul 06974Korea higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia h.angshan University Huangshan 245000China hubei University of Automotive Technology Shiyan 442002China hunan Normal University Changsha 410081China hunan University of Science and Technology Xiangtan 411201China hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Refining constitutive relation by integration of finite element simulations and Gleeble experiments

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Journal of Materials Science & Technology 2019年第6期35卷 1039-1043页

作者： D.J. Yu D.S. Xu h. W ang Z.B. Zhao G.Z. Wei R. Yang College of Sciences Northeastern University Shenyang 110004 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Thermo-mechanical coupled finite element calculations were carried out to simulate the Gleeble compression of the samples of a titanium alloy(Ti60), and the results are analyzed and compared with the actual compression tests conducted on a Gleeble 3800 thermo-mechanical simulator. The changes in temperature, stress and strain distribution in the samples and the source of error on the constitutive relations from Gleeble hot compression test were analyzed in detail. Both simulations and experiments showed that the temperature distribution in the specimen is not uniform during hot compression, resulting in significant deformation inhomogeneity and non-ignorable error in the flow stress strain relation,invalidating the uniform strain assumption commonly assumed when extracting the constitutive relation from Gleeble tests. Based on the finite element simulations with iterative corrections, we propose a scheme to refine the constitutive relations from Gleeble tests.

关键词： Titanium alloy Constitutive relation Finite element Compression Temperature distribution

急性药物中毒性脑病患者ICU住院时间预测模型的构建

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中国工业医学杂志 2024年第2期37卷 133-137,I0002页

作者：戴辉水石齐芳巴根李蒙张劲松南京医科大学第一附属医院急诊医学中心江苏南京210029 南京医科大学中毒研究所

目的构建急性药物中毒性脑病患者重症监护室(intensive care unit, ICU)住院时间延长的预测模型并评价其效能。方法选择重症监护医疗信息集市(MIMIC)-Ⅳ2.2数据库中148例急性药物中毒性脑病患者作为研究对象,收集患者临床资料,根据IC... 详细信息

目的构建急性药物中毒性脑病患者重症监护室(intensive care unit, ICU)住院时间延长的预测模型并评价其效能。方法选择重症监护医疗信息集市(MIMIC)-Ⅳ2.2数据库中148例急性药物中毒性脑病患者作为研究对象,收集患者临床资料,根据ICU住院时间分非延长组(≤48 h)与延长组(>48 h)。采用最小绝对收缩和选择算子(LASSO)回归联合Logistic回归筛选变量,构建和绘制列线图。分别采用受试者工作特征曲线下面积(AUC)、hosmer-Lemeshow校准曲线和决策曲线分析(DCA)评价模型的区分度、校准度及临床适用度。结果患者ICU住院时间1~15 d,其中ICU住院时间延长69例,采取LASSO回归与Logistic回归相结合方法筛选预测变量。结果显示SOFA评分、心率、合并心血管疾病、使用机械通气4个变量为独立危险因素,依据以上预测变量构建和绘制列线图,列线图的AUC为0.837,95%CI 0.774~0.900;Bootstrap内部验证AUC 0.873,95%CI 0.817~0.930,说明该列线图预测模型具有较好的预测能力。校准曲线和hosmer-Lemeshow检验(χ^(2)=6.392,P=0.603)均显示该模型具有较高的一致性和拟合度;DCA结果表明,患者可从模型中净获益(阈值范围0.05~1.00),具有较好的临床适用性。结论本研究开发的模型性能良好,有助于评估急性药物中毒性脑病患者ICU住院时间的延长风险。

关键词：急性中毒药物中毒中毒性脑病 ICU住院时间重症监护医疗信息集市(MIMIC)-Ⅳ数据库