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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian Mohammad Asad Shuai wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu Erin Brintnell Hong Chen Ying Mao Guomin Zhou Bo Liao jinsong wu Edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains unclear.By conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA glioma.The RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 mutations.Tumor subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion programs.Furthermore,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct manners.Some specific genes not expressed in normal immune cells were found in glioma-infiltrating lymphocytes.For example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,respectively.Their expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat cells.This finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

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Hierarchical cobalt-molybdenum layered double hydroxide arrays power efficient oxygen evolution reaction

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Nano Research 2024年第6期17卷 5080-5086页

作者： Xinyi Zhu Jiahui Lyu Shanshan Wang Xingchuan Li Xiaoyu Wei Cheng Chen Wanida Kooamornpattana Francis Verpoort jinsong wu Zongkui Kou State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Sanya Science and Education Innovation Park of wuhan University of Technology Sanya 572000China Nanostructure Research Center Wuhan University of TechnologyWuhan 430070China Department of Chemical Engineering Faculty of EngineeringMahidol UniversityNakhon Pathom 73170Thailand

Transition metal-based layered double hydroxides(LDHs)have been capable of working efficiently as catalysts in the basic oxygen evolution reaction(OER)for sustaining hydrogen production of alkaline water electrolysis.Nevertheless,exploring new LDH-based electrocatalysts featuring both remarkable activity and good stability is still in high demand,which is pivotal for comprehensive understanding and impressive improvement of the sluggish OER kinetics.Here,a series of bimetallic(Co and Mo)LDH arrays were designed and fabricated via a facile and controlled strategy by incorporating a Mo source into presynthesized Co-based metal-organic framework(MOF)arrays on carbon cloth(CC),named as ZIF-67/CC arrays.We found that tuning the Mo content resulted in gradual differences in the structural properties,surface morphology,and chemical states of the resulting catalysts,namely CoMox-LDH/CC(x representing the added weight of the Mo source).Gratifyingly,the best-performing CoMo_(0.20)-LDH/CC electrocatalyst demonstrates a low overpotential of only 226 mV and high stability at a current density of 10 mA·cm^(−2),which is superior to most LDH-based OER catalysts reported previously.Furthermore,it only required 1.611 V voltage to drive the overall water splitting device at the current density of 10 mA·cm^(−2).The present study represents a significant advancement in the development and applications of new OER catalysts.

关键词： layered double hydroxides(LDHs) metal-organic frameworks(MOFs) array catalysts Mo modification electrocatalytic oxygen evolution reaction(OER)

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Ultraviolet Photodetector based on Sr_(2)Nb_(3)O_(10) Perovskite Nanosheets

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Journal of wuhan University of Technology(Materials Science) 2024年第2期39卷 282-287页

作者：张斌斌 JIA Mengmeng LIANG Qi wu jinsong ZHAI Junyi 李宝文 School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijin 100083China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Liquid-phase exfoliation was employed to synthesize Sr_(2)Nb_(3)O_(10) perovskite nanosheets with thicknesses down to 1.76 nm.Transmission electron microscopy(TEM),atomic force microscope(AFM),X-ray photoelectron spectrometer(XPS),and other characterization techniques were used to evaluate the atomic structure and chemical composition of the exfoliated nanosheets.A UV photodetector based on individual Sr_(2)Nb_(3)O_(10) nanosheets was prepared to demonstrate the application of an ultraviolet(UV) photodetector.The UV photodetector exhibited outstanding photocurrent and responsivity with a responsivity of 3×10^(5) A·W^(-1) at 5 V bias under 280 nm illumination,a photocurrent of 60 nA,and an on/off ratio of 3×10^(2).

关键词： perovskite nanosheets liquid-phase exfoliation ultraviolet photodetector

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Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation

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Science China(Life Sciences) 2024年第5期67卷 1035-1050页

作者： Yaling Wang Jingwen Chen Xueying Huang Bangguo wu Peng Dai Feng Zhang jinsong Li Lingbo Wang State Key Laboratory of Genetic Engineering Shanghai Key Laboratory of Metabolic Remodeling and HealthInstitute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Institute of Reproduction and Development Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China NHC Key Lab of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies) School of PharmacyFudan UniversityShanghai 200433China Shanghai Key Laboratoryof Maternal and Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchoolof Life Sciences and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

Cytosine base editing achieves C·G-to-T·A substitutions and can convert four codons(CAA/CAG/CGA/TGG)into STOP-codons(induction of STOP-codons,iSTOP)to knock out genes with reduced mosaicism.iSTOP enables direct phenotyping in founders’somatic cells,but it remains unknown whether this works in founders’germ cells so as to rapidly reveal novel genes for fertility.Here,we initially establish that iSTOP in mouse zygotes enables functional characterization of known genes in founders’germ cells:Cfap43-iSTOP male founders manifest expected sperm features resembling human“multiple morphological abnormalities of the flagella”syndrome(i.e.,MMAF-like features),while oocytes of Zp3-iSTOP female founders have no zona pellucida.We further illustrate iSTOP’s utility for dissecting the functions of unknown genes with Ccdc183,observing MMAF-like features and male infertility in Ccdc183-iSTOP founders,phenotypes concordant with those of Ccdc183-KO offspring.We ultimately establish that CCDC183 is essential for sperm morphogenesis through regulating the assembly of outer dynein arms and participating in the intra-flagellar transport.Our study demonstrates iSTOP as an efficient tool for direct reproductive disease modeling and phenotyping in germ cells of the founder generation,and rapidly reveals the essentiality of Ccdc183 in fertility,thus providing a time-saving approach for validating genetic defects(like nonsense mutations)for human infertility.

关键词： disease modeling infertility multiple morphological abnormalities of the flagella(MMAF) induction of STOP-codons(iSTOP CRISPR-STOP) sperm motility

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Multi-resolution network based image steganalysis model

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Intelligent and Converged Networks 2023年第3期4卷 198-205页

作者： Zimiao Wang jinsong wu the School of Computer Science Beijing University of Posts and TelecommunicationsBeijing 100876China the School of Artificial Intelligence Guilin University of Electronic Technology510004China the Department of Electrical Engineering University of ChileSantiago 8370451Chile

Recently, many steganalysis approaches improve their feature extraction ability through addingconvolutional layers. However, it often leads to a decrease of resolution in the feature map during downsampling,which makes it challenging to extract weak steganographic signals accurately. To address this issue, this paperproposes a multi-resolution steganalysis net (MRS-Net). MRS-Net adopts a multi-resolution network to extract globalimage information, fusing the output feature map to ensure high-dimensional semantic information andsupplementing low-level detail information. Furthermore, the model incorporates an attention module which cananalyze image sensitivity based on different channel and spatial information, thus effectively focusing on areas withrich steganographic signals. Multiple benchmark experiments on the BOSSBase 1.01 dataset demonstrate that theaccuracy of MRS-Net significantly improves by 9.9% and 3.3% compared with YeNet and SRNet, respectively,demonstrating its exceptional steganalysis capability.

关键词： image steganalysis multi-resolution attention module

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Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice

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Journal of Genetics and Genomics 2024年第4期51卷 407-418页

作者： Yaling Wang Xueying Huang Guoying Sun Jingwen Chen Bangguo wu Jiahui Luo Shuyan Tang Peng Dai Feng Zhang jinsong Li Lingbo Wang Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Institute of Reproduction and Development Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Shanghai Key Laboratory of Maternal and Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

During spermiogenesis,haploid spermatids undergo dramatic morphological changes to form slender sperm flagella and cap-like acrosomes,which are required for successful fertilization.Severe deformities in flagella cause a male infertility syndrome,multiple morphological abnormalities of the flagella(MMAF),while acrosomal hypoplasia in some cases leads to sub-optimal embryonic developmental potential.However,evidence regarding the occurrence of acrosomal hypoplasia in MMAF is limited.Here,we report the generation of base-edited mice knocked out for coiled-coil domain-containing 38(Ccdc38)via inducing a nonsense mutation and find that the males are infertile.The Ccdc38-KO sperm display acrosomal hypoplasia and typical MMAF phenotypes.We find that the acrosomal membrane is loosely anchored to the nucleus and fibrous sheaths are disorganized in Ccdc38-KO sperm.Further analyses reveal that Ccdc38 knockout causes a decreased level of TEKT3,a protein associated with acrosome biogenesis,in testes and an aberrant distribution of TEKT3 in sperm.We finally show that intracytoplasmic sperm injection overcomes Ccdc38-related infertility.Our study thus reveals a previously unknown role for CCDC38 in acrosome biogenesis and provides additional evidence for the occurrence of acrosomal hypoplasia in MMAF.

关键词： Acrosomal hypoplasia Multiple morphological abnormalities of the flagella(MMAF) Infertility Sperm motility Asthenoteratozoospermia Disease modeling

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Unraveling the reaction mechanisms of electrode materials for sodiumion and potassium‐ion batteries by in situ transmission electron microscopy

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Interdisciplinary Materials 2022年第2期1卷 196-212页

作者： Hong Wang Fang Liu Ruohan Yu jinsong wu Nanostructure Research Center(NRC) Wuhan University of TechnologyWuhanHubeiChina State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhanHubeiChina School of Mathematics and Physics Jingchu University of TechnologyJingmenHubeiChina

Sodium ion batteries(SIBs)and potassium ion batteries(PIBs)have caught numerous attention due to the low cost and abundant availability of sodium and potassium.However,their power density,cycling stability and safety need further improvement for practical applications.Investigations on the reaction mechanisms and structural degradation when cycling are of great importance.In situ transmission electron microscopy(TEM)is one of the most significant techniques to understand and monitor electrochemical processes at an atomic scale with real-time imaging.In this review,the current progress in unraveling reaction mechanisms of electrode materials for SIBs and PIBs via in situ TEM is summarized.First,the importance of in situ TEM is highlighted.Then,based on the three types of electrochemical reaction,i.e.,intercalation reac-tion,conversion reaction and alloying reaction,the structural evolution and reaction kinetics at atomic resolution,and their relation to the electrochemical performance of electrode materials are reviewed and described in detail.Fi-nally,future directions of in situ TEM for SIBs and PIBs are proposed.Therefore,the in‐depth understanding revealed by in situ TEM will give an instructive guide in rational design of electrode materials for high performance electrode materials of SIBs and PIBs.

关键词： in situ transmission electron microscopy potassium ion batteries sodiumion batteries

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Design of high-performance and sustainable Co-free Ni-rich cathodes for next-generation lithium-ion batteries

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SusMat 2024年第1期4卷 48-71页

作者： Hao Ge Zhiwen Shen Yanhong Wang Zhijia Sun Xiaoman Cao Chaoyue Wang Xinyue Fan jinsong Bai Rundong Li Tianhua Yang Gang wu School of Energy and Environment Shenyang Aerospace UniversityShenyangP.R.China Shenyang Aircraft Airworthiness Certification Center of CAAC ShenyangP.R.China College of Chemistry and Materials Engineering Bohai UniversityJinzhouP.R.China Liaoning General Aviation Academy ShenyangP.R.China Department of Chemical and Biological Engineering University at BuffaloState University of New YorkBuffaloNew YorkUSA

Great attention has been given to high-performance and inexpensive lithiumion batteries(LIBs)in response to the ever-increasing demand for the explosive growth of electric vehicles(EVs).High-performance and low-cost Co-freeNi-rich layered cathodes are considered one of the most favorable candidates for nextgeneration LIBs because the current supply chain of EVs relies heavily on scarce and expensive Co.Herein,we review the recent research progress on Co-free Nirich layered cathodes,emphasizing on analyzing the necessity of replacing Co and the popular improvment methods.The current advancements in the design strategies of Co-free Ni-rich layered cathodes are summarized in detail.Despite considerable improvements achieved so far,the main technical challenges contributing to the deterioration of Co-free Ni-rich cathodes such as detrimental phase transitions,crack formation,and severe interfacial side reactions,are difficult to resolve by a single technique.The cooperation of multiple modification strategies is expected to accelerate the industrialization of Co-free Ni-rich layered cathodes,and the corresponding synergistic mechanisms urgently need to be studied.More effects will be aroused to explore high-performance Co-free Ni-rich layered cathodes to promote the sustainable development of LIBs.

关键词： Co-free cathodes electrochemical performance lithium-ion batteries modification strategies Ni-rich layered cathodes

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Revealing structural degradation in layered structure oxides cathode of lithium ion batteries via in-situ transmission electron microscopy

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Journal of Materials Science & Technology 2023年第23期154卷 189-201页

作者： Fanjie Xia Weihao Zeng Haoyang Peng Hong Wang Congli Sun Ji Zou jinsong wu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and Engineering Wuhan University of Technology Wuhan 430070 China Nanostructural Research Center (NRC) Wuhan University of Technology Wuhan 430070 China Hubei Longzhong Laboratory Xiangyang 441000 China

Transition metal oxides with layered structure have been widely used as cathode materials for lithium-ion batteries(LIBs)which have relatively high energy density,large capacity and long life.However,in the long-term electrochemical cycle,the inevitable degradation of performance of LIBs due to structural degradation in cathodes severely restricts their large-scale practical applications.Understanding the underlying mechanism of structural degradation is the most critical scientific problem.Recently,in situ transmission electron microscopy(TEM)has become a useful tool to study the structural and compositional evolutions at atomic scale in electrochemical reactions,which provided a unique and in-depth understanding of the structural degradation.In this review,we discuss the recent advances in the in situ TEM,focusing on its role in revealing the structural degradation mechanisms in the four key places:(1)the interface between the cathodes and electrolyte;(2)the cathode surface;(3)the particle interior and(4)those induced by thermal effect.The insight gained by the in-situ TEM which is still developing at its fast pace is unique and expected to provide guidance for designing better layered cathode materials.

关键词： Li-ion battery Layered cathodes Structural degradations Electron microscopy In-situ

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Consensus of Chinese experts on glioma multidisciplinary team management (2nd edition)

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中华医学杂志(英文版) 2024年第11期137卷 1267-1270页

作者： wu jinsong Zhou Zhirui wu Zanyi Tang Zhiwei Li Ming Yin Siyuan Luo Xufei Wang Ling Chen Yaolong Zhao Guoguang Jiang Tao Mao Ying The National Glioma MDT Alliance of National Center for Neurological Diseases Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China Department of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China Department of Radiation Oncology Huashan Hospital Shanghai Medical College Fudan University Shanghai China Department of Neurosurgery The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian China Neurosurgery Department The First Affiliated Hospital of Kunming Medical University Kunming Yunnan China Department of Neurosurgery Henan Provincial People’s Hospital People’s Hospital of Zhengzhou University Zhengzhou Henan China State Key Laboratory of Pharmaceutical Biotechnology Institute for Brain Sciences Advanced Institute for Life Sciences School of Life Sciences Nanjing University Nanjing Jiangsu China Evidence-Based Medicine Center School of Basic Medical Sciences Lanzhou University Lanzhou Gansu China School of Public Health Lanzhou University Lanzhou Gansu China Department of Neurosurgery Xuanwu Hospital Capital Medical University Beijing China

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