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Stem cell, basis and application

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Science Bulletin 2015年第20期60卷 1711-1712页

作者： jinsong li Group of Epigenetic Reprogramming State Key Laboratory of Cell Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological Sciences Chinese Academy of Sciences

Stem cells sustain the capacity of self-renewal and differentiation into specialized cells,offering exciting promises in both basic and applied *** an example of an applied purpose,stem cells can be used as a resource... 详细信息

关键词：成体干细胞应用程序基础研究替代治疗自我更新能力体外分化胚胎干细胞细胞类型

Genome tagging project: tag every protein in mice through 'artificial spermatids'

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National Science Review 2019年第3期6卷 394-396页

作者： Jing Jiang Meng Yan Dangsheng li jinsong li CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences

The Human Genome Project (HGP),launched in 1990 and finished in 2004,has not only provided the complete human genome sequence of more than2.85 billion nucleotides and evidence of 20 000–25 000 protein-coding genes[1], but has also been making huge impacts on biomedical research. One major task of the post-genomic era is to develop the definitive catalog of proteincoding genes, and illustrate proteins' in

关键词： tag every protein in mice through Genome tagging project artificial spermatids

High-accuracy and Low-complexity Phasor Estimation Method for PMU Calibration

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CSEE Journal of Power and Energy Systems 2021年第6期7卷 1202-1212页

作者： jinsong li Sudi Xu Hao liu Tianshu Bi North China Electric Power University and China Electric Power Research Institute Beijing 102206China State Key Lab of Alternate Electric Power System With Renewable Energy Sources North China Electric Power UniversityBeijing 102206China

Due to the increasing development of renewables in power systems,the requirements for phasor measurement units(PMUs)becomes higher.A PMU calibrator is an important tool to test and calibrate PMUs to ensure their measurement *** device can provide accurate reference values for error analysis of *** this paper,a phasor algorithm with low computational complexity and high accuracy is proposed for the PMU *** method reduces the processor requirements and development costs of the calibrator,thereby facilitating its *** first,an enhanced discrete Fourier transform(DFT)method is put forward:1)the frequency response of the windowed DFT method is analyzed to reveal its large measurement errors under dynamic conditions;2)the parameter requirements of the DFT window that is regarded as a lowpass filter are analyzed,and thus a lowpass filter with better filtering performance is designed as the window coefficients to improve the estimation ***,based on the enhanced DFT algorithm,a calibrator algorithm framework consisting of two-stage filters and a signal recognition module is *** algorithm can consider the anti-interference ability and dynamic measurement accuracy at a low reporting *** and experimental test results show that the proposed calibrator algorithm provides high-accuracy measurements of the static and dynamic signals with low computational complexity.

关键词： Phasor measurement unit(PMU) PMU calibrator PMU test windowed DFT algorithm

Exergy Analysis of a Novel Chemical Looping Hydrogen Generation System Integrated with SOFC

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Journal of Thermal Science 2021年第1期30卷 313-323页

作者： ZHANG Xiaosong CHEN Zhewen CHEN Zhenbin li jinsong Mechanical and Electrical Engineering College Hainan UniversityHaikou 570228China Beijing Key Laboratory of Multiphase Flow and Heat Transfer North China Electric Power UniversityBeijing 102206China

In this paper,a novel system integrating chemical-looping hydrogen generation(CLH)system and solid oxide fuel cell(SOFC)has been *** new methane-fuelled energy system was investigated with energy balance and exergy *** produces the hydrogen as the fuel of the SOFC,and the Fe O and Fe3O4 are selected as the looping *** heat from the SOFC is absorbed by the CLH and converted to chemical energy through the reduction reaction of *** to the cascade utilization of the fuel between the CLH and SOFC,the net efficiency of this novel system can achieve 62.8%considering CO_(2)separation,more than 10 percentage points higher than a methane reforming fuelled SOFC ***,by using the CLH to produce the hydrogen,the CO_(2)can be recovered without an energy *** the analysis of the graphical exergy,the cascade utilization of waste heat and the high-efficiency hydrogen production is the main reason of high *** novel system also has the advantage of CO_(2)capture without energy penalty,so this combined system is an advantaged method to accomplish the efficient utilization of methane.

关键词： chemical looping fuel cell exergy analysis

Expansion of the mutant monkey through cloning

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Science China(life Sciences) 2019年第6期62卷 865-867页

作者： lingbo Wang jinsong li State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular Andrology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai 200031 China NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research) Fudan University Shanghai 200032 China Obstetrics and Gynecology Hospital NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research) School of Life Sciences Fudan University Shanghai 200011 China

Non-human primates with gene-modifications have been considered as the ideal models for some complex human diseases that are extremely difficult to be recapitulated in other animal models, especially for neural disord... 详细信息

关键词： Non-human primates considered similarity

The evolving CRISPR technology

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Protein & Cell 2019年第11期10卷 783-786页

作者： Meng Yan jinsong li State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China

Adva nces in genome editi ng tech no logy have revoluti on ized basic and applied biology research in recent years,particu?larly due to the newly emerged CRISPR/Cas technique(Ren et al.,2017b).The classical CRISPR/Cas system was derived from a bacterial defense system,which consists of a single guide RNA(sgRNA)for precise targeting and one Cas protein for DNA binding and nuclease *** on high precision of CRISPR/Cas system,multiple functions have been exploited in addition to original nuclease activity,such as genome base editing,gene knock-down and activation,chromatin imaging systems etc.

关键词： CRISPR/Cas nuclease system

Preface to the special topic on tissue stem cell research

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Science China(life Sciences) 2021年第12期64卷 1995-1997页

作者： jinsong li Yi Arial Zeng State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China School of life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China

Stem cells have the ability to self-renew,divide for a long period of time,and differentiate into specialized cells with distinct *** are hopeful that,in the future,stem cells will be used to cure a wide range of diseases and traumatic injuries with some application of cell ***,donated organs and tissues are used to replace lost or damaged tissue in many disorders.

关键词： injuries organs functions.

Haploid embryonic stem cells:an ideal tool for mammalian genetic analyses

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Protein & Cell 2012年第11期3卷 806-810页

作者： linyu Shi Hui Yang jinsong li Group of Epigenetic Reprogramming State Key Laboratory of Cell BiologyInstitute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

Identification of the function of all genes in the mammalian genome is critical in understanding basic mechanisms of ***,the diploidy of mammalian somatic cells has greatly hindered efforts to elucidate the gene function in numerous biological processes by mutagenesis-based genetic ***,mouse haploid embryonic stem(haES)cells have been successfully isolated from parthenogenetic and androgenetic embryos,providing an ideal tool for genetic *** these studies,mouse haES cells have already shown that they could be used in cell-based forward or reverse genetic screenings and in generating gene-targeting via homologous *** particular,haES cells from androgenetic embryos can be employed as novel,renewable form of fertilization agent for yielding live-born mice via injection into oocytes,thus showing the possibility that genetic analysis can be extended from cellular level to organism level.

关键词： haploid embryonic stem cells parthenogenetic embryos androgenetic embryos genetic screening diploid genomic imprinting

Fabricating sustainable lignin-derived porous carbon as electrode for high-performance supercapacitors

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Frontiers of Chemical Science and Engineering 2023年第8期17卷 1065-1074页

作者： Wei liu Zhikun li Ranran Sang jinsong li Xueping Song Qingxi Hou Guangxi Key Laboratory of Clean Pulp&Papermaking and Pollution Control College of Light Industry and Food EngineeringGuangxi UniversityNanning 530004China Tianjin Key Laboratory of Pulp&Paper Tianjin University of Science&TechnologyTianjin 300457China Mudanjiang Hengfeng Paper Co. Ltd.Mudanjiang 157013China

lignocellulosic biomass such as plants and agricultural waste are ideal to tackle the current energy crisis and energy-related environmental ***-rich lignin is abundant in lignocellulosic biomass,whose high-value transformation and utilization has been the most urgent problem to be ***,we propose a method for the preparation of porous carbon from lignin employing an H_(3)PO_(4)-assisted hydrothermal *** characterize the as-prepared lignin-derived porous carbon and investigate its potential for energy *** assisted hydrothermal treatment followed by carbonization at 800℃,the lignin-derived porous carbon displays a high specific capacitance(223.6 F·g^(–1) at 0.1 A·g^(–1))and excellent cycling ability with good capacitance *** this present study,the resultant lignin-derived porous carbon was used as the electrode of a supercapacitor,illustrating yet another potential high-value use for lignin,namely as a candidate for the sustainable fabrication of main supercapacitor components.

关键词： lignin porous carbon electrode supercapacitor