检索结果-南通市图书馆

Efficacy and safety of gemcitabine plus S-1 vs. gemcitabine plus nab-paclitaxel in treatment-na?ve advanced pancreatic ductal adenocarcinoma

引用

Cancer Biology & Medicine 2023年第10期20卷 765-778页

作者： Zhou Zhu Hui Tang jinrong ying Yuejuan Cheng Xiang Wang yingyi Wang Chunmei Bai Department of Medical Oncology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China 4+4 Medical Doctor Program Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective:Gemcitabine plus nab-paclitaxel(GnP)is the standard first-line therapy for advanced pancreatic ductal adenocarcinoma(PDAC).S-1,an oral fluoropyrimidine derivative,as compared with gemcitabine,is non-inferior in terms of overall survival(OS)and is associated with lower hematologic toxicity.Accordingly,S-1 is a convenient oral alternative treatment for advanced PDAC.This study was aimed at comparing the efficacy and safety of gemcitabine plus S-1(GS)vs.GnP as first-line chemotherapy for advanced PDAC.Methods:Patients with advanced PDAC who received first-line GS or GnP at the Peking Union Medical College Hospital between March 2011 and November 2022 were evaluated.Results:A total of 300 patients were assessed,of whom 84 received GS and 216 received GnP.The chemotherapy completion rate was higher with GS than GnP(50.0%vs.30.3%,P=0.0028).The objective response rate(ORR)was slightly higher(14.3%vs.9.7%,P=0.35),and the median OS was significantly longer(17.9 months vs.13.3 months,P=0.0078),in the GS group than the GnP group.However,the median progression-free survival(PFS)did not significantly differ between groups.Leukopenia risk was significantly lower in the GS group than the GnP group(14.9%vs.28.1%,P=0.049).Conclusions:As first-line chemotherapy for advanced PDAC,the GS regimen led to a significantly longer OS than the GnP regimen.The PFS,ORR,and incidence of severe adverse events were comparable between the GS and GnP groups.

关键词： Advanced pancreatic cancer first-line chemotherapy gemcitabine S-1 nab-paclitaxel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation

引用

Science China(Life Sciences) 2024年第3期67卷 488-503页

作者： Xiao Fan Fangzhou Liu Xiang Wang ying Wang Yu Chen Chengyu Shi Xinwan Su Manman Tan Qingfeng Yan jinrong Peng Jianzhong Shao Yan Xiong Aifu Lin MOE Laboratory of Biosystem Homeostasis and Protection College of Life SciencesZhejiang UniversityHangzhou 310058China Key Laboratoryof Cancer Prevention and Intervention China National Ministry of EducationHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory for Cell and Gene Engineering of Zhejiang Province Hangzhou 310058China Department of Central Laboratory the First People's Hospital of HuzhouHuzhou 313000China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006China MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou 310058China Department of Orthopedic Surgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000China Breast Center of the First Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310003China International School of Medicine International Institutes of MedicineThe 4th Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China

Ferroptosis, a unique type of non-apoptotic cell death resulting from iron-dependent lipid peroxidation, has a potential physiological function in tumor suppression, but its underlying mechanisms have not been fully elucidated. Here, we report that the long non-coding RNA(lncRNA) LncFASA increases the susceptibility of triple-negative breast cancer(TNBC) to ferroptosis. As a tumor suppressor, LncFASA drives the formation of droplets containing peroxiredoxin1(PRDX1), a member of the peroxidase family, resulting in the accumulation of lipid peroxidation via the SLC7A11-GPX4 axis. Mechanistically, LncFASA directly binds to the Ahpc-TSA domain of PRDX1, inhibiting its peroxidase activity by driving liquid-liquid phase separation, which disrupts intracellular ROS homeostasis. Notably, high LncFASA expression indicates favorable overall survival in individuals with breast cancer, and LncFASA impairs the growth of breast xenograft tumors by modulating ferroptosis. Together, our findings illustrate the crucial role of this lncRNA in ferroptosis-mediated cancer development and provide new insights into therapeutic strategies for breast cancer.

关键词： long non-coding RNA peroxiredoxin liquid-liquid phase separation ferroptosis breast cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

化学外加剂对龙首矿充填料浆配合比优化的影响研究

引用

矿业研究与开发 2023年第11期43卷 33-38页

作者：应金荣龙卫国王瑛冯航韩斌北京科技大学土木与资源工程学院北京100083 北京科技大学金属矿山高效开采与安全教育部重点实验室北京100083 金川集团股份有限公司甘肃金昌市737100

为降低充填材料成本,在保证充填体单轴抗压强度和料浆流动性的前提下,对添加外加剂的充填料浆配合比优化进行了研究,并对试验结果进行方差分析。结果表明:在扩散度为(91±2) cm的前提下,灰砂比为1∶4时,通过添加外加剂,充填料浆的质量... 详细信息

为降低充填材料成本,在保证充填体单轴抗压强度和料浆流动性的前提下,对添加外加剂的充填料浆配合比优化进行了研究,并对试验结果进行方差分析。结果表明:在扩散度为(91±2) cm的前提下,灰砂比为1∶4时,通过添加外加剂,充填料浆的质量浓度可从78.0%提高至83.6%;相同水泥掺量条件下,充填体单轴抗压强度随着料浆质量浓度的提高而增大;充填体的单轴抗压强度随着水泥掺量的增大而增大,在水泥掺量不小于15.5%时,质量浓度82.4%及以上的料浆配合比下的充填体单轴抗压强度均超过现用78.0%的充填体单轴抗压强度;在保证经济性的前提下,推荐使用质量浓度为82.4%、水泥掺量为15.5%、外加剂掺量为300 mL/t的料浆配合比。

关键词：充填料浆配合比外加剂掺量扩散度方差分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

非金属喷锚网巷道支护工艺优化研究

引用

矿业研究与开发 2023年第9期43卷 119-126页

作者：骆玉琦龙卫国应金荣金川集团股份有限公司龙首矿甘肃金昌市737100 北京科技大学金属矿山高效开采与安全教育部重点实验室北京100083

针对金属锚杆和锚网的价格高、质量大、耐腐蚀性差等问题,以金川集团龙首矿为研究对象,基于理论分析、数值模拟及现场试验等手段,开展了非金属喷锚网巷道支护工艺优化研究。通过锚杆、锚网强度指标计算并综合考虑支护效果评价指标,初步... 详细信息

针对金属锚杆和锚网的价格高、质量大、耐腐蚀性差等问题,以金川集团龙首矿为研究对象,基于理论分析、数值模拟及现场试验等手段,开展了非金属喷锚网巷道支护工艺优化研究。通过锚杆、锚网强度指标计算并综合考虑支护效果评价指标,初步确定非金属锚杆、锚网规格参数;采用MIDAS/GTS数值模拟软件构建金属、非金属(喷)锚网支护巷道的二维数值模型,分析围岩应力(位移)场、锚杆内力等分布规律;对永久支护巷道及临时回采进路进行现场支护试验,对比分析金属材料与非金属材料的支护效果,验证了非金属喷锚网支护工艺在地下开采支护工程中应用的可行性。研究结果可为非金属材料在巷道支护中的应用提供参考。

关键词：非金属材料喷锚网巷道支护工艺优化数值模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于脂质与动脉粥样硬化通路探讨菟丝子防治卵巢早衰的作用机制

引用

中国实验方剂学杂志 2024年第6期30卷 109-118页

作者：谢颖萧闵江晓翠张金融史若怡张家玮赵敏湖北中医药大学基础医学院武汉430065 湖北中医药大学中医药实验中心武汉430065 湖北省妇幼保健院武汉430070

目的:通过网络药理学及分子对接技术初步预测菟丝子防治卵巢早衰的活性成分、作用靶点及信号通路,并构建卵巢早衰动物模型,基于脂质与动脉粥样硬化信号通路探讨其作用机制。方法:从中药系统药理学数据库与分析平台(TCMSP)、Swiss Target... 详细信息

目的:通过网络药理学及分子对接技术初步预测菟丝子防治卵巢早衰的活性成分、作用靶点及信号通路,并构建卵巢早衰动物模型,基于脂质与动脉粥样硬化信号通路探讨其作用机制。方法:从中药系统药理学数据库与分析平台(TCMSP)、Swiss Target Prediction、Pharmmapper等数据库中获取药物的有效成分及对应靶点;使用GeneCards数据库收集疾病的相关靶点;利用Venny2.1.0在线工具筛选出药物与疾病的交集靶点,用STRING数据库及Cytoscape v3.7.2软件构建“药物-成分-靶点”与蛋白质-蛋白质互作网络(PPI)网络图;通过运行R语言脚本对交集靶点进行基因本体(GO)及京都基因与基因组百科全书(KEGG)富集分析,利用分子对接技术将药物成分与靶点进行对接,并对其部分对接结果进行可视化;将小鼠随机分为正常组、模型组、菟丝子组与戊酸雌二醇组,采用慢性应激制备卵巢早衰模型,正常组与模型组给予等量生理盐水灌胃,菟丝子组给予菟丝子水煎剂2.6 g·kg^(-1)·d^(-1),戊酸雌二醇组给予戊酸雌二醇溶液0.13 mg·kg^(-1)·d^(-1),4周后取材,苏木素-伊红(HE)染色观察卵巢的组织形态学改变,酶联免疫吸附测定法(ELISA)检测血清中促卵泡素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))、缪勒管抑制物质/抗缪勒管激素(AMH)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的含量,蛋白免疫印迹法(Western blot)检测细胞外调节蛋白激酶(ERK)、核转录因子-κB p65(NF-κB p65)、核转录因子-κB抑制因子α(IκBα)、白细胞介素-1β(IL-1β)、IL-6、肿瘤坏死因子-α(TNF-α)等表达水平。结果:共筛选菟丝子防治卵巢早衰靶点171个,主要包括细胞肿瘤抗原(TP53)、蛋白激酶B1(Akt1)、原癌基因酪氨酸蛋白激酶(SRC)、肿瘤坏死因子(TNF)、表皮生长因子受体(EGFR)等,KEGG通路富集分析预测菟丝子防治卵巢早衰主要涉及脂质与动脉粥样硬化、TNF信号通路、TP53信号通路等。动物实验表明,与卵巢早衰模型组比较,菟丝子组可明显上调AMH、E_(2)、HDL-C(P<0.05,P<0.01),显著下调LH、TC、LDL-C(P<0.01),显著降低IL-1β、IL-6、TNF-α蛋白水平与ERK、NF-κB p65及其磷酸化水平(P<0.01)。结论:菟丝子可通过“多成分-多靶点-多通路”方式,调节激素水平改善卵巢功能,其机制可能与调控脂质与动脉粥样硬化信号通路有关。

关键词：菟丝子网络药理学卵巢早衰分子对接实验验证

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

田耀洲教授辨治慢性萎缩性胃炎经验采撷

引用

光明中医 2024年第8期39卷 1526-1529页

作者：陈颖田耀洲林琳丁金荣南京中医药大学附属中西医结合医院消化科江苏南京210028 南京中医药大学第三临床医学院江苏南京210046 无锡市中医院消化科江苏无锡214071

慢性萎缩性胃炎(CAG)是消化系统常见病,具有病情反复、缠绵难愈的特点。病理主要以胃腺体的萎缩、伴或不伴有肠上皮化生或异型增生为特征。肠上皮化生和异型增生属于癌前病变,与胃癌的发生关系密切,积极控制CAG患者的临床症状,延缓其病... 详细信息

慢性萎缩性胃炎(CAG)是消化系统常见病,具有病情反复、缠绵难愈的特点。病理主要以胃腺体的萎缩、伴或不伴有肠上皮化生或异型增生为特征。肠上皮化生和异型增生属于癌前病变,与胃癌的发生关系密切,积极控制CAG患者的临床症状,延缓其病理进展或逆转其病理变化,有利于改善患者的生活质量、减轻经济负担及预防胃癌发生。田耀洲教授认为此病属本虚标实,脾胃虚弱是本,气滞、湿郁、瘀血为标,虚、滞、湿、瘀相互胶结推动着疾病的进展,在辨证上推崇微观与宏观相结合,用药上推崇中西医结合,并擅用经方与药对,精准辨治与用药。田教授开创的自拟方剂芪芝方,疗效显著,可有效改善脾胃湿热型CAG的临床症状。今将田教授辨治CAG之经验及自拟方剂分享给大家,以期为临床辨治CAG提供参考借鉴。

关键词：慢性萎缩性胃炎脾胃湿热证名医经验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A review on recent advances in hydrogen peroxide electrochemical sensors for applications in cell detection

引用

Chinese Chemical Letters 2022年第9期33卷 4133-4145页

作者： Yan Yu Meng Pan jinrong Peng Danrong Hu ying Hao Zhiyong Qian State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengdu 610065China

Hydrogen peroxide(H_(2)O_(2))is a very simple bioactive small molecule.In living organisms,H_(2)O_(2)plays an important role in intracellular signaling.It is involved in many physiological processes including cellular physiology,intracellular signaling,oxidative damage and disease progression.The tumor microenvironment enriched with H_(2)O_(2).Several electrochemical sensors have been developed and some have been put on the market.Such electrochemical sensors provide efficient,cost-effective,rapid and highly selective method of H_(2)O_(2)detection.So far,much progress has been made in the designing of materials and construction of H_(2)O_(2)sensors.This review describes the advances in the application of H_(2)O_(2)electrochemical sensors in cell detection.Enzyme-based sensors have been applied in diverse applications.In addition,recent advancements in nanotechnology have improved the development of nanozymes-based sensors.The application of noble metals,metal oxides,polymers,carbon materials and other two-dimensional materials in the design of H_(2)O_(2)sensors are discussed in detail.Moreover,the bio-stimulant types of H_(2)O_(2)sensor are summarized.Finally,the challenges and future perspectives in the application of H_(2)O_(2)electrochemical sensors in biological detection are discussed.

关键词： Hydrogen peroxide Electrochemical sensors Cells detection Enzyme Nanozyme

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Black-hole-inspired thermal trapping with graded heat-conduction metadevices

引用

National Science Review 2023年第2期10卷 131-138页

作者： Liujun Xu jinrong Liu Peng Jin Guoqiang Xu Jiaxin Li Xiaoping Ouyang ying Li Cheng-Wei Qiu Jiping Huang Department of Physics State Key Laboratory of Surface Physics and Key Laboratory of Micro and Nano Photonic Structures (MOE) Fudan University Department of Electrical and Computer Engineering National University of Singapore Graduate School of China Academy of Engineering Physics School of Materials Science and Engineering Xiangtan University Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical InstrumentationZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang University International Joint Innovation Center Key Laboratory of Advanced Micro/Nano Electronic Devices and Smart Systems of Zhejiang The Electromagnetics Academy of Zhejiang University Zhejiang University

The curved space-time produced by black holes leads to the intriguing trapping effect.So far,metadevices have enabled analogous black holes to trap light or sound in laboratory spacetime.However,trapping heat in a conductive environment is still challenging because diffusive behaviors are directionless.Inspired by black holes,we construct graded heat-conduction metadevices to achieve thermal trapping,resorting to the imitated advection produced by graded thermal conductivities rather than the trivial solution of using insulation materials to confine thermal diffusion.We experimentally demonstrate thermal trapping for guiding hot spots to diffuse towards the center.Graded heat-conduction metadevices have advantages in energy-efficient thermal regulation because the imitated advection has a similar temperature field effect to the realistic advection that is usually driven by external energy sources.These results also provide an insight into correlating transformation thermotics with other disciplines,such as cosmology,for emerging heat control schemes.

关键词： thermal trapping graded metadevices imitated advection

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Optical Flow with Learning Feature for Deformable Medical Image Registration

引用

Computers, Materials & Continua 2022年第5期71卷 2773-2788页

作者： jinrong Hu Lujin Li ying Fu Maoyang Zou Jiliu Zhou Shanhui Sun Department of Computer Science Chengdu University of Information TechnologyChengdu610225China Curacloud Corporation 999 Third AveSuite 700 SeattleWA98104USA

Deformable medical image registration plays a vital role in medical image applications,such as placing different temporal images at the same time point or different modality images into the same coordinate system.Various strategies have been developed to satisfy the increasing needs of deformable medical image registration.One popular registration method is estimating the displacement field by computing the optical flow between two images.The motion field(flow field)is computed based on either gray-value or handcrafted descriptors such as the scale-invariant feature transform(SIFT).These methods assume that illumination is constant between images.However,medical images may not always satisfy this assumption.In this study,we propose a metric learning-based motion estimation method called Siamese Flow for deformable medical image registration.We train metric learners using a Siamese network,which produces an image patch descriptor that guarantees a smaller feature distance in two similar anatomical structures and a larger feature distance in two dissimilar anatomical structures.In the proposed registration framework,the flow field is computed based on such features and is close to the real deformation field due to the excellent feature representation ability of the Siamese network.Experimental results demonstrate that the proposed method outperforms the Demons,SIFT Flow,Elastix,and VoxelMorph networks regarding registration accuracy and robustness,particularly with large deformations.

关键词： Deformation registration feature extraction optical flow convolutional neural network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于多波位波束搜索的大型相控阵阵列信号处理技术

引用

遥测遥控 2024年第1期45卷 18-23页

作者：李思佳刘胜利张金荣张磊朱颖郑建君北京遥测技术研究所北京100076 北京跟踪与通信技术研究所北京100094

数字波束合成技术是通信对抗领域里一项至关重要的技术,通过在数字域对信号幅度和相位进行控制,可以形成多个独立可控的波束,形成波束指向精度高、灵活可变,且理论上不受波束形成数量的限制。本文针对大型相控阵需求,利用波束合成原理,... 详细信息

数字波束合成技术是通信对抗领域里一项至关重要的技术,通过在数字域对信号幅度和相位进行控制,可以形成多个独立可控的波束,形成波束指向精度高、灵活可变,且理论上不受波束形成数量的限制。本文针对大型相控阵需求,利用波束合成原理,并结合大规模阵列信号同步技术与相控阵幅相校准技术,实现一种可同时产生180个偏馈波束的多波位波束搜索系统。该系统可以利用波束群的实时扫描功能,实现大范围的波束搜索,更快定位目标角度。该系统已在工程上进行应用,并成功执行大型测控任务,取得圆满成功。

关键词：数字波束合成相控阵阵列信号处理多波位

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：