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Acta Pharmaceutica Sinica B 2017年第6期7卷 630-637页

作者： jinqiu yin Linlin Ma Huiqiang Wang Haiyan Yan Jin Hu Wen Jiang Yuhuan Li Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College School of Medical Technology Shanghai University of Medicine and Health Sciences Department of Pharmacy The Sixth Affiliated Hospital of Xinjiang Medical University

As a leading cause of respiratory disease, influenza A virus(IAV) presents a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapies, there remains to be a requirement for new drugs. Compound Yi-Zhi-Hao pellet(CYZH) is a famous traditional Chinese medicine(TCM) used in the clinic, whose formula has been recorded in Complication of National Standard for Traditional Chinese Medicine to treat common cold. In this study, we found that CYZH exhibited a broad-spectrum anti-influenza activity and inhibited the expression of viral RNA and proteins in vitro. Mechanistically, CYZH had no inhibitory activities against viral protein hemagglutinin and IAV RNA-dependent RNA polymerase. Instead, it induced activation of erythroid 2-related factor 2(Nrf2) and nuclear factor kappa B(NF-κB), which subsequently upregulated heme oxygenase-1(HO-1) expression.Also, CYZH protected cells from oxidative damage induced by reactive oxygen series. In conclusions,CYZH inhibits IAV replication in vitro, at least partly by activating expression of the Nrf2/HO-1 pathway.

关键词： TMC Influenza A virus Heme oxygenase 1 Hemagglutinin Nrf2 NF-κB

Atomistic mechanism of high ionic conductivity in lithium ytterbium-based halide solid electrolytes:A first-principles study

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Journal of Rare Earths 2024年第1期42卷 155-162,I0006页

作者： Limin Wang Wei Xiao Lu Sun Rong Yang jinqiu Yu Ligen Wang State Key Laboratory of Nonferrous Metals and Processes China GRINM Group Co.Ltd.Beijing100088China GRIMAT Engineering Institute Co. Ltd.Beijing101407China General Research Institute for Nonferrous Metals Beijing100088China China Automotive Battery Research Institute Co. Ltd.Beijing101407China Rare Earth Functional Materials(Xiong'an)Innovation Center Co. Ltd.Xiong'an071700China

As the next generation of commercial automotive power batteries begins replacing liquid lithium batteries,many look towards all-solid-state batteries to pioneer the future.All-so lid-state batteries have attracted the attention of countless researchers around the world because of their high safety and high energy density.In recent times,halide solid-state electrolytes have become a research hotspot within solid-state electrolytes because of their potentially superior properties.In this paper,in the framework of DFT,we investigated the atomic mechanisms of improving the ionic conductivity and stability of Li_(3)YbCl_(6).Our calculations show that both trigonal and orthorhombic Li_(3)YbCl_(6) exhibit wide electrochemical windows and metastable properties(100 meV/atom>Ehull>0 meV/atom).However,the orthorhombic Li_(3)YbCl_(6) can be stabilized at high temperatures by taking the vibrational entropy into account,which is supported by the experimental results.Moreover,it is expected that because of the Yb/Li synergistic interactions that,due to their strong mutual coulomb repulsion,influence the Li^(+)transport behavior,the orthorhombic Li_(3)YbCl_(6) might have superior ionic conductivities with appropriate Li+migration paths determined by the Yb^(3+) distribution.Also,higher ionic conductivities can be obtained by regulating the random distribution of Li^(+) ions.Further Li^(+)-deficiency can also largely increase the ionic conductivity by invoking vacancies.This study helps gain a deeper understanding of the laws that govern ionic conductivities and stabilities and provides a certain theoretical reference for the experimental development and design of halide solid-state electrolytes.

关键词： Halide solid-state electrolytes Phase stability Ionic conductivity First-principles calculations Rare earths

Quantum-Resistant Multi-Feature Attribute-Based Proxy Re-Encryption Scheme for Cloud Services

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工程与科学中的计算机建模(英文) 2024年第1期138卷 917-938页

作者： jinqiu Hou Changgen Peng Weijie Tan Hongfa Ding State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China Key Laboratory of Advanced Manufacturing Technology Ministry of EducationGuizhou UniversityGuiyang550025China College of Information Guizhou University of Finance and EconomicsGuiyang550025China

Cloud-based services have powerful storage functions and can provide accurate computation.However,the question of how to guarantee cloud-based services access control and achieve data sharing security has always been a research highlight.Although the attribute-based proxy re-encryption(ABPRE)schemes based on number theory can solve this problem,it is still difficult to resist quantum attacks and have limited expression capabilities.To address these issues,we present a novel linear secret sharing schemes(LSSS)matrix-based ABPRE scheme with the fine-grained policy on the lattice in the research.Additionally,to detect the activities of illegal proxies,homomorphic signature(HS)technology is introduced to realize the verifiability of re-encryption.Moreover,the non-interactivity,unidirectionality,proxy transparency,multi-use,and anti-quantum attack characteristics of our system are all advantageous.Besides,it can efficiently prevent the loss of processing power brought on by repetitive authorisation and can enable precise and safe data sharing in the cloud.Furthermore,under the standard model,the proposed learning with errors(LWE)-based scheme was proven to be IND-sCPA secure.

关键词： Lattice learning with errors attribute-based proxy re-encryption linear secret sharing schemes

Modulation of vagal activity to atria electrical remodeling resulted from rapid atrial pacing

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Journal of Geriatric Cardiology 2008年第3期5卷 159-163页

作者： Shulong Zhang yingxue Dong Lianjun Gao Donghui Yang Chunyue Zhao Hongwei Zhao Xiaomeng yin jinqiu Liu Zhihu Lin Yanzong Yang Department of Cardiology, The First Affiliated Hospital, Dalian Medical University, Dalian 116011, China Department of Cardiology First Affiliated Hospital Dalian Medical University Dalian 116011 China

Background Atrial electrical remodeling(AER) plays an important role in the pathogenesis and maintenance of atrial fibrillation.However,little is known about modulation of vagal activity to AER.This study aimed to investigate the relationship between vagal moduation and AER.Methods Twenty four adult mongrel dogs under general anesthesia were randomized into 3 groups.Sympathetic activity was blocked by administration of metoprolol in 3 groups.The changes in vagal modulation to atria after AER were observed in 10 dogs without vagal interruption in group A.The effects ofvagal intervention on AER were investigated in 8 dogs with administration of atropine in group B.The impact of aggressively vagal activity on AER was studied in 6 dogs with bilateral cervical vag sympathetic trunks stimulation during AER in group C.Bilateral cervical vagosympathetic trunks were decentralized. Multipolar catheters were placed into high right atria (RA),coronary sinus (CS) and right ventricle (RV).AER was induced by 600 bpm pacing through RA catheter for 30 minutes.Atrial effective refractory period (ERP) and vulnerability window (VW) of atrial fibrillation were measured with and without vagal stimulation before and after AER.Results In group A,ERP decreased significantly at baseline and during vagal stimulation after AER compared with that before AER (all P0.05).In group C,ERP shortened significantly at baseline and vagal stimulation after AER compared with that before AER (all P<0.05).ERP shortening after AER in Groups A and C increased significantly than that in group B (all P<0.05).Atrial fibrillation could not be induced at baseline (VW close to 0) before and after AER in three groups.VW became widen significantly during vagal stimulation after AER compared with that before AER in Groups A and C (all P<0.05),while VW remained unchanged in group B (VW close to 0).Conclusions Short-term AER results

关键词： atrial fibrillation vagus atrial electrical remodeling

Endothelial phosphodiesterase 4B inactivation ameliorates endothelial-to-mesenchymal transition and pulmonary hypertension

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1726-1741页

作者： Yanjiang Xing Yangfeng Hou Tianfei Fan Ran Gao Xiaohang Feng Bolun Li Junling Pang Wenjun Guo Ting Shu jinqiu Li Jie Yang Qilong Mao Ya Luo Xianmei Qi Peiran Yang Chaoyang Liang Hongmei Zhao Wenhui Chen Jing Wang Chen Wang State Key Laboratory of Respiratory Health and Multimorbidity Institute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100005China Department of Lung Transplantation National Center for Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina–Japan Friendship HospitalInstitute of Respiratory MedicineChinese Academy of Medical SciencesBeijing 100029China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300051China The State Key Laboratory of Complex Severeand Rare DiseasesInstitute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100005China Department of Pharmacy West China HospitalSichuan UniversityChengdu 610044China

Pulmonary hypertension (PH) is a fatal disorder characterized by pulmonary vascular remodeling and obstruction. The phosphodiesterase 4 (PDE4) family hydrolyzes cyclic AMP (cAMP) and is comprised of four subtypes (PDE4A–D). Previous studies have shown the beneficial effects of pan-PDE4 inhibitors in rodent PH;however, this class of drugs is associated with side effects owing to the broad inhibition of all four PDE4 isozymes. Here, we demonstrate that PDE4B is the predominant PDE isozyme in lungs and that it was upregulated in rodent and human PH lung tissues. We also confirmed that PDE4B is mainly expressed in the lung endothelial cells (ECs). Evaluation of PH in Pde4b wild type and knockout mice confirmed that Pde4b is important for the vascular remodeling associated with PH. In vivo EC lineage tracing demonstrated that Pde4b induces PH development by driving endothelial-to-mesenchymal transition (EndMT), and mechanistic studies showed that Pde4b regulates EndMT by antagonizing the cAMP-dependent PKA–CREB–BMPRII axis. Finally, treating PH rats with a PDE4B-specific inhibitor validated that PDE4B inhibition has a significant pharmacological effect in the alleviation of PH. Collectively, our findings indicate a critical role for PDE4B in EndMT and PH, prompting further studies of PDE4B-specific inhibitors as a therapeutic strategy for PH.

关键词： Phosphodiesterase 4B Pulmonary hypertension Endothelial-to-mesenchymal transition

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企业碳排放与融资租赁行为研究

金融理论与实践 2024年第1期 43-54页

作者：徐金球河北金融学院会计学院河北保定071051

利用2009—2022年上市公司融资租赁交易以及与之匹配的企业层面碳排放数据,实证检测了承租方碳排放与融资租赁之间的关系以及作用机制等。研究结果表明,融资租赁出租方向碳排放水平或碳强度较高的承租方提供的融资较少、融资成本较高,... 详细信息

利用2009—2022年上市公司融资租赁交易以及与之匹配的企业层面碳排放数据,实证检测了承租方碳排放与融资租赁之间的关系以及作用机制等。研究结果表明,融资租赁出租方向碳排放水平或碳强度较高的承租方提供的融资较少、融资成本较高,融资租赁具有“绿色”倾向。基于融资租赁供需的机制检验进一步证实,承租人碳排放影响其融资可得性和融资成本的主要驱动因素来源于融资租赁的供给端,由出租方主动调整,并非是由于承租方发展所需资本(资金)需求不足,或者以其他低成本债务替换了融资租赁等因素所决定。因此,应持续健全融资租赁碳风险管理,推进绿色融资租赁,推动承租企业“减碳降排”。

关键词：融资租赁碳风险融资租赁供需

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地方城投债增信效力比较研究

征信 2024年第1期42卷 19-30页

作者：徐金球河北金融学院会计学院河北保定071051

以2015—2022年城投债发行交易数据,实证检验不同增信方式对城投债信用评级、发行定价和利差的影响效果。研究发现,增信能显著提高城投债债项评级,但对于降低城投债发行定价存在分化。第三方专业担保平均降低城投债发行利率1.36%,抵质... 详细信息

以2015—2022年城投债发行交易数据,实证检验不同增信方式对城投债信用评级、发行定价和利差的影响效果。研究发现,增信能显著提高城投债债项评级,但对于降低城投债发行定价存在分化。第三方专业担保平均降低城投债发行利率1.36%,抵质押担保和差额补偿不显著,而信用风险缓释(保护)工具使城投债发行成本上升约0.27%。此外,第三方专业担保能显著收窄城投债的信用利差和期限利差,抵质押担保、差额补偿和信用风险缓释(保护)工具等不显著。

关键词：地方城投债债券增信第三方专业担保利差

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丙泊酚和瑞马唑仑对前列腺癌细胞增殖的影响

临床麻醉学杂志 2024年第5期40卷 520-526页

作者：阳锦秋辛储林尹光芬李娟大理大学临床医学院云南省大理市671000 大理大学基础医学院云南省大理市671000 大理大学第一附属医院麻醉科

目的探讨丙泊酚和瑞马唑仑对前列腺癌细胞增殖的影响及相关机制。方法选择人前列腺癌细胞系DU145和PC3,培养至对数生长期。将细胞随机分为四组:对照组(C组)、丙泊酚组(P组)、瑞马唑仑组(R组)和丙泊酚复合瑞马唑仑组(PR组)。C组用完全培... 详细信息

目的探讨丙泊酚和瑞马唑仑对前列腺癌细胞增殖的影响及相关机制。方法选择人前列腺癌细胞系DU145和PC3,培养至对数生长期。将细胞随机分为四组:对照组(C组)、丙泊酚组(P组)、瑞马唑仑组(R组)和丙泊酚复合瑞马唑仑组(PR组)。C组用完全培养基培养,P组和R组分别在完全培养基中加入丙泊酚和瑞马唑仑的半数抑制浓度(IC_(50))培养(DU145和PC3细胞中丙泊酚的IC_(50)分别为120μg/ml和100μg/ml,瑞马唑仑的IC_(50)分别为500μmol/L和400μmol/L),PR组DU145细胞加入低浓度丙泊酚100μg/ml和瑞马唑仑400μmol/L共培养,PC3细胞加入低浓度丙泊酚80μg/ml和瑞马唑仑300μmol/L共培养。于培养后0、6、12、24、36 h采用CCK-8法测定待检测孔的吸光度。于培养后14 d采用平板克隆形成实验计算集落数量。采用qPCR法和Western blot法检测c-Myc和cyclin D1 mRNA表达量和蛋白含量。通过网络药理学分析找出丙泊酚和瑞马唑仑作用于前列腺癌细胞的关键靶基因,并采用qPCR法和Western blot法检测该靶基因的mRNA表达量和蛋白含量。结果与C组比较,DU145和PC3细胞P组、R组和PR组培养后36 h吸光度均明显降低、集落数量明显减少、c-Myc和cyclin D1 mRNA表达量和蛋白含量明显降低(P<0.05)。与P组比较,DU145细胞R组和PR组培养后36 h吸光度、cyclin D1 mRNA表达量明显降低,R组c-Myc mRNA表达量明显升高,PR组集落数量明显减少、c-Myc蛋白含量明显降低(P<0.05);PC3细胞R组cyclin D1 mRNA表达量和蛋白含量明显降低,PR组培养后36 h吸光度明显降低、c-Myc和cyclin D1 mRNA表达量和蛋白含量明显降低(P<0.05)。与R组比较,DU145和PC3细胞PR组集落数量明显减少,c-Myc mRNA表达量和蛋白含量明显降低(P<0.05)。网络药理学分析结果显示:丙泊酚、瑞马唑仑与前列腺癌的共同靶点为信号传导及转录激活蛋白3(STAT3)。与C组比较,DU145和PC3细胞P组、R组和PR组STAT3 mRNA表达量和蛋白含量明显降低(P<0.05)。与P组比较,DU145细胞R组STAT3 mRNA表达量和蛋白含量明显升高,PR组STAT3蛋白含量明显升高(P<0.05);PC3细胞R组STAT3 mRNA表达量明显降低(P<0.05)。与R组比较,DU145细胞PR组STAT3蛋白含量明显降低(P<0.05)。结论丙泊酚和瑞马唑仑可以单独或协同抑制前列腺癌细胞增殖,降低前列腺癌细胞c-Myc和cyclin D1 mRNA表达量和蛋白含量,其机制可能与抑制HIF-1α通路中的STAT3靶点有关。

关键词：前列腺癌丙泊酚瑞马唑仑细胞增殖信号传导及转录激活蛋白3

基于多任务学习的同行评审细粒度情感分析模型

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中北大学学报（自然科学版） 2024年第1期45卷 105-113页

作者：朱金秋檀健韩斌彬殷秀秀南京邮电大学理学院江苏南京210023

学术论文同行评审能够直接反映审稿人对论文的主观评价,对审稿文本进行情感分析有利于挖掘审稿人对论文多维度的评价信息。现有的情感分析模型仅能挖掘专家单一的评审维度和相应的情感倾向,本文提出了一种基于多任务学习的同行评审细粒... 详细信息

学术论文同行评审能够直接反映审稿人对论文的主观评价,对审稿文本进行情感分析有利于挖掘审稿人对论文多维度的评价信息。现有的情感分析模型仅能挖掘专家单一的评审维度和相应的情感倾向,本文提出了一种基于多任务学习的同行评审细粒度情感分析模型。该模型在多任务学习框架下,通过在BERT-LCF模型的基础上增加BiLSTM-CRF模块,使其具备了同时完成属性词抽取和细粒度情感分析任务的能力。与传统的基于Pipeline模式的单任务细粒度情感分析模型相比,本模型在保证精度的情况下可以同时完成评审属性提取和情感分析任务。在这两项任务中,所提出模型的F1分数分别达到了89.01%和90.71%。对比实验证明,在多任务场景下,引入BiLSTM-CRF模块对评审文本属性词提取任务有一定的提升作用。

关键词：同行评审多任务学习属性词抽取细粒度情感分析 BiLSTM-CRF

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流密码框架下的SM4专用认证加密算法

计算机工程与应用 2024年第2期60卷 272-278页

作者：李胡彭长根侯金秋公共大数据国家重点实验室贵阳550025 贵州大学计算机科学与技术学院贵阳550025

认证加密算法是能同时满足数据机密性与完整性的对称密码算法,在数据安全领域具有广泛应用。针对基于分组密码的认证加密算法的安全性以及效率需求,提出一种基于SM4轮函数的专用认证加密算法SMRAE。算法采用流密码思想,从SM4底层部件出... 详细信息

认证加密算法是能同时满足数据机密性与完整性的对称密码算法,在数据安全领域具有广泛应用。针对基于分组密码的认证加密算法的安全性以及效率需求,提出一种基于SM4轮函数的专用认证加密算法SMRAE。算法采用流密码思想,从SM4底层部件出发,结合Feistel结构设计状态更新函数用于轮变换,处理256 bit消息只需调用4个SM4轮函数指令。在初始化阶段将初始向量和密钥经过16轮迭代,使差分充分随机化;利用SM4加密消息,将生成的密文参与轮变换,实现状态更新和加密并行;解密时先进行消息认证,降低时间消耗,提高算法安全性。安全性分析与实验结果表明SMRAE能够抵抗伪造攻击、差分攻击和猜测攻击等主流攻击,效率高于AES-GCM,与SM4效率相当,具备一定的实用性。

关键词： SM4 认证加密分组密码 Feistel结构流密码