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An intravascular needle coated by ZnO nanoflowers for in vivo elimination of circulating tumor cells

Nano Research 2023年第1期16卷 873-881页

作者： Jinqi Li Xinlei li Yangfeng Zhang Kun Jin Ye Yuan Ruiqi Ming Yuhua Yang Tongsheng Chen MOE Key Laboratory of Laser life Science&Institute of Laser life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China SCNU Qingyuan Institute of Science and Technology Innovation Co. Ltd.South China Normal UniversityQingyuan 511500China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterSchool of Materials Science&EngineeringSun Yat-sen UniversityGuangzhou 510275China

Circulating tumor cells(CTCs)are recognized as the main source of tumor recurrence and metastasis.Eliminating the CTCs in peripheral blood provides a new strategy to reduce the probability of recurrence or metastasis.Here,we proposed a concept to eliminate CTCs by inserting a needle in the superficial blood vessel.Using the property of ZnO and the structure of nanoflowers,we designed a medical needle coated with ZnO nanoflowers(ZNFs),which killed about 90%of captured CTCs in vitro and prevented the injecting CTCs from spreading to lung tissue in BABL/c mouse model.Results in vitro and in vivo demonstrated that the CTCs not only were captured and killed,but also detached from the needle surface after dead,enabling the ZNFs needle continually eliminate CTCs.Furthermore,a theoretical model was presented to explain the penetration mechanism of cells by nanostructures,which indicated that nanoflowers structure can puncture CTCs more easily than vertical nanowire structure.The concept of inserting an intravascular needle provides a potential strategy to lower the concentration of CTCs in blood and reduce the probability of tumor recurrence or metastasis.

关键词： ZnO nanoflowers circulating tumor cells elimination cancer treatment theoretical model

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Coupling Agent Grafting Assisted Synthesis of C3N4-ZrO_(2) Heterojunction Composites with Enhanced Photocatalytic Performance

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China Petroleum Processing & Petrochemical Technology 2023年第1期25卷 123-132页

作者： liu Yanxiu Luo Jing li jinqi Wang Xueqin Song Hua Provincial Key Laboratory of Oil&Gas Chemical Technology College of Chemistry&Chemical EngineeringNortheast Petroleum UniversityDaqingHeilongjiang 163318China North China Branch of SINOPEC Sales Co. LtdTianjin 300450China

Heterojunction composites were prepared by silane coupling agent grafting from synthesized graphitic carbon nitride(g-C_(3)N_(4))and commercially available zirconia(ZrO_(2)).The samples were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),Fourier transform infrared(FT-IR)spectroscopy,UV-vis diffuse reflectance spectroscopy(DRS),photoluminescence(PL)spectroscopy,and electrochemical impedance spectroscopy(EIS).The photocatalytic activity of the composites was evaluated by the degradation of methylene blue(MB)under visible light irradiation.The results showed that heterojunction composites of g-C_(3)N_(4) and ZrO_(2) could be successfully prepared by coupling agent grafting.The optimal mass ratio of g-C_(3)N_(4) and ZrO_(2) was 2:1,with an activity that was 3.8 times higher than g-C_(3)N_(4) and 15.3 times higher than ZrO_(2).This was ascribed to the stronger light absorption,faster interfacial charge transfer,and lower photogenerated carrier recombination of the heterojunction composites.

关键词： heterojunction graphitic carbon nitride zirconia coupling grafting

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Classical swine fever virus NS5A protein antagonizes innate immune response by inhibiting the NF-κB signaling

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Virologica Sinica 2023年第6期38卷 900-910页

作者： Jinfu Sun Jiaying li liming li Haixiao Yu Ping Ma Yingnan Wang jinqi Zhu Zezhong Feng Changchun Tu Key Laboratory of Bioresource Research and Development of liaoning Province College of Life and Health SciencesNortheastern UniversityShenyang110169China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun130122China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses Yangzhou UniversityYangzhou225009China

The NS5A non-structural protein of classical swine fever virus(CSFV)is a multifunctional protein involved in viral genomic replication,protein translation,assembly of infectious virus particles,and regulation of cellular signaling pathways.Previous report showed that NS5A inhibited nuclear factor kappa B(NF-κB)signaling induced by poly(I:C);however,the mechanism involved has not been elucidated.Here,we reported that NS5A directly interacted with NF-κB essential modulator(NEMO),a regulatory subunit of the IκB kinase(IKK)complex,to inhibit the NF-κB signaling pathway.Further investigations showed that the zinc finger domain of NEMO and the aa 126–250 segment of NS5A are essential for the interaction between NEMO and NS5A.Mechanistic analysis revealed that NS5A mediated the proteasomal degradation of NEMO.Ubiquitination assay showed that NS5A induced the K27-linked but not the K48-linked polyubiquitination of NEMO for proteasomal degradation.In addition,NS5A blocked the K63-linked polyubiquitination of NEMO,thus inhibiting IKK phosphorylation,IκBαdegradation,and NF-κB activation.These findings revealed a novel mechanism by which CSFV inhibits host innate immunity,which might guide the drug design against CSFV in the future.

关键词： Classical swine fever virus(CSFV) NS5A NF-κB signaling NEMO Polyubiquitination Proteasomal degradation

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A New Enantiornithine Bird from the Lower Cretaceous Jiufotang Formation in Jinzhou Area, Western liaoning Province, China

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Acta Geologica Sinica(English Edition) 2012年第5期86卷 1039-1044页

作者： li li WANG jinqi ZHANG Xi HOU Shilin Paleontology Institute Shenyang Normal UniversityShenyangLiaoning 110034China

A new Early Cretaceous enantiornithine bird from liaoning Province of northeastern China, Shengjingornis yangi, gen. et sp. nov., is reported. This new bird possesses the following unique combination of features： a long rostrum, with some teeth in the front; short nasal; slender jugal; Y-shaped furcula, with expanded distal end of the hypocleidum; cake-like sternum, with a low and caudally distributed keel; strut-like and caudally concave coracoid. The derived features of the scapula and the wings suggest a powerful flapping flight capability.

关键词： Early Cretaceous Jiufotang Formation Enantiornithine liaoning Province

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Investigation on environment monitoring system for a combination of hydroponics and aquaculture in greenhouse

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Information Processing in Agriculture 2022年第1期9卷 123-134页

作者： Shanhong Zhang Yu Guo Shuai li Zhixin Ke Huajian Zhao jinqi Yang Yang Wang Daoliang li liang Wang Wenhua Yang Zhili Zhang National Innovation Center for Digital Fishery China Agricultural UniversityBeijing 100083China College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Beijing Zhong Nong Tianlu Micro-nano Bubble Water Science and Technology Co. LtdChina

This work develops a distributed environmental monitoring system for the combination of hydroponics and aquaculture based on the internet of things technology,which mainly includes the information perception layer,the information transmission layer and the sys-tem architecture.The system has employed multiple sensors terminal to real-time acqui-sition,including air and water temperatures,dissolved oxygen etc.LoRa protocol is suitable for sending small data and the 4G was employed to collect data and send to the cloud plat-form.Java is used to develop background applications,to access cloud platforms and local data processing.Based on the collection and processing of environmental data and cloud service platform,the mobile application program client and remote login desktop have been developed.It has been implemented and tested in Tongzhou,Beijing for 3 months in 2020.The results showed the proposed monitoring system stability for overall operation and accuracy data transmission,which can support the actual hydroponics and aquacul-ture production management.After analysis of monitoring data collected from the devel-oped monitoring system,indoor air and water temperature have the obvious correlation with atmospheric pressure(0.7 and 0.9)and outdoor temperature(1.0 and 0.9),respectively.

关键词： Monitoring system Hydroponics Aquaculture Greenhouse Internet of things Greenhouse environment

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Construction of Ultrathin Layered MXene-TiN Heterostructure Enabling Favorable Catalytic Ability for High-Areal-Capacity lithium-Sulfur Batteries

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Nano-Micro Letters 2022年第11期14卷 324-340页

作者： Hao Wang Zhe Cui Shu-Ang He jinqi Zhu Wei Luo Qian liu Rujia Zou State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China Department of Physics College of ScienceDonghua UniversityShanghai 201620People’s Republic of China

Catalysis has been regarded as an effective strategy to mitigate sluggish reaction kinetics and serious shuttle effect of li-S batteries.Herein,a spherical structure consists of ultrathin layered Ti_(3)C_(2)T_(x)-TiN heterostructures(MX-TiN)through in-situ nitridation method is reported.Through controllable nitridation,highly conductive TiN layer grew on the surface and close coupled with interior MXene to form unique 2D heterostructures.The ultrathin heterostructure with only several nanometers in thickness enables outstanding ability to shorten electrons diffusion distance during electrochemical reactions and enlarge active surface with abundant adsorptive and catalytic sites.Moreover,the(001)surface of TiN is dominated by metallic Ti-3d states,which ensures fast transmitting electrons from high conductive MX-TiN matrix and thus guarantees efficient catalytic performance.Calculations and experiments demonstrate that polysulfides are strongly immobilized on MX-TiN,meanwhile the bidirectional reaction kinetics are catalytically enhanced by reducing the conversion barrier between liquid liPSs and solid li_(2)S_(2)/li_(2)S.As a result,the S/MX-TiN cathode achieves excellent long-term cyclability with extremely low-capacity fading rate of 0.022%over 1000 cycles and remarkable areal capacity of 8.27 mAh cm^(−2) at high sulfur loading and lean electrolytes.

关键词： li-S batteries Ultrathin 2D structures Electrochemical catalysis MXenes Ti_(3)C_(2)T_(x)-TiN

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技术集聚何以提升城市劳动生产率?——基于中国发明专利微观数据的解释

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浙江社会科学 2022年第9期 14-23,156页

作者：陈锦其李金昌中共浙江省委党校马克思主义研究院杭州311121 浙江财经大学党委杭州310018

以创新重构经济增长新动力和以生产率重塑经济质量新内涵是经济高质量发展的两大战略。本文利用中国发明专利微观数据测算了城市技术集聚水平,并在理论分析技术集聚影响城市劳动生产率机制的基础上,基于2003—2018年285个地级以上城市... 详细信息

以创新重构经济增长新动力和以生产率重塑经济质量新内涵是经济高质量发展的两大战略。本文利用中国发明专利微观数据测算了城市技术集聚水平,并在理论分析技术集聚影响城市劳动生产率机制的基础上,基于2003—2018年285个地级以上城市的面板数据进行实证检验。研究发现:技术集聚能显著提升城市劳动生产率,这一结论在经过一系列稳健性检验后仍然成立;机制分析表明,城市技术集聚主要通过优化就业结构、降低资本错配和激发创业活力等渠道提升劳动生产率;拓展分析表明,城市蔓延、技术市场和知识产权保护等环境因素在技术集聚提升劳动生产率的过程中都具有重要作用。研究结论对我国以创新驱动生产率提升为内核的高质量发展战略的政策设计具有一定的参考价值。

关键词：技术集聚劳动生产率高质量发展

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中国式现代化视域下江西农业高质量发展研究

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农业考古 2023年第6期 203-208页

作者：杨锦琦李华旭江西省社会科学院农业农村发展研究所江西师范大学管科中心江西省社会科学院经济所

高质量发展是中国式现代化的本质要求之一,农业高质量发展是中国式现代化的重要基础。江西是我国的农业大省,将江西农业高质量发展融入中国式现代化的研究框架进行深入研究,对推进农业强国建设、加快中国式现代化进程具有重要实践指引... 详细信息

高质量发展是中国式现代化的本质要求之一,农业高质量发展是中国式现代化的重要基础。江西是我国的农业大省,将江西农业高质量发展融入中国式现代化的研究框架进行深入研究,对推进农业强国建设、加快中国式现代化进程具有重要实践指引作用。因此,本文在全面厘清中国式现代化视域下江西农业高质量发展的内在逻辑、主要瓶颈的基础上,提出了具体的实践路径。

关键词：中国式现代化江西农业高质量发展

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Synthesis and Bioactivity of a Novel Bismuthoxide Schiff-base Complex Derived from Salen-like ligand and Bismuth（III） Nitrate

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Chemical Research in Chinese Universities 2016年第2期32卷 207-211页

作者： li Chuanhua JIANG Jianhong li Xu XIAO Shengxiong WEI Deliang JIANG Chao XIE jinqi PENG Mengna GU Huiwen li Qiangguo Hunan Provincial Key Laboratory of Xiangnan Rare-precious Metals Compounds and Applications Department of Chemistry and Life Science Xiangnan University Chenzhou 423000 P. R. China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. China

In this paper, a novel bismuthoxide Schiff-base complex [Bi9O8（vanen）3（NO3）2（CH3OH）2（H2O）·3NO3· 5.5H2O]（abbreviated as Bivanen） was synthesized with Salen-like ligand Hzvanen[Hzvanen=N,N＇-ethylene bis（3-methoxysalicylideneimine）] and bismuth（III） nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaecharomyees pombe（S, pombe） were studied using biological mierocalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00 ℃. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant（k）, inhibition ratio（I） and half inhibition concentration（IC50） were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC50 of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively.

关键词： Bismuthoxide Schiff-base complex Mieroealorimetriy Thermokinetie property Schizosaecharomyces pombe（S, pombe）

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遗传性口形红细胞增多症发病机制及诊断

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中华血液学杂志 2020年第6期41卷 521-524页

作者：李津杞钱宝华海军军医大学附属长海医院输血科全军儿童溶血性贫血研究创新基地上海200433

遗传性口形红细胞增多症(HSt)属于常染色体显性遗传病,由于红细胞膜转运蛋白的遗传缺陷导致Na+和K+异常通透,影响细胞水和离子间平衡,从而引起红细胞体积变化,使得红细胞形态似口形。临床上以不同程度的慢性溶血性贫血、黄疸、脾大为特... 详细信息

遗传性口形红细胞增多症(HSt)属于常染色体显性遗传病,由于红细胞膜转运蛋白的遗传缺陷导致Na+和K+异常通透,影响细胞水和离子间平衡,从而引起红细胞体积变化,使得红细胞形态似口形。临床上以不同程度的慢性溶血性贫血、黄疸、脾大为特征。迄今为止,报道了6种不同的膜蛋白突变导致体积稳态改变的HSt[1]。现将其发病机制及诊断介绍如下。

关键词：红细胞形态慢性溶血性贫血红细胞体积口形红细胞增多遗传缺陷常染色体显性遗传病发病机制膜蛋白

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