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A KTAP Framework of DNA Damage Repair Mechanism Under Ion Radiation（IR）Perturbation

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A KTAP Framework of DNA Damage Repair Mechanism Under Ion Ra...

Cellular Responding DNA Damage:A Predictive Model of P53.Gene Regulatory Networks under Continuous Ion Radiation （IR）

第三十届中国控制会议

作者： qi jinpeng~*,ding {3.,HAN Fang {3. of information sciences and technology,donghua university shanghai 201620,P.R.China

＜正＞In order to illustrate the cellular self-defense mechanisms in response to acute perturbations from outer environment,a mathematical model of DNA damage repair kinetics is proposed based on the method of Kinetic Theory of Active Particles（KTAP）.Under acute Ion Radiation（IR）,the complex interactions between the molecular pairs of DNA damage,repair mRNA,repair protein（RP）,and double-strand breaks complex（DSBC） are represent by using mathematical framework of *** kinetics of DNA damage and RP generation,DSBC synthesis are implemented,and then the cellular self-repair capability and genome stability are analyzed in response to external perturbation furthermore.

关键词： Cellular self-repair IR DNA damage KTAP Modeling

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Cellular Responding DNA Damage:A Predictive Model of P53 Gen...

基于Internet的房地产投资决策分析系统

第二十七届中国控制会议

作者： qi jinpeng,shao {3.,Shen Yizhen,Gu Xiaojing {3. of information sciences and technology donghua university,shanghai 201620,P.R.China

P53.a vital anticancer gene,controls the cell cycle arrest and cell apoptosis by regulating the downstream genes and their complicated signal *** simulate the investigation of the cellular response under continuous Ion Radiation（IR） ,a predictive model of P53.gene regulatory networks is proposed at single cell *** model can be used to simulate the dynamic processes of the double-strand breaks（DSBs） generating and their repair,ataxia telangiectasia mutated（ATM） and ARF activation,as well as the oscillations in the P53.MDM2 feedback loop under continuous effect of acute ***,the model can predict the plausible outcomes of cellular responding DNA damage under different conditions.

关键词： P53 DNA damage IR Oscillations odelling

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计算机工程与应用 2003年第35期39卷 189-191,224页

作者：游艳琴王训国丁永生邵世煌东华大学信息科学与技术学院长宁区土地规划管理局上海200336

针对我国房地产开发活动的特点,为房地产投资者开发了一个投资决策分析系统。系统采用C/S与B/S模式相结合的总体架构。详细讨论了该系统的功能设计,探讨了系统实施过程中模型库的设计、工作流过程模型的设计及系统的安全性等关键技术。

关键词：智能决策支持系统(IDSS) 投资分析房地产工作流 1』VV’ o''''1 ,^,㈣1f …… ……… …….一 ~

Single-cell omics:experimental workflow,data analyses and applications

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Science China Life sciences 2024年

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin shao qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biology the Institute of Biomedical Sciences and School of Life Sciences East China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life sciences Academy for Advanced Interdisciplinary Studies Center for Quantitative Biology (CQB) Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women’s Hospital Zhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of Statistics East China Normal University Shanghai 200062 China Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji university) Ministry of Education Orthopaedic Department Tongji Hospital Bioinformatics Department School of Life Sciences and Technology Tongji University Frontier Science Center for Stem Cells School of Life Sciences and Technology Tongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East Hospital Bioinformatics Department School of Life Sciences and Technology Tongji University Research Institute of Intelligent Computing Zhejiang Lab shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public Health Shanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River Delta Zhejiang University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial scRNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

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Probing the Gamma-Ray Emission Region of Five TeV Flat Spectrum Radio Quasars

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Research in Astronomy and Astrophysics 2024年第6期24卷 156-169页

作者： Hu-Bing Xiao Hai-Tao Cao Rui Xue Jin-Ting Cai Ge-Ge Wang Marina Manganaro shao-Hua Zhang Zhi-Hao Ouyang Li-Ping Fu Jun-Hui Fan shanghai Key Lab for Astrophysics Shanghai Normal UniversityShanghai 200234China School of information Engineering Guangzhou Panyu PolytechnicGuangzhou 511483China Department of Physics Zhejiang Normal UniversityJinhua 321004China college of Mathematics and Physics Guangxi Minzu UniversityNanning 530006China Key Laboratory of Cosmology and Astrophysics(Liaoning) College of SciencesNortheastern UniversityShenyang 110819China Department of Physics University of RijekaRijeka 51000Croatia Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Key Laboratory for Astronomical Observation and technology of Guangzhou Guangzhou 510006China Astronomy Science and technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China

The location ofγ-ray emission of blazars remains a contested topic,inspiring the development of numerous investigative techniques to address this *** this work,we analyzed Fermiγ-ray light curves in the GeV and MeV bands,employing the discrete cross-correlation function method to discern time lags between the two *** 4C+21.3.,Ton 599,B21420+3.,and PKS 1510-089,we identified a time lag spanning several days,while for PKS 1441+25,the time lag was not statistically *** results imply that the soft photons necessary for inverse Compton scattering predominantly originate from the dusty torus in the first four sources,whereas for PKS1441+25,they seem to be sourced mainly from the broad-line *** analysis of the opacity(τγγ)and the GeV spectra study supports the conclusion that the location of the dissipation region must be beyond the BLR to avoid significant ***,for PKS 1441+25,the emission region is also posited to lie outside yet proximate to the *** parameters of describing the emission region were obtained by fitting broadband spectral energy distribution with contemporaneous observation *** findings suggest that for the five TeV FSRQs,during Te V flaring events,the jet appears to maintain an equilibrium between the energy density of the magnetic field and that of the particles for all investigated sources,with the exceptions of 4C+21.3. and PKS1441+*** terms of the overall jet power,particle energy is the dominant contributor,and the observed blazar radiation cannot be solely attributed to the magnetic field,except in the case of 4C+***,magnetic reconnection is unlikely to be the primary mechanism behind particle acceleration in these systems.

关键词： galaxies:active gamma-rays:galaxies galaxies:jets

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DNA计算与软计算

系统仿真学报 2001年第Z1期13卷 198-201,213页

作者：丁永生任立红邵世煌东华大学信息科学与技术学院上海200051

最近,DNA计算引起了人们的广泛兴趣,尤其是DNA计算与软计算的集成。本文较系统地介绍了与DNA计算相关的生物学知识、主要生物操作,给出了DNA计算模型及其算法实现,探讨了DNA计算与进化计算、模糊控制、神经网络和人工免疫系统进行集成... 详细信息

最近,DNA计算引起了人们的广泛兴趣,尤其是DNA计算与软计算的集成。本文较系统地介绍了与DNA计算相关的生物学知识、主要生物操作,给出了DNA计算模型及其算法实现,探讨了DNA计算与进化计算、模糊控制、神经网络和人工免疫系统进行集成的概念与方法。

关键词： DNA计算软计算进化计算模糊控制神经网络人工免疫系统

Observation of spectral lines in the exceptional GRB 221009A

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-qiu Zhang shao-Lin Xiong Ji-Rong Mao Shuang-Nan Zhang Wang-Chen Xue Chao Zheng Jia-Cong Liu Zhen Zhang Xi-Lu Wang Ming-Yu Ge Shu-Xu Yi Li-Ming Song Zheng-Hua An Ce Cai Xin-qiao Li Wen-Xi Peng Wen-Jun Tan Chen-Wei Wang Xiang-Yang Wen Yue Wang Shuo Xiao Fan Zhang Peng Zhang Shi-Jie Zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of sciences Beijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China college of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China college of Electronic and information Engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 221009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 3. to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2,*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao shao-Lin Xiong Xiang-Yang Wen Xin-qiao Li Ce Cai Shuo Xiao qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan Liao Yan-qiu Zhang Yue Huang Lu Li Xing Wen Fei Zhang Jing Duan Chen-Wei Wang Dong-Li Shi Peng Zhang qi-Bin Yi Chao-Yang Li Yan-Bing Xu Xiao-Hua Liang Ya-qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu Wang Sheng Yang Xiao-Jing Liu Min Gao Mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong Liu Xing-Bo Han Jin-Ling qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa Wang Rui qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-Ming Song Shi-Jie Zheng Bing Li Hong-Mei Zhang Yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of sciences Chinese Academy of SciencesBeijing 100049China School of information Science and technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science college China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun university of Science and technology Changchun 130022China Chinese Academy of sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Polyp-PVT:Polyp Segmentation with Pyramid Vision Transformers

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CAAI Artificial Intelligence Research 2023年第1期2卷 1-15页

作者： Bo Dong Wenhai Wang Deng-Ping Fan jinpeng Li Huazhu Fu Ling shao college of Computer Science Nankai UniversityTianjin 300350China shanghai Artificial Intelligence Laboratory Shanghai 200232China Computer Vision Lab Inception Institute of Artificial IntelligenceAbu DhabiUnited Arab Emirates Institute of High Performance Computing Agency for ScienceTechnology and ResearchSingapore 138632Singapore UCAS-Terminus AI Lab Terminus GroupChongqing 400042China

Most polyp segmentation methods use convolutional neural networks(CNNs)as their backbone,leading to two key issues when exchanging information between the encoder and decoder:(1)taking into account the differences in contribution between different-level features,and(2)designing an effective mechanism for fusing these *** existing CNN-based methods,we adopt a transformer encoder,which learns more powerful and robust *** addition,considering the image acquisition influence and elusive properties of polyps,we introduce three standard modules,including a cascaded fusion module(CFM),a camouflage identification module(CIM),and a similarity aggregation module(SAM).Among these,the CFM is used to collect the semantic and location information of polyps from high-level features;the CIM is applied to capture polyp information disguised in low-level features,and the SAM extends the pixel features of the polyp area with high-level semantic position information to the entire polyp area,thereby effectively fusing cross-level *** proposed model,named Polyp-PVT,effectively suppresses noises in the features and significantly improves their expressive *** experiments on five widely adopted datasets show that the proposed model is more robust to various challenging situations(e.g.,appearance changes,small objects,and rotation)than existing representative *** proposed model is available at https://***/DengPingFan/Polyp-PVT.

关键词： polyp segmentation pyramid vision transformer colonoscopy computer vision