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Molecular markers and pathogenically targeted therapy innon-small cell lung cancer

Frontiers of Medicine 2009年第3期3卷 245-255页

作者： Bo PENG jinnong zhang Jamile S.WOODS Wei PENG College of Arts and Sciences University of PennsylvaniaPhiladelphiaPA 19104USA Pulmonary Division of Union Hospital Huazhong University of Science and TechnologyWuhan 430022China Department of Pulmonary and Critical Care Medicine Salt Lake Regional Medical CenterIasis HealthcareUT 84102USA

Lung cancer is one of the most common human cancers and the number one cancer killer in the United *** general,lung cancer includes small cell lung cancer(SCLC)and non-small cell lung cancer(NSCLC),but NSCLC accounts for approximately 90%of lung *** early diagnosis and therapy of lung cancer still presents a big challenge because validated screening tools,which can improve current early detection to reduce mortality from lung cancer,do not *** the last decade,molecular genetic abnormalities have been described in NSCLC,including chromosomal aberrations,overexpression of oncogenes,and deletion and/or muta-tions in tumor suppressor *** molecular markers in NSCLC demonstrated close associations with the development of lung cancer such as Ras,the epidermal growth factor receptor(EGFR,or c-erbB-1),HER2(c-erbB-2),c-Met,and ***,this information may be applied for early cancer detection,classiﬁcation,novel targeted therapy,and prognosis in *** clinical data have revealed that targeted therapy might be the second-line therapy as an alternative ***,the targeted therapies are mainly focused on two lung cancer pathways,the EGFR and the vascular endothelial growth factor(VEGF)*** clinical trials are very encouraging,but some of them are ***,these trials have not identiﬁed a subgroup of NSCLC with ***,it is very important to select NSCLC patients with biomarkers to match targeted agents so that we can further identify effectiveness of targeted therapy in the future.

关键词： lung cancer carcinoma,non-small cell lung cancer molecular markers targeted therapy

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Accuracy and Consistency of Respiratory Inductive Plethysmography for Overnight Tidal Volume Measurement

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第1期21卷 35-37,58页

作者：张劲农 Eric W Ruch Konrad E Bloch Respiratory Disease Research Laboratory Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Abteilung Pneumologie Unisipital Zuerich

To validate the accuracy and consistency of respiratory inductive plethysmography (RIP) in measuring tidal volume after an overnight sleep, tidal volumes of 18 patients with suspected sleep disordered breathing and 8 normal volunteers were measured simultaneously with RIP (V TRIP ) and with an ultrasonic airflow meter (V TUFM ) before and after an unstrained overnight sleep on supine and lateral decubitus. The bias of the V TRIP was expressed as (V TRIP V TUFM )/ V TUFM ·100 %, limits of agreement between V TRIP and V TUFM was measured by averaged bias ±2 s . Results showed that in normal subjects, the bias of RIP before and after overnight sleep was precise and consistent in both supine (0.7 % and -1.6 %) and lateral decubitus (3.7 % and -0.56 %). In these patients, the bias of RIP before and after sleep in supine also remained small (1.9 % and 1.7 %), but it became larger in lateral decubitus (24.5 % and 20.4 %) and 11.5 % exceeded the limits of agreement observed in the evening. The patients′ body mass indices (BMI) were higher than those of normal subjects (median 34.2 vs. 27.8 kg/m 2). Pooled data showed that the bias of V TRIP in the morning on lateral decubitus but not on supine was correlated to BMI (Spearman R=0.32, n =52, P =0.02). Thus, we were led to conclude that the accuracy of V TRIP overnight was precise and consistent in normal subjects, but the deviation of V TRIP measured on lateral decubitus in patients especially in those with excessive obesity was greater, thus, the method should not be used for quantitative determination.

关键词： sleep study respiratory inductive plethysmography (RIP) tidal volume

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Dynamic Expression of Tumor Necrosis Factor-α and Vascular Endothelial Growth Factor in Rat Model of Pulmonary Emphysema Induced by Smoke Exposure

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第5期27卷 505-507页

作者：张劲农郑灵白明 Department of Respiratory Diseases Union Hospital Tongji Medical College Huazhong University of Science and Technology

In order to explore the roles of tumor necrosis factor-α （TNF-α） and vascular endothelial growth factor （VEGF） in the pathogenesis of pulmonary emphysema, male Wistar rats were randomized into group At, group A2.5 and group A4, each with smoke exposure for 1 month, 2.5 months or 4 months, respectively. Group B t, group B2.5 and group B4 were used as non smoking controls at corresponding time points. TNF-α in bronchoalveolar lavage fluid （BALF） and expression of VEGF in lung tissue was determined by ELISA or by SABC immunohistochemistry assay either. Lung slices were stained with hematoxylin and eosin （HE）. Results showed that in animal with smoke exposure the mean linear interceptor （Lm）, an index of pulmonary emphysema and the content of TNF-α in BALF increased gradually, on contrary, the expression of VEGF in lung tissue decreased （P〈0.05）. This phenomenon was not obvious in animals without smoke exposure. Lm was negatively correlated to the VEGF expression （7=--0.81, P〈0.01） and positively correlated to TNF-α concentration （7 = 0.52, P〈0.004）, which implies that smoke exposure decreased the expression of VEGF and increased the expression of TNF-α. It is plausible to speculate that the imbalance of TNF-α and VEGF may play an important role in the pathogenesis of smoke-induced pulmonary emphysema.

关键词： smoke exposure tumor necrosis factor-α vascular endothelial growth factor pulmonary emphysema

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Preliminary suggestions on diagnosis and treatment of pregnancy complicated with COVID-19 in Wuhan Union Hospital

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中华妇产科杂志 2020年第2期 77-80页

作者： Zhu Ying Wu Qiulei Wang Lin Liu Xiaoli Yuan Hongfang Wang Zheng zhang jinnong Zhao Lei Deng Feitao Jin Jing zhang Yanling Tang Qianqian Chen Hui Zeng Xiangzhi Wu Min Tian Yanhong Xia Geqing Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Laboratory Wuhan Red Cross Hospital Wuhan 430015 Department of Surgery Department of Emergency Department of Infection the first people''s Hospital of Tianmen City Tianmen 431700 China

By analyzing the clinical characteristics and diagnosis and treatment of COVID-19 in pregnancy, the preliminary suggestions on diagnosis and treatment of pregnancy complicated with COVID-19 in Wuhan Union Hospital were established. Five pregnant patients with COVID-19 were collected before January 26, 2020. One case was <28 pregnant weeks, the others for≥28 weeks; 3 cases were confirmed by nucleic acid test of novel coronavirus, and 2 cases were clinically diagnosed as suspected infection. The relevant clinical symptoms, auxiliary examination and treatment were summarized and analyzed. The main respiratory symptom was dry cough, the others were not typical in the early stage of pregnancy with COVID-19. The blood oxygen saturation decreased significantly within 72 hours after delivery and were significantly improved with symptomatic treatment. The blood routine examination showed that the lymphocyte count decreased and the eosinophil number decreased significantly, which was synchronized with the lymphocyte decline. Eosinophil count was 0 in typical clinical symptoms, and increased with the improvement of clinical symptoms. Severe cases and pregnant women on medium and late stage should be hospitalized and they should be admitted to ICU if necessary. Obstetric treatment should be used according to the specific conditions of mother and fetus. Pregnant patients with COVID-19 should be carefully distinguished during pregnancy due to its insidious, thus to avoid delay in early diagnosis and treatment. 72 hours after delivery is a critical period for close monitoring. The trend of eosinophil is declined significantly and correlated to the clinical manifestations, but the universality of this conclusion needs large sample study.

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浅谈构建和谐社会与人的全面发展

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山西科技 2007年第1期22卷 20-21页

作者：张进农长沙民政职业技术学院

构建和谐社会是当今中国的热门话题,文章以结合人的发展为主题展开论述,既阐述了“以人为本”的内涵,也综述了构建和谐社会的理念。并以促进人的全面发展框架为主,介绍了构建和谐社会的方法。

关键词：以人为本发展和谐社会

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房地产限购对三线城市房地产市场的影响——以福建省为例

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福建工程学院学报 2015年第4期13卷 392-399页

作者：张劲农漳州职业技术学院房地产研究所福建漳州363000

通过对用地推出面积、土地出让金溢价率和住宅成交面积等数据的分析,研究房地产限购政策对三线城市政府、开发商和购房者的影响。研究表明,限购对三线城市的购房者影响有限;开发商则对住宅市场预期不乐观;与限购区相邻近的三线城市政府... 详细信息

通过对用地推出面积、土地出让金溢价率和住宅成交面积等数据的分析,研究房地产限购政策对三线城市政府、开发商和购房者的影响。研究表明,限购对三线城市的购房者影响有限;开发商则对住宅市场预期不乐观;与限购区相邻近的三线城市政府对房地产市场保持克制,而边远三线城市政府看好房地产市场且行动积极。2014年下半年房地产限购已进入政策蜕化期,房地产限购对三线城市房地产市场的影响基本结束。

关键词：房地产限购三线城市购房者开发商

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我国古典园林中水的文化意义

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广东园林 2005年第1期27卷 8-9页

作者：张劲农首都师范大学

水在我国古典园林中不仅起到组景的作用,还有助于生发园林意境,寄托着我们民族的基本哲学思想。我国古典园林中的理水手法是中华民族深层文化的象征。

关键词：中国古典园林水文化水景设计园林建设

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肺纤维化形成中整合素相关激酶的表达与上皮-间充质细胞转化

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中国组织化学与细胞化学杂志 2007年第4期16卷 428-433页

作者：施维张劲农汪铮徐清华中科技大学附属协和医院呼吸病研究室武汉430022

目的观察整合素相关激酶(ILK)在博莱霉素致小鼠肺纤维化中的动态表达,探讨其在肺纤维化中与上皮-间充质细胞转化(EMT)的关系。方法将32只小鼠随机分成正常对照组,博莱霉素(BLM)致肺纤维化组。后者以博莱霉素腹腔注射致肺纤维化,正常对... 详细信息

目的观察整合素相关激酶(ILK)在博莱霉素致小鼠肺纤维化中的动态表达,探讨其在肺纤维化中与上皮-间充质细胞转化(EMT)的关系。方法将32只小鼠随机分成正常对照组,博莱霉素(BLM)致肺纤维化组。后者以博莱霉素腹腔注射致肺纤维化,正常对照组仅在相同处理条件下注射生理盐水。治疗的第28天和40天处死动物取出肺组织,用苏木精-伊红(HE)和Massontrichrome染色,分别观察实验动物肺炎症和纤维化的程度,以样本碱水解法检测肺组织中羟脯氨酸的量,逆转录-聚合酶链反应(RT-PCR)检测ILK mRNA表达、免疫组化检测不同实验组小鼠ILK,并同时检测间充质细胞标记物α-平滑肌肌蛋白(α-SMA)和上皮细胞标记物上皮钙粘附素(E-Cad)的表达。结果组织学结果显示小鼠肺组织胶原含量在第28d明显增加,第40d达高峰,羟脯氨酸测定动态增高。与正常对照组比较,肺纤维化组中ILK、α-SMA蛋白表达增高(P<0.01),E-Cad的蛋白表达降低(P<0.01)。RT-PCR结果显示肺纤维化组ILKmRNA的表达显著增高(P<0.01)。ILK的表达不仅与羟脯氨酸的含量成正相关(r分别为0.867、0.886,P均小于0.05),也与α-SMA/E-Cad比值成正相关(r分别为0.830、0.844,P均小于0.05);α-SMA与E-Cad成负相关(r分别为-0.820、-0.833,P均小于0.05)。结论ILK在小鼠肺纤维化中表达与纤维化的程度呈正相关增高,表明其可能是肺纤维化形成的促进因子,且由于ILK与α-SMA/E-Cad比值成正相关,推测ILK在肺纤维化形成中的机制可能与促进EMT有关。

关键词：整合素相关激酶肺纤维化上皮细胞-间充质细胞转化博莱霉素

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Atrial of arbidol hydrochloride in adults with COVID-19

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Chinese Medical Journal 2022年第13期135卷 1531-1538页

作者： Jingya Zhao jinnong zhang Yang Jin Zhouping Tang Ke Hu Hui Sun Mengmeng Shi Qingyuan Yang Peiyu Gu Hongrong Guo Qi Li Haiying zhang Chenghong Li Ming Yang Nian Xiong Xuan Dong Juanjuan Xu Fan Lin Tao Wang Chao Yang Bo Huang Jingyi zhang hi Chen Qiong He Min Zhou Jieming Qu Department of Pulmonary and Critical Care Medicine Rujin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China institute of Respiratory Diseases School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Emergency Union Medical College Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430058China Department of Respiratory and Critical Care Medicine Union Medical Collge Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430058China Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Respiratory and Critical Care Medicine Renmin HospitalWuhan UniversityWuhanHubei 430060China Department of Endocrinology Union Medical Cllege Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430058China Department of Respiratory Medicine Wuhan Bauhinia HospitalWuhanHubei 430062China Department of Respiratory Medicine Guanggu Hospital DistrictThe Third Hospital of WuhanWuhanHubei 430074China Department of Respiratory and Crtical Care Medicin Puren HosptalWuhan University of Science and TechnologyWuhanHubei 430081China Department of Respiratory Medicine The Third People's Hospital of Hubei ProvinceWuhanHubei 430030China Department of Respiatory Medicine The Sixth General Hospital of Hubei ProvinceWuhanHubei 430015China Tuberculosis Department of Chengdu Public Health Clinical Medical Center ChengduSichuan 610066China Department of Neurology Wuhan Red Cross HospitalWuhanHubei 430015China Department of Tuberculosis Jinyintan HospiaWuhanHubei 430048China Department of Cardiology The Third People's Hospital of Hubei ProvinceWuhanHubei 430030China.

Background: To date, there is no effective medicine to treat coronavirus disease 2019 (COVID-19), and the antiviral efficacy of arbidol in the treatment for COVID-19 remained equivocal and controversial. The purpose of this study was to evaluate the efficacy and safety of arbidol tablets in the treatment of ***: This was a prospective, open-label, controlled and multicenter investigator-initiated trial involving adult patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients were stratified 1:2 to either standard-of-care (SOC) or SOC plus arbidol tablets (oral administration of 200 mg per time, three times a day for 14 days). The primary endpoint was negative conversion of SARS-CoV-2 within the first week. The rates and 95% confidential intervals were calculated for each ***: A total of 99 patients with laboratory-confirmed SARS-CoV-2 infection were enrolled;66 were assigned to the SOC plus arbidol tablets group, and 33 to the SOC group. The negative conversion rate of SARS-CoV-2 within the first week in patients receiving arbidol tablets was significantly higher than that of the SOC group (70.3% [45/64]vs. 42.4% [14/33];difference of conversion rate 27.9%;95% confidence interval [CI], 7.7%-48.1%;P=0.008). Compared to those in the SOC group, patients receiving arbidol tablets had a shorter duration of clinical recovery (median 7.0 daysvs. 12.0 days;hazard ratio [HR]: 1.877, 95% CI: 1.151-3.060,P=0.006), symptom of fever (median 3.0 daysvs. 12.0 days;HR: 18.990, 95% CI: 5.350-67.410,P 0.05). The most common adverse event in the arbidol tablets group was the elevation of transaminase (5/200, 2.5%), and no one withdrew from the study due to adverse events or disease progression.C

关键词： Arbidol Coronavirus disease 2019(COVID-19) Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)

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基于BP神经网络的睡眠呼吸综合症智能检测系统

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计算机应用与软件 2006年第3期23卷 64-66页

作者：潘俊君张艳宁罗刚张劲农西北工业大学计算机学院陕西省语音与图像处理重点实验室陕西西安710072 华中科技大学同济医学院附属协和医院湖北武汉430200

提出了应用BP网络对睡眠呼吸暂停病症进行检测的技术方法。考虑到临床检测采集具有数据量大,伴有噪音干扰等特点,采用BP网络,其并行性、容错性较好,具有较强的自适应性及通过实例学习的能力,有助于克服单个诊断医师在知识获取方面存在... 详细信息

提出了应用BP网络对睡眠呼吸暂停病症进行检测的技术方法。考虑到临床检测采集具有数据量大,伴有噪音干扰等特点,采用BP网络,其并行性、容错性较好,具有较强的自适应性及通过实例学习的能力,有助于克服单个诊断医师在知识获取方面存在的“瓶颈”问题。开发出来的睡眠呼吸综合症智能检测系统可以选择采集好的病人样本数据进行自学习,建立病人的特征模型,自动进行数据分析和异常情况的识别与分类,对病人的患病率进行预测。通过实验测试,该系统预测的准确率在88.5%左右,高于单纯的人工诊断,并显著提高了诊断效率。

关键词：睡眠呼吸综合症智能检测系统神经网络 BP算法

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