检索结果-南通市图书馆

Frontiers of Environmental Science & Engineering 2013年第1期7卷 77-84页

作者： Nannan LIU Mei MA Yiping XU jinmiao zha Kaifeng RAO Zijian WANG State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicity in in vitro assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from in vivo tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micronucleus assay was conducted on medaka (Oryzias latipes) after a 28-day exposure to 2,4,6-TCP. In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCP. Moreover, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 μg·L?1. This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP in vivo exposure.

关键词： 2 4 6-trichlorophenol genotoxicity Japanese medaka piscine micronucleus test in peripheral erythrocytes gender difference

Impact of dissolved humic acid on the bioavailability of acenaphthene and chrysene assessed by membrane-based passive samplers

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2007年第19期52卷 2642-2648页

作者： CHEN Shan KE RunHui HUANG ShengBiao SUN LiWei zha jinmiao WANG ZiJian State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-environmental Science Chinese Academy of Sciences Beijing 100085 China

Dissolved organic carbon (DOC) is known to reduce the bioavailability of hydrophobic organic compounds (HOCs) in aqueous environments. This reduction occurs as a result of adsorption to DOC, apparently reducing the freely dissolved concentration of HOCs. In the present study, triolein-embedded cellulose acetate membrane (TECAM) and Japanese medaka (Oryzias latipes) were used to measure the uptake of acenaphthene and chrysene in the presence of commercial humic acid (HA) at different concentrations (0―15 mg C·L-1) under controlled laboratory conditions. Apparent uptake rate constants for PAHs in TECAM and medaka were compared and DOC-water partition coefficients (KDOCs) of two PAHs were calculated with different sampling methods by model fit. Results showed that HA present in water significantly reduced the uptake of PAHs in TECAM and medaka. The obtained values of log KDOC of acenaphthene and chrysene measured by TECAM were 4.63 and 5.83, respectively, whereas biologically determined values were 4.52 and 5.76, respectively. These log KDOC values were comparable to earlier published KDOCs toward commercial HA, thereby indicating that TECAM accumulated only the freely dissolved fraction of chemicals and uptake PAHs in a manner similar to that of fish. All these results suggested that the TECAM method can provide a good means for assessing the impact of DOC on bioavailability of PAHs in the aqueous environment.

关键词：生物利用度多环芳香烃萘嵌戊烷化学物质

A review on China's constructed wetlands in recent three decades:Application and practice

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2021年第6期33卷 53-68页

作者： Hong zhang Wenzhong Tang Weidong Wang Wei Yin Honglei Liu Xiaomin Ma Yiqi Zhou Pei Lei Dongyang Wei Litian zhang Cao Liu jinmiao zha State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Changjiang Water Resources Protection Institute Wuhan 430051China Tianjin Academy of Environmental Sciences Tianjin 300191China Agricultural Science and Technology Information Research Center Agricultural Information InstituteChinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory of Pollution Control and Resources Reuse School of the EnvironmentNanjing UniversityNanjing 210046China Environmental Development Center of the Ministry of Ecology and Environment Beijing 100029China Beijing Academy of Science and Technology Beijing 100048China University of Chinese Academy of Sciences Beijing 100049China

Constructed wetlands(CWs)have been introduced to and developed in China for environmental engineering over the most prosperous three decades(1990–2020).To study the origin,development process,and future trend of CWs,this review summarized a wide range of literatures between 1990 and 2020 by Chinese ***,the publication number over years,research highlights,and the author contributions with the most published papers in this field were conducted through bibliometric ***,the most principal components of CWs,substrates and macrophytes were summarized and ***,the typical application cases from traditional CWs,pond systems to combined pond-wetland systems were *** China,CWs were predominately distributed in the east of the so-called'Hu Huanyong Line'.Therefore CWs were limited by the socio-economic level and climatic *** is unquestionable that the overall level of China's CWs has improved significantly,and one of the most prominent features has started towards the plural pattern *** has been a trend of large-scale or low-cost CW application in the recent ***,lifecycle research and management are required for better strategies in the future.

关键词： Constructed wetlands Bibliometric analysis Substrates Macrophytes Applications Future concerns and challenges

Toxicokinetics and the related metabolites in rainbow trout(Oncorhynchus mykiss) after exposure to decabromodiphenyl ether

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2010年第11期53卷 2379-2386页

作者： FENG ChengLian,XU YiPing,zha jinmiao,LUO Qian,SHAN XiaoQuan & WANG ZiJian State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China 1. State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Decabromodiphenyl ether(BDE209) is poorly absorbed by mammals,and little information is available on the toxicokinetics of BDE209 and its metabolites in *** the present study,rainbow trout(Oncorhynchus mykiss) were administered to 100 ng/g and 500 ng/g body wet weight of BDE209 via a single intraperitoneal injection and parent BDE209 and its metabolites were sequentially monitored for 28 *** results showed that toxicokinetic profiles of BDE209 could be described by the one-compartment *** the higher dose group(500 ng/g wet weight),the calculated half-life(t1/2) and elimination rate(ke) were 17.7 d and 0.039/d in the liver,and 100.3 d and 0.007/d in the muscle,*** major methoxylated brominated diphenyl ethers(MeO-BDEs) were detected with 2,2',4,4'-tetrabromo-5-methoxydiphenyl ether(5-MeO-BDE47) being detected in all tissue *** was no significant temporal change of 5-MeO-BDE47 concentration in the muscle,whereas an exponential increase was observed in the ***,the metabolism rate of BDE209 depended on the administered ***209 was hardly accumulated in the muscle of rainbow trout,while the liver was a primary metabolic ***-BDEs were formed via metabolism of BDE209,which probably played a significant role in fish toxicology as a potential indicator.

关键词： decabromodiphenyl ether(BDE209) polybrominated diphenyl ethers(PBDEs) methoxylated brominated diphenyl ethers(MeO-BDEs) toxicokinetics rainbow trout

Debrominated and methoxylated polybrominated diphenyl ether metabolites in rainbow trout(Oncorhynchus mykiss) after exposure to decabromodiphenyl ether

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2010年第9期22卷 1425-1434页

作者： Chenglian Feng,Yiping Xu,Yue He,Qian Luo,jinmiao zha,Zijian Wang State Key Laboratory of Environmental Aquatic Chemistry,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China. [a] State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Decabromodiphenyl ether （BDE209） is the primary component in a commonly used flame retardant. Previous studies had proved that BDE209 itself was not toxic, while its metabolites including debrominated diphenyl ethers （De-BDEs） and methoxylated brominated diphenyl ethers （MeO-BDEs） posed a potential threat to organisms. Many studies had indicated that BDE209 could metabolize quickly in mammals, but lacking in the basic data about the metabolism of BDE209 in fish. In the present study, two replicate treatment groups of rainbow trout （Oncorhynchus rnykiss） were exposed to BDE209 via a single intraperitoneal injection approximately 100 and 500 ng/g, respectively. Muscle, liver and blood samples were collected to analyze the specific metabolites on day 1 and day 28 post injection. The highest concentration of BDE209 was detected in muscle tissues, from 796.1 ng/g wet weight （day 1） to 687.1 ng/g wet weight （day 28） in high dose group, suggesting that BDE209 could accumulate slightly in muscle tissues. However, BDE209 was not detected in the blood for all treatments. Most congeners of De-BDEs were found in muscle and liver tissues, with the highest concentration in the liver. The main De-BDEs were nona-, octa-, hepta- and penta-De-BDEs. A total of seven MeO-BDE metabolites were observed among different fish tissues. Blood had the highest contribution of the MeO-BDE metabolites. Each MeO-BDE congener increased over the 28 days. These results in contrast to other studies suggested possible species-specific differences in metabolic abilities.

关键词： decabromodiphenyl ether (BDE209) methoxylated brominated diphenyl ethers (MeO-BDEs) debrominated diphenyl ethers (De-BDEs) rainbow trout

利用日本青鳉早期发育阶段暴露评估排水的急、慢性毒性和内分泌干扰效应

在线全文

学校读者我要写书评

暂无评论

环境科学学报 2005年第12期25卷 1682-1686页

作者：查金苗王子健中国科学院生态环境研究中心环境水质学国家重点实验室北京100085

提出一套利用日本青鳉胚胎-幼鱼阶段生长、形态学改变和雌雄比例变化的指标体系评价排水的毒性和内分泌干扰效应的方法.该方法属于活体动物的短期和部分生命阶段暴露测试,整个实验周期为21d,测试过程不依赖复杂的仪器设备,操作简单、成... 详细信息

提出一套利用日本青鳉胚胎-幼鱼阶段生长、形态学改变和雌雄比例变化的指标体系评价排水的毒性和内分泌干扰效应的方法.该方法属于活体动物的短期和部分生命阶段暴露测试,整个实验周期为21d,测试过程不依赖复杂的仪器设备,操作简单、成本低.通过在北京市污水、工业废水及其经过生物处理后的排水进行测试,表明其能够比较准确判断排水中是否存在急性毒性、致畸和内分泌干扰效应物质.将其应用于评价不同深度处理工艺出水毒性效果,结果表明反渗透工艺能够去除大部分毒性物质.

关键词：排水毒性内分泌干扰效应日本青鳉早期发育

定量构效关系模型在化合物毒性预测领域的应用、发展与展望

在线全文

学校读者我要写书评

暂无评论

环境科学学报 2022年第10期42卷 1-11页

作者：查金苗郑子廷闫赛红中国科学院生态环境研究中心中国科学院饮用水科学与技术重点实验室北京100085 中国科学院大学北京100049

定量构效关系(Quantitative Structure Activity Relationship,QSAR)在化合物毒性虚拟计算领域被广为使用,能够高效、准确地用于化合物毒性的预测和风险评估.本文综述了利用QSAR方法开展化合物毒性预测中数据集、数据输入和模型方法 3... 详细信息

定量构效关系(Quantitative Structure Activity Relationship,QSAR)在化合物毒性虚拟计算领域被广为使用,能够高效、准确地用于化合物毒性的预测和风险评估.本文综述了利用QSAR方法开展化合物毒性预测中数据集、数据输入和模型方法 3个领域的发展与变化,分析了研究的发展历程,提出了当前研究热点,并针对定量构效关系在化合物毒性预测领域的未来发展提出了展望.

关键词：计算毒理学定量构效关系毒性预测

在线全文

学校读者我要写书评

暂无评论

氯酚类化合物对青鱼和细鳞斜颌鯝幼鱼的毒性

环境科学学报 2010年第6期30卷 1235-1242页

作者：金小伟查金苗许宜平王子健中国科学院生态环境研究中心环境水质学国家重点实验室北京100085

以我国特有青鱼和细鳞斜颌鯝为受试物种,利用其生命早期阶段的急性毒性LC50值和28d慢性生长抑制试验所获得的最大可接受浓度(MATC)评价了3种氯酚类化合物的毒性效应.实验结果显示,2,4-二氯酚(2,4-DCP),2,4,6-三氯酚(2,4,6-TCP)和五氯酚(... 详细信息

以我国特有青鱼和细鳞斜颌鯝为受试物种,利用其生命早期阶段的急性毒性LC50值和28d慢性生长抑制试验所获得的最大可接受浓度(MATC)评价了3种氯酚类化合物的毒性效应.实验结果显示,2,4-二氯酚(2,4-DCP),2,4,6-三氯酚(2,4,6-TCP)和五氯酚(PCP)对青鱼和细鳞斜颌鯝的的96hLC50值分别为4.01(3.61～4.68)、1.22(1.12～1.31)、0.10(0.08～0.11)mg·mL-1和2.48(1.94～2.89)、1.10(0.38～1.36)、0.09(0.08～0.10)mg·mL-1,且3种氯酚类化合物对青鱼的毒性和细鳞斜颌鲴的毒性存在良好的线性相关性.根据化学物质对鱼类毒性分级标准,PCP对青鱼和细鳞斜颌鲴均为剧毒,2,4-DCP和2,4,6-TCP对青鱼和细鳞斜颌鲴均为高毒.青鱼对2,4-DCP,2,4,6-TCP和PCP的MATC分别为0.05mg·mL-1、<0.10mg·mL-1和0.015mg·mL-1,对应的急慢性毒性比(ACR)分别为80.2、12.2和6.67;细鳞斜颌鲴对2,4-DCP、2,4,6-TCP和PCP的MATC分别为0.30mg·mL-1、0.15mg·mL-1和<0.01mg·mL-1,对应ACR分别为8.27、7.33和9.00.

关键词：毒性青鱼细鳞斜颌鯝氯酚

稀有鮈鲫Ras信号通路相关基因的克隆、序列分析及其组织分布

在线全文

学校读者我要写书评

暂无评论

生态毒理学报 2015年第2期10卷 338-345页

作者：王妙查金苗王子健中国科学院生态环境研究中心环境水质学国家重点实验室北京100085

Ras基因是一类在生物进化过程中较为保守的原癌基因,在多种细胞生命活动中起到细胞增殖、分化和细胞骨架构建等重要作用。本文克隆了稀有鮈鲫Ras信号通路相关的k-ras、n-ras、pik3cd、pin1和raf1基因的部分c DNA片段,并分析了其序列。... 详细信息

Ras基因是一类在生物进化过程中较为保守的原癌基因,在多种细胞生命活动中起到细胞增殖、分化和细胞骨架构建等重要作用。本文克隆了稀有鮈鲫Ras信号通路相关的k-ras、n-ras、pik3cd、pin1和raf1基因的部分c DNA片段,并分析了其序列。序列分析结果表明,k-ras的氨基酸序列与鲤鱼相对应的氨基酸序列同源性最高,为99%;n-ras、pik3cd、pin1和raf1的氨基酸序列均与斑马鱼相对应的氨基酸序列同源性最高,分别为99%、87%、96%和97%,结果表明稀有鮈鲫与鲤鱼、斑马鱼的亲缘关系较近。组织表达分析表明,k-ras、n-ras、pik3cd、pin1和raf1基因在肝脏、鳃、肾脏、脑和性腺等组织中具有表达差异性。本文为研究环境污染物对鱼类致癌作用机制和安全性评估提供分子生物学基础和科学依据。

关键词：稀有鮈鲫 Ras基因基因克隆

乙烯菌核利对稀有鮈鲫性腺组织及相关基因转录水平的影响

在线全文

学校读者我要写书评

暂无评论

生态毒理学报 2014年第2期9卷 245-252页

作者：杨丽华査金苗王子健中国科学院生态环境研究中心环境水质学国家重点实验室北京100085

乙烯菌核利在哺乳动物实验中被广泛证实具有抗雄激素效应,而对鱼类的研究结论目前并不统一。将性成熟稀有鮈鲫分别暴露于0、2、10、50μg·L-1乙烯菌核利21 d,研究环境浓度下乙烯菌核利对鱼类生殖系统的影响及作用机制。结果表明,雌鱼... 详细信息

乙烯菌核利在哺乳动物实验中被广泛证实具有抗雄激素效应,而对鱼类的研究结论目前并不统一。将性成熟稀有鮈鲫分别暴露于0、2、10、50μg·L-1乙烯菌核利21 d,研究环境浓度下乙烯菌核利对鱼类生殖系统的影响及作用机制。结果表明,雌鱼的性腺指数(GSI)、肝脏指数(HSI)在所有浓度组均显著降低(p<0.05),同时卵巢组织中卵泡的发育受到了抑制;而雄鱼仅HSI在最高浓度组(50μg·L-1)出现显著降低(p<0.05),精巢组织切片也未观察到明显损伤,说明乙烯菌核利对雌鱼生殖系统的影响大于雄鱼。在转录水平上,雌鱼性腺中er mRNA、vtg mRNA分别在50μg·L-1和10、50μg·L-1时显著升高(p<0.05),ar mRNA在所有浓度组显著升高(p<0.05);而雄鱼性腺中ar mRNA、dmrt1 mRNA水平分别在10μg·L-1浓度组和所有浓度组显著降低(p<0.05),er mRNA在所有浓度组显著降低(p<0.05),说明雌雄鱼对乙烯菌核利暴露的分子响应机制存在差异。综上,环境浓度下乙烯菌核利短期暴露会对稀有鮈鲫生殖系统产生一定的影响,并且雌雄鱼在敏感性和分子响应机制上都存在差异。

关键词：乙烯菌核利稀有鮈鲫性腺组织转录