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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

Neural Regeneration Research 2025年第6期 1541-1554页

作者： jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Department of Psychiatry First Hospital of Shanxi Medical University Shanghai Key Laboratory of Psychotic Disorders Brain Health Institute National Center for Mental Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Co-Innovation Center of Neuroregeneration Nantong University

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

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Mesenchymal stromal cell biotherapy for Parkinson’s disease premotor symptoms

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Chinese Neurosurgical Journal 2023年第4期9卷 300-314页

作者： jinmei sun Wei Zhang Zheng Zachory Wei Xiaopeng Song Liu Jian Feng Jiang Shuanglin Wang Haibo Li Yongbo Zhang Houzhen Tuo The CtrLyin Group Clinical Diagnosis and Treatment Center for Parkinson’s Disease Beijing Friendship HospitalBeijingChina Laboratories of Biological Therapeutic Medical Technology Department of NeurologyBeijing Friendship Hospital Center for Neurological DisordersCapital Medical UniversityBeijingChina National Clinical Research Center for Digestive Diseases Beijing Friendship HospitalNeuroscience InstituteBeijingChina Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Beijing Tropical Medicine Research Institute BeijingChina McLean Imaging Center McLean HospitalHarvard Medical SchoolBelmontMAUSA Neuroscience Research Institute Peking UniversityBeijingChina Casstar Zhongguancun No.1 Global Key&Core Technology(AI)Innovation CenterBeijingChina Department of Critical Care Medicine Airport Hospital of Tianjin Medical University General HospitalTianjinChina Department of Cardiovascular Thoracic Surgery Tianjin Medical University General HospitalTianjinChina Department of Biochemistry and Cell Biology Geisel School of MedicineDartmouth CollegeHanoverNHUSA 不详

Parkinson’s disease(PD)is a neurodegenerative disorder with motor deficits due to nigrostriatal dopamine depletion and with the non-motor/premotor symptoms(NMS)such as anxiety,cognitive dysfunction,depression,hyposmia,and sleep disorders.NMS is presented in at least one-fifth of the patients with PD.With the histological information being investigated,stem cells are shown to provide neurotrophic supports and cellular replacement in the damaging brain areas under PD conditions.Pathological change of progressive PD includes degeneration and loss of dopaminergic neurons in the substantia nigra of the midbrain.The current stem cell beneficial effect addresses dopamine boost for the striatal neurons and gliovascular mechanisms as competing for validated PD drug targets.In addition,there are clinical interventions for improving the patient’s NMS and targeting their autonomic dysfunction,dementia,mood disorders,or sleep problems.In our and many others’research using brain injury models,multipotent mesenchymal stromal cells demonstrate an additional and unique ability to alleviate depressive-like behaviors,independent of an accelerated motor recovery.Intranasal delivery of the stem cells is discussed for it is extensively tested in rodent animal models of neurological and psychiatric disorders.In this review,we attempt to discuss the repairing potentials of transplanted cells into parkinsonism pathological regions of motor deficits and focus on preventive and treatment effects.From new approaches in the PD biological therapy,it is believed that it can as well benefit patients against PD-NMS.

关键词： Cell therapy Cognitive impairment Depression Neuronal survival and differentiation Parkinson's disease

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Vascular protection and regenerative effects of intranasal DL-3-N butylphthalide treatment after ischaemic stroke in mice

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Stroke & Vascular Neurology 2021年第1期6卷 74-79页

作者： Mengyao Qu Jingjie Zhao Yingying Zhao jinmei sun Liping Liu Ling Wei Yongbo Zhang Neurology Capital Medical University Affiliated Beijing Friendship HospitalBeijingChina Anesthesiology Emory University School of MedicineAtlantaGeorgiaUSA Chinese Traditional Medicine Capital Medical University Affiliated Beijing Friendship HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Neurology Tiantan Clinical Trial and Research Center for StrokeBeijingChina

Objective To investigate the effects of DL-3-N butylphthalide(NBP)via intranasal delivery after ischaemic stroke in mice.Methods C57BL/6 mice were divided into three groups:sham,stroke with vehicle and stroke with NBP treatment.Ischaemic stroke was induced by permanent ligation of right middle cerebral artery with 7 min common carotid artery occlusion.NBP(100 mg/kg)or vehicle was intranasally administered at 1 hour after stroke and repeated once a day until sacrifice.Bromodeoxyuridine(BrdU)(50 mg/kg/day)was given from the third day until sacrifice.Sensorimotor function was tested during 1-21 days after stroke.Local cerebral blood flow in the ischaemic and peri-infarct regions was measured using laser Doppler flowmetry before,during and 3 days after ischaemia.Expressions of vascular endothelial growth factor(VEGF)and endothelial nitric oxide synthase as well as regenerative marker BrdU in the peri-infarct region were analysed by western blotting and immunohistochemical methods.Results Compared with the vehicle group,NBP treatment significantly increased the VEGF expression in the poststroke brain.Stroke mice that received NBP showed significantly less vascular damage after stroke and more new neurons and blood vessels in the peri-infarct region at 21 days after stroke.In the adhesive removal test,the sensorimotor function of stroke mice treated with NBP performed significantly better at 1,3 and 7 days after stroke compared with vehicle controls.Conclusion Daily intranasal NBP treatment provides protective and neurogenic/angiogenic effects in the poststroke brain,accompanied with functional improvements after a focal ischaemic stroke in mice.

关键词： nasal protective treatment

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In_(2)O_(3)-CuO的制备及其光活化下的室温甲醛气敏性能

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精细化工 2024年第4期41卷 810-819页

作者：韩君林刘锦梅孙建华孙丽霞廖丹葵广西大学化学化工学院广西石化资源加工及过程强化技术重点实验室广西南宁530004

以InCl_(3)•4H_(2)O和Cu(NO_(3))2•3H_(2)O为原料、尿素为沉淀剂,采用水热法制备了In_(2)O_(3)-CuO复合材料。通过XRD、SEM、TEM、UV-Vis吸收光谱、XPS、EIS对其进行了表征,探究了紫外光活化In_(2)O_(3)-CuO复合材料的气敏性能与传感机制。结果表明,In_(2)O_(3)-CuO复合材料在375 nm紫外光照射室温(25℃)条件下对质量浓度50 mg/L甲醛气体的灵敏度为298,与纯In_(2)O_(3)(2.4)相比灵敏度提高123倍,气敏性能的巨大提升得益于In_(2)O_(3)与CuO形成的p-n异质结,协同光活化条件下异质结界面产生的光生电子-空穴与氧物种(O_(2)和O_(2)-)间建立了氧的光活化吸附-解吸循环,使室温下材料的气体吸附-解吸过程和表面反应增强。

关键词： In_(2)O_(3)-CuO 紫外光活化室温气敏 p-n异质结甲醛功能材料

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薪火相传守正创新——在新时代新机遇中激发院团生机活力

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中国京剧 2024年第4期 82-83页

作者：孙劲梅福建京剧院党总支

记者:福建京剧院在传统剧目传承和新编剧目创排方面分别做了哪些努力?孙劲梅:“旧中有新,新中有根”,福建京剧院成立七十五年来,继承前辈基业,秉承前辈志向,始终坚持以人民为中心的创作导向,艺术创作遵循传统戏、新编历史剧、现代戏“... 详细信息

记者:福建京剧院在传统剧目传承和新编剧目创排方面分别做了哪些努力?孙劲梅:“旧中有新,新中有根”,福建京剧院成立七十五年来,继承前辈基业,秉承前辈志向,始终坚持以人民为中心的创作导向,艺术创作遵循传统戏、新编历史剧、现代戏“三并举”方针,建立大、中、小型兼顾,新创和复排并行的剧目培育发展机制,创作演出了《真假美猴王》《山花》《北风紧》《才女鱼玄机》《赵武灵王》《红土》《林祥谦》、京剧电影《大闹天宫》等一批具有广泛影响的优秀作品。坚持守正创新,复排、新创作品通过福建省艺术精品创作“火花茶会”机制,听取专家修改提升意见,在传承中演绎经典,在创新中打造精品。

关键词：新编剧目《大闹天宫》新编历史剧艺术创作林祥谦复排真假美猴王精品创作

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Antithrombin gene Arg197Stop mutation-associated venous sinus thrombosis in a Chinese family

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Neural Regeneration Research 2011年第20期6卷 1575-1579页

作者： Ang Li Tianhui Liu Zhandong Liu Jimei Li Chunling Zhang Jun Chen jinmei sun Yanfei Han Lili Wang Dexin Wang Qiming Xue Baoen Wang Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China Liver Research Center Beijing Friendship Hspital Capital Medical University Beijing 100050 China Department of Neurology Health Care Center Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

This study sought to elucidate the genetic correlation of cerebral venous sinus thrombosis caused by a hereditary antithrombin deficiency in a Chinese family, at the genetic and protein levels. A nonsense mutation from C to T on locus 6431 in exon 3B of the antithrombin gene was observed, leading to an arginine （CGA） to stop codon （TGA） change in the protein. This is the first report of this mutation in China. Ineffective heparin therapy in the propositus patient is associated with a lack of heparin binding sites after antithrombin gene mutation. Characteristic low intracranial pressure in the acute phase might be specific to this patient with cerebral venous sinus thrombosis.

关键词： antithrombin cerebral venous sinus thrombosis intracranial hypotension nonsense mutation brain edema

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宁夏城市建设用地节约集约利用与高质量发展耦合协调研究

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干旱区地理 2024年第5期47卷 872-884页

作者：曹佳琳刘艳芳赵金梅安睿胡艺川孙文杰辛格格武汉大学资源与环境科学学院湖北武汉430072 宁夏回族自治区自然资源勘测调查院宁夏银川750004

当前中国进入高质量发展阶段,缓解城市快速扩张伴随的土地利用粗放问题对城市可持续发展具有重要意义。现有研究多单方面关注城市建设用地节约集约水平或高质量发展状态,较少讨论两系统间的耦合协调关系。通过构建多维指标体系,测度201... 详细信息

当前中国进入高质量发展阶段,缓解城市快速扩张伴随的土地利用粗放问题对城市可持续发展具有重要意义。现有研究多单方面关注城市建设用地节约集约水平或高质量发展状态,较少讨论两系统间的耦合协调关系。通过构建多维指标体系,测度2018年宁夏22个区县城市建设用地节约集约利用水平和高质量发展状态,并采用耦合协调度、相对发展度和影响协调力分析两系统间的耦合协调关系。结果表明:(1)2018年宁夏城市建设用地节约集约水平呈现出“中部低、南北高”的分布态势,而高质量发展水平呈现出“西北高、东南低”的空间分布格局。(2)两系统耦合协调度空间上呈现出“中部低、南北高”的分布格局,宁夏大部分区县处于基本协调状态且两系统关系呈良性循环。(3)创新和安全子系统对两系统的耦合协调度普遍起反向阻滞作用;绿色和协调子系统对两系统的耦合协调度普遍起正向推动作用。研究结果可为黄河流域高质量发展情境下促进建设用地节约集约利用提供实证依据。

关键词：建设用地节约集约利用高质量发展耦合协调度相对发展度宁夏

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不同饲草组合对乌珠穆沁羔羊血液生化指标及生产性能和经济效益的影响

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中国草地学报 2024年第3期46卷 118-124页

作者：赵金梅殷国梅孙世贤张晓庆薛艳林冀超李薇卫媛中国农业科学院草原研究所内蒙古呼和浩特010010 内蒙古自治区农牧业科学院草原研究所内蒙古呼和浩特010031

为分析不同饲草组合代替部分精饲料对羔羊健康状况、生产性能和经济效益的影响,选用4~5月龄健康乌珠穆沁公羔羊30只,分为5组分别接受对照组、青贮组、苜蓿组、柠条组、完全组5种不同日粮处理(对照组日粮的精粗比为75∶25,其余组为50∶5... 详细信息

为分析不同饲草组合代替部分精饲料对羔羊健康状况、生产性能和经济效益的影响,选用4~5月龄健康乌珠穆沁公羔羊30只,分为5组分别接受对照组、青贮组、苜蓿组、柠条组、完全组5种不同日粮处理(对照组日粮的精粗比为75∶25,其余组为50∶50),测定各组的日采食量、体重和血清生化指标,并计算毛利润。结果表明:(1)对照组的丙氨酸氨基转移酶(ALT)活性显著低于苜蓿组和柠条组(P<0.05),天冬氨酸氨基转移酶(AST)和AST/ALT显著高于其他组(P<0.05),对照组、苜蓿组和柠条组的血清尿素含量显著高于完全组和青贮组(P<0.05),青贮组、完全组和柠条组的血清甘油三酯含量显著低于对照组。完全组的血清胆固醇含量显著低于其他组(P<0.05)。(2)对照组的干物质采食量显著高于其他组(P<0.05),日增重表现为完全组显著高于其他组(P<0.05),青贮组最低,苜蓿组和柠条组与对照组差异不显著。对照组的料重比最高,显著高于完全组、苜蓿组和柠条组(P<0.05)。(3)青贮组的日粮价格及成本最低,完全组、柠条组和苜蓿组次之,对照组最高;完全组每只羊增重价值和毛利润最高,苜蓿组次之,青贮组最低。综合以上,优质饲草组合取代舍饲羔羊日粮中25%的精饲料有利于改善羔羊的健康状况,5个组合中10%苜蓿干草+10%柠条粉+15%青贮玉米+15%玉米秸秆+50%精饲料组合效果最好,羔羊生产性能和经济效益显著提高,适合内蒙古牧区家庭牧场应用。

关键词：饲草组合乌珠穆沁羔羊血液生化指标增重经济效益

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福建梅仙铅锌矿田磁铁矿成因类型与指示意义

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地质学刊 2024年第1期48卷 25-32页

作者：李秋金聂顺义孙学娟李金梅江苏华东基础地质勘查有限公司江苏南京210007

梅仙铅锌矿田为闽中地区的大型铅锌矿集区,矿床成矿年代与成因类型尚有争议。梅仙铅锌矿石中普遍发育磁铁矿,通过电子探针分析磁铁矿成分特征,判别其成因类型,对矿床成矿过程进行约束。研究表明,铅锌矿石中磁铁矿成矿可分为3个阶段,不... 详细信息

梅仙铅锌矿田为闽中地区的大型铅锌矿集区,矿床成矿年代与成因类型尚有争议。梅仙铅锌矿石中普遍发育磁铁矿,通过电子探针分析磁铁矿成分特征,判别其成因类型,对矿床成矿过程进行约束。研究表明,铅锌矿石中磁铁矿成矿可分为3个阶段,不同阶段磁铁矿主量与微量元素含量差异明显;微量元素地球化学特征指示第一阶段磁铁矿属于喷流沉积成因,第二、三阶段磁铁矿为矽卡岩型;不同阶段磁铁矿的成因类型反映了梅仙矿田多期次岩浆活动与成矿作用的特征。

关键词：磁铁矿成因类型电子探针铅锌矿田福建梅仙

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Immunoregulatory polysaccharides from Apocynum venetum L.flowers stimulate phagocytosis and cytokine expression via activating the NF-κB/MAPK signaling pathways in RAW264.7 cells

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Food Science and Human Wellness 2022年第4期11卷 806-814页

作者： Honglin Wang Changyang Ma Dongxiao sun-Waterhouse jinmei Wang Geoffrey Ivan Neil Waterhouse Wenyi Kang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Functional Food Engineering Technology Research Center Kaifeng 475004China School of Chemical Sciences University of AucklandAuckland 1142New Zealand Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China

Two immunomodulatory polysaccharides(Vp2a-Ⅱ and Vp3) were isolated and identified from Apocynum venetum L. flowers, and their innate immune-stimulating functions and working mechanisms were evaluated in RAW264.7 cells. Both the level of released nitric oxide(NO) and expression of inducible nitric oxide synthase(iNOS) m RNA were significantly enhanced in the RAW264.7 macrophages cells treated by Vp2a-Ⅱ and Vp3. Vp2a-Ⅱ(100–800 μg/m L) and Vp3(400 μg/mL) could significantly increase the phagocytic activity of RAW264.7 cells and the secretion and m RNA expression of TNF-α and IL-6 in a concentrationdependent manner through affecting mitogen-activated protein kinase(MAPK) activity and nuclear factor κB(NF-κB) nuclear translocation. Vp2a-Ⅱ might activate the MAPK signaling pathways and induce the nuclear translocation of NF-κB p65, whilst Vp3 likely activated the NF-κB and MAPK signaling pathways without influencing the p38 MAPK route.

关键词： Apocynum venetum L.flowers Immunomodulatory polysaccharide RAW264.7 cells NF-κB signaling pathway MAPK signaling pathway

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