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Fall Prevention Education Reduces the Falling Rate on the Osteoporosis Patients Treated with Zoledronic Acid

Case Reports in Clinical Medicine 2019年第8期8卷 222-230页

作者： Ermei Jie jinmei deng Department of Endocrinology The First Affiliated Hospital Sun Yat-sen University Guangzhou China Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Objective: Falls are one of the most common direct causes of fractures which are major causes of morbidity and mortality in osteoporosis patient. There are many factors related to falls, by interfering of fall prevention education on the patients with osteoporosis, our study is to investigate whether fall prevention education can reduce the falling rate on the osteoporosis patients treated with zoledronic acid. Methods: A total of 178 eligible female patients who first visited our osteoporosis department during January 2016 to June 2017 were invited to participate in this study, and all participants were randomly divided into an observation group (92 cases) and an intervention group (86 cases). All patients were administrated zoledronic acid once and received a questionnaire survey about factors related to falls at the beginning and a year later. The patients in the observation group only received regular orders of adopting a healthy lifestyle while those in the intervention group received fall prevention assessment and education, and a telephone follow-up and reinforced fall prevention education a month after discharge. A year later, relevant data regarding the falls of each patient of both groups during the year and the data of the questionnaire survey were collected for intergroup comparison. Results: The difference of the improvement of fall risk factors between the two groups is statistically significant (P Conclusion: For an osteoporosis patient treated with zoledronic acid, fall prevention education is an effective method to reduce the risk of falling, which would result in a lower risk of fractures and a better prognosis.

关键词： Fall Prevention Education Osteoporosis Zoledronic Acid

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METTL3介导的m6A甲基修饰促进膀胱癌侵袭转移的研究进展

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新疆医学 2024年第4期54卷 470-476,502页

作者：龙钰洁郑宏陈飞龙罗俊豪邓金妹严琛心王栋洋湘南学院临床学院湖南郴州423000 湘南学院附属医院泌尿外科湖南郴州423000

真核生物中的信使RNA,即mRNA,它是一种含有基因信息的RNA分子,其进行了三种不同的修饰类型:N6-甲基腺苷(m6A)、5-甲基胞嘧啶和N1-甲基腺苷。其中,m6A是最为丰富和常见的修饰类型之一。这种修饰过程涉及到三种不同类型的分子:甲基转移酶... 详细信息

真核生物中的信使RNA,即mRNA,它是一种含有基因信息的RNA分子,其进行了三种不同的修饰类型:N6-甲基腺苷(m6A)、5-甲基胞嘧啶和N1-甲基腺苷。其中,m6A是最为丰富和常见的修饰类型之一。这种修饰过程涉及到三种不同类型的分子:甲基转移酶、去甲基化酶和甲基化阅读。

关键词：基因信息甲基转移酶信使RNA 去甲基化酶甲基化真核生物修饰过程

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A Case Report of Alendronate Treatment over 20 Years on Osteoporosis and Literature Review

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Case Reports in Clinical Medicine 2018年第6期7卷 430-440页

作者： jinmei deng Enjing Chen Suming Jie Xiuzhen Cai Dongmei Cai Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Osteoporosis The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Osteoporosis is commonly seen in aged people, but not much attention is paid to it. Patient compliance is challenged by many factors, including long-time treatment and high rates of fatality and disability caused by fragility fractures. With age-related changes, the treatment will last for a lifetime. A clinical case of postmenopausal patient who had received incontinuous treatment of alendronate for 20 years was studied in this article. As the level of compliance varied in different treatment phases, the curative outcome of this patient was altered. This study also presented a literature review to discuss the current situation, treatment and compliance of osteoporosis in China and the corresponding influences on bone mineral density (BMD) and prognosis. Hopefully, this study can increase physicians’ awareness of osteoporosis in clinical treatment and its pharmacotherapy and treatment course.

关键词： Osteoporosis Alendronate BMD Treatment Course Compliance Prognosis

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Curative Effect Analysis of Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis with Different Bone Turnover Rates

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International Journal of Clinical Medicine 2018年第8期9卷 621-628页

作者： Suming Jie jinmei deng Caixia Lin Xiuzhen Cai Dongmei Cai Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital of Sun Yat-sen University Guangzhou China

Objective: To explore the clinical efficacy of Zoledronic Acid Injection in the treatment of postmenopausal osteoporosis with different bone turnover rates. Methods: A total of 63 patients diagnosed with postmenopausal osteoporosis were included in this study. Each patient was administrated 5 mg/100mL Zoledronic Acid (Aclasta) intravenously once and then given a one-year prescription of 600 mg/d oral Caltrate. The bone turnover parameters (PINP, β-cross, N-MID) were measured prior to the injection of Zoledronic Acid while the bone mineral density (BMD) and the pain scores of each patient were tested before treatment and after the one-year medication. On this basis, the patients were divided into several groups according to their bone turnover rates for intergroup comparison of treatment outcomes. Results: BMD results and pain scores of all participants were significantly improved at different levels after treatment. However, these improvements had no significant differences between the patients with high and low bone turnover rates. Conclusion: Zoledronic Acid Injection can relieve bone pain, enhance the quality of life and increase the BMD in patients with postmenopausal osteoporosis, regardless of the bone turnover status.

关键词： Osteoporosis Postmenopausal Bone Turnover Rate Zoledronic Acid

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Sequential Treatment Reduces the Acute Phases of Adverse Effect of Zoledronic Acid in First Time Users

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Open Journal of Preventive Medicine 2018年第7期8卷 189-205页

作者： jinmei deng Dongmei Cai Suming Jie Enjing Chen Xiuzhen Cai Yanbing Li Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Endocrinology The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Objective: To investigate whether sequential regimen such as traditional anti-reabsorption medications followed by zoledronic acid could reduce the side effects after initiation of zoledronic acid in postmenopausal osteoporosis patients. Methods: A total of 156 postmenopausal osteoporosis patients who presented at our osteoporosis outpatient clinic were enrolled in this study. They were randomly divided into four groups: the control group, alendronate group, calcitonin group, and raloxifene group. All participants were treated with Caltrate 600 mg per day and calcitriol 0.25 ug per day as a baseline treatment, followed by administrating 5 mg/100 mL of zoledronic acid intravenously for one single time three months afterwards. During the abovementioned course of three months, the alendronate group received 70 mg of alendronate sodium orally once a week, the calcitonin group received nasal spray form of salmon calcitonin 10iu daily, the raloxifene group received 60mg of raloxifene orally daily, and the control group received nothing but only the baseline treatment. We tested parameters such as β-cross, blood calcium level, renal function both pre and post zoledronic acid treatment. We also documented those side effects that typically occurred within one week of treatment initiation, which included the proportion, severity, onset time, and duration of the fever, demand for pain medication, severity of bone and joint pain, flu-like symptoms, arrhythmia, blood calcium level, and kidney function impairment. We also evaluated how willing the patients were to receive a second dose of zoledronic acid. Then we did comparative analysis between control group and sequential group. Results: The side effects such as fever, bone and joint pain, flu-like symptoms after zoledronic acid treatment in alendronate group and calcitonin group were all significantly lower than that in control group, while raloxifene group showed no significant difference compared to that in the control group

关键词： Zoledronic Acid Alendronate Sodium Raloxifene Calcitonin Postmenopausal Osteoporosis Adverse Reaction

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The Role of Health Education in Improving Patient Compliance with Zoledronic Acid

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Open Journal of Nursing 2018年第10期8卷 709-716页

作者： Suming Jie jinmei deng Ermei Jie Enjing Chen Caixia Lin Xiuzhen Cai Dongmei Cai Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Endocrinology The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Objective: To define the role of health education in improving patient compliance with Zoledronic Acid for osteoporosis treatment and management and draw closer attention of patients and physicians to the importance of health education. Methods: A total of 198 postmenopausal patients with osteoporosis who were admitted by the osteoporosis outpatient clinic of our hospital and had the first administration of Zoledronic Acid in 2015 were invited to participate in the follow-up visit that involved questions concerning the frequency of health education and the questionnaire survey on osteoporosis in 2015 and the administration of Zoledronic Acid during the past three years. The patients were divided into five groups according to the frequency of health education to compare the survey results of each group in 2015 and 2018 and investigate the differences in the scores and frequency of administration among the five groups. Results: Among the 198 patients, there were 182 attending the follow-up visit. In terms of the frequency of health education (FREQ = 0, 1, 2, 3, 4), these patients were divided into five groups of 47, 63, 35, 18 and 19 members respectively. After three years of treatment, the questionnaire score of each group was higher than the pre-treatment level and the difference showed statistical significance (p Conclusion: Health education is an effective approach to influence a patient’s knowledge connected to relevant diseases in a positive way and improve patient compliance with Zoledronic Acid treatment. An enhanced health education program can be developed to assist the patients in chronic disease management.

关键词： Osteoporosis Health Education Health Management BMD Zoledronic Acid Compliance

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多孔材料负载型水处理剂对金属离子废水的应用研究进展

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化工进展 2016年第7期35卷 2186-2194页

作者：祝婷罗序燕邓金梅黄瑞宇谢小华江西理工大学冶金与化学工程学院江西赣州341000

多孔材料负载型水处理剂是以多孔材料为载体而制备的一种高效环保的新型复合材料,具有高比表面积、高效率、易回收等优点,能够广泛应用于去除金属离子废水。本文扼要介绍了近年来国内外关于多孔材料负载型水处理剂的新型制备方法,介绍... 详细信息

多孔材料负载型水处理剂是以多孔材料为载体而制备的一种高效环保的新型复合材料,具有高比表面积、高效率、易回收等优点,能够广泛应用于去除金属离子废水。本文扼要介绍了近年来国内外关于多孔材料负载型水处理剂的新型制备方法,介绍了超临界技术、微乳液技术、微波技术、溶胶-凝胶技术等制备方法的研究进展,以及各制备方法的特点;同时分析介绍了负载型水处理剂对有色金属离子、稀土离子、贵金属离子废水的应用新进展。特别提出今后该类水处理剂在去除金属离子废水方面的发展方向为:进一步提高水处理剂的活性、吸附性和光催化性协同作用;选择含有功能基团的材料为载体,与金属离子络合作用;制备磁性负载型水处理剂,便于后期回收利用;开发环境友好和可循环使用的水处理剂,提高使用寿命,不造成二次污染。

关键词：载体复合材料活性水处理剂金属离子应用

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清热除湿汤与皮炎汤治疗湿热内蕴型面部脂溢性皮炎的效果对比

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当代医药论丛 2022年第10期20卷 154-156页

作者：邓金枚湖北省大悟县中医医院湖北大悟432800

目的:比较用清热除湿汤与皮炎汤治疗湿热内蕴型面部脂溢性皮炎的效果。方法:选取2019年11月至2021年1月期间湖北省大悟县中医医院收治的100例湿热内蕴型面部脂溢性皮炎患者作为研究对象。随机将其分为对照组和观察组,每组各有患者50例... 详细信息

目的:比较用清热除湿汤与皮炎汤治疗湿热内蕴型面部脂溢性皮炎的效果。方法:选取2019年11月至2021年1月期间湖北省大悟县中医医院收治的100例湿热内蕴型面部脂溢性皮炎患者作为研究对象。随机将其分为对照组和观察组,每组各有患者50例。分别用清热除湿汤与皮炎汤对对照组患者和观察组患者进行治疗,然后比较两组患者的面部皮肤评分、中医证候积分及临床疗效。结果:治疗后,观察组患者的面部皮肤瘙痒评分、面部皮疹面积评分和面部皮肤颜色评分均低于对照组患者,差异有统计学意义(P<0.05)。治疗后,观察组患者的面部皮肤油腻积分、便干积分和口渴积分均低于对照组患者,差异有统计学意义(P<0.05)。观察组患者治疗的总有效率高于对照组患者,差异有统计学意义(P<0.05)。结论:与用清热除湿汤治疗湿热内蕴型面部脂溢性皮炎相比,用皮炎汤治疗此病的效果更好,能更有效地减轻患者的临床症状,提高其疗效。

关键词：清热除湿汤皮炎汤湿热内蕴型面部脂溢性皮炎中医证候积分

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选择性脊神经后根切断术治疗小儿痉挛性脑瘫的护理

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中华护理杂志 2004年第11期39卷 827-829页

作者：莫海英陶桂花邓金梅南宁市第六人民医院护理部 530003

报告了对 5 8例接受选择性脊神经后根切断术 (SPR)的痉挛性脑瘫 (CP)患儿的护理。术前向患儿和家长讲解SPR的知识 ,说明术后坚持康复训练的重要性 ,并进行床上大小便训练和活动训练。术后注意保持正确的卧位 ,观察有无高热、脑脊液漏、... 详细信息

报告了对 5 8例接受选择性脊神经后根切断术 (SPR)的痉挛性脑瘫 (CP)患儿的护理。术前向患儿和家长讲解SPR的知识 ,说明术后坚持康复训练的重要性 ,并进行床上大小便训练和活动训练。术后注意保持正确的卧位 ,观察有无高热、脑脊液漏、排尿功能障碍、褥疮等并发症 ,术后 3d开始分 2个阶段进行康复训练。本组术后无一例手术并发症发生 ,痉挛解除率在 80 %以上 ,功能改善率在 95 %以上。

关键词：术后痉挛性脑瘫选择性脊神经后根切断术护理治疗小儿康复训练并发症讲解家长活动训练

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溶胶-凝胶法制备Ag^+掺杂Bi_2WO_6及其可见光光催化性能研究

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化工新型材料 2016年第10期44卷 137-140页

作者：罗序燕赵东方黄瑞宇祝婷邓金梅江西理工大学冶金与化学工程学院赣州341000

以硝酸铋[Bi(NO3)3·5H2O]和偏钨酸铵[(NH4)6H2W12O40·XH2O]为原料,采用溶胶-凝胶法制备了Bi2WO6及系列Ag+掺杂Bi2WO6新型光催化剂,通过降解罗丹明B发现当Ag掺杂为0.8%时,催化效果最好;并通过X射线衍射仪、扫描电镜、透射电镜、比表面... 详细信息

以硝酸铋[Bi(NO3)3·5H2O]和偏钨酸铵[(NH4)6H2W12O40·XH2O]为原料,采用溶胶-凝胶法制备了Bi2WO6及系列Ag+掺杂Bi2WO6新型光催化剂,通过降解罗丹明B发现当Ag掺杂为0.8%时,催化效果最好;并通过X射线衍射仪、扫描电镜、透射电镜、比表面积测试仪和红外光谱仪等技术对其进行了表征。结果表明:Ag+掺杂前后Bi2WO6均为斜方晶系,无其他杂质相生成。Ag+掺杂Bi2WO6光吸收性能发生红移,改善了其晶粒的分散性且其表面积也有所增加。Ag+掺杂有效提高了Bi2WO6的可见光催化活性,当掺杂量为0.8%(摩尔分数),罗丹明B溶液呈酸性时,135min内对罗丹明B的降解率达到95.40%。

关键词：溶胶-凝胶法钨酸铋光催化剂 Ag+掺杂

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