检索结果-南通市图书馆

Cancer Pathogenesis and Therapy 2024年第3期2卷 180-186页

作者： Chao Ji Silin Liu Che Wang Jie Chen Jin Wang Xinyue Zhang jinlu ma Mengjiao Cai Department of Radiation Oncology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China

Background:Concurrent chemoradiotherapy is the preferred treatment for stage IVB cervical cancer;however,some patients experience a poor *** prognostic significance of body composition indicators,including visceral obesity,has been extensively investigated in patients with *** study aimed to assess the impact of body composition indicators,specifically pretreatment fat content,on the survival outcomes of patients with stage IVB cervical ***:We retrospectively analyzed clinical information from patients diagnosed with stage IVB cervical cancer between 2010 and *** measured visceral obesity(visceral-to-subcutaneous adipose tissue area ratio[VSR])and skeletal muscle index(SMI)on pretreatment computed tomography(CT)*** evaluated the impact of these body composition parameters on the prognosis of patients with cervical ***:Overall,116 patients were included,81 of whom had complete clinical and imaging *** on the cut-off values from X-tile analysis,we categorized patients into high and low VSR and SMI *** overall survival(OS)rate of patients with a high VSR was significantly higher than that of patients with a low VSR(P=0.022).Multivariate Cox regression analysis showed that a low VSR was an independent risk factor for the prognosis of patients with stage IVB cervical ***:Visceral obesity before radiotherapy and chemotherapy has a protective effect on the prognosis of patients with stage IVB cervical cancer,while low muscle index and VSR are associated with poor prognosis.

关键词： Cervical cancer Chemoradiotherapy Visceral obesity Prognosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

双耳板焊接空心球节点轴拉力学性能研究

沈阳建筑大学学报（自然科学版） 2024年第4期40卷 678-689页

作者：焦晋峰刘佳敏马晋鲁陈鹏程路国运吕梁学院建筑与土木工程系山西吕梁033001 太原理工大学土木工程学院山西太原030024 山西潇河建筑产业有限公司山西太原030000

目的探究双耳板焊接空心球节点的受拉力学特性,揭示破坏机理并探讨影响其承载力的主要因素。方法针对8个双耳板焊接空心球节点进行轴心受拉极限承载力试验,并采用ABAQUS有限元分析软件对节点进行参数化数值分析,重点讨论节点几何尺寸对... 详细信息

目的探究双耳板焊接空心球节点的受拉力学特性,揭示破坏机理并探讨影响其承载力的主要因素。方法针对8个双耳板焊接空心球节点进行轴心受拉极限承载力试验,并采用ABAQUS有限元分析软件对节点进行参数化数值分析,重点讨论节点几何尺寸对其承载力的影响。结果在轴向拉力作用下,双耳板焊接空心球节点破坏形式分为空心球开裂破坏,耳板与空心球连接处焊缝失效,且个别试件出现球面局部起皮;空心球与耳板连接端部处应力集中明显,随着荷载增大,在空心球与耳板连接处沿径向逐步进入屈服阶段。结论节点轴拉极限承载力,与空心球直径、耳板宽度与球外径比、耳板厚度与球壁厚度比呈正相关,与空心球径厚比呈负相关,且上述影响因素中空心球壁厚与耳板厚度比对承载力影响相对较小。

关键词：双耳板焊接空心球节点轴心受拉破坏形式参数化分析

Cocktail hepatocarcinoma therapy by a super-assembled nano-pill targeting XPO1 and ATR synergistically

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2023年第6期13卷 603-615页

作者： Liuyun Gong Yinliang Lu Jing Wang Xinyue Li Jing Zhao Yuetong Chen Rongze ma jinlu ma Tianya Liu Suxia Han Department of Radiation Oncology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China National&Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710004China Department of Radiotherapy The First Affiliated Hospital Soochow UniversitySuzhouJiangsu215000China

Intensive cancer treatment with drug combination is widely exploited in the clinic but suffers from inconsistent pharmacokinetics among different therapeutic *** overcome it,the emerging nanomedicine offers an unparalleled opportunity for encapsulating multiple drugs in a ***,a two-step super-assembled strategy was performed to unify the pharmacokinetics of a peptide and a small molecular *** this proof-of-concept study,the bioinformatics analysis firstly revealed the potential synergies towards hepatoma therapy for the associative inhibition of exportin 1(XPO1)and ataxia telangiectasia mutated-Rad3-related(ATR),and then a super-assembled nano-pill(gold nano drug carrier loaded AZD6738 and 97110 amino acids of apoptin(AP)(AA@G))was constructed through camouflaging AZD6738(ATR small-molecule inhibitor)-binding human serum albumin onto the AP-Au supramolecular *** expected,both in vitro and in vivo experiment results verified that the AA@G possessed extraordinary biocompatibility and enhanced therapeutic effect through inducing cell cycle arrest,promoting DNA damage and inhibiting DNA repair of hepatoma *** work not only provides a co-delivery strategy for intensive liver cancer treatment with the clinical translational potential,but develops a common approach to unify the pharmacokinetics of peptide and small-molecular compounds,thereby extending the scope of drugs for developing the advanced combination therapy.

关键词： Liver cancer Drug combination Cancer therapy ATR inhibitor XPO1 inhibitor

Dimensional reduction enhances photocatalytic carbon dioxide reduction performance of metal-organic frameworks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第5期17卷 3653-3659页

作者： Kaiyue ma Jixin Li jinlu Liu Chunguang Li Zhan Shi Shouhua Feng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

Metal-organic frameworks(MOFs)have shown significant potential as *** has been widely assumed that all catalytic active sites within MOFs are functional in photocatalytic reactions but for a three-dimensional MOF,whether the internal catalytic active sites can effectively absorb light and actively contribute to photocatalytic reactions remains to be *** this context,we synthesized a two-dimensional nanosheet MOF(2D-MOF)and a three-dimensional bulk MOF(3D-MOF)composed of Zr^(6) clusters and tetracarboxylic porphyrin(TCPP)by the approach described in the ***(bpy)(CO)^(3)Cl(bpy=2,2’-bipyridine),which has remarkable CO_(2) photoreduction ability,was introduced to the two MOFs to create two new photocatalysts 2D-MOF-Re and 3D-MOF-Re,*** CO_(2) reduction experiments show that based on the equal number of catalytic active sites,the CO turnover number(TON)of 2D-MOF-Re reaches 27.8 in 6 h,which is 50 times that of *** result shows that certain catalytic active sites inside the bulk MOF are inactive due to the inability to absorb *** study illuminates the potential of the dimensional reduction approach in the design of photocatalysts to exploit the capabilities fully.

关键词： photocatalysis CO_(2)reduction metal-organic frameworks(MOFs) nanosheets light absorption

2021年度国家自然科学基金肿瘤Ⅰ学科面上类项目分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国肿瘤临床 2022年第7期49卷 352-361页

作者：马瑾璐吕群燕国家自然科学基金委员会医学科学部北京市100085 西安交通大学第一附属医院肿瘤放射治疗科

2021年国家自然科学基金委员会医学科学部肿瘤学科采用了以科学问题为引导的新申请代码体系,申请与资助项目也呈现出新的特点与趋势。本文介绍了2021年度国家自然科学基金肿瘤Ⅰ学科面上类项目(包括面上项目、青年科学基金项目、地区科... 详细信息

2021年国家自然科学基金委员会医学科学部肿瘤学科采用了以科学问题为引导的新申请代码体系,申请与资助项目也呈现出新的特点与趋势。本文介绍了2021年度国家自然科学基金肿瘤Ⅰ学科面上类项目(包括面上项目、青年科学基金项目、地区科学基金项目)的申请与资助情况,并根据新申请代码体系、肿瘤发生部位、研究热点等方面,对2021年度肿瘤Ⅰ学科申请与资助的项目进行深入分析。

关键词：国家自然科学基金肿瘤Ⅰ学科申请代码面上类项目

浅析以中国式现代化推动交通安全治理开启新时代新征程

在线全文

学校读者我要写书评

暂无评论

汽车与安全 2023年第3期 80-84页

作者：马金路公安部道路交通安全研究中心

习近平总书记在二十大报告中聚焦中国式现代化,深刻阐述了中国式现代化的一系列重大理论和实践问题。党的二十大报告还以专章论述推进国家安全体系和能力现代化,将国家安全摆在突出位置。道路交通管理作为事关人民群众生命财产安全、事... 详细信息

习近平总书记在二十大报告中聚焦中国式现代化,深刻阐述了中国式现代化的一系列重大理论和实践问题。党的二十大报告还以专章论述推进国家安全体系和能力现代化,将国家安全摆在突出位置。道路交通管理作为事关人民群众生命财产安全、事关民生福祉的行业,承载着服务经济社会发展和保障改善民生的责任使命。坚持人民至上、生命至上,牢牢守住安全发展底限,切实守护人民群众生命财产安全,是公安交管部门的重要使命任务。本文以贯彻学习党的二十大重要精神为引领,深入领会中国共产党的中心任务以及中国式现代化的科学内涵,特别是坚持以人民为中心、坚持全面深化改革、坚持依法治国等内容,浅析在新的重要历史节点,改革和重塑交通安全治理体系,提升交通安全治理能力的重要性,为以中国式现代化推动交通安全治理开启新征程提供建设性意见。

关键词：中国式现代化中国特色社会主义以人民为中心交通安全治理体系对策建议

A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第2期6卷 235-237页

作者： Mingming Xiao Joshua S.Fried jinlu ma Yang Su Rebecca J.Boohaker Qinghua Zeng Yaqi Mo Fanbiao Meng Rong Xiang Bo Xu Department of Biochemistry and Molecular Biology Key Laboratory of Breast Cancer Prevention and TherapyMinistry of EducationTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300060China Department of Oncology Southern Research InstituteBirminghamAL 35205USA Cell Biology Program University of Alabama at BirminghamBirminghamAL 35205USA Department of Radiation Oncology First Afliated HospitalXian Jiaotong UniversityXi'anChina Department of Biochemistry and Molecular Biology Nankai University School of MedicineTianjinChina Center for Itelligent Oncology Chongqing University Cancer HospitalChongqing University School of MedicineChongqing 400030China

Dear Editor,Accumulating evidence supports that,as a critical genome guardian mechanism,the DNA damage response(DDR)is a barrier to early *** a crucial DDR pathway,Ataxia Telangiectasia Mutated(ATM)-mediated phosphorylation of downstream targets is essential for activation of cell cycle checkpoints,DNA repair,and programed cell death in the presence of DNA *** extensive biochemical and cellular studies on ATM phosphorylation,these phosphorylation sites are rarely mutated in cancers,challenging the pathophysio-logical relevance of ATM-mediated phosphorylation in the disease setting.

关键词： damage DDR ATM

机动车礼让行人的基本通行规则设计与执行提升对策

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

综合运输 2023年第6期45卷 3-7,28页

作者：马金路巩建国公安部道路交通安全研究中心北京100062 东南大学交通学院江苏南京211189

多年来通过公安交管部门常态长效治理,我国路口交通秩序明显改善,过街设施不断完善,行人过街安全体验不断提升。但“斑马线”的安全问题仍是城市交通管理的重点难点,人车冲突矛盾仍是问题的主要根源,人车行为的规范则是解决问题的基础... 详细信息

多年来通过公安交管部门常态长效治理,我国路口交通秩序明显改善,过街设施不断完善,行人过街安全体验不断提升。但“斑马线”的安全问题仍是城市交通管理的重点难点,人车冲突矛盾仍是问题的主要根源,人车行为的规范则是解决问题的基础和前提。因此,论文从规范驾驶人行为角度,广泛借鉴国内外机动车驾驶人礼让行人的经验和做法,系统梳理“斑马线”周边交通运行的法理、伦理和物理,明晰驾驶人在不同场景下礼让行人的操作规范。这对于提升机动车驾驶人礼让行人法律条款的执行力,切实提高斑马线的安全性和通行效率,以此为切入点提高城市道路交通管理水平具有重要意义。

关键词：交通安全驾驶人文明礼让通行规则城市交通管理

The expression of Fas, FasL and their biological behavior in human cervical carcinoma

在线全文

学校读者我要写书评

暂无评论

Journal of Nanjing Medical University 2006年第3期20卷 150-154页

作者： Suxia Han Qing Zhu Mingzhong Li Baoshan Su jinlu ma Department of Radiation Oncology First Hospital of Xi ＇an Jiaotong University Xi ＇an 710061 China

Objective： To investigate the relationship between the expression of Fas and Fas ligand （FasL） and its biological behavior in human cervix carcinoma. Methods： Immunohistochemisty technique was used to detect the expression of Fas and FasL in 47 cases of cervical carcinoma, 16 cases of cervical interaepithelial neoplasia, 10 cases of chronic cervicitis and 10 cases of normal cervix. TUNEL technique was used to observe the apoptic cells in 47 cases of cervical carcinoma. Retrospective study was carried out to find the relationship between the expression of Fas and FasL and cell apoptosis, clinical stage, pathological classification, lymph node metastasis, prognosis and age. Results： The expression of Fas and FasL was significantly different in different cervix （P 〈 0.01）, and also related to the degree of differentiation, lymph node metastasis and prognosis （P 〈 0.05）. But had no relation with clinical stage or age （P 〉 0.05） ; Cervix carcinoma cells apoptosis in different pathological classification appeared negative relation （Rs=-0.35, P 〈 0.05 ）. Cervix carcinoma cell apoptosis was significantly higher in Fas-positive and FasL- positive than that in Fas-negative and FasL-negative （P 〈 0.05）. By retrospective investigation, Fas-negative and FasL-positive were related to poor prognoses of the patients with cervical carcinoma （P 〈 0.05 ）. Conclusion： The development of apoptosis in cervix carcinoma has a promoting regulation function in Fas and FasL expression. Gene treatment can alter apoptosis abnormality, thus induce apoptosis in cancerous cell expressing Fas and FasL. Fas or FasL may be taken as a marker in the prognostic character- ization.

关键词： cervix carcinoma immunohistochemisty TdT-mediated dUTP nick and labeling (TUNEL) Fas Fas ligand

在线全文

学校读者我要写书评

暂无评论

我国新能源汽车安全驾驶管理对策研究

汽车与安全 2022年第10期 72-75页

作者：马金路巩建国公安部道路交通安全研究中心

我国新能源汽车产业发展迅速，产销量连续7年位居世界第一，截至今年6月底，我国新能源汽车保有量已突破1000万辆。但与此同时，新能源汽车自燃起火、驾驶误操作冲撞人员等一系列事件频频引起社会关注。据2018至2020年统计数据显示，我... 详细信息

我国新能源汽车产业发展迅速，产销量连续7年位居世界第一，截至今年6月底，我国新能源汽车保有量已突破1000万辆。但与此同时，新能源汽车自燃起火、驾驶误操作冲撞人员等一系列事件频频引起社会关注。据2018至2020年统计数据显示，我国新能源汽车事故数年平均以171%速度递增，死亡人数以157%速度递增。深究其因，主要是由于新能源汽车特别是电动汽车的动力来源不同，导致车辆性能改变，进而产生车辆安全、驾驶安全等方面的风险，对交通安全的影响不可忽视。本文简要分析了我国新能源汽车发展趋势特点，分类挖掘新能源汽车的交通安全风险，并提出相应改进意见建议。

关键词：新能源汽车安全驾驶电动智能交通风险对策建议