检索结果-南通市图书馆

Safety and activity of WX-0593(Iruplinalkib)in patients with ALK-or ROS1-rearranged advanced non-small cell lung cancer:a phase 1 dose-escalation and dose-expansion trial

引用

Signal Transduction and Targeted Therapy 2022年第2期7卷 573-582页

作者： Yuankai Shi Jian Fang Xuezhi Hao Shucai Zhang Yunpeng Liu Lin Wang Jianhua Chen Yi Hu Xiaosheng Hang Juan Li Chunling Liu Yiping Zhang Zhehai Wang Yanping Hu Kangsheng Gu Jian’an Huang Liangming Zhang jinlu shan Weiwei Ouyang Yanqiu Zhao Wu Zhuang Yan Yu Jun Zhao Helong Zhang Pei Lu Weidong Li Meimei Si Mingjing Ge Huaize Geng National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs100021 BeijingP.R.China Beijing Cancer Hospital 100142 BeijingP.R.China Beijing Chest Hospital Capital Medical University101149 BeijingP.R.China The First Hospital of China Medical University 110001 ShenyangP.R.China Hunan Cancer Hospital 410000 ChangshaP.R.China Chinese PLA General Hospital 100853 BeijingP.R.China Affiliated Hospital of Jiangnan University 214062 WuxiP.R.China Sichuan Cancer Hospital 610041 ChengduP.R.China Affiliated Tumour Hospital of Xinjiang Medical University 830000 UrumqiP.R.China Zhejiang Cancer Hospital 310022 HangzhouP.R.China shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences250117 JinanP.R.China Hubei Cancer Hospital 430079 WuhanP.R.China The First Affiliated Hospital of Anhui Medical University 230022 HefeiP.R.China The First Affiliated Hospital of Soochow University 215006 SuzhouP.R.China Yantai Yuhuagding Hospital Yantai 264000P.R.China Army Medical Center of People’s Liberation Army 400042 ChongqingP.R.China Guizhou Cancer Hospital 520100 GuiyangP.R.China Henan Cancer Hospital 450008 ZhengzhouP.R.China Fujian Province Cancer Hospital 350014 FuzhouP.R.China Harbin Medical University Cancer Hospital 150081 HarbinP.R.China Tangdu Hospital of the Fourth Military Medical University 710038 Xi’anP.R.China Liuzhou People’s Hospital 545006 LiuzhouP.R.China Cancer Center of Guangzhou Medical University 510095 GuangzhouP.R.China Qilu Pharmaceutical Co. Ltd250101 JinanP.R.China

WX-0593(Iruplinalkib)is a novel,highly selective oral ALK and ROS1 tyrosine kinase inhibitor(TKI).In this study,the safety,antitumor activity,and pharmacokinetics of WX-0593 were evaluated in advanced non-small cell lung cancer(NSCLC)patients with ALK or ROS1 *** the dose-escalation phase and dose-expansion phase,patients were treated with WX-0593 until disease progression,unacceptable toxicity,or subject *** the dose-escalation phase,the primary endpoints were maximum tolerated dose(MTD),dose-limiting toxicity(DLT),and safety assessed by *** the dose-expansion phase,the primary endpoint was objective response rate(ORR)assessed by *** September 25,2017 and October 15,2018,a total of 153 patients received WX-0593 *** dose-limiting toxicities(DLTs)including one grade 3 QT interval prolonged and one grade 2 chronic heart failure were reported at the dose of 300 mg in one *** was not ***,140 of the 152(92%)patients experienced treatment-related adverse events(TRAEs)and 35 of the 152(23%)patients had TRAEs≥grade *** overall ORR was 59.3%(32 of 54)for the dose-escalation phase and 56.6%(56 of 99)for the dose-expansion *** patients who were ALK-rearranged and ALK TKI naive,the ORR were 81.0%(17 of 21)in the dose-escalation phase and 76.3%(29 of 38)in the dose-expansion phase,and for patients who previously received crizotinib as the only ALK TKI,the ORR were 38.1%(8 of 21)and 45.7%(21 of 46)for the two phases,*** patients who were ROS1-rearranged,the ORR were 30.0%(3 of 10)in the dose-escalation phase and 44.4%(4 of 9)in the dose-expansion ***-0593 showed favorable safety and promising antitumor activity in advanced NSCLC patients with ALK or ROS1 rearrangement.

关键词： patients expansion phase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肺癌患者血液流变学及相关指标变化的临床分析

引用

中国临床医生杂志 2021年第1期49卷 35-37页

作者：何静郭玲单锦露陆军军医大学大坪医院干细胞再生医学科重庆400042 陆军军医大学大坪医院武器杀伤生物效应评估研究室重庆400042 陆军军医大学大坪医院肿瘤中心重庆400042

目的分析肺癌患者早晚期血小板参数及血液流变学指标检测的临床意义。方法选取2019年6月至2020年6月陆军军医大学大坪医院肺癌患者67例为肺癌组及健康体检者40位为对照组,两组均行血小板参数及血液流变学指标检测,比较两组的血小板计数... 详细信息

目的分析肺癌患者早晚期血小板参数及血液流变学指标检测的临床意义。方法选取2019年6月至2020年6月陆军军医大学大坪医院肺癌患者67例为肺癌组及健康体检者40位为对照组,两组均行血小板参数及血液流变学指标检测,比较两组的血小板计数、血细胞比容、全血黏度(低切、中切、高切)、血浆黏度、红细胞聚集指数、红细胞变形指数、红细胞刚性指数及卡松黏度等指标。结果肺癌组全血黏度(高切、中切、低切)、血浆黏度、红细胞变形指数、红细胞刚性指数、血小板计数、卡松黏度指标均高于对照组,而血细胞比容低于对照组;肺癌晚期组全血黏度(高切、低切)、血浆黏度、红细胞变形指数、红细胞刚性指数及卡松黏度指标均高于肺癌早期组,而血细胞比容低于肺癌早期组;肺癌转移组全血黏度(低切)、红细胞刚性指数、红细胞变形指数、血浆黏度、卡松黏度指标均高于肺癌未转移组,而血细胞比容低于肺癌未转移组(P<0.05)。结论肺癌患者普遍存在血液高凝状态,在肺癌晚期及肺癌转移患者中表现更突出,因此监测血液流变学及血小板参数指标,对肺癌的进展及病程的观察具有实用的临床意义。

关键词：肺癌血小板参数血液流变学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

P2Y1 receptor in Alzheimer’s disease

引用

Neural Regeneration Research 2025年第2期20卷 440-453页

作者： shan Luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

数字化喉标本模型的建立与虚拟现实仿真

引用

解剖学杂志 2009年第2期32卷 230-233页

作者：谭立文张肖莎宋林单锦露李振强张绍祥第三军医大学基础部解剖学教研室重庆市计算医学研究所第三军医大学学员旅二队重庆400038

目的:为喉的解剖学教学提供丰富多样的教学模型,模拟喉区解剖结构的虚拟仿真解剖学教学,拓展解剖学的教学模式和教学手段。方法:利用人工识别的方法对第2例中国数字化可视人体喉区段的图像进行图像分割,建立高精度的彩色分割数据集,利... 详细信息

目的:为喉的解剖学教学提供丰富多样的教学模型,模拟喉区解剖结构的虚拟仿真解剖学教学,拓展解剖学的教学模式和教学手段。方法:利用人工识别的方法对第2例中国数字化可视人体喉区段的图像进行图像分割,建立高精度的彩色分割数据集,利用自主开发的图像格式转换软件将彩色分割数据自动转换为灰度分割数据。利用Amira可视化软件对灰度分割数据进行阈值分割,经三维重建,建立喉区主要器官结构的数字解剖模型。在立体显示环境中,并利用交互式设备实现了数字模型的显示与隐藏、旋转与切割等虚拟仿真解剖,模拟喉区主要解剖结构的虚拟仿真解剖学教学。结果:建立了喉的精细数字解剖标本模型,该模型真实地反映了实际的解剖标本,具有形象直观的特点,可无限次使用,在虚拟现实环境中真实仿真了喉区标本的解剖学展示。结论:利用中国数字化可视人体可建立喉区细小结构的数字解剖标本,对模型可实时交互式地进行仿真解剖教学。

关键词：数字解剖学数字解剖标本中国可视化人体虚拟仿真

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Successful emergency surgical intervention in acute non-STsegment elevation myocardial infarction with rupture:A case report

引用

World Journal of Clinical Cases 2025年第4期13卷 41-47页

作者： Xing-Po Li Zi-shan Wang Hong-Xia Yu shan-shan Wang Department of Cardiovascular Medicine Huantai County Hospital of Traditional Chinese MedicineZibo 256400Shandong ProvinceChina Department of Cardiovascular Medicine Zibo Hospital of Integrated Traditional Chinese and Western MedicineZibo 255500Shandong ProvinceChina

BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with *** of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle *** FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be *** septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair *** SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary *** resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient *** This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.

关键词： Acute non-ST segment elevation myocardial infarction Cardiac rupture Acute myocardial infarction Free wall rupture Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

多肿瘤标志物蛋白芯片检测中CA125对恶性肿瘤的诊断价值

引用

中国肿瘤临床 2012年第9期29卷 607-610页

作者：蒋萱王东杨雪琴单锦露王阁杨镇洲李增鹏杨宇馨隋江东第三军医大学大坪医院野战外科研究所肿瘤中心重庆市400042 第三军医大学在读博士生

目的:探讨多肿瘤标志物蛋白芯片中糖链抗原CA125对恶性肿瘤的诊断价值方法:收集第三军医大学大坪医院可供分析的25 076例多肿瘤蛋白芯片检测结果,分析CA125在不同人群、不同肿瘤中升高情况,以及CA125升高伴随其他检测指标升高在肿瘤中... 详细信息

目的:探讨多肿瘤标志物蛋白芯片中糖链抗原CA125对恶性肿瘤的诊断价值方法:收集第三军医大学大坪医院可供分析的25 076例多肿瘤蛋白芯片检测结果,分析CA125在不同人群、不同肿瘤中升高情况,以及CA125升高伴随其他检测指标升高在肿瘤中的分布情况。结果:CA125在恶性肿瘤患者中明显高于良性病变患者及正常体检者,而且卵巢癌最高(51.92%),其次为胰腺癌(49.25%)和肝癌(42.56%);同时升高的指标以CEA最为常见,其次为CA199、CA242和Ferritin,CA125/CEA同时升高最常见于结直肠癌(83.87%),其次为乳腺癌(59.72%),CA125/CA199同时升高最常见于结直肠癌(90.97%)和胰腺癌(78.63%),CA125/CA242伴随升高最常见于结直肠癌(92.26%)和胰腺癌(74.81%),CA125+CEA+CA199及CA125+CEA+CA199+CA242升高均最常见于肺癌。结论CA125单项指标升高对卵巢癌、胰腺癌及肝癌的诊断有较高的价值,CA125伴随或联合CEA、CA199、CA242检测有利于提高结直肠癌、胰腺癌、肺癌的诊断阳性率。

关键词：肿瘤标志物多肿瘤蛋白质芯片 CA125

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

引用

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan Ping Yu Emily Choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

引用

Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu shan Ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

引用

Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

223例非小细胞肺癌骨转移发生骨相关事件的临床因素与预后

引用

重庆医学 2015年第32期44卷 4504-4506页

作者：王帅李钱卿毅仲召阳单锦露关伟杨雪琴王阁杨镇洲王东第三军医大学大坪医院野战外科研究所肿瘤中心重庆400042

目的研究非小细胞肺癌（NSCLC）骨转移发生骨相关事件（SREs）的风险因素及其对患者预后的影响。方法回顾性研究2010-2012年该院223例NSCLC骨转移患者的临床特征,用单因素分析和多因素分析对SREs的预测因素分析。结果223例NSCLC骨转移... 详细信息

目的研究非小细胞肺癌（NSCLC）骨转移发生骨相关事件（SREs）的风险因素及其对患者预后的影响。方法回顾性研究2010-2012年该院223例NSCLC骨转移患者的临床特征,用单因素分析和多因素分析对SREs的预测因素分析。结果223例NSCLC骨转移患者中,发生SREs患者为119例（53.4%）。单因素分析显示女性、无吸烟史、腺癌、单发骨转移病灶患者发生SREs风险低于男性、吸烟史、非腺癌、多发骨转移病灶患者,差异有统计学意义（P〈0.05）,其余各项差异无统计学意义（P〉0.05）。多因素分析显示多发骨转移是发生SREs的独立风险因素。NSCLC骨转移患者的中位生存时间为15.3个月,生存分析显示NSCLC骨转移患者发生SREs对预后无显著影响（P〉0.05）。结论 NSCLC骨转移患者中,女性、腺癌、不吸烟史、单发骨转移病灶患者发生SREs风险更低,多发骨转移是发生SREs的独立风险因素,应注意监测和预防。

关键词：癌,非小细胞肺骨转移骨相关事件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：