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Loss of CO_2 sensing by the olfactory system of CNGA3 knockout mice

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Current Zoology 2010年第6期56卷 793-799页

作者： jinlong han Minmin LUO National Institute of Biological Sciences Beijing 102206 China College of Life Sciences Beijing Normal University Beijing 100875 China

Atmospheric CO2 can signal the presence of food, predators or environmental stress and trigger stereotypical behaviors in both vertebrates and invertebrates. Recent studies have shown that the necklace olfactory system in mice sensitively detects CO2 in the air. Olfactory CO2 neurons are believed to rely on cyclic gnanosine monophosphate （cGMP） as the key second messenger; however, the specific ion channel underlying CO2 responses remains unclear. Here we show that CO2-evoked neuronal and behavioral responses require cyclic nucleotide-gated （CNG） channels consisting of the CNGA3 subunit. Through Ca2＋-imaging, we found that CO2-triggered Ca2＋ influx was abolished in necklace olfactory sensory neurons （OSNs） of CNGA3-knockout mice. Olfactory detection tests using a Go/No-go paradigm showed that these knockout mice failed to detect 0.5% CO2. Thus, sensitive detection of atmospheric CO2 depends on the function of CNG channels consisting of the CNGA3 subunit in necklace OSNs. These data support the important role of the necklace olfactory system in CO2 sensing and extend our understanding of the signal transduction pathway mediating CO2 detection in mammals [Current Zoology 56 （6）： 793-799, 2010].

关键词： Olfactory sensory neurons Ca2+ imaging Go/No-go cGMP Guanylyl cyclase CNG channels

Puerariae Radix protects against ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation

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Food Science and Human Wellness 2024年第4期13卷 2266-2276页

作者： Yu Ga Yuanyuan Wei Qingyu Zhao Yimeng Fan Yannan Zhang Zhifang Zhang Sijia Hao Lixia Wang Zhifen Wang jinlong han Shuang Wu Zhihui Hao Innovation Centre of Chinese Veterinary Medicine College of Veterinary MedicineChina Agricultural UniversityBeijing 100086China National Center of Technology Innovation for Medicinal Function of Food National Food and Strategic Reserves AdministrationBeijing 100193China Inner Mongolia Medical University Hohhot 010059China China Agricultural University Yantai Institute Yantai 264670China Shandong Academy of Agricultural Sciences Jinan 250100China

Ulcerative colitis(UC)is a common inflammatory disease of the gastrointestinal *** Chinese medicine(TCM)has long been used in Asia as a treatment for UC and Puerariae Radix(PR)is a reliable anti-diarrheal *** aims of this study were to investigate the protective effect of PR using the dextran sulfate sodium salt(DSS)-induced UC model in mice and identify molecular mechanisms of PR *** chemical constituents of PR via ultra-performance liquid chromatography/tandem mass spectrometry and identified potential PR and UC targets using a network pharmacology(NP)approach were obtained to guide mouse experiments.A total of 180 peaks were identified from PR including 48 flavonoids,46 organic acids,14 amino acids,8 phenols,8 carbohydrates,7 alkaloids,6 coumarins and 43 other *** results showed that caspase-1 was the most dysregulated of the core genes associated with UC.A PR dose of 0.136 mg/g administered to DSS treated mice reversed weight loss and decreased colon lengths found in UC *** also alleviated intestinal mucosal shedding,inflammatory cell infiltration and mucin *** treatment suppressed upregulation of NOD-like receptor protein 3(NLRP3),cysteinyl aspartate-specific proteases-1(caspase-1),apoptosis-associated speck-like(ASC)and gasdermin D(GSDMD)at both the protein and m RNA expression *** addition of a small molecule dual-specificity phosphatase inhibitor NSC 95397 inhibited the positive effects of *** results indicated that PR exerts a protective effect on DSS-induced colitis by inhibiting NLRP3 inflammasome activation in mice.

关键词： Puerariae Radix Ulcerative colitis Molecular mechanisms Pyroptosis NOD-like receptor protein 3 inflammasome

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孤立电网中风电和储能的联合非线性鲁棒控制

西安交通大学学报 2023年第9期57卷 152-161页

作者：韩金龙杜正春江晗袁枭添西安交通大学电气工程学院西安710049

为优化风储孤立电网的暂态特性以提升其在恶劣运行环境下的抗干扰能力,提出了孤立电网中风电和储能的联合非线性鲁棒控制策略。基于状态反馈精确线性化及鲁棒H∞最优控制理论,并综合考虑了系统建模时同步电机的转矩扰动、功率扰动、电... 详细信息

为优化风储孤立电网的暂态特性以提升其在恶劣运行环境下的抗干扰能力,提出了孤立电网中风电和储能的联合非线性鲁棒控制策略。基于状态反馈精确线性化及鲁棒H∞最优控制理论,并综合考虑了系统建模时同步电机的转矩扰动、功率扰动、电压扰动等各种干扰因素,首先通过构造微分同胚非线性坐标变换,建立了风储孤立电网的精确线性化动态模型,进而设计了风电和储能的联合鲁棒控制器;所提控制策略可使风机实时地保持最优转速以输出最大风功率,并通过风电与储能的联合控制使系统出力跟踪负荷变化,实现了多目标控制。仿真验证表明,提出的风电和储能的联合非线性鲁棒控制策略对外界风速及负荷的扰动具有很强的鲁棒性;当外界风速突变或系统负荷突变时,风储孤网在非线性鲁棒控制器作用下可以迅速且平滑地过渡至稳态,有效避免了采用传统PI控制时调节过程中出现的超调及2~3次振荡,能显著提升风储孤立电网的暂态特性。该研究为风储孤立电网的联合控制提供设计理论基础及工程实践。

关键词：孤立电网储能精确线性化非线性鲁棒控制联合控制

Morphological characteristics in the area off eastern Taiwan Island and their tectonic implications

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Acta Oceanologica Sinica 2004年第3期23卷 449-461页

作者： LIUBaohua ZHENGYanpeng WUjinlong hanGuozhong ZhanGDeyu FirstInstituteofOceanography StateOceanicAdministrationQingdao266061China KeyLaboratoryofMarineSedimentologyandEnvironmentalGeologyofStateOceanicAdministration Qingdao2660061China

On the basis of bathymetric data and other geological and geophysical data obtained during the first survey conducted by Chinese Mainland in the area off eastern Taiwan Island from May to June in 2000, the morphological features of the region, the tectonic control to the seafloor topography and their tectonic implication are studied and discussed. The results have revealed that both the slope zone of the Ryukyu arc and the Ryukyu Trench present a typical morphotectonic characteristics controlled by the trench-arc system in the West Pacific Ocean. At the slope of eastern Taiwan Island the isobathic lines parallel to the coastline and distribute densely in nearly N-S direction and the slope gradient of topography is large. Such a unique feature is attributed to the collision of the Luzon arc and Eurasia continent. In the Huatung Basin, turbidity fans and submarine canyons are well developed, the formations of which are mainly related to the steep topography of the slope of the Luzon arc and the abundant supply of sediments. These submarine canyons are controlled by basement highs and strike-slip faults. On eastern side and western side of the Gagua Ridge, both the water depth and morphological features are different, but the basement of Gagua Ridge belongs to the Huatung Basin. The eastern side of the Gagua Ridge (123°12′E) corresponds to the boundary of two plates with different ages. In the West Philippine Basin, linear ridges and troughs in a NW trending are identified, which are dissected by a NE trending transform fault. According to the seafloor topography features, the direction of the transform fault and the magnetic anomaly lineations, the seafloor of this region was formed during 60-45 Ma B. P. when the West Philippine Basin was spreading along NE-SW relative to the present orientation.

关键词： Taiwan Island morphological characteristics tectonic implications

外语教学与信息技术的深度融合路径研究——学术英语教学改革与实践

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外语界 2021年第2期 46-53,62页

作者：朱琳徐鹰韩金龙华南理工大学外国语学院广东广州510630

课堂教学与信息技术的深度融合是外语教学改革的重要途径,是新时代提高教学质量的关键。本研究基于华南理工大学"学术英语"课程建设与教学改革实践,探索依托立体化教材、线上课程和翻转课堂教学,实现学术英语教学与信息技术深度融合的... 详细信息

课堂教学与信息技术的深度融合是外语教学改革的重要途径,是新时代提高教学质量的关键。本研究基于华南理工大学"学术英语"课程建设与教学改革实践,探索依托立体化教材、线上课程和翻转课堂教学,实现学术英语教学与信息技术深度融合的有效路径。研究结果表明,学术英语立体化教材能够满足学生的学习需求,线上课程促进了学生自主学习和主动学习,翻转课堂教学提高了学生的学术英语能力及综合能力。本研究对我国学术英语教学改革与实践具有启示意义。

关键词：学术英语立体化教材慕课翻转课堂

IMPROVEMENT OF AERODYNAMIC PERFORMANCE OF SUPERSONIC AIRCRAFT USING CANARD SURFACE WITH TVFC

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Transactions of Nanjing University of Aeronautics and Astronautics 2006年第3期23卷 173-184页

作者： Abbas L K 陈前韩景龙南京航空航天大学航空宇航学院

The purpose of increasing the aerodynamic efficiency and enhancing the supermaneuverability for the selected supersonic aircraft is presented. Aerodynamic characteristics, the surface pressure distribution and the maximum lift are estimated for the baseline configuration for different Mach numbers and attack angles in subson- ic and supersonic potential flows, using a low-order three-dimensional panel method supported with the semi-empirical formulas of the data compendium （DATCOM）. Total nose-up and nose-down pitching moments about the center of gravity of the complete aircraft in the subsonic region depending on flight conditions and aircraft performance limitations are estimated. A software package is developed to implement the two-dimensional thrust vectoring flight control technique （pitch vectoring up and down） controlled by the advanced aerodynamic and control surface （the foreplane or the canard）. Results show that the canard with the thrust vectoring produces enough nose-down moment and can support the stabilizer at high maneuvers. The suggested surface can increase the aerodynamic efficiency （lift-to-drag ratio） of the baseline configuration by 5%-6% in subsonic and supersonic flight regimes.

关键词： aerodynamic efficiency maneuverability canard thrust vectoring flight control (TVFC)

几种直方图变换法在输电接头红外热像增强中的对比研究

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光学技术 2010年第5期36卷 662-667页

作者：齐超韩金龙梁浩齐赛哈尔滨工业大学哈尔滨150001 黑龙江省计量检定测试院哈尔滨150036 齐齐哈尔电业局齐齐哈尔161005

由红外热像仪直接得到的热像会受很多外来因素的干扰而致使图像模糊不清、对比度差,由此在故障诊断过程中,需要对热像进行后续增强处理。总结了影响热故障红外检测准确性的外部因素,分析了输电接头热像的基本特征,采用了基于平方根灰度... 详细信息

由红外热像仪直接得到的热像会受很多外来因素的干扰而致使图像模糊不清、对比度差,由此在故障诊断过程中,需要对热像进行后续增强处理。总结了影响热故障红外检测准确性的外部因素,分析了输电接头热像的基本特征,采用了基于平方根灰度变换直方图修正和全局均衡化两种方法对热像进行了增强处理。在分析上述两种方法优劣的基础上,提出了一种基于线性平滑滤波的局部均衡化方法。结果表明,基于线性平滑滤波的局部均衡化方法对于处理输电接头热像更有效。

关键词：红外热像故障诊断直方图平滑滤波

基于状态反馈精确线性化的双馈异步风机最优控制策略

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中国电机工程学报 2024年第9期44卷 3508-3517,I0014页

作者：韩金龙袁枭添江晗戴耀辉杨锐杜正春西安交通大学电气工程学院陕西省西安市710116

该文基于微分几何理论,从状态空间的角度出发对双馈异步风机(doubly fed induction generator,DFIG)的机侧变换器和网侧变换器独立设计,通过构造微分同胚变换将其动态模型精确线性化并设计相应的非线性控制律,实现了多目标最优控制。通... 详细信息

该文基于微分几何理论,从状态空间的角度出发对双馈异步风机(doubly fed induction generator,DFIG)的机侧变换器和网侧变换器独立设计,通过构造微分同胚变换将其动态模型精确线性化并设计相应的非线性控制律,实现了多目标最优控制。通过仿真验证表明,基于状态反馈精确线性化的双馈异步风机最优控制策略能有效抵御外界风况和电网电压的剧烈变动并快速恢复稳定,呈现优良的抗扰特性。

关键词：双馈异步风机状态反馈精确线性化非线性控制多目标最优控制微分同胚

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新形势下的建筑设计与城市规划

鞋类工艺与设计 2024年第12期4卷 177-179页

作者：韩进龙甘肃星河工程咨询有限公司甘肃酒泉735000

本文以新形势下城市规划设计与建筑设计为研究对象,深入分析了它们之间的内在联系,探讨了城市规划设计的主要要求和重要性。基于此,本文揭示了当前存在的主要问题,包括缺乏合理的规划管理实施手段、对文化遗迹保护的忽视、公众参与机制... 详细信息

本文以新形势下城市规划设计与建筑设计为研究对象,深入分析了它们之间的内在联系,探讨了城市规划设计的主要要求和重要性。基于此,本文揭示了当前存在的主要问题,包括缺乏合理的规划管理实施手段、对文化遗迹保护的忽视、公众参与机制的匮乏等。针对这些问题,提出了一系列既可行又有益的规划设计策略,有助于推动建筑设计与城市规划的创新发展。

关键词：新形势建筑设计城市规划