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Polyphenol components in black chokeberry(Aronia melanocarpa)as clinically proven diseases control factors——an overview

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Food Science and Human Wellness 2024年第3期13卷 1152-1167页

作者： Ningxuan Gao Chi Shu Yuehua Wang jinlong tian Yuxi Lang Chenyu Jin Xingyue Cui Hanqian Jiang Shi’an Liu Zhiying Li Wei Chen Hao Xu Bin Li Department of Food Science College of FoodShenyang Agricultural UniversityShenyang 110161China Department of Food Science and Nutrition College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058China Chaoyang Beihe Food Co. Ltd.Chaoyang 122100China

The black chokeberry is rich in polyphenols,including flavonoids with anthocyanins,flavanols and lavonols as the main components and a variety of phenolic acids represented by chlorogenic *** of these polyphenols,black chokeberry has the effect of preventing and adjuvant therapy *** study summarized the current research results on the types and contents of functional components in black chokeberry,and analyzed their digestion,absorption and metabolism in human *** this basis,the disease control functions that have been proved effective in clinical research were reviewed and *** studies showed that black chokeberry have good prevention and adjuvant therapy effects on hyperlipidemia,hypertension,diabetes and *** there are different functional components in black chokeberry,its prevention and treatment of the same disease can come from multiple pathways,which provides a more reliable effectiveness for the disease control of different populations.

关键词： Black chokeberry Hyperlipidemia Hypertension Diabetes Inflammation

加工及贮藏条件下蔗糖降解产物对蓝莓花色苷稳定性及抗氧化活性的影响

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食品科学 2024年第14期45卷 51-59页

作者：辛美丽梁琪田金龙杨曙方杨一鋆李斌沈阳农业大学食品学院辽宁沈阳110866 浙江蓝美技术股份有限公司浙江诸暨311800

研究不同加工及贮藏条件下蔗糖降解产物(糠醛(2-furaldehyde,2-F)和5-羟甲基糠醛(5-hydroxymethylfurfural,5-HMF))对花色苷稳定性及抗氧化活性的影响。结果表明,在生产加工过程中,应控制加热温度≤85℃、pH值为3.0,此时对花色苷的保护... 详细信息

研究不同加工及贮藏条件下蔗糖降解产物(糠醛(2-furaldehyde,2-F)和5-羟甲基糠醛(5-hydroxymethylfurfural,5-HMF))对花色苷稳定性及抗氧化活性的影响。结果表明,在生产加工过程中,应控制加热温度≤85℃、pH值为3.0,此时对花色苷的保护效果最好且保留率最高,抗氧化活性最强。此外,苹果酸浓度低于0.1mol/L时和VC质量分数在0.05%~0.5%范围内对花色苷的稳定性也具有明显的破坏作用。在贮藏稳定性方面,避光贮藏会减少2-F和5-HMF的生成,进而提高花色苷的稳定性。研究结果为今后含蔗糖的花色苷制品制备及贮存提供了参考及技术指导,对加工过程中保持花色苷稳定性具有重要意义。

关键词：花色苷糠醛 5-羟甲基糠醛加工条件稳定性抗氧化活性

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基于熵权-AHP的海空目标威胁度评估方法

雷达与对抗 2024年第2期44卷 32-35页

作者：田金龙鲍鹏飞中国船舶集团有限公司第八研究院南京211153

针对目标威胁评估中主观与客观、数据与知识有效利用及其带来的综合评价等难题,提出基于熵权-AHP的海空目标威胁度评估方法。构建以隶属度计算为基础的海空目标指标体系,结合熵权的客观权重和AHP专家知识定性定量分析的优势,引入权重因... 详细信息

针对目标威胁评估中主观与客观、数据与知识有效利用及其带来的综合评价等难题,提出基于熵权-AHP的海空目标威胁度评估方法。构建以隶属度计算为基础的海空目标指标体系,结合熵权的客观权重和AHP专家知识定性定量分析的优势,引入权重因子,得到综合权重,实现海空目标威胁度综合评估,仿真表明了算法的有效性和适应性,为目标威胁评估研究提供借鉴和参考。

关键词：威胁评估熵权 AHP 指标体系

高果糖诱导2型糖尿病机制及中药多糖缓解2型糖尿病的靶点通路研究进展

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中草药 2024年第13期55卷 4598-4607页

作者：张晶玉董墨思郭乃菲韩晓伟田金龙王松杨宇峰石岩辽宁中医药大学辽宁沈阳110032 沈阳农业大学辽宁沈阳110866 辽宁晟启昊天生物医药科技有限公司辽宁沈阳110168

果糖作为膳食中的主要糖,通常以蔗糖或高果糖玉米糖浆的形式添加到饮食中。流行病学研究表明,过量摄入果糖是2型糖尿病(type 2 diabetes mellitus,T2DM)的一个风险因素,并且T2DM是在全球范围内流行的疾病。大量研究表明,中药具有明显的... 详细信息

果糖作为膳食中的主要糖,通常以蔗糖或高果糖玉米糖浆的形式添加到饮食中。流行病学研究表明,过量摄入果糖是2型糖尿病(type 2 diabetes mellitus,T2DM)的一个风险因素,并且T2DM是在全球范围内流行的疾病。大量研究表明,中药具有明显的降糖作用,其生物活性成分主要包含多糖、黄酮、皂苷等。通过阐明高果糖摄入可能影响肝脏胰岛素抵抗和糖代谢导致T2DM的发生,讨论中药多糖改善这2种糖尿病发生机制的靶点和通路,为开发含有中药多糖的降血糖药物和功能性食品提供参考。

关键词：中药多糖高果糖摄入 2型糖尿病胰岛素抵抗糖代谢

基于工程认证导向的“5E”教学模式在机械基础课程中的应用研究

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农业科技与装备 2024年第3期 138-140页

作者：田金龙胡博文赵金李斌沈阳农业大学食品学院沈阳110866

机械基础是食品科学与工程专业重要的基础课,对食品专业工科课程教学起到支撑作用,是工程教育人才培养中的关键环节。以提高机械基础的教学质量为目的,提出基于工程认证导向的“5E”教学模式,通过探究(exploration)、吸引(engagement)... 详细信息

机械基础是食品科学与工程专业重要的基础课,对食品专业工科课程教学起到支撑作用,是工程教育人才培养中的关键环节。以提高机械基础的教学质量为目的,提出基于工程认证导向的“5E”教学模式,通过探究(exploration)、吸引(engagement)、解释(explanation)、评价(evaluation)和迁移(elaboration)5个方法,同时借助雨课堂在线教学平台将教学过程分为课前、课中和课后3个部分,可提升学生的知识理解能力,提高教学质量,优化教学效果,并为提高食品专业院校机械基础课程的教学水平提供参考。

关键词：工程认证 “5E”教学模式机械基础课程改革

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The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities

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Food Science and Human Wellness 2023年第5期12卷 1590-1600页

作者： Ningxuan Gao Xu Si Wenzhong Han Ersheng Gong Chi Shu jinlong tian Yuehua Wang Jiyue Zhang Binxu Li Bin Li Department of Food Science College of FoodShenyang Agricultural UniversityShenyang 110161China National R&D Professional Center For Berry Processing Shenyang 110161China Agriculture and Forest Institute in Arid of Liaoning Chaoyang 122000China

Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition from 7 chokeberry varieties produced in China. Totally, 11 kinds of main polyphenol monomers were identified and quantified by UPLC-Q-TOF-MS and UPLC-PDA. HepG2 cells were used to evaluate their cellular antioxidant and antiproliferative activities. Partial least squares method was utilized to analyze multivariate correlations between proportion of different composition and monomers in total polyphenols with these activities. The results showed that the highest proportion in chokeberry polyphenols was proanthocyanidins. In comparing the bioactivities of 7 varieties of chokeberry, ‘Viking' and purple chokeberry had the strongest antioxidant activity, while 'Fukangyuan 1#' had the strongest antiproliferative activity. In terms of the contribution sources of these bioactivities, the total antioxidant activity of chokeberry mainly depended on the contribution of free polyphenols. As the main source of cellular antioxidant activity, anthocyanins and neochlorogenic acid can provide more contribution. The antiproliferative activity mainly depended on the proportion of free polyphenols and proanthocyanidins in total polyphenols. The results may provide some new possibilities for the comprehensive utilization of polyphenols from chokeberry.

关键词： Chokeberry Anthocyanins Proanthocyanidins Antioxidant Antiproliferation

Lonicera caerulea polyphenols inhibit fat absorption by regulating Nrf2-ARE pathway mediated epithelial barrier dysfunction and special microbiota

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Food Science and Human Wellness 2023年第4期12卷 1309-1322页

作者： Yuehua Wang Ningxuan Gao Andrea Nieto-Veloza Lingxi Zhou Xiyun Sun Xu Si jinlong tian Yang Lin Xinyao Jiao Bin Li College of Food Science Shenyang Agricultural UniversityShenyang 110161China Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing of Liaoning Province Shenyang 110161China Instituto de Ciencia y Tecnología de Alimentos Universidad Nacional de ColombiaBogotá111311Colombia Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China College of Food Science and Technology Zhejiang University of TechnologyHangzhou 310014China

Scope:High-fat diet(HFD)induces imbalance in the small intestine environment,where fat digestion and absorption mainly take *** study aimed to elucidate the mechanisms by which Lonicera caerulea polyphenols(LCP)might inhibit fat absorption,from the perspective of small intestine microbiota and epithelial barrier *** and results:Male Sprague-Dawley rats were given HFD with or without co-administration of LCP for 8 *** results showed that LCP supplementation significantly decreased the levels of serum triglycerides(TG),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C),and increased the contents of fecal sterols,in HFD *** also inhibited the dysfunction of the small intestine epithelial barrier,via alleviating the oxidative stress activated by Nrf2-ARE pathway,and by modulating the expressions of pro-inflammatory factors such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),cyclooxygenase-2(COX-2),nuclear factor kappa-B p65(NF-κB p65)and inducible nitric oxide synthase(iNOS)in the small ***,LCP administration restored the balance in small intestine microbiota and increased the abundance of the specific bacteria,such as Lactobacillus,involved in fat ***:Our results demonstrated that LCP may be beneficial to inhibit fat *** mechanism seems to be associated with the protection of the epithelial barrier integrity and the modulation of specific bacteria in the small intestine.

关键词： Lonicera caerulea berries Polyphenols Gut microbiota Oxidative stress Intestinal epithelial barrier

Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice

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Acta Pharmaceutica Sinica B 2018年第2期8卷 306-315页

作者： Zhizhen Qin Shoubao Wang Yihuang Lin Ying Zhao Shengqian Yang Junke Song Tao Xie jinlong tian Song Wu Guanhua Du Beijing Key Laboratory of Drug Target and Screening Research Department of New Drug R&D Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College

A mangiferin aglycon derivative J99745 has been identified as a potent xanthine oxidase(XOD) inhibitor by previous in vitro study. This study aimed to evaluate the hypouricemic effects of J99745 in experimental hyperuricemia mice, and explore the underlying mechanisms. Mice were orally administered 600 mg/kg xanthine once daily for 7 days and intraperitoneally injected 250 mg/kg oxonic acid on the 7 th day to induce hyperuricemia. Meanwhile, J99745(3, 10, and 30 mg/kg), allopurinol(20 mg/kg) or benzbromarone(20 mg/kg) were orally administered to mice for 7 days. On the 7 th day,uric acid and creatinine in serum and urine, blood urea nitrogen(BUN), malondialdehyde(MDA) content and XOD activities in serum and liver were determined. Morphological changes in kidney were observed using hematoxylin and eosin(H&E) staining. Hepatic XOD, renal urate transporter 1(URAT1), glucose transporter type 9(GLUT9), organic anion transporter 1(OAT1) and ATP-binding cassette transporter G2(ABCG2) were detected by Western blot and real time polymerase chain reaction(PCR). The results showed that J99745 at doses of 10 and 30 mg/kg significantly reduced serum urate, and enhanced fractional excretion of uric acid(FEUA). H&E staining confirmed that J99745 provided greater nephroprotective effects than allopurinol and benzbromarone. Moreover, serum and hepatic XOD activities and renal URAT1 expression declined in J99745-treated hyperuricemia mice. In consistence with the ability to inhibit XOD, J99745 lowered serum MDA content in hyperuricemia mice. Our resultssuggest that J99745 exerts urate-lowering effect by inhibiting XOD activity and URAT1 expression, thus representing a promising candidate as an anti-hyperuricemia agent.

关键词： Antihyperuricemic effect Mangiferin aglycon Derivative Xanthine oxidase Urate transporter 1

Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways

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Food Science and Human Wellness 2020年第2期9卷 136-145页

作者： Jie Lina jinlong tian Chi Shu Zhen Cheng Yunen Liu Weisheng Wang Ruihai Liu Bin Li Yuehua Wang National R&D Professional Center For Berry Processing Shenyang Agricultural UniversityLiaoningPR China Key Laborotary of Healthy Food Nutrition and Innovative Manufacturing LiaoningPR China Emergency Medicine Department of General Hospital of Shenyang Military Command Laboratory of Rescue Center of Severe Trauma PLALiaoningPR China Shenyang Blueberry Industry co.LTD. LiaoningPR China Department of Food Science Cornell UniversityIthacaNYUSA

Malvidin-3-galactoside(Mv-3-gal)is the major anthocyanin monomer in blueberry *** compound is well-characterized by its anti-oncogenesis function in multiple organs including *** the current study,the mechanism driving the anti-hepatocellular carcinoma(HCC)function of Mv-3-gal was further explored by focusing on apoptosis and metastases *** cell line Huh-7 was firstly administrated with Mv-3-gal of different concentrations and the effect of Mv-3-gal on cell proliferation,apoptosis,colony formation ability,metastasis potential as well as the activity of Akt/PTEN and MAPK pathways was *** results showed that Mv-3-gal inhibited the cell proliferation and colony formation ability,induced cell cycle arrest and apoptosis in a dose-dependent *** the metastasis potential,Mv-3-gal suppressed the migration and invasion potential of Huh-7 cells by regulating MMPs *** together,the findings highlighted the anti-HCC potent of Mv-3-gal,which was associated with the inhibition of Akt/PTEN,MAPK and MMP pathways.

关键词： Malvidin-3-galactoside Hepatocellular carcinoma Apoptosis MAPK signaling