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Unlock the full potential of carbon cloth-based scaffolds towards magnesium metal storage via regulation on magnesiophilicity and surface geometric structure

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Journal of Energy Chemistry 2024年第3期90卷 423-434,I0010页

作者： Jing liu Min Wang Zhonghua Zhang jinlei Zhang Yitao He Zhenfang Zhou Guicun li College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongChina Department of Pharmacy Jining Medical UniversityRizhao 276826ShandongChina Department of Energy and Power Engineering School of Energy and EnvironmentAnhui University of TechnologyMa’anshan 243000AnhuiChina

The development of rechargeable magnesium(Mg) batteries is of practical significance to upgrade the electric energy storage devices due to exceptional capacity and abundant resources of Mg-metal anode.However,the reversible Mg electrochemistry suffers from unsatisfied rate capability and lifespan,mainly caused by non-uniform distribution of electrodeposits.In this work,a fresh design concept of threedimensional carbon cloths scaffolds is proposed to overcome the uncontrollable Mg growth via homogenizing electric field and improving magnesiophilicity.A microscopic smooth and nitrogen-containing defective carbonaceous layer is constructed through a facile pyrolysis of ZIF8 on carbon cloths.As revealed by finite element simulation and DFT calculation results,the smooth surface endows with uniform electric field distribution and simultaneously the nitrogen-doping species enable good magnesiophilicity of scaffolds.The fine and uniform Mg nucleus as well as the inner electrodeposit behavior are also disclosed.As a result,an exceptional cycle life of 500 cycles at 4.0 mA cm^(-2) and 4.0 mA h cm^(-2) is firstly realized to our best knowledge.Besides,the functional scaffolds can be cycled for over 2200 h at 2.0 mA cm^(-2) under a normalized capacity of 5.0 mA h cm^(-2),far exceeding previous results.This work offers an effective approach to enable the full potential of carbon cloths-based scaffolds towards metal storage for next generation battery applications.

关键词： Magnesium metal anodes Electrodeposition Heterogeneous nucleation

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Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 751-764页

作者： Wen li Jiali Huang Chen Shen Weiye Jiang Xi Yang Jingxuan Huang Yueqing Gu Zhiyu li Yi Ma jinlei Bian State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of Drug Design and Optimization Department of Medicinal ChemistrySchool of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Recent progress in targeted metabolic therapy of cancer has been limited by the considerable toxicity associated with such drugs.To address this challenge,we developed a smart theranostic prodrug system that combines a fluorophore and an anticancer drug,specifically 6-diazo-5-oxo-L-norleucine(DON),using a thioketal linkage(TK).This system enables imaging,chemotherapy,photodynamic therapy,and on-demand drug release upon radiation exposure.The optimized prodrug,DON-TK-BM3,incorporating cyanine dyes as the fluorophore,displayed potent reactive oxygen species release and efficient tumor cell killing.Unlike the parent drug DON,DON-TK-BM3 exhibited no toxicity toward normal cells.Moreover,DON-TK-BM3 demonstrated high tumor accumulation and reduced side effects,including gastrointestinal toxicity,in mice.This study provides a practical strategy for designing prodrugs of metabolic inhibitors with significant toxicity stemming from their lack of tissue selectivity.

关键词： Smart prodrug system Glutamineantagonists Immunotherapy Photodynamictherapy Reactive oxygen species Metabolicinhibitor Cyaninedye Non-small-cell lung cancer(NSCLC)

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A novel lightweight computerized ECG interpretation approach based on clinical 12-lead data

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Science China(Technological Sciences) 2024年第2期67卷 449-463页

作者： liU YunQing QIN ChengJin liU jinlei JIN YanRui li ZhiYuan ZHAO liQun liU Chengliang School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Key Labof Artificial Intelligence(Ministryof Education) AI InstituteShanghai Jiao Tong UniversityShanghai 200240China Department of Cardiology Shanghai First Peoples Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200080China

Although 12-lead electrocardiograms(ECGs)provide a wide range of spatiotemporal characteristics,interpreting them for arrhythmia detection is difficult due to a lack of reliable large-scale clinical datasets.Herein,we proposed an innovative lightweight computerized ECG interpretation approach based on 12-lead data.Our model was trained,validated,and tested on 53845 standard 12-lead ECG records collected at Shanghai First People’s Hospital in affiliation with Shanghai Jiao Tong University.The experiments revealed that our approach had a classification accuracy of 94.41%in the classification task of seven types of rhythms,which was markedly superior to related single-lead and 12-lead ECG classification methods.Moreover,the average receiver operating characteristic area under the curve reached a value of 0.940,and the precision values for sinus tachycardia and sinus bradycardia were 0.945 and 0.91,respectively,with specificity values of 0.996 and 0.994.By employing our boosting method,we were able to improve the accuracy to 94.85%.To investigate the performance degradation of the proposed neural network in some classes,an ECG cardiologist was enlisted to review questionable ECGs;this process provides a promising direction for network performance improvement.Therefore,the proposed computerized ECG interpretation approach has practical significance because it could help professional physicians analyze patients’heart conditions based on real-time 12-lead ECG or grade their disease severity in advance.

关键词： computerized ECG interpretation large-scale 12-lead clinical ECG database lightweight neural network

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Manipulating fast li_(2)S redox via carbon confinement and oxygen defect engineering of In_(2)O_(3)for lithium-sulfur batteries

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Nano Research 2024年第6期17卷 5179-5187页

作者： jinlei Qin Rui Wang Zilong Yuan Pei Xiao Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

lithium-sulfur(li-S)batteries have been considered as promising energy storage systems due to the merits of high energy density and low cost.However,the lithium polysulfides(liPSs)diffusion and sluggish redox kinetics hamper the battery performance.In this work,low-bandgap indium oxide(In_(2)O_(3))with dense oxygen vacancies(In_(2)O_(3−x),0liPSs immobilizer and promoter to address these intractable problems.The NC confined In_(2)O_(3−x)with rich O vacancies(In_(2)O_(3−x)@NC)lowers the bandgap of 1.78 eV,strengthens the chemical adsorbability to liPSs,and catalyzes the bidirectional li_(2)S redox.Attributed to the structural and chemical cooperativities,the obtained sulfur electrodes exhibit a stable cycling over 550 cycles at 1.0 C and splendid rate capability up to 4.0 C.More significantly,when the sulfur-loading reaches as high as 5.5 mg·cm^(−2),the cathodes achieve an areal capacity of 5.12 mAh·cm^(−2)at 0.1 C.The strategy of NC confined catalyst with rich defects engineering demonstrates great promise in the development of practical li-S batteries.

关键词： li-S batteries nitrogen-doped carbon confinement oxygen vacancies bidirectional li_(2)S redox

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Belowground Bud Bank Is Insensitive to Short-Term Nutrient Addition in the Meadow Steppe of Inner Mongolia

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1129-1141页

作者： Jin Tao Jiatai Tian Dongmei li jinlei Zhu Qun Ma Zhiming Zhang Jungang Chen Yipeng liu Jianqiang Qian College of Forestry Henan Agricultural UniversityZhengzhou450002China Institute of Ecological Conservation and Restoration Chinese Academy of ForestryBeijing100093China Institute of Applied Ecology Chinese Academy of SciencesShenyang110164China Institute of Botany Chinese Academy of SciencesBeijing100093China liaoning Metallurgical Geological Exploration Research Institute Co. Anshan114038China

Human activities and industrialization have signiﬁcantly increased soil nutrients,such as nitrogen(N)and phos-phorus(P),profoundly impacting the composition and structure of plant community,as well as the ecosystem functions,especially in nutrient-limited ecosystems.However,as the key propagule pool of perennial grasslands,how belowground bud bank and its relationship with aboveground vegetation respond to short-term changes in soil nutrients was still unclear.In this study,we conducted a short-term(2021–2022)soil fertilization experiment with N addition(10 g N m^(-2) yr^(-1))and P addition(5 g N m^(-2) yr^(-1))in the meadow steppe of Inner Mongolia,China,to explore the responses of belowground bud bank,aboveground shoot population and their relationships(represented by the ratio of bud to shoot density-meristem limitation index(Mli))for the whole community and three plant functional groups(perennial rhizomatous grasses-PR,perennial bunchgrasses-PB,and perennial forbs-PF)to nutrient addition.The short-term nutrient addition had no signiﬁcant inﬂuences on belowground bud density,aboveground shoot density,and Mli of the whole plant community.Plant functional groups showed different responses to soil fertilization.Speciﬁcally,N addition signiﬁcantly increased the bud density and shoot density of PR,especially in combination with P addition.N addition reduced the shoot density of PF but had no inﬂuence on its bud density and Mli.Nutrient addition had signiﬁcant effects on the three indicators of PB.Our study indicates that the belowground bud bank and its relationship with aboveground vegetation in temperate meadow steppe are insensitive to short-term soil fertilization,but plant functional groups exhibit speciﬁc responses in terms of population regeneration,which implies that plant community composition and ecosystem functions will be changed under the ongoing global change.

关键词： Clonal trait population regeneration community dynamics soil resource availability nitrogen addition

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In-situ catalytic decomposition of emitted ammonia from municipal solid waste gasification by Ni–M bimetallic catalysts supported on sewage sludge-derived biochar

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Waste Disposal and Sustainable Energy 2023年第2期5卷 113-124页

作者： Xueyu Ding Yaji Huang Xinxin Dong Jiaqi Zhao Mengzhu Yu Xinqi Tian jinlei li Xuewei Zhang Yuxin li Zekun Wei Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing210096China Department of Transdisciplinary Science and Engineering School of Environment and SocietyTokyo Institute of TechnologyYokohamaKanagawa2268503Japan

Gasification technology can effectively realize energy recovery from municipal solid waste(MSW)to reduce its negative impact on the environment.However,ammonia,as a pollutant derived from MSW gasification,needs to be treated because its emission is considered harmful to mankind.This work aims to decompose the NH3 pollutant from MSW gasification by an in-situ catalytic method.The MSW sample is composed of rice,paper,polystyrene granules,rubber gloves,textile and wood chips.Ni–M(M=Co,Fe,Zn)bimetallic catalysts supported on sewage sludge-derived biochar(SSC)were prepared by co-impregnation method and further characterized by X-ray diffraction,N2 isothermal adsorption,scanning electron microscopy,transmission electron microscopy and NH3 temperature programmed desorption.Prior to the experiments,the catalysts were first homogeneously mixed with the MSW sample,and then in-situ catalytic tests were conducted in a horizontal fixed-bed reactor.The effect of the second metal(Co,Fe,Zn)on the catalytic performance was compared to screen the best Ni-M dual.It was found that the Ni–Co/SSC catalyst had the best activity toward NH3 decomposition,whose decomposition rate reached 40.21%at 650℃.The best catalytic performance of Ni–Co/SSC can be explained by its smaller Ni particle size that facilitates the dispersion of active sites as well as the addition of Co reducing the energy barrier for the associative decomposition of NH species during the NH3 decomposition process.Besides,the activity of Ni–Co/SSC increased from 450℃to 700℃as the NH3 decomposition reaction was endothermic.

关键词： Ammonia decomposition Municipal solid waste Gasification In-situ catalysis Ni-based catalyst Biochar

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Weighted Heterogeneous Graph-Based Incremental Automatic Disease Diagnosis Method

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Journal of Shanghai Jiaotong university(Science) 2024年第1期29卷 120-130页

作者：田圆圆金衍瑞李志远刘金磊刘成良 State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The objective of this study is to construct a multi-department symptom-based automatic diagnosis model.However,it is dificult to establish a model to classify plenty of diseases and collect thousands of disease-symptom datasets simultaneously.Inspired by the thought of"knowledge graph is model",this study proposes to build an experience-infused knowledge model by continuously learning the experiential knowledge from data,and incrementally injecting it into the knowledge graph.Therefore,incremental learning and injection are used to solve the data collection problem,and the knowledge graph is modeled and containerized to solve the large-scale multi-classification problems.First,an entity linking method is designed and a heterogeneous knowledge graph is constructed by graph fusion.Then,an adaptive neural network model is constructed for each dataset,and the data is used for statistical initialization and model training.Finally,the weights and biases of the learned neural network model are updated to the knowledge graph.It is worth noting that for the incremental process,we consider both the data and class increments.We evaluate the diagnostic effectiveness of the model on the current dataset and the anti-forgetting ability on the historical dataset after class increment on three public datasets.Compared with the classical model,the proposed model improves the diagnostic accuracy of the three datasets by 5%,2%,and 15%on average,respectively.Meanwhile,the model under incremental learning has a better ability to resist forgetting.

关键词： knowledge graph disease diagnosis incremental learning adaptive neural network knowledge model

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基于N-EKF的非合作低轨目标双星无源定位跟踪算法

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系统工程与电子技术 2024年第5期46卷 1777-1782页

作者：李罗钢路鹰晁鲁静任金磊中国航天科技创新研究院北京100088

针对两颗天基光学卫星对低轨非合作目标进行无源定位跟踪的问题,提出了一种基于Newton迭代与扩展卡尔曼滤波(Newton iteration and extended Kalman filter,N-EKF)的定位跟踪算法。首先,将基于角度测量信息的双星观测模型转化为双直线... 详细信息

针对两颗天基光学卫星对低轨非合作目标进行无源定位跟踪的问题,提出了一种基于Newton迭代与扩展卡尔曼滤波(Newton iteration and extended Kalman filter,N-EKF)的定位跟踪算法。首先,将基于角度测量信息的双星观测模型转化为双直线公垂线中点问题,并进一步转化为非线性方程问题,使用Newton迭代算法得到非合作目标的初始定位信息。然后,采用扩展卡尔曼滤波(extended Kalman filter,EKF)方法,在初始定位信息基础上,结合近地轨道动力学模型,实现对非合作在轨目标的精确跟踪滤波。最后,通过仿真验证了所提方法的可行性及优势。

关键词：双星无源定位非合作低轨目标跟踪滤波

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血小板伪装银纳米颗粒水凝胶加速1型糖尿病大鼠创面愈合

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中国组织工程研究 2024年第17期28卷 2659-2666页

作者：王金磊李科赵亮锦州医科大学药学院辽宁省锦州市121001 锦州医科大学生命科学研究院辽宁省锦州市121001

背景:细菌感染和血管生成功能受损一直是糖尿病创面愈合的障碍,多药耐药的问题同样不容忽视,因此迫切需要寻找一种新的治疗策略。目的:制备血小板伪装银纳米颗粒水凝胶,观察其对糖尿病创面的治疗作用。方法:①体外实验:通过回流加热的... 详细信息

背景:细菌感染和血管生成功能受损一直是糖尿病创面愈合的障碍,多药耐药的问题同样不容忽视,因此迫切需要寻找一种新的治疗策略。目的:制备血小板伪装银纳米颗粒水凝胶,观察其对糖尿病创面的治疗作用。方法:①体外实验:通过回流加热的方式制备超小银纳米颗粒(ultra-small silver nanoparticles,usAgNPs),将其与血小板(platelets,PL)偶联后加入羧甲基纤维素(carboxymethyl cellulose,CMC)水凝胶中,制备usAgNPs-PL/CMC水凝胶,表征水凝胶的微观结构、溶胀性能及力学性能,采用二甲氧唑黄比色法、活性氧法、细菌生物膜法、细菌活性等方法检测该水凝胶的抗菌能力。②体内实验:将40只SD大鼠随机分为假手术组、模型组、CMC水凝胶组、usAgNPs/CMC水凝胶组和usAgNPs-PL/CMC水凝胶组,每组8只,除假手术组外,其余4组建立1型糖尿病模型,造模成功后在5组大鼠背部制作1个深达筋膜层的皮肤创面(直径20 mm),假手术组、模型组大鼠创面注射生理盐水,CMC水凝胶组、usAgNPs/CMC水凝胶组和usAgNPs-PL/CMC水凝胶组大鼠创面分别植入对应的水凝胶。治疗14 d后,观察创面愈合情况与愈合质量。结果与结论:①体外实验:usAgNPs-PL/CMC水凝胶具有均匀的三维网状结构、良好的力学性能与较强的吸水能力,可明显抑制大肠杆菌和金黄色葡萄球菌的生长,并且对两细菌生物膜形成具有良好的抑制和清除作用,具有良好的抗菌能力;②体内实验:治疗14 d后,usAgNPs-PL/CMC水凝胶组创面基本闭合,创面愈合率最高,创面菌落数量明显少于模型组;治疗14 d的苏木精-伊红、Masson染色显示,usAgNPs-PL/CMC水凝胶组、usAgNPs/CMC水凝胶组和CMC水凝胶组创面出现再生真皮的组织结构,新生肉芽组织表皮均完整且厚,其中usAgNPs-PL/CMC水凝胶组可见堆积的平行的成熟胶原纤维;治疗7 d的CD31免疫组化及Ki67免疫荧光染色显示,usAgNPs-PL/CMC水凝胶组创面微血管数量、成纤维细胞数量最多;③结果表明:usAgNPs-PL/CMC水凝胶可通过快速抑菌和促进血管生成来加速1型糖尿病大鼠创面的愈合。

关键词：超小纳米银颗粒血小板羧甲基纤维素水凝胶糖尿病创面创面愈合抑菌

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Specific Recognition of Breast Cancer Cells In Vitro Using Near Infrared-Emitting Long-Persistence Luminescent Zn_3Ga_2Ge_2O_(10):Cr^(3+)Nanoprobes

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Nano-Micro Letters 2015年第2期7卷 138-145页

作者： jinlei li Junpeng Shi Jiangshan Shen Huizi Man Mingxi Wang Hongwu Zhang School of Biomedical Sciences Huaqiao University and Engineering Research Center of Molecular Medicine Ministry of Education Institute of Urban Environment Chinese Academy of Science

In this paper, near-infrared emitting long-persistence luminescent Zn3Ga2Ge2O10:Cr3?(ZGG) nanoparticles with diameters of 30–100 nm and bright luminescence were prepared by a sol–gel synthesis method. After the surface amination, the nanoparticles were further bioconjugated with breast cancer-specific monoclonal antibody(anti-Ep CAM) to form ZGG-Ep CAM nanoprobes which can specifically target breast cancer cell lines(MCF7) in vitro. The results of in vitro images show that the luminescence signals from the cells treated with ZGG-Ep CAM nanoprobes are stronger than those from cells treated with ZGG-unconjugated antibody, indicating that the prepared ZGG-Ep CAM nanoprobes possessed excellent specific recognition capability. Furthermore, due to their long afterglow properties, the imaging could persist more than 1 h. Therefore, these nanoprobes could not only provide a high specificity detection method for cancer cells but also realize the long-time monitoring. Developed near-infrared emitting long-persistence luminescent nanoprobes will be expected to find new perspectives for cell therapy research and diagnosis applications.

关键词： Nanoprobes Long afterglow Near-infrared luminescence Target imaging

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