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涉外税务 2005年第3期 70-71页

作者：陈进军陈争鸣湖北省随州市地方税务局湖北随州441300

税收法规规定,全年一次性奖金是指行政机关、企事业单位等扣缴义务人根据其全年经济效益和对雇员全年工作业绩的综合考核情况,向雇员发放的一次性奖金.上述一次性奖金也包括年终加薪、实行年薪制和绩效工资办法的单位根据考核情况兑现... 详细信息

税收法规规定,全年一次性奖金是指行政机关、企事业单位等扣缴义务人根据其全年经济效益和对雇员全年工作业绩的综合考核情况,向雇员发放的一次性奖金.上述一次性奖金也包括年终加薪、实行年薪制和绩效工资办法的单位根据考核情况兑现的年薪和绩效工资.

关键词：奖金雇员个人所得税兑现加薪年薪制扣缴义务人根据行政机关税收法规

Spider venom peptides targeting on a novel α2δ-1–NMDA receptor coupling in neuropathic pain

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Spider venom peptides targeting on a novel α2δ-1–NMDA rec...

New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Yiying Ding Shengmei Yang Fang Qu Hui-Lin Pan jinjun chen College of Bioscience and Biotechnology Hunan Agricultural University

Spiders are traditional medicine used for the treatment of chronic pain,but the molecular mechanism involved is not *** use their venom to rapidly paralyze their prey through targeting their prey’s nervous system efficiently and *** spider toxin peptides has received much attention in the pain field in recent ***,previous work is mainly focused on the pore-forming subunits of the channels,which often produce intolerable side effects.α2δ-1 was previously considered as a subunit of voltage-gated calcium channels and is up-regulated in primary sensory neurons and spinal cord dorsal horn neurons in peripheral nerve injury-induced chronic pain.α2δ-1 is also the target of gabapentin and pregabalin,which are commonly used analgesics for treating neuropathic *** identified that a novel α2δ-1–NMDA receptor coupling is critically involved in neuropathic pain and gabapentin *** study the spider venom peptides targeting on α2δ-1 by using membrane system yeast two-hybrid and pull-down,dual high-throughput screening,which can then be applied to study the functions in the cells and animal models to determine their molecular mechanisms in treating neuropathic *** put forward an innovative project to study the molecular basis of spider toxins pertinent to their analgesic effects,based on the studies of spider venom peptidomics and the mechanism of α2δ-1 in neuropathic pain by our *** present study is expected to discover new research tools that can be used for studying the mechanism of acute and chronic pain and may develop novel drug leads for treating various painful conditions.

关键词： Spider venom Neuropathic pain Accessory subunit CACNA2D1 NMDA receptor

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 550-559页

作者： Xiaoting Tang Hai Li Guohong Deng Xin Zheng Xianbo Wang Yan Huang Yanhang Gao Zhongji Meng Zhiping Qian Feng Liu Xiaobo Lu Yu Shi Beiling Li Wenyi Gu Xiaomei Xiang Yan Xiong Yixin Hou Jun chen Na Gao Sen Luo Liujuan Ji Jing Li Rongjiong Zheng Haotang Ren jinjun chen Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Gastroenterology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShang-haiChina Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and HepatologyChinese Ministry of Health(Shanghai Jiao Tong University)ShanghaiChina Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangshaHunanChina Department of Hepatology The First Hospital of Jilin UniversityChangchunJilinChina Department of Infectious Diseases Hubei Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyanHubeiChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong Univer-sityJinanShandongChina Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityXinjiangChina The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhouZhejiangChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease HangzhouZhejiangChina National Clinical Research Center of Infectious Disease HangzhouZhejiangChina Hepatology Unit Zengcheng BranchNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina.

Background and Aims:Approximately 10%of patients with acute decompensated(AD)cirrhosis develop acute-on-chronic liver failure(ACLF)within 28 *** cases have high mortality and are difficult to ***,we aimed to establish and validate an algorithm to identify these patients on ***:Hospitalized patients with AD who developed ACLF within 28 days were considered *** dysfunction was defined accord-ing to the chronic liver failure-sequential organ failure as-sessment(CLIF-SOFA)criteria,and proven bacterial infec-tion was taken to indicate immune system dysfunction.A retrospective multicenter cohort and prospective one were used to derive and to validate the potential algorithm,re-spectively.A miss rate of<5%was acceptable for the calcu-lating algorithm to rule out ***:In the deri-vation cohort(n=673),46 patients developed ACLF within 28 *** total bilirubin,creatinine,international normalized ratio,and present proven bacterial infection at admission were associated with the development of *** patients with≥2 organ dysfunctions had a higher risk for pre-ACLF patients[odds ratio=16.58195%confidence interval:(4.271-64.363),p<0.001].In the derivation co-hort,67.5%of patients(454/673)had≤1 organ dysfunction and two patients(0.4%)were pre-ACLF,with a miss rate of 4.3%(missed/total,2/46).In the validation cohort,65.9%of patients(914/1388)had≤1 organ dysfunction,and four(0.3%)of them were pre-ACLF,with a miss rate of 3.4%(missed/total,4/117).Conclusions:AD patients with≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and could be safely ruled out with a pre-ACLF miss rate of<5%.

关键词： Liver cirrhosis Prognosis Liver failure End-stage liver disease Organ dysfunction scores.

新型镇痛靶点α2δ-1-NMDAR稳定表达细胞株构建及镇痛药物筛选的应用

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生物工程学报 2022年第3期38卷 1149-1158页

作者：董琳张亦雅陈金军湖南农业大学生物科学技术学院湖南长沙410128 中南大学湘雅医院国家老年疾病临床研究中心湖南长沙410008 湖南省细胞力学与功能分析工程技术研究中心湖南长沙410006

在多种神经性疼痛动物模型中均发现周围神经损伤可导致由CACNA2D1编码的α2δ-1蛋白在脊髓和背根神经节(DRG)中表达显著上调。CACNA2D1过表达使脊髓背角神经元的突触前和突触后NMDAR活性增强,引起疼痛过敏症。α2δ-1与NMDAR相互作用,... 详细信息

在多种神经性疼痛动物模型中均发现周围神经损伤可导致由CACNA2D1编码的α2δ-1蛋白在脊髓和背根神经节(DRG)中表达显著上调。CACNA2D1过表达使脊髓背角神经元的突触前和突触后NMDAR活性增强,引起疼痛过敏症。α2δ-1与NMDAR相互作用,促进了NMDAR在细胞表面转运和突触膜上的定位,可引起神经病理性疼痛,且α2δ-1-NMDAR复合物也被发现存在于其他多种病理状态下,如某些神经源性的高血压、脑缺血。本研究使用慢病毒转染构建稳定表达α2δ-1-NMDAR复合物的人肾胚HEK293T细胞株;通过荧光显微镜、RT-qPCR及Western blotting方法对所建立的稳转细胞系进行鉴定,结果显示HEK293T被成功转染且基因能够稳定表达;并采用膜片钳技术成功建立该细胞株靶向药物筛选体系。该细胞株为进一步研究α2δ-1-NMDAR复合物的相互作用机制及针对慢性疼痛和相关疾病的低副作用的药物筛选提供了良好应用前景的细胞模型。

关键词： α2δ-1 NMDA受体 α2δ-1-NMDAR复合物神经病理性疼痛靶向药物筛选

One-year status of hepatic venous pressure gradient measurement from 85 hospitals in China

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Portal Hypertension & Cirrhosis 2024年第2期3卷 116-123页

作者： Jitao Wang Ting Cui Linpeng Zhang Zhiping Yan Lei Li jinjun chen Junhui Sun Hua Xiang He Zhu Hao Wu Jiancuo Gengzang Feng Zhang Wei Wu Guohong Cao Wuhua Guo Haibin Shi Hui Xue Guangjun Huang Qiang Yu Meng Niu Huiling Xiang Derun Kong Wei Gou Xuefeng Luo Fuliang He Min Yuan Wei Liu Yong Wang Hongjie Hu Xiaoli Zhu Tao Yu Qinxue Sun Wei Qu Ting Lu Deqiang Ma Li Zhang Jun Ma Jun Yang Ketao Mu Xiaoliang Zhu Kai Xiong Huiguo Ding Shengjuan Yao Mingsheng Huang Fang Wang Zexin Wang Yong Huang Jianan Li Hongfeng Yi Birun Huang Zhongwei Zhao Duiping Feng Yanming Lei Changlong Hou Wenbo Guo Shirong Liu Gaojun Teng Kangshun Zhu Fan Wu Xiaogang Hu Wenfeng Zhang Shaoqi Yang Zhouchao Hu Pengfei Pang Shaowu Zhuang Weidong Wang Qingliang Zhu Kunpeng Zhang chengyu Liu Dongliang Li Chao Ma Hong Jiang Xingong Zhao Weixin Ren Zhiwei Wang Lei Yu Fuhuang Lin Chaoguang Yan Feng Wang Lei Yu Hui Huan Wenyong Shen Shaofei He chengda Zhang Jinlun Bao Jiangtao Liu Jun Wu Jianbo Zhao Jian Zhang Xiaolong Qi Hebei Provincial Key Laboratory of Cirrhosis&Portal Hypertension Xingtai People's HospitalXingtaiHebeiChina Center of Portal Hypertension Department of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuChina Department of Interventional Therapy Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijingChina Department of Intervention Taiyuan Third People's HospitalTaiyuanShanxiChina Department of Intervention Zhongshan Hospital Affiliated to Fudan UniversityShanghaiChina Department of Interventional Medicine The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Infectious Diseases Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdongChina Hepatobiliary and Pancreatic Intervention Center The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangChina Interventional Vascular Surgery Hunan Provincial People's HospitalChangshaHunanChina Department of Intervention Sixth People's Hospital of ShenyangShenyangLiaoningChina Department of Gastroenterology West China Hospital of Sichuan UniversityChengduSichuanChina Department of Intervention The Fourth People's Hospital of Qinghai ProvinceXiningQinghaiChina Department of Gastroenterology Nanjing Drum Tower HospitalNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Radiology Shulan(Hangzhou)HospitalHangzhouZhejiangChina Department of Intervention Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouFujianChina Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Department of Interventional Radiology Fifth Medical Center

Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in *** article aimed to investigate the status of hepatic venous pressure gradient measurement in China in ***:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online *** counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in ***:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured *** average cost of HVPG measurement was 5646.8±2327.9 *** the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy ***:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this *** is still necessary to continue promoting and popularizing this technology in the future.

关键词： application status hepatic vein pressure gradient questionnaire survey

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Buck变换器非线性控制器设计

电力自动化设备 2008年第12期28卷 56-59页

作者：沈艳霞陈进军纪志成江南大学电气自动化研究所江苏无锡214122

针对Buck变换器的非线性特性,提出了采用反步法和反步滑模法控制非线性系统的控制策略。基于对Buck变换器数学模型的分析,论述了反步法控制器的设计,实现了当Buck变换器参数发生变化时,电容电压和电感电流对给定参考信号较好的跟踪;将... 详细信息

针对Buck变换器的非线性特性,提出了采用反步法和反步滑模法控制非线性系统的控制策略。基于对Buck变换器数学模型的分析,论述了反步法控制器的设计,实现了当Buck变换器参数发生变化时,电容电压和电感电流对给定参考信号较好的跟踪;将反步法与滑模控制相结合,设计了反步滑模控制器,进一步改善了系统的跟踪性能。使用System Generator在Matlab环境下进行系统建模及仿真研究,结果表明,反步法和反步滑模法的非线性系统控制器效果良好。

关键词： Buck变换器反步法反步滑模法

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一种基于单CPU芯片的电容测量仪

实验技术与管理 2010年第12期27卷 113-114,140页

作者：陈进军王丽贵州大学电气工程学院

研制了仅用一个单片机和二极管环形电桥测量电路构成的电容测量仪,其单片机提供了二极管环形电桥测量电路所需的激励矩形波,并完成模数转换、数据处理以及显示等功能。对于电容量为5～30 pF范围的电容进行了测量,输出电压与电容量的对... 详细信息

研制了仅用一个单片机和二极管环形电桥测量电路构成的电容测量仪,其单片机提供了二极管环形电桥测量电路所需的激励矩形波,并完成模数转换、数据处理以及显示等功能。对于电容量为5～30 pF范围的电容进行了测量,输出电压与电容量的对应关系经回归分析,得到判定系数R2=0.989 1,R为相关系数。

关键词：电容测量仪单片机二极管环形电桥激励矩形波

肝硬化门静脉高压的进展及挑战:以BavenoⅦ共识为新起点

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临床肝胆病杂志 2022年第6期38卷 1217-1219页

作者：张晓丰陈金军南方医科大学南方医院肝病中心广州510515 南方医科大学南方医院增城分院肝病科广州511300 广东省肝脏疾病研究所广州510515

Baveno协作组发布门静脉高压的新共识(BavenoⅦ共识),总结了门静脉高压的诊断标准、无创筛查和诊断、包括病因治疗及非病因治疗的一级预防、包括内镜和血管介入下诊治的二级预防、肝硬化失代偿相关新观念,以及肝脏血管病等方向的主要进... 详细信息

Baveno协作组发布门静脉高压的新共识(BavenoⅦ共识),总结了门静脉高压的诊断标准、无创筛查和诊断、包括病因治疗及非病因治疗的一级预防、包括内镜和血管介入下诊治的二级预防、肝硬化失代偿相关新观念,以及肝脏血管病等方向的主要进展和研究日程。BavenoⅦ共识对我国门静脉高压相关领域临床实践和研究具有重要借鉴价值。本文从临床实践角度简述我国肝硬化门静脉高压的主要进展和挑战。

关键词：肝硬化门静脉高压 BavenoⅦ共识

CT脑灌注成像在基底节区腔隙性脑梗死的初步应用

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临床放射学杂志 2009年第10期28卷 1362-1364页

作者：陈进军宁景春肇庆市中医院放射科广东省526020 深圳市龙华人民医院神经内科广东省518109

目的探讨CT脑灌注成像在基底节区腔隙性脑梗死的应用价值。资料与方法对35例超早期(发病5 mm(5 mm(5 mm(0.5);患侧及对侧局部平均TTP分别为(10.1±2.0)s和(9.3±1.3),两侧之间差异无统计学意义(t=1.039,P>0.5)。结论CT脑灌注成像能为基... 详细信息

目的探讨CT脑灌注成像在基底节区腔隙性脑梗死的应用价值。资料与方法对35例超早期(发病5 mm(5 mm(5 mm(0.5);患侧及对侧局部平均TTP分别为(10.1±2.0)s和(9.3±1.3),两侧之间差异无统计学意义(t=1.039,P>0.5)。结论CT脑灌注成像能为基底节区腔隙性脑梗死提供有价值的脑血流动力学信息,为临床超早期诊断和治疗提供依据。

关键词：脑缺血基底节脑灌注脑血流量体层摄影术 X线计算机

肝病无创诊断新策略:DSA-FACE技术的糖组学方法

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中华肝脏病杂志 2020年第9期28卷 803-808页

作者：卢观婷陈萃英黎倍伶陈金军南方医科大学南方医院肝病中心广州510515 先思达(南京)生物科技有限公司 210046

慢性肝病已经逐渐成为严重的全球性健康问题。肝活体组织检查是目前评价肝脏病变的金标准,但其属于有创操作且会造成严重并发症;因此,亟需一种可用于诊断的经济快速的无创检测方法应用于临床。近十几年来,蛋白质糖基化已成为研究热点;... 详细信息

慢性肝病已经逐渐成为严重的全球性健康问题。肝活体组织检查是目前评价肝脏病变的金标准,但其属于有创操作且会造成严重并发症;因此,亟需一种可用于诊断的经济快速的无创检测方法应用于临床。近十几年来,蛋白质糖基化已成为研究热点;血清蛋白聚糖结构的变化是肝脏损伤的指征这一理念也逐渐得到众多研究者们的认可。同时,高效的糖谱分析技术(基于DNA测序仪的荧光毛细管电泳技术,DSA-FACE)也为各种慢性肝病带来了具有较高灵敏度和特异度的诊断模型(GlycoHepatoTest),是肝病无创诊断的新策略。

关键词：肝疾病无创诊断糖组学荧光毛细管电泳技术