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Privacy Computing: Concept, Computing Framework, and Future Development Trends

Engineering 2019年第6期5卷 1179-1192页

作者： Fenghua Li Hui Li Ben Niu jinjun chen Institute of Information Engineering Chinese Academy of SciencesBeijing 100093China School of Cyber Security University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Integrated Services Networks School of Cyber EngineeringXidian UniversityXi’an 710071China Department of Computer Science and Software Engineering Swinburne University of TechnologyHawthornVIC 3122Australia

With the rapid development of information technology and the continuous evolution of personalized ser- vices, huge amounts of data are accumulated by large internet companies in the process of serving users. Moreover, dynamic data interactions increase the intentional/unintentional persistence of private infor- mation in different information systems. However, problems such as the cask principle of preserving pri- vate information among different information systems and the dif culty of tracing the source of privacy violations are becoming increasingly serious. Therefore, existing privacy-preserving schemes cannot pro- vide systematic privacy preservation. In this paper, we examine the links of the information life-cycle, such as information collection, storage, processing, distribution, and destruction. We then propose a the- ory of privacy computing and a key technology system that includes a privacy computing framework, a formal de nition of privacy computing, four principles that should be followed in privacy computing, ffect algorithm design criteria, evaluation of the privacy-preserving effect, and a privacy computing language. Finally, we employ four application scenarios to describe the universal application of privacy computing, and discuss the prospect of future research trends. This work is expected to guide theoretical research on user privacy preservation within open environments.

关键词： Privacy computing Private information description Privacy metric Evaluation of the privacy-preserving effect Privacy computing language

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New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 550-559页

作者： Xiaoting Tang Hai Li Guohong Deng Xin Zheng Xianbo Wang Yan Huang Yanhang Gao Zhongji Meng Zhiping Qian Feng Liu Xiaobo Lu Yu Shi Beiling Li Wenyi Gu Xiaomei Xiang Yan Xiong Yixin Hou Jun chen Na Gao Sen Luo Liujuan Ji Jing Li Rongjiong Zheng Haotang Ren jinjun chen Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Gastroenterology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShang-haiChina Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and HepatologyChinese Ministry of Health(Shanghai Jiao Tong University)ShanghaiChina Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangshaHunanChina Department of Hepatology The First Hospital of Jilin UniversityChangchunJilinChina Department of Infectious Diseases Hubei Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyanHubeiChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong Univer-sityJinanShandongChina Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityXinjiangChina The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhouZhejiangChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease HangzhouZhejiangChina National Clinical Research Center of Infectious Disease HangzhouZhejiangChina Hepatology Unit Zengcheng BranchNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina.

Background and Aims:Approximately 10%of patients with acute decompensated(AD)cirrhosis develop acute-on-chronic liver failure(ACLF)within 28 days.Such cases have high mortality and are difficult to predict.Therefore,we aimed to establish and validate an algorithm to identify these patients on hospitalization.Methods:Hospitalized patients with AD who developed ACLF within 28 days were considered pre-ACLF.Organ dysfunction was defined accord-ing to the chronic liver failure-sequential organ failure as-sessment(CLIF-SOFA)criteria,and proven bacterial infec-tion was taken to indicate immune system dysfunction.A retrospective multicenter cohort and prospective one were used to derive and to validate the potential algorithm,re-spectively.A miss rate of<5%was acceptable for the calcu-lating algorithm to rule out pre-ACLF.Results:In the deri-vation cohort(n=673),46 patients developed ACLF within 28 days.Serum total bilirubin,creatinine,international normalized ratio,and present proven bacterial infection at admission were associated with the development of ACLF.AD patients with≥2 organ dysfunctions had a higher risk for pre-ACLF patients[odds ratio=16.58195%confidence interval:(4.271-64.363),p<0.001].In the derivation co-hort,67.5%of patients(454/673)had≤1 organ dysfunction and two patients(0.4%)were pre-ACLF,with a miss rate of 4.3%(missed/total,2/46).In the validation cohort,65.9%of patients(914/1388)had≤1 organ dysfunction,and four(0.3%)of them were pre-ACLF,with a miss rate of 3.4%(missed/total,4/117).Conclusions:AD patients with≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and could be safely ruled out with a pre-ACLF miss rate of<5%.

关键词： Liver cirrhosis Prognosis Liver failure End-stage liver disease Organ dysfunction scores.

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A pigeon-inspired optimization algorithm for many-objective optimization problems

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Science China(Information Sciences) 2019年第7期62卷 131-138页

作者： Zhihua CUI Jiangjiang ZHANG Yechuang WANG Yang CAO Xingjuan CAI Wensheng ZHANG jinjun chen Complex System and Computational Intelligence Laboratory Taiyuan University of Science and Technology Beijing Institute of Petrochemical Technology Faculty of Information Technology Beijing University of Technology State Key Laboratory of Intelligent Control and Management of Complex Systems Institute of Automation Chinese Academy of Sciences School of Software University of Technology Sydney

Dear editor,Swarm intelligence optimization algorithms are inspired by the behaviour of biological groups in nature. Such algorithms have the advantages of a clear structure, simple operation, comprehensible principles, strong parallelism, effective search abilities, and strong robustness. They can effectively solve difficult problems that traditional methods cannot. Pigeon-inspired optimization (PIO), a novel biomimetic swarm intelligence optimization algorithm, was proposed by Duan and Qiao in

关键词： A pigeon-inspired optimization algorithm for many-objective optimization problems Pareto

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主诊医师负责制提升医疗质量管理水平的探究

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中国卫生标准管理 2024年第7期15卷 76-79页

作者：杨柳陈进军李琼彬深圳市儿童医院医务科广东深圳518038

主诊医师负责制这一医疗管理制度在医疗服务工作中扮演着举足轻重的角色。其核心在于明确主诊医师对患者诊疗全过程的直接责任,这不仅简化了医疗服务流程,提高了效率,还显著促进了医疗质量管理水平的提升。主诊医师负责制也强化了医师... 详细信息

主诊医师负责制这一医疗管理制度在医疗服务工作中扮演着举足轻重的角色。其核心在于明确主诊医师对患者诊疗全过程的直接责任,这不仅简化了医疗服务流程,提高了效率,还显著促进了医疗质量管理水平的提升。主诊医师负责制也强化了医师的职业责任感和使命感,使他们更加关注患者的需求和满意度。文章将对主诊医师负责制的应用意义进行深入分析,并从医师培训与考核、诊疗流程优化、团队协作与沟通强化以及医疗质量管理机制完善等方面,探讨如何通过这一制度进一步提升医疗质量管理水平的实践策略,以期为广大医疗机构提供有益的参考和借鉴。

关键词：主诊医师负责制医疗质量质量管理管理水平责任制

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枯草芽孢杆菌CH-1降解羽毛产物对Cr(Ⅵ)的还原作用

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中国农学通报 2024年第15期40卷 117-123页

作者：李茹桥刘颖陈清旺吴嘉沛陈金军湖南农业大学生物科学技术学院长沙410128

本研究旨在探索一种对环境友好的方法以减少重金属六价铬Cr(Ⅵ)的毒性。采用枯草芽孢杆菌(Bacillus subtilis)CH-1发酵羽毛,制备出富含半胱氨酸的羽毛发酵液(Feather Fermentation Broth,FFB)。实验结果显示FFB能够有效地将有毒的六价... 详细信息

本研究旨在探索一种对环境友好的方法以减少重金属六价铬Cr(Ⅵ)的毒性。采用枯草芽孢杆菌(Bacillus subtilis)CH-1发酵羽毛,制备出富含半胱氨酸的羽毛发酵液(Feather Fermentation Broth,FFB)。实验结果显示FFB能够有效地将有毒的六价铬还原为相对无害的三价铬。通过对FFB的β-角蛋白酶酶活性、半胱氨酸浓度以及对六价铬Cr(Ⅵ)的还原率的测定。我们发现FFB中β-角蛋白酶酶活性在21 h左右达到最大值,而半胱氨酸含量在36 h达到最高值,Cr(Ⅵ)的还原效果最佳时间也是36 h。值得注意的是,即使经过高压高温处理,FFB对Cr(Ⅵ)的还原力并未受到影响,表明还原过程不依赖于生物酶的作用。进一步实验,将FFB上清原液浓缩5倍后处理重铬酸钾溶液,发现浓缩液的还原效果是原始上清液效果的1.5倍。研究表明枯草芽孢杆菌CH-1能较好地降解羽毛废弃物,水解产物中含大量半胱氨酸,对Cr(Ⅵ)具有显著的还原能力。综上所述,本研究提供了一种使用枯草芽孢杆菌CH-1无公害处理羽毛废弃物的新策略,并为其在循环农业生态系统中的应用提供了理论依据和精确计算方法。这一发现对于实现农业废弃物资源化利用,以及环境中有毒六价铬的安全处理具有重要意义。

关键词： Cr(Ⅵ)还原羽毛水解产物枯草芽孢杆菌CH-1 角蛋白酶活性半胱氨酸环境治理

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一种新型共轭聚合物塑料光纤放大器材料制备及性能研究

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粘接 2024年第1期51卷 102-105页

作者：康健刘俊陶正晖李瑞陈进军国网甘肃省电力公司天水供电公司甘肃天水741000

针对传统塑料光纤在传输过程中损耗大,使用长度较短的问题,提出在光纤连接部位制备一种新型共轭聚合物CN-PPV掺杂塑料光纤放大器材料,并对其制备工艺、荧光特性和增益特性进行研究。试验结果表明,在25 mL MMA、0.032 g BPO、20~75μL n... 详细信息

针对传统塑料光纤在传输过程中损耗大,使用长度较短的问题,提出在光纤连接部位制备一种新型共轭聚合物CN-PPV掺杂塑料光纤放大器材料,并对其制备工艺、荧光特性和增益特性进行研究。试验结果表明,在25 mL MMA、0.032 g BPO、20~75μL n-BM的工艺条件下制备的预制棒表面状态良好,内部无气泡出现,并在拉伸温度为150~177℃的条件下成功拉丝。塑料光纤最大发射截面为1.7×10^(-20) m^(2);当泵浦光传输距离增加,光谱出现明显红移现象,最大红移波长为12 nm。在光纤长度为50 cm的条件下,掺杂质量浓度为1 mg/L的光纤存在最大增益值,达到25 dB。而掺杂质量浓度为0.2 mg/L的光纤具备持续光放大能力,更适合作为光纤放大器的制备材料。

关键词：共轭聚合物塑料光纤光纤放大器荧光特性增益特性

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Investigation on the short-term outcome and prognostic impact of predisposition,and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE(CATCH-LIFE)cohorts

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Portal Hypertension & Cirrhosis 2023年第3期2卷 115-126页

作者： Yan Zhang Wenting Tan Xiaobo Wang Xin Zheng Yan Huang Beiling Li Zhongji Meng Yanhang Gao Zhiping Qian Feng Liu Xiaobo Lu Jia Shang Yubao Zheng Weituo Zhang Shan Yin Wenyi Gu Tongyu Wang Jianyi Wei Zixuan Shen Guohong Deng Yi Zhou Yixin Hou Qun Zhang Shue Xiong Jing Liu Liyuan Long Ruochan chen jinjun chen Xiuhua Jiang Sen Luo Yuanyuan chen Chang Jiang Jinming Zhao Liujuan Ji Xue Mei Jing Li Tao Li Rongjiong Zheng Xinyi Zhou Haotang Ren Yu Shi Hai Li for the CATCH‐LIFE Study Investigators of Chinese(Acute‐on)Chronic Liver Failure(CLIF)Consortium(Ch‐CLIFC) Department of Gastroenterology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Institute of Digestive Disease NHC Key Laboratory of Digestive DiseasesShanghaiChina Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Hunan Key Laboratory of Viral Hepatitis Department of Infectious DiseasesXiangya HospitalCentral South UniversityChangshaHunanChina Department of Infectious Diseases Hepatology UnitNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyanHubeiChina Department of Hepatology The First Hospital of Jilin UniversityJilinChangchunChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghaiChina Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjinChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinanShandongChina Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Infectious Diseases Henan Provincial People's HospitalZhengzhouHenanChina Deparment of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou CityGuangdongChina Clinical Research Center Shanghai Jiao Tong University School of MedicineShanghaiChina The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhouZhejiangChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease HangzhouZhejiangChina Nati

Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality.

关键词： cirrhosis precipitant prior decompensation short‐term mortality

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Examining the characteristics between time and distance gaps of secondary crashes

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Transportation Safety and Environment 2024年第1期6卷 116-131页

作者： Xinyuan Liu jinjun Tang chen Yuan Fan Gao Xizhi Ding Smart Transport Key Laboratory of Hunan Province School of Transport and Transportation EngineeringCentral South UniversityChangsha 410075China Department of Computer Science City University of Hong Kong999077Kowloon TongHong KongChina Department of Geography and Resource Management The Chinese University of Hong KongShatinNT 999077Hong KongChina

Understanding the characteristics of time and distance gaps between the primary(PC)and secondary crashes(SC)is crucial for preventing SC ccurrences and improving road safety.Although previous studies have tried to analyse the variation of gaps,there is limited evidence in quantifying the relationships between different gaps and various influential factors.This study proposed a two-layer stacking framework to discuss the time and distance gaps.Specifically,the framework took random forests(RF),gradient boosting decision tree(GBDT)and eXtreme gradient boosting as the base classifiers in the first layer and applied logistic regression(LR)as a combiner in the second layer.On this basis,the local interpretable model-agnostic explanations(LIME)technology was used to interpret the output of the stacking model from both local and global perspectives.Through SC dentification and feature selection,346 SCs and 22 crash-related factors were collected from California interstate freeways.The results showed that the stacking model outperformed base models evaluated by accuracy,precision,and recall indicators.The explanations based on LIME suggest that collision type,distance,speed and volume are the critical features that affect the time and distance gaps.Higher volume can prolong queue length and increase the distance gap from the SCs to PCs.And collision types,peak periods,workday,truck involved and tow away likely induce a long-distance gap.Conversely,there is a shorter distance gap when secondary roads run in the same direction and are close to the primary roads.Lower speed is a significant factor resulting in a long-time gap,while the higher speed is correlated with a short-time gap.These results are expected to provide insights into how contributory features affect the time and distance gaps and help decision-makers develop accurate decisions to prevent SCs.

关键词： secondary crash(SC) time and distance gaps stacking framework local interpretable model-agnostic explanations(LIME)

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红树林沉积物聚乙烯降解菌的筛选和降解特性

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广东海洋大学学报 2024年第3期44卷 143-149页

作者：卫婉聂芳红张敏林红英魏云丽吕广洲照那木拉康丹菊 HAY Anthony GOONERATNE Ravi 陈进军广东海洋大学滨海农业学院广东湛江524088 广东海洋大学食品科技学院广东湛江524088 Department of Microbiology Cornell UniversityUSA Ithaca NY 14853 Department of Wine Food and Molecular BiosciencesFaculty of Agriculture and Life SciencesLincoln UniversityNew Zealand Lincoln 7647

【目的】探究湛江市麻章区红树林沉积物中微生物对聚乙烯(PE)塑料的降解特性,丰富红树林塑料降解菌种类。【方法】在湛江市麻章区红树林的高、中、低潮带随机选取9个样点,并采用五点采样法从红树林表层2~5 cm的沉积物中取样。将采集到... 详细信息

【目的】探究湛江市麻章区红树林沉积物中微生物对聚乙烯(PE)塑料的降解特性,丰富红树林塑料降解菌种类。【方法】在湛江市麻章区红树林的高、中、低潮带随机选取9个样点,并采用五点采样法从红树林表层2~5 cm的沉积物中取样。将采集到的沉积物样本在以聚乙烯为唯一碳源的无机盐培养基中进行富集、分离、纯化,以筛选出能够降解PE的菌株,并通过显微形态分析、分子鉴定等方法确定其种属;通过测定生长曲线、失重率、以及分析官能团变化来验证菌株对PE塑料的降解性能。【结果与结论】从沉积物中共筛选出K1-1、K1-2和K1-3三株PE降解能力较强的菌,分别为威尼斯不动杆菌(Acinetobacter venetianus)、Pseudomonas juntendi和维德曼芽孢杆菌(Bacillus wiedmannii)。在120 d的培养周期中,这些菌株的生长曲线均呈抛物线形态。经三株菌作用后,PE表面生成羟基,并形成氨基和羟基化合物,羟基取代羰基,导致PE表观和内部结构明显改变。经120 d处理后,PE膜的失重率分别为6.42%、5.38%和5.73%,其中K1-1菌株处理后PE塑料的失重率相较于目前报道的红树林沉积物中最高降解效率菌株Bacillus gottheilii处理后塑料的失重率提升3.55%。威尼斯不动杆菌(A.venetianus)在PE塑料降解上具有一定潜力,这丰富了湛江红树林沉积物中PE降解菌的种类,为PE塑料的生物降解提供理论支持。

关键词：红树林沉积物聚乙烯塑料降解菌降解性能

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Isolation and identification of two feather-degrading strains of bacterium from spider gut and the purification and analysis of related key microbial enzymes

Isolation and identification of two feather-degrading strain...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2...

作者： Fang Qu jinjun chen College of Bioscience and Biotechnology Hunan Agricultural University

Microbial enzymes play an increasingly important role in industrial production,agriculture and daily life nowadays.Particularly,some of these enzymes are derived from human-safe microorganisms.In our study,two novel feather-degrading bacteria,named CA-1 and CH-1 respectively,were isolated from the gut of the spider Chilobrachys guangxiensis,and were identified by sequence analysis of 16 S rRNA genes and phenotypic characteristics,which can degrade native whole chicken feathers.Based on morphologic and molecular analysis,the CA-1 was confirmed to belong to Stenotrophomonas maltophilia,CH-1 as a Bacillus subtilis.Furthermore,the purified enzymes under the optimal and suppressive conditions were analyzed respectively by SDS-PAGE and LC-MS/MS,and proteomic analysis of protein bands included.Three enzymes,namely alkaline serine protease(29.1 kDa),ABC transporter permease(27.5 kDa),and alkaline phosphatase(40.8 kDa),were purificated and identified from the supernatant of the CA-1 optimal culture and were considered to play principal roles.Four kinds of enzymes which include extracellular protease Vpr(68 kDa),g-glutamyl transpeptidase(64 kDa),peptidase T(45 kDa) and glyoxalmethylglyoxal reductase(32 kDa) derived from CH-1.This study provides a new angle for discovering featherdegrading bacterium.The purification and analysis of the enzymes shines a light on further understanding the molecular mechanism of feather degrading by microbes.There are also potential applications in cost-effectively degrading feathers into feeds and fertilizers through careful optimization and engineering of the newly identified enzymes.

关键词： Stenotrophomonas maltophilia Bacillus subtilis feather degradation Keratinase spider gut synergic enzymes symbiotic microorganism

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