检索结果-南通市图书馆

Lattice Boltzmann study of the interaction between a single solid particle and a thin liquid film

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2020年第8期41卷 1179-1194页

作者： Xiaojun QUAN Xuewen liU jinjing li Xunji GAO MOE Key Laboratory for Power Machinery and Engineering School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The isothermal single-component multi-phase lattice Boltzmann method(LBM)combined with the particle motion model is used to simulate the detailed process of liquid film rupture induced by a single spherical *** entire process of the liquid film rupture can be divided into two *** Stage 1,the particle contacts with the liquid film and moves into it due to the interfacial force and finally penetrates the liquid *** in Stage 2,the upper and lower liquid surfaces of the thin film are driven by the capillary force and approach to each other along the surface of the particle,resulting in a complete *** is found that a hydrophobic particle with a contact angle of 106.7°shows the shortest rupture duration when the liquid film thickness is less than the particle *** the thickness of the liquid film is greater than the immersed depth of the particle at equilibrium,the time of liquid film rupture caused by a hydrophobic particle will be *** the other hand,a moderately hydrophilic particle can form a bridge in the middle of the liquid film to enhance the stability of the thin liquid film.

关键词： lattice Boltzmann method(LBM) liquid film defoaming wettability solid particle

Advances in detecting and reducing off-target effects generated by CRISPR-mediated genome editing

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2019年第11期46卷 513-521页

作者： jinjing li Shunyan Hong Wanjin Chen Erwei Zuo Hui Yang Department of Neurology and Institute of Neurology The First Affiliated Hospital of Fujian Medical UniversityFuzhou350005China Fujian Key Laboratory of Molecular Neurology Fujian Medical UniversityFuzhou350005China lingnan Guangdong Laboratory of Modern Agriculture Genome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen518124China Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Research Center for Brain Science and Brain-Inspired IntelligenceShanghai Institutes for Biological SicencesChinese Academy of SciencesShanghai200031China

CRISPR-mediated genome editing is a revolutionary technology for genome manipulation that uses the CRISPR-Cas systems and base ***,poor efficiency and off-target problems have impeded the application of CRISPR *** on-target efficiency has been improved in several advanced versions of CRISPR systems,whereas the off-target detection still remains a key ***,we outline the different versions of CRISPR systems and off-target detection strategies,discuss the merits and limitations of off-target detection methods,and provide potential implications for further gene editing research.

关键词： Gene editing CRISPR-Cas9 Base editors Off-target

Motor relearning program and Bobath method improve motor function of the upper extremities in patients with stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2006年第9期1卷 850-852页

作者： jinjing liu Fengsheng li Guihua liu Department of Neurology General Hospital of Beijing Jingmei Group Beijing 102300 China Department of NeurologyGeneral Hospital of Beijing Jingmei Group Beijing 102300 China Department of NeurologyGeneral Hospital of Beijing Jingmei Group Beijing 102300 China

BACKGROUND: In the natural evolution of cerebrovascular disease, unconscious use of affected extremity during drug treatment and daily life can improve the function of affected upper extremity partially, but it is very slow and also accompanied by the formation of abnormal mode. Therefore, functional training should be emphasized in recovering the motor function of extremity. OBJECTIVE: To observe the effects of combination of motor relearning program and Bobath method on motor function of upper extremity of patients with stroke. DESIGN: Comparison of therapeutic effects taking stroke patients as observation subjects. SETTING: Department of Neurology, General Hospital of Beijing Jingmei Group. PARTICIPANTS: Totally 120 stroke patients, including 60 males and 60 females, averaged (59±3) years, who hospitalized in the Department of Neurology, General Hospital of Beijing Jingmei Group between January 2005 and June 2006 were recruited. The involved patients met the following criteria: Stroke attack within 2 weeks; diagnosis criteria of cerebral hemorrhage or infarction made in the 4th National Cerebrovascular Disease Conference; confirmed by skull CT or MRI; Informed consents of therapeutic regimen were obtained. The patients were assigned into 2 groups according to their wills: rehabilitation group and control group, with 30 males and 30 females in each group. Patients in rehabilitation group averaged (59±2)years old, and those in the control group averaged (58±2)years old. METHODS: ① Patients in two groups received routine treatment in the Department of Neurology. When the vital signs of patients in the rehabilitation group were stable, individualized treatment was conducted by combined application of motor relearning program and Bobath method. Meanwhile, training of activity of daily living was performed according to the disease condition changes of patients at different phases, including the nursing and instruction of body posture, the maintenance of good extremity

关键词： Motor relearning program and Bobath method improve motor function of the upper extremities in patients with stroke

enOsCas12f1-mediated exon skipping for Duchenne muscular dystrophy therapy in humanized mouse model

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 256-259页

作者： Ming Jin Jiajia lin Yu Zhang Qingquan Xiao Xiangfeng Kong Xiumei Zhang Zhurui Shao Yin Wang Yuyang Yu jinjing li Wan-Jin Chen Guoling li Hui Yang Ning Wang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350004China HUIDAGENE Therapeutics Co. Ltd.Shanghai 200131China Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

Duchenne muscular dystrophy(DMD)is a severe neuromuscular disorder caused by mutations in the dystrophin gene,which encodes the essential protein *** genetic condition,affecting approximately 1 in 5000 male births worldwide(Birnkrant et al.,2018),is characterized by progressive muscle weakness and wasting,leading to premature death in the second or third decade of life(Farini et al.,2016).The absence of dystrophin protein causes instability in the sarcolemma,which predisposes individuals to myonecrosis and activation of inflammatory signaling ***,there is currently no effective cure for DMD,and glucocorticoid steroids are commonly used in clinical settings to delay symptom development(Merlini et al.,2003).

关键词： dystrophy Duchenne

Highly selective methanol-to-olefin reaction on pyridine modified H-mordenite

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2017年第3期26卷 354-358页

作者： TingHe Guangjin Hou jinjing li Xianchun liu Shutao Xu Xiuwen Han Xinhe Bao State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina National Engineering Laboratory for Methanol to Olefins Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Department of Chemistry and Biochemistry University of DelawareNewarkDelaware 19716United States

The effects of the acid site in main channels of MOR zeolites on their product selectivity and deactivation in the MTO（methanol to olefin） reactions were investigated. The catalytic analysis demonstrates that the pyridine modified MOR zeolite yielded high selectivity（> 65.3%） of C;-C;, although the conversion dropped from 100% to 54%. Furthermore, both the catalytic lifetime of MOR and the stability of yielding the lower olefins were increased from less than 30 min to more than 120 min after the modification with pyridine.1H MAS NMR on MOR and modified MOR shows that the acid sites in main channel do not benefit the productivity of lower olefins and catalysts’ lifetime. It can be concluded from ex-situ;C CP MAS NMR that the deposit species during the MTO reaction depend on the pore sizes, and the formation of large alkyl aromatic species more likely occurs in the 12-ring main channels rather than the 8-ring side pocket.

关键词： Catalysis Mordenite Pyridine MTO NMR

经济欠发达地区农村宅基地流转的地域差异研究——以河北省张家口市为例

在线全文

学校读者我要写书评

暂无评论

资源科学 2014年第6期36卷 1229-1234页

作者：郭贯成李金景南京农业大学土地管理学院南京210095

通过对经济欠发达的张家口地区近郊和远郊农户宅基地流转意愿的抽样调查,采用统计分析法和Logit分析法,探讨了近郊和远郊农户宅基地流转方式和流转意愿影响因素的地域差异,为农村宅基地流转政策的改革提供依据。研究结果表明:①宅基地... 详细信息

通过对经济欠发达的张家口地区近郊和远郊农户宅基地流转意愿的抽样调查,采用统计分析法和Logit分析法,探讨了近郊和远郊农户宅基地流转方式和流转意愿影响因素的地域差异,为农村宅基地流转政策的改革提供依据。研究结果表明:①宅基地流转方式在近郊地区以出售和国家征收为主,在远郊地区以出租为主;②在流转意愿的影响因素方面,远郊与户主的受教育年限、家庭支出、社会保障以及房屋数量呈现正相关关系,与职业负相关;近郊地区与受教育年限、家庭支出以及房屋数量正相关,与家庭人数、职业类型以及治安状况负相关,与远郊相比,近郊剔除了社会保障方面的影响,增加了社会治安和家庭人口数量的影响。

关键词：宅基地地域差异近郊远郊影响因素土地流转张家口市

核壳结构催化剂Cr-Zn@SiO_2@SAPO-34催化合成气直接转化制低碳烃的性能（英文）

在线全文

学校读者我要写书评

暂无评论

催化学报 2015年第7期36卷 1131-1135页

作者：李津京潘秀莲包信和中国科学院大连化学物理研究所催化基础国家重点实验室辽宁大连116023

合成气直接转化高选择性制烃类产物仍是巨大的挑战.本文合成了以Cr-Zn氧化物为核,Si O2为中间过渡层,再通过原位水热合成覆盖一层SAPO-34分子筛为壳的核壳结构催化剂.合成气转化反应结果显示,与纯Cr-Zn金属氧化物相比,核壳结构催化剂将... 详细信息

合成气直接转化高选择性制烃类产物仍是巨大的挑战.本文合成了以Cr-Zn氧化物为核,Si O2为中间过渡层,再通过原位水热合成覆盖一层SAPO-34分子筛为壳的核壳结构催化剂.合成气转化反应结果显示,与纯Cr-Zn金属氧化物相比,核壳结构催化剂将产物分布由甲醇和甲烷移动至C2–C4烃(所有烃类产物中占66.9%).这表明核壳结构催化剂用于合成气一步法直接转化制液化石油气的反应具有可行性,但是催化剂结构和组成有待于进一步优化,以提高其催化反应性能.

关键词：铬锌金属氧化物分子筛核壳结构 C2–C4烃合成气直接转化

在线全文

学校读者我要写书评

暂无评论

市场一体化对黄河流域经济高质量发展的影响

资源科学 2024年第3期46卷 462-474页

作者：生延超李金婧徐珊李倩湖南工商大学公共管理与人文地理学院长沙410205 浙江工业大学管理学院杭州310014

[目的]加快建设统一大市场是落实黄河流域生态保护和高质量发展战略的重要推手,研究市场一体化对黄河流域经济高质量发展的影响及机制,可为黄河流域经济高质量发展提供理论支撑和政策参考。[方法]选取2011-2020年黄河流域的69个地级市... 详细信息

[目的]加快建设统一大市场是落实黄河流域生态保护和高质量发展战略的重要推手,研究市场一体化对黄河流域经济高质量发展的影响及机制,可为黄河流域经济高质量发展提供理论支撑和政策参考。[方法]选取2011-2020年黄河流域的69个地级市的面板数据作为样本,利用双向固定效应模型、中介模型和门槛模型探讨市场一体化对黄河流域经济高质量发展的影响。[结果]①市场一体化能够显著促进黄河流域经济高质量发展,市场一体化程度每提升1个单位,黄河流域经济高质量发展水平提升0.579个单位。②完善基础设施、要素流动和产业结构升级是市场一体化促进黄河流域经济高质量发展的重要机制。③经济集聚存在显著的单一门槛效应,当经济集聚程度超过门槛值0.020,市场一体化对黄河流域经济高质量发展的促进作用降低。④市场一体化对黄河流域经济高质量发展的促进作用存在区域异质性,中小城市市场一体化对其经济高质量发展的促进作用更强烈,特大城市市场一体化抑制其经济高质量发展。[结论]要加快推进黄河流域市场一体化建设,完善地区基础设施,畅通要素流动,促进产业结构升级,合理控制经济集聚程度和城市规模,借助政策因地制宜发挥市场一体化的高质量红利效应。

关键词：市场一体化经济高质量发展基础设施要素流动产业结构升级黄河流域

CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 184-196页

作者： Yan Shi Chunyan Cao Yiheng Zeng Yuanliang Ding Long Chen Fuze Zheng Xuejiao Chen Fanggui Zhou Xiefeng Yang jinjing li liuqing Xu Guorong Xu Minting lin Hiroyuki Ishiura Shoji Tsuji Ning Wang Zhiqiang Wang Wan-Jin Chen Kang Yang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Department of Neurology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350212China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan 471000China Department of Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujian 363000China Department of Neurology Jian'ou Municipal Hospital of Fujian ProvinceJian'ouFujian 353100China Department of Radiology First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Department of Neurology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Neurology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Institute of Medical Genomics International University of Health and WelfareChiba 286-0048Japan

CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with ***,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/***,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal *** CGG repeat expansions range from 161 to 669 repeat *** of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle *** one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance *** biopsies from three patients show a myopathic pattern and rimmed *** of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to *** study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers.

关键词： Oculopharyngeal myopathy with leukoencephalopathy Oculopharyngodistal myopathy CGG repeat expansion Rimmed vacuoles