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敲低TROAP基因对胆管癌细胞系增殖和迁移能力的影响

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中国医药导刊 2024年第3期26卷 285-290页

作者：赵晋江郭伟梁少华程杰长治医学院附属和济医院山西长治046000

目的:探究Trophinin相关蛋白(Trophinin-associated protein,TROAP)基因沉默对人胆管癌细胞系RBE细胞增殖和迁移能力的影响。方法:培养人胆管癌细胞系RBE,并对其分别转染阴性对照序列和TROAP干扰序列,分别命名为si-NC组和siTROAP组。采... 详细信息

目的:探究Trophinin相关蛋白(Trophinin-associated protein,TROAP)基因沉默对人胆管癌细胞系RBE细胞增殖和迁移能力的影响。方法:培养人胆管癌细胞系RBE,并对其分别转染阴性对照序列和TROAP干扰序列,分别命名为si-NC组和siTROAP组。采用细胞计数试剂盒(CCK-8)和平板克隆形成实验检测细胞增殖能力;流式细胞术检测细胞凋亡率;细胞划痕实验和Transwell法检测细胞迁移和侵袭能力;蛋白质印迹实验(Western blot)检测RBE细胞中上皮间充质化(EMT)相关蛋白E-cadherin、N-cadherin,PCNA以及凋亡相关蛋白Bcl-2、Bax和caspase-3的相对表达量。结果:与si-NC组细胞相比,si-TROAP组细胞增殖率降低,克隆个数降低,细胞凋亡率升高,迁移和侵袭能力降低(P<0.05)。与si-NC组细胞相比,si-TROAP组细胞E-cadherin蛋白相对表达水平升高,N-cadherin蛋白相对表达水平降低,Bax和caspase-3蛋白相对表达水平升高,Bcl-2和PCNA蛋白相对表达水平降低(P<0.05)。结论:TROAP基因是RBE细胞潜在的致癌基因,TROAP基因沉默可降低人胆管癌细胞系RBE细胞增殖和迁移能力,并通过缓解上皮间质转化来发挥效应。

关键词：胆管癌 Trophinin相关蛋白迁移增殖上皮间质转化

An Investigation of a Confirmed Imported Case of COVID-19 Infected Abroad—Qingpu District,Shanghai Municipality,China,November 15,2020

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China CDC weekly 2021年第10期3卷 207-210页

作者： Hongrang Zhou Xiaoling Wang Qiufang Xu Xiaoming Wang Yadong Ma Yiru Shi Zhouli Wu Peifeng Zhu jinjiang zhao Ruifang Xu Changpo Lin Ning Xiao Qingpu District Center for Disease Control and Prevention ShanghaiChina National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghaiChina Program in Public Health College of Health SciencesUniversity of California at IrvineIrvineUSA.

Summary What is already known about this topic?A passenger who was from the United States was taken to the hotel for the required isolation on November 13,*** the quarantine she was diagnosed as the COVID-19 patient o... 详细信息

关键词： November fir COV

Influence of Holding Time on Hot Deformation Behavior of Hard-Deformed Superalloy U720Li

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稀有金属材料与工程 2024年第9期53卷 2446-2457页

作者： Zang Ximin zhao Guangdi Wu jinjiang Jiang Haoyuan Yao Xiaoyu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

To improve the hot workability of hard-deformed superalloy U720Li,the effect of holding time before deformation(5 and 10 min)on hot deformation behavior was investigated by hot compression *** show that the flow stress increases with increase in strain rate,while decreases with increase in deformation temperature and holding *** on the obtained Arrhenius-type constitutive models,the calculated peak stresses are in good agreement with experimental values,indicating that this model can accurately predict the hot deformation behavior of U720Li alloy,and the deformation activation energies for the holding time of 5 and 10 min were calculated to be 992.006 and 850.996 kJ·mol^(-1),***,processing maps of U720Li alloy with these two holding durations were *** observation of deformation microstructures in each domain of the processing maps,the optimal hot working conditions for the holding time of 5 min are determined to be 1090‒1110℃/1‒10 s^(-1) and 1146‒1180℃/1‒10 s^(-1),and the optimal hot working conditions for the holding time of 10 min are 1080‒1090℃/1‒10 s-1 and 1153‒1160℃/1‒10 s^(-1),indicating that the safe processing window can be obviously enlarged by shortening the holding time *** the absence of cracking,the dynamic recrystallization(DRX)grain size increases gradually with increasing the deformation temperature and holding time,but it first decreases and then increases with the increase in strain *** the deformation temperature is below 1100℃,the DRX mechanism is mainly the particle-induced continuous *** the temperature is raised to above 1130℃,the main DRX mechanism changes to discontinuous DRX.

关键词： hard-deformed superalloy hot deformation behavior processing map dynamic recrystallization

剖腹手术与腹腔镜联合内镜逆行胰胆管造影术治疗胆囊结石合并胆总管结石的疗效比较

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中国药物经济学 2015年第4期10卷 108-109页

作者：赵晋江长治医学院附属和济医院普外二科山西医科大学山西长治046000

目的探讨腹腔镜联合内镜逆行胰胆管造影术(ERCP)与剖腹手术治疗胆总管结石合并胆囊结石的疗效比较。方法选取胆总管结石合并胆囊结石患者88例,完全随机分为对照组和治疗组,各44例。对照组患者给予剖腹手术,治疗组患者给予腹腔镜联合ERC... 详细信息

目的探讨腹腔镜联合内镜逆行胰胆管造影术(ERCP)与剖腹手术治疗胆总管结石合并胆囊结石的疗效比较。方法选取胆总管结石合并胆囊结石患者88例,完全随机分为对照组和治疗组,各44例。对照组患者给予剖腹手术,治疗组患者给予腹腔镜联合ERCP。比较两组患者的治疗效果。结果治疗组患者手术时间及术后恢复时间明显短于对照组,治疗效果明显优于对照组,差异均有统计学意义(均P<0.05)。结论腹腔镜联合ERCP治疗胆总管结石合并胆囊结石患者效果明显,且手术时间及术后恢复时间短于剖腹手术。

关键词：腹腔镜内镜逆行胰胆管造影术胆总管结石胆囊结石

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新生代农民工城市住房解困路径研究

价格理论与实践 2018年第6期 50-53页

作者：林永民赵金江史孟君华北理工大学管理学院

新时代背景下,解决新生代农民工住房问题,是促进城乡深度融合,推进有质量的新型城镇化的关键。目前,我国新生代农民工住房情况总体上还处于"两难"困境:高房价与低收入使新生代农民工"望楼兴叹";而将新生代农民工纳入保障房体系还需要逐... 详细信息

新时代背景下,解决新生代农民工住房问题,是促进城乡深度融合,推进有质量的新型城镇化的关键。目前,我国新生代农民工住房情况总体上还处于"两难"困境:高房价与低收入使新生代农民工"望楼兴叹";而将新生代农民工纳入保障房体系还需要逐步落实。为破解新生代农民工住房困境,缓解新生代农民工的购房压力、消除后顾之忧、使其租有所选,应建立住房"梯级"消费理念、切实推进"租售同权"、实现租赁性住房产业专业化和规模化,将新生代农民工逐步纳入公共租赁性住房保障体系。

关键词：新生代农民工租赁性住房梯级消费理念租售同权

Study on Recycled Applications of SRR99 Single Crystal Superalloy

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Study on Recycled Applications of SRR99 Single Crystal Super...

MLSE-assisted decision feedback equalizer for error-propagation suppression in high-speed IM-DD transmission systems

第69届世界铸造会议暨2010中国铸造活动周

作者： Yu jinjiang zhao Nairen Lang Haixia Sun Xiaofeng Guan Hengrong Hu Zhuangqi Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

＜正＞The effects of application of recycled scraps on the composition,microstructure and mechanical properties of SRR99 alloy were *** compositions of recycle master alloy are similar to that of the fresh ***,nitrogen content,the size and amount of microporosity increase significantly with the recycle material ***,lamellar and strip-like MC particles are mainly present in the interdendritc regions of the revert *** the addition of the recycled material proportion,the amount of the granular ones rapidly drop and the lamelar ones gently *** stress rupture life decline with the addition of the recycled material *** oxide and sulphide inclusions in the revert alloy can be effectively captured and removed by a foam ceramic filter so that the tensile and stress rupture property has been significantly improved.

关键词： revert nickel-based single crystal microstructure mechanical properties nitrogen

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Chinese Optics Letters 2024年第5期22卷 36-40页

作者：周家豪张静赵雪王芮李劲江胡少华张倩武杨奇许渤邱昆 Key Laboratory of Optical Fiber Sensing and Communication University of Electronic Science and Technology of ChinaChengdu 611731China Key Laboratory of Specialty Fiber Optics and Optical Access Networks Shanghai UniversityShanghai 200444China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China

We propose a trellis-compressed maximum likelihood sequence estimation(TC-MLSE)-assisted sliding-block decision feedback equalizer(DFE)to suppress the error propagation resulting from the DFE in high-speed *** use an out-ofrange detector to detect the end of burst errors from the DFE and activate the optional TC-MLSE to correct burst *** conduct experiments to transmit a 201-Gbit/s PAM-8 *** results show that the proposed method achieves a bit error rate of 3.65×10^(-3),which is close to that of *** optional MLSE is only activated when needed and processes 11.4%of the total ***,the proposed method compresses the maximum length of burst errors from 19 to 5.

关键词： intensity modulation direct detection sliding-block decision feedback equalizer error propagation maximum likelihood sequence estimation out-of-range detector

胆囊切除术不同手术时机对急性胆石性胰腺炎疗效的影响

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中国基层医药 2017年第16期24卷 2456-2459页

作者：赵晋江胡文庆长治医学院附属和济医院普通外科山西省长治046000

目的探讨手术时机对腹腔镜胆囊切除术治疗急性胆石性胰腺炎疗效的影响.方法回顾性分析93例急性胆石性胰腺炎患者临床资料,手术方式均为腹腔镜胆囊切除术,按手术时机分为研究组45例（早期：48 h内）与对照组48例（延期：8~12周后）,比较... 详细信息

目的探讨手术时机对腹腔镜胆囊切除术治疗急性胆石性胰腺炎疗效的影响.方法回顾性分析93例急性胆石性胰腺炎患者临床资料,手术方式均为腹腔镜胆囊切除术,按手术时机分为研究组45例（早期：48 h内）与对照组48例（延期：8~12周后）,比较两组患者手术指标、生化指标、生活质量改善情况、复发及并发症发生情况.结果术中出血量及手术时间比较差异均无统计学意义（t=0.332、0.486,均P〉0.05）.研究组住院时间较对照组短[（11.43±2.65）d比（20.51±3.42）d],差异有统计学意义（t=14.245,P〈0.05）.术后7 d时两组生化指标均明显降低,与术后1 d时比较差异均有统计学意义（t=17.184、35.209、12.018、7.452、16.045、36.124、12.337、7.038,均P〈0.05）.术后1 d及术后7 d时两组生化指标差异均无统计学意义（t=0.431、0.663、0.664、1.118、0.085、0.156、0.283、0.262,均P〉0.05）.治疗后两组生活质量明显改善,与治疗前比较差异均有统计学意义（t=5.017、7.028、6.124、3.095、6.023、6.995、6.184、3.128,均P〈0.05）.两组患者复发及并发症发生情况（4.44%比2.08%、6.67%比10.42%）比较差异均无统计学意义（x2=0.412、0.081,均P〉0.05）.结论早期行腹腔镜胆囊切除术可缩短急性胆石性胰腺炎患者住院时间,疗效与安全性良好.

关键词：胆囊结石病胰腺炎胆囊切除术腹腔镜

加热工艺对难变形高温合金U720Li中γ'相溶解及晶粒长大行为的影响

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稀有金属材料与工程 2024年第8期53卷 2205-2216页

作者：武金江赵广迪姜昊源孙乙轩王博辽宁科技大学材料与冶金学院辽宁鞍山114051

变形前的加热工艺对高温合金的热加工性能具有重要影响。本研究通过开展等温加热实验研究了难变形高温合金U720Li中γ'相特征及晶粒组织随加热温度及保温时间的演变行为,进而为改善其热加工性能提供理论指导。为了更准确地描述γ'相和... 详细信息

变形前的加热工艺对高温合金的热加工性能具有重要影响。本研究通过开展等温加热实验研究了难变形高温合金U720Li中γ'相特征及晶粒组织随加热温度及保温时间的演变行为,进而为改善其热加工性能提供理论指导。为了更准确地描述γ'相和晶粒的特征,本实验采用电解腐蚀与化学腐蚀试样相结合的方法开展研究。结果表明,一次γ'的面积分数及尺寸随加热温度的升高及保温时间的延长逐渐减小。细小二次γ'比粗大一次γ'更易溶解,前者在1100℃保温30 min就可完全溶解,而后者在1180℃保温30 min才能完全溶解;一次γ'的不断溶解减弱了其对晶界的钉扎作用,导致合金的平均晶粒尺寸随加热温度升高及保温时间的延长逐渐增大,且在1180℃(高于γ'溶解温度)短时保温就发生了晶粒异常长大现象,形成混晶组织。最后,根据不同加热条件的晶粒长大行为,建立了U720Li合金在1050~1160℃的晶粒长大动力学模型。

关键词： U720Li合金加热工艺 γ'相晶粒长大