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220kV氧化锌避雷器不拆一次引线试验分析

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河北电力技术 2023年第1期42卷 80-83页

作者：赵冀宁刘晓飞付炜平祝洁肖方勇国网河北省电力有限公司超高压分公司河北石家庄050070 国网河北省电力有限公司衡水供电分公司河北衡水053000 国网西藏电力有限公司超高压分公司西藏拉萨850000

直流参考电压和泄漏电流测试是氧化锌避雷器例行试验项目,其测量的准确性是保证氧化锌避雷器安全、稳定运行的基础。针对220 kV氧化锌避雷器不拆一次引线测试直流参考电压和泄漏电流时避雷器拐点电压不一致的情况,采用电阻分压法提高避... 详细信息

直流参考电压和泄漏电流测试是氧化锌避雷器例行试验项目,其测量的准确性是保证氧化锌避雷器安全、稳定运行的基础。针对220 kV氧化锌避雷器不拆一次引线测试直流参考电压和泄漏电流时避雷器拐点电压不一致的情况,采用电阻分压法提高避雷器上节试验电压和电源抬升法提高避雷器下节试验电压,分析了试验线角度对测试结果的影响,通过在法兰外部包覆绝缘层的方法降低干扰,并在现场试验过程中验证了方法的可行性。

关键词：氧化锌避雷器泄漏电流直流参考电压

现代建筑设计中传统建筑文化的传承与发展解析

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城市建筑 2019年第9期16卷 93-94页

作者：赵济宁武汉理工大学土木工程与建筑学院

随着经济社会的不断发展,我国建筑文化的发展也越来越快,传统建筑文化在现代建筑设计中仍然有一定的地位。本文主要分析了传统建筑文化在现代建筑设计中的特质,阐述了传统建筑文化的核心要点,进而对传统建筑文化在现代建筑设计中传承与... 详细信息

随着经济社会的不断发展,我国建筑文化的发展也越来越快,传统建筑文化在现代建筑设计中仍然有一定的地位。本文主要分析了传统建筑文化在现代建筑设计中的特质,阐述了传统建筑文化的核心要点,进而对传统建筑文化在现代建筑设计中传承与发展的表现进行了说明,最后对传统建筑文化在现代建筑设计中传承和发展的应用进行了探析。

关键词：传统建筑文化现代建筑传承与发展

Identification and validation of novel prognostic fatty acid metabolic gene signatures in colon adenocarcinoma through systematic approaches

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Oncology Research 2024年第2期32卷 297-308页

作者： HENG ZHANG WENJING CHENG HAIBO zhao WEIDONG CHEN QIUJIE ZHANG QING-QING YU Department of Laboratory Shandong Daizhuang HospitalJining272051China jining No.1 People’s Hospital Shandong First Medical UniversityJining272000China

Colorectal cancer(CRC)belongs to the class of significantly malignant tumors found in ***,dysregulated fatty acid metabolism(FAM)has been a topic of attention due to its modulation in cancer,specifically ***,the regulatory FAM pathways in CRC require comprehensive ***:The clinical and gene expression data of 175 fatty acid metabolic genes(FAMGs)linked with colon adenocarcinoma(COAD)and normal cornerstone genes were gathered through The Cancer Genome Atlas(TCGA)-COAD corroborating with the Molecular Signature Database v7.2(MSigDB).Initially,crucial prognostic genes were selected by uni-and multi-variate Cox proportional regression analyses;then,depending upon these identified signature genes and clinical variables,a nomogram was ***,to assess tumor immune characteristics,concomitant evaluation of tumor immune evasion/risk scoring were ***:A 8-gene signature,including ACBD4,ACOX1,CD36,CPT2,ELOVL3,ELOVL6,ENO3,and SUCLG2,was generated,and depending upon this,CRC patients were categorized within high-risk(H-R)and low-risk(L-R)***,risk and age-based nomograms indicated moderate discrimination and good *** data confirmed that the 8-gene model efficiently predicted CRC patients’***,according to the conjoint analysis of tumor immune evasion and the risk scorings,the H-R cohort had an immunosuppressive tumor microenvironment,which caused a substandard ***:This investigation established a FAMGs-based prognostic model with substantially high predictive value,providing the possibility for improved individualized treatment for CRC individuals.

关键词： Fatty acid metabolism Colorectal cancer Gene signatures Machine learning

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3449-3466页

作者： Xixi Guo Xiaosa zhao Xi Lu Liping zhao Qingxuan Zeng Fenbei Chen Zhimeng Zhang Mengyi Xu Shijiao Feng Tianyun Fan Wei Wei Xin Zhang Jing Pang xuefu You Danqing Song Yanxiang Wang Jiandong Jiang Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College100050 BeijingChina School of Information Science and Technology Northeast Normal UniversityChangchun 130117China Department of Pharmacy Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272029 ShandongChina Institute of Health and Medicine Hefei Comprehensive National Science CenterHefei230601AnhuiChina

Helicobacter pylori(***)is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis,and its high prevalence and resistance make it difficult to tackle.A graph neural network-based deep learning model,employing different training sets of 13,638 molecules for pre-training and fine-tuning,was aided in predicting and exploring novel molecules against ***.A positively predicted novel berberine derivative 8 with 3,13-disubstituted alkene exhibited a potency against all tested drug-susceptible and resistant *** strains with minimum inhibitory concentrations(MICs)of 0.25-0.5μg/*** studies demonstrated an ideal gastric retention of 8,with the stomach concentration significantly higher than its MIC at 24 h post *** administration of 8 and omeprazole(OPZ)showed a comparable gastric bacterial reduction(2.2-log reduction)to the triple-therapy,namely OPZ+amoxicillin(AMX)+clarithromycin(CLA)without obvious disturbance on the intestinal flora.A combination of OPZ,AMX,CLA,and 8 could further decrease the bacteria load(2.8-log reduction).More importantly,the mono-therapy of 8 exhibited comparable eradication to both triple-therapy(OPZ+AMX+CLA)and quadrupletherapy(OPZ+AMX+CLA+bismuth citrate)*** and BamD,playing a major role in outer membrane protein(OMP)transport and assembling,were identified and verified as the direct targets of 8 by employing the chemoproteomics technique.n summary,by targeting the relatively conserved OMPs transport and assembling system,8 has the potential to be developed as a novel *** candidate,especially for the eradication of drug-resistant strains.

关键词： berberine stomach retention

Mechanism Exploration of Euphorbia fischeriana Steud. for Liver Cancer Based on Aspartic Acid Identification in Metabolomics

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Chinese Journal of Integrative Medicine 2024年第6期30卷 507-514页

作者： zhao Jing TIAN Xin-chen ZHANG Jia-qi HUANG Chen SUN Yan QIAO Sen JIANG Shu-long Clinical Medical Laboratory Center Jining First People’s HospitalJiningShandong Province272000China Cheeloo College of Medicine Shandong UniversityJinan250000China

Objective:To investigate the anti-liver cancer effects and aspartic acid(Asp)-related action mechanism of Euphorbia fischeriana Steud.(LD).Methods:The mice model of liver cancer was established by injection of H22 *** 5 days,mice were randomly divided into model group,sorafenib group(20 mg/kg),LD high-dose(LDH,1.36 g/kg) group,LD medium-dose(LDM,0.68 g/kg) group,and LD low-dose(LDL,0.34 g/kg)group,10 mice each *** were intragastrically administered to the mice once daily for 10 days,*** weight,tumor size and tumor weight were *** index was *** changes of liver cancer tissues were evaluated by hematoxylin and eosin staining and TUNEL *** chromatography-mass spectrometer was used to analyze different metabolites between the model and LDH ***:After LD treatment,tumor weight,tumor size and hepatic index were reduced compared with the model *** and karyorrhexis of tumor cells were ***,61 differential metabolites(18 up-regulated,43 down-regulated) were affirmed and 20 pathways of KEGG(P<0.05) were *** addition,Bel-7402,HepG2 and H22 cell viabilities were significantly increased after adding Asp into the *** then,the cell proliferation effect induced by Asp was ameliorated by ***:The anti-liver cancer efficacy of LD extract was validated in H22 mice model,and inhibition of Asp level might be the underlying mechanism.

关键词： liver cancer Euphorbia fischeriana Steud. aspartic acid metabolomics

An integrated assessment method of urban drainage system:A case study in Shenzhen City,China

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Frontiers of Environmental Science & Engineering 2008年第2期2卷 150-156页

作者： Xin DONG Siyu ZENG jining CHEN Dongquan zhao Department of Environmental Science&Engineering Tsinghua UniversityBeijing 100084China

In recent years,the urban drainage system in China is facing the dual pressure of renovation and *** requires that the integrated assessment for the planning and operation of the urban drainage system is *** evaluate the urban drainage system,an integrated assessment methodology based on the analytic hierarchy process(AHP),integrated simulation,and fuzzy assessment is *** method is a multi-criteria decision adding app roach to the assessment of the urban drainage system *** the integration of the Storm Water Management Model(SWMM),a simple wastewater treatment plant model,and a surface water quality model,an integrated modelling system for the urban drainage system is developed and applied as a key tool for *** the established method,a case study in Shenzhen City has been implemented to evaluate and compare two urban drainage system reno vation plans,the distributed plan and the centralized *** of the particularity of this case study,the established method is not applied *** the water environ mental impact,ecological impact,technological feasibility,and economic cost,the integrated performance of the distri buted plan is *** shown in this case study,the proposed method is found to be both effective and practical.

关键词： analytic hierarchy process(AHP) centralized plan distributed plan fuzzy assessment integrated assessment integrated simulation urban drainage system

Proteomic study of vitreous in proliferative diabetic retinopathy patients after treatment with aflibercept:a quantitative analysis based on 4D label-free technique

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 676-685页

作者： Ting-Ting Feng Xiang Gao An-Ran Liang Bo-Wen zhao Guang-Hui He Song Chen Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye InstituteTianjin Eye HospitalTianjin 300020China Key Laboratory of Ophthalmology Anyang Eye HospitalAnyang 455000Henan ProvinceChina Department of Ophthalmology Jining No.1 People’s HospitalJining 272011Shandong ProvinceChina

AIM:To identify different metabolites,proteins and related pathways to elucidate the causes of proliferative diabetic retinopathy(PDR)and resistance to anti-vascular endothelial growth factor(VEGF)drugs,and to provide biomarkers for the diagnosis and treatment of ***:Vitreous specimens from patients with diabetic retinopathy were collected and analyzed by Liquid Chromatography-Mass Spectrometry(LC-MS/MS)analyses based on 4D label-free *** differentially expressed proteins(DEPs),Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway representation and protein interactions were ***:A total of 12 samples were *** proteomics results showed that a total of 58 proteins were identified as DEPs,of which 47 proteins were up-regulated and 11 proteins were *** found that C1q and tumor necrosis factor related protein 5(C1QTNF5),Clusterin(CLU),tissue inhibitor of metal protease 1(TIMP1)and signal regulatory protein alpha(SIRPα)can all be specifically regulated after aflibercept *** functional analysis showed that some DEPs are related to changes in inflammatory regulatory pathways caused by *** addition,protein-protein interaction(PPI)network evaluation revealed that TIMP1 plays a central role in neural *** addition,CD47/SIRPαmay become a key target to resolve anti-VEGF drug resistance in ***:Proteomic analysis is an approach of choice to explore the molecular mechanisms of *** data show that multiple proteins are differentially changed in PDR patients after intravitreal injection of aflibercept,among which C1QTNF5,CLU,TIMP1 and SIRPαmay become targets for future treatment of PDR and resolution of anti-VEGF resistance.

关键词： vitreous proliferative diabetic retinopathy proteome 4D label-free