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Comparison of developmental toxicity of different surface modified CdSe/ZnS QDs in zebrafish embryos

Journal of Environmental Sciences 2021年第2期33卷 240-249页

作者： Naying Zheng Jinhui Yan Wang Qian Chao Song Zhenghong Zuo Chengyong He State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen 361005China Freshwater Fisheries Research Center Chinese Academy of Fishery SciencesWixi 214081China

Quantum dots(QDs)are new types of nanomaterials.Few studies have focused on the effect of different surface modified QDs on embryonic development.Herein,we compared the in vivo toxicity of Cd Se/Zn S QDs with carboxyl(-COOH)and amino(-NH 2)modification using zebrafish embryos.After exposure,the two Cd Se/Zn S QDs decreased the survival rate,hatching rate,and embryo movement of zebrafish.Moreover,we found QDs attached to the embryo membrane before hatching and the eyes,yolk and heart after hatching.The attached amount of carboxyl QDs was more.Consistently,the Cd content in embryos and larvae was higher in carboxyl QD-treatment.We further observed that the two QDs caused zebrafish pericardial edema and cardiac dysfunction.In line with it,both carboxyl and amino QDs upregulated the transcription levels of cardiac development-related genes,and the levels were higher in carboxyl QD-treated groups.Furthermore,the chelator of Cd^2+diethylene triamine pentacetate acid could partially rescued the developmental toxicity caused by the two types of QDs suggesting that both the nature of QDs and the release of Cd^2+contribute to the developmental toxicity.In conclusion,the two Cd Se/ZnS QDs have developmental toxicity and affect the cardiac development,and the carboxyl QDs is more toxic possibly due to the higher affinity and more release to embryos and larvae.Our study provides new knowledge that the surface functional modification of QDs is critical on the development on aquatic species,which is beneficial to develop and applicate QDs more safely and environmentfriendly.

关键词： Quantum dots Surface modification Fish Cardiac development Developmental toxicity

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Deciphering the critical effect of cathode-electrolyte interphase by revealing its dynamic evolution

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Journal of Energy Chemistry 2023年第6期81卷 192-199,I0006页

作者： Zhengfeng Zhang Changdong Qin Kuan Wang Xiao Han jinhui Li Manling Sui Pengfei yan Beijing Key Laboratory of Microstructure and Property of Solids Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China

Cathode electrolyte interphase(CEI)layer plays a crucial role in determining the electrochemical performance of lithium-ion batteries.Limited by the sensitive nature of CEI and the lack of characterization techniques,its dynamic evolution during cycling,its formation mechanism,and its specific impact on battery performance are not yet fully understood.Herein,we systematically investigate the dynamic evolution of CEI layer and its critical effect on the cycling performance of LiCoO_(2)cathode by diverse characterization techniques.We find that cycling voltage plays a key role in affecting CEI formation and evolution,and a critical potential(4.05 V vs.Li)is identified,which acts as the switching potential between CEI deposition and decomposition.We show that CEI starts deposition in the discharge process when the potential is below 4.05 V,and CEI decomposition occurs when the potential is higher than 4.05 V.When the battery is cycled below such a critical potential,a stable CEI layer is developed,which leads to superior cycling stability.When the battery is cycled above such a critical potential,a CEI-free cathode interface is observed,which also demonstrates good cycle stability.However,when the critical potential falls in the cycling voltage range,CEI deposition and decomposition are repeatedly switched on during cycling,leading to the dynamically unstable CEI layer.The unstable CEI layer causes continuous interfacial reaction and degradation,resulting in battery performance decay.Our work deepens the understanding of the CEI formation and evolution mechanisms,and clarifies the critical effect of CEI layer on cycling performance,which provides new insights into stabilizing the electrode-electrolyte interface for high-performance rechargeable batteries.

关键词： LiCoO_(2) CEI Lithium-ion battery Electron microscopy XPS

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Catalyst-free and solvent-free oxidation of cycloalkanes(C5-C8) with molecular oxygen:Determination of autoxidation temperature and product distribution

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Chinese Journal of Chemical Engineering 2018年第5期26卷 1064-1070页

作者： Haimin Shen yan Wang jinhui Deng Long Zhang Yuanbin She State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology College of Chemical Engineering Zhejiang University of Technology

Autoxidation of cycloalkanes(C5–C8) with molecular oxygen under catalyst-free and solvent-free conditions was conducted systematically for the first time, focusing on the autoxidation temperature and product distribution. The autoxidation of cyclopentane, cyclohexane, cycloheptane and cyclooctane occurs at 120 ℃,130 ℃, 120 ℃, and 105 ℃ respectively, with obvious oxidized products formation. At 140 ℃, 145 ℃, 130 ℃ and 125 ℃, acceptable yields of the oxidized products could be obtained for them, and the oxidized product distributions were investigated in detail. The autoxidation of cycloalkanes follows the pseudo-first-order kinetic model and the apparent activation energies(E_a) for the autoxidation of cyclopentane and cyclohexane are 159.76 kJ·mol^(-1) and 86.75 kJ·mol^(-1) respectively. This study can act as an important reference in screen of suitable reaction temperature and comparison of the performance of various catalysts in the catalytic oxidation of cycloalkanes in the attempt to enhance the oxidized product selectivity.

关键词：氧化温度自然氧化产品分布催化剂分子分发溶剂运动模型

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Probing Allosteric Modulation of Membrane Receptor in the Native State by Data Mining-Integrated Tracking Microscopy

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CCS Chemistry 2022年第9期4卷 3150-3161页

作者： Bin Xiong Jia Wu jinhui Shang yancao Chen yan He Xiao-Bing Zhang Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082 Department of Chemistry Tsinghua UniversityBeijing 100084

As a general mechanism for governing the bioactivity of membrane receptors,allosteric modulation is critical in cell signaling and cell communication but remains difficult to measure in situ.Herein,we introduce a data mining-integrated tracking microscopy(DMITM)to investigate allosteric modulation of membrane receptors in the native state in live cells.Using Kmeans clustering-based hidden Markov modeling to uncover the ligand binding and unbinding events with diffusivity variations of ligand-conjugated nanoprobes as observations.

关键词： single-particle tracking allosteric modulation receptor activity binding kinetics free energy landscape

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Selective core-shell doping enabling high performance 4.6 V-LiCoO2

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Journal of Energy Chemistry 2024年第8期95卷 684-693页

作者： Yueming Xia Jianrui Feng jinhui Li yan Li Zhengfeng Zhang Xiaoqi Wang Jianli Shao Manling Sui Pengfei yan Beijing Key Laboratory of Microstructure and Property of Solids College of Materials Science & Engineering Beijing University of Technology Petro China Research Institute of Petroleum Exploration & Development State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

Constructing robust surface and bulk structure is the prerequisite for realizing high performance high voltage LiCoO2(LCO).Herein,we manage to synthesize a surface Mg-doping and bulk Al-doping coreshell structured LCO,which demonstrates excellent cycling performance.Half-cell shows 94.2% capacity retention after 100 cycles at 3.0-4.6 V(vs.Li/Li+) cycling,and no capacity decay after 300 cycles for fullcell test(3.0-4.55 V).Based on comprehensive microanalysis and theoretical calculations,the degradation mechanisms and doping effects are systematically revealed.For the undoped LCO,high voltage cycling induces severe interfacial and bulk degradations,where cracks,stripe defects,fatigue H2 phase,and spinel phase are identified in grain bulk.For the doped LCO,Mg-doped surface shell can suppress the interfacial degradations,which not only stabilizes the surface structure by forming a thin rock-salt layer but also significantly improves the electronic conductivity,thus enabling superior rate performance.Bulk Al-doping can suppress the lattice "breathing" effect and the detrimental H3 to H1-3 phase transition,which minimizes the internal strain and defects growth,maintaining the layered structure after prolonged cycling.Combining theoretical calculations,this work deepens our understanding of the doping effects of Mg and Al,which is valuable in guiding the future material design of high voltage LCO.

关键词： Doping effect Electron microscopy Failure mechanism High-voltage LiCoO2 Lithium-ion battery

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Passively Q-switched Tm/Ho composite laser

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Opto-Electronic Advances 2020年第4期3卷 14-19页

作者： Haizhou Huang jinhui Li Jing Deng yan Ge Huagang Liu Jianhong Huang Wen Weng Wenxiong Lin Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3117576Singapore.

We explored Q-switching mechanism for the newly proposed Tm/Ho composite laser via developing a hybrid resonator for separating the intra-cavity Tm laser modulated by the saturable absorber(SA).With a Cr:ZnSe SA,successful passively Q-switching process with the maximum average output power of 474 mW and the shortest pulse width of 145 ns were obtained at the pulse repetition frequency of 7.14 kHz,where dual wavelength oscillation in both 2090 nm and 2097 nm was observed.This work provides an effective way for a direct laser diode(LD)pumped Q-switched Ho laser,which is compact and accessible.Furthermore,the current SA could be replaced by the 2D materials with broadband saturable absorption such as topological insulators or transition-metal dichalcogenides for seeking novel PQS lasers.

关键词： Ho laser Tm laser Tm/Ho composite passively Q-switched Cr:ZnSe

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基于三维坐姿的压力数据自动标注方法

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仪器仪表学报 2023年第10期44卷 71-79页

作者：郑台台姚燕蔡晋辉中国计量大学计量测试工程学院杭州310018

针对当前传统坐姿标注方法,存在操作繁琐、人工标注效率低等问题,提出了一种基于三维坐姿的压力数据自动标注方法。该方法基于双指针时间戳匹配实现双目视觉数据和压力数据同步实时采集;采取归一化、自适应中值滤波处理压力数据,去除压... 详细信息

针对当前传统坐姿标注方法,存在操作繁琐、人工标注效率低等问题,提出了一种基于三维坐姿的压力数据自动标注方法。该方法基于双指针时间戳匹配实现双目视觉数据和压力数据同步实时采集;采取归一化、自适应中值滤波处理压力数据,去除压力数据量纲影响和尖峰噪声;利用二维姿态估计与匹配优化、坐标变换和多点三角测量处理视觉数据,提取6个三维人体关键点信息;构造基于坐姿特征的骨架图和基于邻接节点间空间三维投影角度特征,建立一个基于三维坐姿的标注信息生成模型;利用标注信息标注压力数据,构建带标注的坐姿压力数据集。实际应用中,单个样本数据对视觉-压力端采集平均时间差仅为21 ms,生成标注准确率达98.98%,自动标注平均耗时0.199 s,标注速度较人工标注提升13.3倍。

关键词： YOLOv7-Pose 阵列式压力传感器图卷积网络自动标注

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基于脉冲激光的河道水位远程监测系统研究

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电子测量技术 2022年第12期45卷 26-30页

作者：高金辉闫琼河南师范大学电子与电气工程学院新乡453000 河南省光电传感集成应用重点实验室新乡453000

水涝灾害的发生会严重影响河道周边人民生命安全和财产安全,及时准确掌握河道的水位变化十分重要。针对目前传统水位测量与监测方式的时效性、安全性等不足,设计了一种基于脉冲激光和云平台的水位远程监测系统。该测量装置以STM32单片... 详细信息

水涝灾害的发生会严重影响河道周边人民生命安全和财产安全,及时准确掌握河道的水位变化十分重要。针对目前传统水位测量与监测方式的时效性、安全性等不足,设计了一种基于脉冲激光和云平台的水位远程监测系统。该测量装置以STM32单片机为核心,发射脉冲激光到测量桶内漂浮板,探测装置到水面漂浮板的距离,最终计算得出待监测的河道水位深度。实验室模拟实验结果表明:将测量装置固定在1 m高度处,当水位深度在200~800 mm时,相对误差小于1.7%,变异系数小于1.2%。经过无线传输模块可以实现对水位数据的实时上传,云平台能够准确显示水位及测量时间,表明该远程水位监测系统可行,能够实现对河道水位的远程实时监测,有一定的应用价值。

关键词：激光测距河道水位无线传输云平台

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Complementary multicolor electrochromic devices with excellent stability based on porous tin oxide nanosheet scaffold

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Nano Research 2024年第4期17卷 3035-3042页

作者： Chenchen Bian jinhui Wang Huanhuan Liu Yin yan Ping Zhang Weilong yang Sensen Jia Xiaodan Guo Guofa Cai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologySchool of Materials and Engineeringand Collaborative Innovation Center of Nano Functional Materials and ApplicationsHenan UniversityKaifeng 475004China

Electrochromic devices(ECDs)have been extensively investigated as promising candidates in broad cutting-edge applications,such as smart windows,electronic labels,adaptive camouflage,etc.However,they have suffered from either inadequate color variations or poor cycling stability for a long time.Herein,we developed a general strategy to boost the cyclic stability and enrich the color variations of ECDs by scrupulous design of the composition and nanostructure of electrodes,in which porous tin oxide(SnO_(2))nanosheets serve as the scaffold and typical metal oxides or conducting polymers as the active electrochromic materials.Various electrochromic composite materials,including polyaniline(PANI)@SnO_(2),V2O5@SnO_(2),and WO_(3)@SnO_(2) heterostructured nanoarrays were prepared by the facile wet-chemical method.These composite electrodes exhibit remarkable electrochromic performances,e.g.,superior cycling stability(more than 2000 cycles),rich color variations(more than 5 colors for PANI@SnO_(2)),and enlarged optical modulation.These excellent performances account for the heterogenous porous nanoarrays,which not only facilitate the intercalation/extraction of ions but also relieve the stress generated during the electrochemical process.In addition,diverse prototypes of complementary multicolor ECD with excellent cycling stability(over thousands of cycles)and rich color variations(8 colors)were realized for the first time.We believe that our work put forward a general strategy for developing high-quality multicolor complementary electrochromic devices.

关键词： electrochromism tin oxide metal oxide cycling stability multicolor complementary device

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Structure-tissue exposure/selectivity relationship(STR) correlates with clinical efficacy/safety

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2462-2478页

作者： Wei Gao Hongxiang Hu Lipeng Dai Miao He Hebao Yuan Huixia Zhang jinhui Liao Bo Wen yan Li Maria Palmisano Mohamed Dit Mady Traore Simon Zhou Duxin Sun Department of Pharmaceutical Sciences College of PharmacyUniversity of MichiganAnn ArborMI 48109USA Translational Development and Clinical Pharmacology Bristol Myers SquibbSummitNJ 07920USA

Drug optimization, which improves drug potency/specificity by structure-activity relationship(SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However,the current drug optimization may overlook the structure-tissue exposure/selectivity-relationship(STR) in disease-targeted tissues vs. normal tissues, which may mislead the drug candidate selection and impact the balance of clinical efficacy/toxicity. In this study, we investigated the STR in correlation with observed clinical efficacy/toxicity using seven selective estrogen receptor modulators(SERMs) that have similar structures, same molecular target, and similar/different pharmacokinetics. The results showed that drug’s plasma exposure was not correlated with drug’s exposures in the target tissues(tumor, fat pad, bone, uterus),while tissue exposure/selectivity of SERMs was correlated with clinical efficacy/safety. Slight structure modifications of four SERMs did not change drug’s plasma exposure but altered drug’s tissue exposure/selectivity.Seven SERMs with high protein binding showed higher accumulation in tumors compared to surrounding normal tissues, which is likely due to tumor EPR effect of protein-bound drugs. These suggest that STR alters drug’s tissue exposure/selectivity in disease-targeted tissues vs. normal tissues impacting clinical efficacy/toxicity. Drug optimization needs to balance the SAR and STR in selecting drug candidate for clinical trial to improve success of clinical drug development.

关键词： Structure-activity-relationship(SAR) Structure-tissue exposure/selectivity relationship(STR) Drug optimization Clinical efficacy/toxicity Drug development

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