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Formulation,characterization and in vivo and in vitro evaluation of aloe-emodin-loaded solid dispersions for dissolution enhancement

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Journal of Traditional Chinese Medicine 2024年第1期44卷 54-62页

作者： LI Xiuyan LUO Yuting wang jinhui DU Zhimin Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese MedicineMinistry of EducationHarbin 150040China College of Pharmacy Harbin Medical UniversityHarbin 150081China Institute of Clinical Pharmacology the Second Affliated Hospital of Harbin Medical University(University Key aboratory of Drug ResearchHeilongjiang Province)Harbin 150086China Department of Clinical Pharmacology College of Pharmacy Harbin Medical UniversityHarbin 150081China State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyMacao 999078China

OBJECTIVE:To prepare aloe-emodin solid dispersion(AE-SD)and determine the metabolic process of AE and AE-SD in ***:AE-SD was prepared via solvent evaporation or solvent melting using PEG-6000 and PVP-K30 as *** analysis,X-ray diffraction spectroscopy,differential scanning calorimetry,Fourier transform infrared spectroscopy and scanning electron microscopy were used to identify the physical state of *** prescriptions were screened via the dissolution degree determination *** Phoenix software,AE suspension and AE-SD were subjected to a pharmacokinetic comparison study analyzing the alteration of behavior in vivo after AE was prepared as a solid *** toxicity was assessed in mice,and the physiological toxicity was used as the determination criterion for ***:AE-SD showed that AE existed in the carrier in an amorphous *** with polyethylene glycol,polyvinylpyrrolidone(PVP)inhibited AE crystallization,causing the drug to transform from a dense crystalline state to an amorphous form and increasing the degree of drug ***,it was more suitable as a carrier material for *** addition of poloxamer(POL)was more beneficial to the stability of solid dispersions and could reduce the amount of *** dissolution test confirmed that the optimal ratio of AE to the composite vector AE-PVP-POL was 1:2:2,and its dissolution effect was also *** on the pharmacokinetic comparison,the drug absorption was faster and quickly reached the peak of blood drug concentration in AE-SD compared to AE,the Cmax of AE-SD was greater than that of AE,and t1/2 and mean residence time of AE-SD were less than *** results showed that the drug metabolism in AE-SD was better,and the residence time was *** toxicology study showed that both AE and AE-SD had no ***:This paper established that the solubility of the drug could be increased after preparing a solid dispersion,

关键词： aloe-emodin solid dispersion solvent evaporation drug liberation pharmacokinetics

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Hot Deformation Behavior and Microstructures Evolution of GNP-Reinforced Fine-Grained Mg Composites

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 407-424页

作者： Hengrui Hu Jiayu Qin Yunpeng Zhu jinhui wang Xiaoqiang Li Peipeng Jin Qinghai Provincial Key Laboratory of New Light Alloys Qinghai UniversityXining 810016China Qinghai Provincial Engineering Research Center of High Performance Light Metal Alloys and Forming Qinghai UniversityXining 810016China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China School of Material Science and Engineering Lanzhou University of TechnologyLanzhou 730050China

Graphene nanoplates(GNPs)-reinforced magnesium matrix composites have been attracted great ***,knowledge is lack for the hot deformation behavior of GNP-reinforced magnesium(GNPs/Mg)*** this study,the fine-grained GNPs/Mg composite was fabricated by powder metallurgy process followed by *** hot deformation behavior,microstructure evolution and dynamic recrystallization(DRX)mechanism of fine-grained GNPs/Mg composite were investigated by hot compression test and electron back-scatter diffraction(EBSD).The hot compression tests of the composite were conducted at temperatures between 423 and 573 K with the strain rates from 0.001 to 1 s^(-1).The strain compensated power law equation was established to describe the hot deformation behavior of the *** stress exponent and activation energy of the composite are 7.76 and 83.23 kJ/mol,respectively,suggesting that the deformation mechanism is grain boundary slip controlled dislocation climb *** abnormally high stress exponent and activation energy are unattainable in the composite due to the fine grain size of the composites and the absence of Zener pinning and Orowan effects of GNPs *** grain size increases with the decrease in Zener-Hollomn(Z)parameter,which can be well fitted by power-law *** the increase in grain size and decrease in Z parameter,the geometrically necessary dislocation density decreases,which shows the approximately power-law relationship.A random and weak texture was formed after hot *** discontinuous dynamic recrystallization and continuous dynamic recrystallization mechanism dominated the DRX behavior at 473 K/0.001 s^(-1) and 573 K/0.001 s^(-1),respectively.

关键词： GNPs Mg composite Hot deformation behavior Constitutive equations Microstructure evolution Dynamic recrystallization

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Mass Transfer-Promoted Fe^(2+)/Fe^(3+)Circulation Steered by 3D Flow-Through Co-Catalyst System Toward Sustainable Advanced Oxidation Processes

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Engineering 2024年第5期36卷 264-275页

作者： Weiyang Lv Hao Li jinhui wang Lixin wang Zenglong Wu Yuge wang Wenkai Song Wenkai Cheng Yuyuan Yao National Engineering Lab of Textile Fiber Materials and Processing Technology(Zhejiang) Zhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang Provincial Innovation Center of Advanced Textile Technology Shaoxing 312000China Jiangsu Ruiya Stirring Technology Co. Ltd.Yixing 214200China

Realizing fast and continuous generation of reactive oxygen species(ROSs)via iron-based advanced oxidation processes(AOPs)is significant in the environmental and biological ***,current AOPs assisted by co-catalysts still suffer from the poor mass/electron transfer and non-durable promotion effect,giving rise to the sluggish Fe^(2+)/Fe^(3+)cycle and low dynamic concentration of Fe^(2+)for ROS ***,we present a three-dimensional(3D)macroscale co-catalyst functionalized with molybdenum disulfide(MoS_(2))to achieve ultra-efficient Fe^(2+)regeneration(equilibrium Fe^(2+)ratio of 82.4%)and remarkable stability(more than 20 cycles)via a circulating flow-through *** the conventional batch-type reactor,experiments and computational fluid dynamics simulations demonstrate that the optimal utilization of the 3D active area under the flow-through mode,initiated by the convectionenhanced mass/charge transfer for Fe^(2+)reduction and then strengthened by MoS_(2)-induced flow rotation for sufficient reactant mixing,is crucial for oxidant activation and subsequent ROS ***,the flow-through co-catalytic system with superwetting capabilities can even tackle the intricate oily wastewater stabilized by different surfactants without the loss of pollutant degradation *** findings highlight an innovative co-catalyst system design to expand the applicability of AOPs based technology,especially in large-scale complex wastewater treatment.

关键词： Advanced oxidation processes 3D co-catalyst Flow-through mode Enhanced mass transfer Complex wastewater treatment

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Complementary multicolor electrochromic devices with excellent stability based on porous tin oxide nanosheet scaffold

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Nano Research 2024年第4期17卷 3035-3042页

作者： Chenchen Bian jinhui wang Huanhuan Liu Yin Yan Ping Zhang Weilong Yang Sensen Jia Xiaodan Guo Guofa Cai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologySchool of Materials and Engineeringand Collaborative Innovation Center of Nano Functional Materials and ApplicationsHenan UniversityKaifeng 475004China

Electrochromic devices(ECDs)have been extensively investigated as promising candidates in broad cutting-edge applications,such as smart windows,electronic labels,adaptive camouflage,***,they have suffered from either inadequate color variations or poor cycling stability for a long ***,we developed a general strategy to boost the cyclic stability and enrich the color variations of ECDs by scrupulous design of the composition and nanostructure of electrodes,in which porous tin oxide(SnO_(2))nanosheets serve as the scaffold and typical metal oxides or conducting polymers as the active electrochromic *** electrochromic composite materials,including polyaniline(PANI)@SnO_(2),V2O5@SnO_(2),and WO_(3)@SnO_(2) heterostructured nanoarrays were prepared by the facile wet-chemical *** composite electrodes exhibit remarkable electrochromic performances,e.g.,superior cycling stability(more than 2000 cycles),rich color variations(more than 5 colors for PANI@SnO_(2)),and enlarged optical *** excellent performances account for the heterogenous porous nanoarrays,which not only facilitate the intercalation/extraction of ions but also relieve the stress generated during the electrochemical *** addition,diverse prototypes of complementary multicolor ECD with excellent cycling stability(over thousands of cycles)and rich color variations(8 colors)were realized for the first *** believe that our work put forward a general strategy for developing high-quality multicolor complementary electrochromic devices.

关键词： electrochromism tin oxide metal oxide cycling stability multicolor complementary device

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Buxu Tongyu Granule Alleviates Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble Guanylate Cyclase to Inhibit Abnormal Vasomotion

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Engineering 2024年第7期38卷 133-143页

作者： Shuang Yang Yixiu Zhao Xiaoling Cheng Tingting Zhan Jiaying Tian Xue Liu Chunyue Ma Zhiqi wang Luying Jin Qian Liu Yanli wang Jian Huang jinhui wang Yan Zhang Baofeng Yang Department of Pharmacology&Key Laboratory of Cardiovascular Medicine Research Ministry of Education of the People’s Republic of ChinaCollege of PharmacyHarbin Medical UniversityHarbin 150081China National Key Laboratory of Frigid Zone Cardiovascular Diseases(NKLFZCD) Harbin Medical UniversityHarbin 150081China Department of Medicinal Chemistry and Natural Medicine Chemistry College of PharmacyHarbin Medical UniversityHarbin 150081China Research Unit of Noninfectious Chronic Diseases in Frigid Zones Chinese Academy of Medical SciencesHarbin 150081China

Myocardial ischemia is a serious threat to human health,and vascular dysfunction is its main *** Tongyu(BXTY)Granule is an effective traditional Chinese medicine(TCM)for treating myocardial ***,the underlying mechanism of BXTY is still *** this study,we demonstrate that BXTY ameliorates myocardial ischemia by activating the soluble guanylate cyclase(sGC)-30,50-cyclic guanosine monophosphate(cGMP)-protein kinase G(PKG)signaling pathway in vascular smooth muscle cells(VSMCs)to dilate the *** was given by gavage for ten consecutive days before establishing an animal model of acute myocardial ischemia in mice via the intraperitoneal injection of *** results showed that BXTY alleviated the symptoms of myocardial ischemia induced by pituitrin in mice,including electrocardiogram abnormalities and changes in plasma *** addition,BXTY dilated pre-constricted blood vessels and inhibited the vasoconstriction of the superior mesenteric artery in a dose-dependent but endothelial-independent *** effects were eliminated by preincubating vascular rings with the sGC inhibitors NS 2028 or ODQ,or with the PKG inhibitor KT ***,BXTY increased the protein expression of sGC-b1 and the intracellular second messenger cGMP level in mouse aortic vascular smooth muscle cells(MOVAs).NS 2028 or ODQ reversed these effects of *** expression level of the cGMP downstream effector protein PKG-1 increased after treating MOVAs with *** 2028,ODQ,or KT 5823 also reversed this effect of *** conclusion,BXTY can improve the symptoms of acute myocardial ischemia in mice,and activating the sGC-cGMP-PKG pathway in VSMCs to induce vasodilation is its key pharmacodynamic mechanism.

关键词： Myocardial ischemia Vasomotion Soluble guanylate cyclase Buxu Tongyu Granule

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7 m大采高工作面巷道转载机改进设计与应用

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煤炭工程 2024年第2期56卷 213-218页

作者：王金辉国能神华新街能源有限责任公司内蒙古鄂尔多斯017200

针对神东7 m大采高工作面巷道转载机在使用中存在刮板弯曲断裂、链轮密封失效等问题,通过分析刮板和链轮组件的失效特征及零部件的受力状况,采取升级链条、增大刮板断面和链轮轴直径、优化链条中心距等措施,全面改善刮板和链轮组件受力... 详细信息

针对神东7 m大采高工作面巷道转载机在使用中存在刮板弯曲断裂、链轮密封失效等问题,通过分析刮板和链轮组件的失效特征及零部件的受力状况,采取升级链条、增大刮板断面和链轮轴直径、优化链条中心距等措施,全面改善刮板和链轮组件受力状态,刮板强度提高1.7倍,轴承支撑部位链轮轴的挠度降为1/8,零部件性能显著提高。设备改造时充分考虑到零部件的通用性,机头架和槽体可以直接使用,降低了改造成本。通过对进口设备进行改造,积累了经验,推动国产煤机装备的发展。

关键词：转载机刮板链轮组件圆环链失效分析

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严格双对角占优矩阵的Schur补的双对角占优度及其应用

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工程数学学报 2024年第4期41卷 595-608页

作者：王金辉李耀堂云南大学数学与统计学院昆明650500

矩阵Schur补是矩阵理论及其应用中的一个重要内容,具有广泛的应用背景。严格双对角占优矩阵是一类十分重要的特殊矩阵,流体力学的计算、材料模拟与设计、电磁场计算等领域与其有着密不可分的联系。对严格双对角占优矩阵的研究主要集中... 详细信息

矩阵Schur补是矩阵理论及其应用中的一个重要内容,具有广泛的应用背景。严格双对角占优矩阵是一类十分重要的特殊矩阵,流体力学的计算、材料模拟与设计、电磁场计算等领域与其有着密不可分的联系。对严格双对角占优矩阵的研究主要集中在两个方面:严格双对角占优矩阵的Schur补的特征值定位;严格双对角占优矩阵Schur补的逆的无穷范数估计。首先,给出了严格双对角占优矩阵的Schur补的双对角占优度的新下界估计式;然后,利用所给估计式获得了严格双对角占优矩阵Schur补新的特征值包含集和严格对角占优矩阵Schur补的逆的无穷范数的新上界。数值例子表明所获结果改进了一些现有结果。

关键词：双对角占优矩阵双对角占优度 Schur补特征值

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血细胞形态分析在骨髓增生异常综合征患者病情及预后评估中的应用价值

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中国实用医刊 2024年第13期51卷 79-82页

作者：田霞路云王金辉鹤壁煤业(集团)有限责任公司总医院鹤壁市第二人民医院检验科鹤壁鹤壁煤业(集团)有限责任公司总医院鹤壁市第二人民医院妇产科鹤壁鹤壁煤业(集团)有限责任公司总医院鹤壁市第二人民医院骨科鹤壁

目的探讨血细胞形态分析用于骨髓增生异常综合征(MDS)病情、预后评估的价值。方法回顾性抽取2021年6月至2023年6月鹤壁煤业(集团)有限责任公司总医院收治的85例MDS患者作为观察组, 另抽取同期接待的健康体检者85例作为对照组。两组对象... 详细信息

目的探讨血细胞形态分析用于骨髓增生异常综合征(MDS)病情、预后评估的价值。方法回顾性抽取2021年6月至2023年6月鹤壁煤业(集团)有限责任公司总医院收治的85例MDS患者作为观察组, 另抽取同期接待的健康体检者85例作为对照组。两组对象均进行血细胞形态分析, 且根据国际预后指数修改版(IPSS-R)标准对观察组MDS患者分级, 比较两组血细胞形态分析结果;比较不同IPSS-R分级MDS患者血细胞形态分析结果;比较观察组治疗前与治疗后血细胞形态分析结果。结果观察组红细胞计数(RBC)、白细胞计数(WBC)、血小板计数(PLT)、红细胞比容(Hct)水平均低于对照组(P均<0.05)。观察组MDS患者随着IPSS-R分级升高, 其RBC、WBC、PLT、Hct水平随之下降(P<0.05)。治疗后, 观察组患者RBC、WBC、PLT、Hct水平均低于治疗前(P均<0.05)。结论 MDS患者有明显的血细胞形态分析指标异常情况, 将血细胞形态分析用于MDS患者病情与预后评估中有不错的价值;MDS患者IPSS-R分级越高其RBC、WBC、PLT、Hct越低, 且治疗后血细胞形态分析结果明显下降, 从而能为临床评估预后提供依据。

关键词：骨髓增生异常综合征血细胞形态分析病情评估预后评估

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U肋全熔透焊接正交异性板构造疲劳性能试验研究

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世界桥梁 2024年第3期52卷 104-110页

作者：汪金辉李雪健中铁大桥勘测设计院集团有限公司湖北武汉430056 合肥工业大学土木与水利工程学院安徽合肥230009

为研究U肋与钢桥面不同焊接工艺接头的疲劳性能,以主跨408 m的中承式连续钢桁拱桥——武汉汉江湾桥主桥为背景,在传统单面埋弧焊基础上,提出一种先平位内焊再船位外焊的双面埋弧全熔透焊接技术,制作不同焊接工艺U肋与钢面板试件,开展丁... 详细信息

为研究U肋与钢桥面不同焊接工艺接头的疲劳性能,以主跨408 m的中承式连续钢桁拱桥——武汉汉江湾桥主桥为背景,在传统单面埋弧焊基础上,提出一种先平位内焊再船位外焊的双面埋弧全熔透焊接技术,制作不同焊接工艺U肋与钢面板试件,开展丁字接头弯曲疲劳试验、焊接接头拉伸疲劳试验及3种典型构造细节疲劳试验,分析U肋与钢面板构造细节疲劳性能。结果表明:不同焊接方式下U肋与钢面板的疲劳强度差异明显,埋弧焊丁字接头的疲劳强度较高,大于342 MPa。U肋与钢面板双面埋弧熔透焊试件轴向拉伸状态下最低疲劳强度121.6 MPa,在-50~50 MPa拉-压循环应力幅和100 MPa拉应力幅下试件均未开裂;在120 MPa拉应力幅下,疲劳开裂加载次数均大于200万次,顶板内侧焊缝焊趾发生疲劳开裂。U肋与钢面板双面埋弧全熔透焊接构造细节疲劳性能优于单面焊及不开坡口的双面焊部分熔透构造细节,可以提高结构的耐久性和使用寿命。

关键词：钢桥正交异性钢桥面板 U肋与钢面板构造细节双面埋弧全熔透焊接疲劳性能疲劳试验

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铁路工程总承包项目管理要素评价研究

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建筑经济 2024年第3期45卷 28-34页

作者：王晋辉中铁工程设计咨询集团有限公司北京100071

工程总承包模式近些年来在我国各行各业已被逐渐认可并推广,也是未来铁路工程项目建设的发展方向之一,对其管理要素的评价研究具有多项重要的指导意义。通过分析铁路工程总承包项目管理要素层级间传递性和系统内关联集成性,建立基于系... 详细信息

工程总承包模式近些年来在我国各行各业已被逐渐认可并推广,也是未来铁路工程项目建设的发展方向之一,对其管理要素的评价研究具有多项重要的指导意义。通过分析铁路工程总承包项目管理要素层级间传递性和系统内关联集成性,建立基于系统工程原理的分级评价模型,综合采用AHP法和熵值法将主观与客观分析相结合,得到各要素在模型中的重要程度权重,再依据定性与定量分析相结合的原则,通过群决策法获得反映各项目管理要素真实管理水平的综合评价得分。

关键词：总承包铁路工程管理要素 AHP 熵值法

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