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Busuishengxue ranules mediate their effects upon non-severe aplastic anemia via mitogen-activated protein kinase/extracellular signal-regulated kinase pathway

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Journal of Traditional Chinese Medicine 2014年第1期34卷 23-29页

作者： jinhuan wang Feng Sun Weizheng Sun Yanli Yong Haitao Shi Sijia Liu Limei Liu Department of Hematology First Affiliated HospitalHeilongjiang University of Chinese Medicine Department of Traditional Chinese Medicine Longnan Hospital of Daqing City Department of Encephalopathy Chinese Medicine Hospital of Harbin Renal Department of Internal Medicine Heilongjiang Provincial Academy of Traditional Chinese Medicine

OBJECTIVE:To observe the clinical efficacy of Busuishengxue granules on non-severe aplastic anemia(NSAA)and investigate its effect on the mitogen-activated protein kinase/extracellular signal-regulated kinase(MAPK/ERK)***:Sixty NSAA patients were divided equally into two *** in the experimental group were treated with Busuishengxue granules,and the control group with Zaizaoshengxue *** treatment course was 6 months and cu-rative efficacy was compared between the two groups as well as with 10 healthy *** cytometry(FCM)was used to detect the intracellular concentration of Ca2+([Ca2+]i).Western blotting was employed to detect the expression of enzymes in the MAPK/ERK ***:The efficacy of Busuishengxue granules was significantly better than that of Zaizaoshengxue tablets(P<0.05).Before treatment,expression of JNK,phospho-ERK 1/2 and p-JNK was higher,and[Ca2+]i higher,than that of the control group(P<0.05).After treatment with Busuishengxue granules,expression of all enzymes related to signal transduction pathways in the blood cells of NSSA patients were altered to different ***:Busuishengxue granules had a better effect with regard to improving symptom scores,increasing the number of blood leukocytes,and increasing hemoglobin levels than Zaizaoshengxue tablets,and they differed slightly in terms of increasing the number of platelets.

关键词： Anemia aplastic MAP kinase signaling system Busuishengxue granule Zaizaoshengxue tablet

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基于碳稳定同位素比值和矿物元素区分贵州不同产地的博落回花

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实验与分析 2024年第1期2卷 1-6页

作者：王晓卉金宏标巩京慧王金换张显强贵州警察学院贵州贵阳550005 铜仁市公安局贵州铜仁554300

探讨碳同位素比值和矿物元素在博落回花的产地推断中的可行性,为毒蜂蜜来源判别以及博落回原材料地理推断提供技术支撑。采集贵州省12个地域的博落回样本,采用元素分析-稳定同位素质谱仪(EA-IRMS)和电感耦合等离子体质谱仪(ICP-MS)测定... 详细信息

探讨碳同位素比值和矿物元素在博落回花的产地推断中的可行性,为毒蜂蜜来源判别以及博落回原材料地理推断提供技术支撑。采集贵州省12个地域的博落回样本,采用元素分析-稳定同位素质谱仪(EA-IRMS)和电感耦合等离子体质谱仪(ICP-MS)测定博落回花的碳同位素比值(δ^(13)C)和19种矿物元素含量,结合主成分分析、偏最小二乘判别分析和正交偏最小二乘判别分析,建立了博落回花产地推断模型。根据矿物元素主成分分析,五个主成分代表了总指标88.289%的信息,Cs、Ba、Al、V、Mn、Fe、Ni和Li可做因子分析。基于正交-偏最小二乘法判别分析方法建立的判别模型确定了As、Rb、Pb、δ^(13)C、Cs、Cu、Sr共7个指标,可进一步建立博落回花的指纹图谱。基于碳同位素比值和矿物元素可用于区分博落回花的生产地域。

关键词：博落回花碳同位素比值矿物元素

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Effect of Stocking Density on Water Quality and(Growth, Body Composition and Plasma Cortisol Content) Performance of Pen-Reared Rainbow Trout(Oncorhynchus mykiss)

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Journal of Ocean University of China 2016年第4期15卷 667-675页

作者： LIU Qun HOU Zhishuai WEN Haishen LI Jifang HE Feng wang jinhuan GUAN Biao wang Qinglong College of Fisheries Ocean University of China Key Laboratory of Mariculture Ministry of EducationOcean University of China

The goal of the study was to examine the effect of stocking density on the water quality of culture area, as well as the growth, body composition and cortisol content of rainbow trout(Oncorhynchus mykiss). Pen-reared trout were stocked in densities of 40, 60, 80 fish individuals m^(-3)(4.6, 6.6, 8.6 kg m^(-3), SD1, SD2 and SD3 groups, respectively) for 300 days. Compared to the water from SD1 and SD2, that from SD3 exhibited significantly higher NH_4^+-N content and COD(chemical-oxygen-demand), and a significant reduction of dissolved oxygen in day 180(40.6 kg m^(-3)). Stocking density was significantly associated with body weight, standard length, VSI(viscerosomatic index), CF(condition factor) and FC(food coefficient) in group SD3, particularly in day 240 and day 300(45 or 49.3 kg m^(-3)). Increased crude fat and decreased crude protein were displayed in high density group when the density reached to 36 kg m^(-3). As a cumulative effect of density-related stress, VSI, CF, FC, moisture, and crude protein content varied over time in each density group(SD1, SD2, and SD3). In summary, trout exhibited a better growth performance in low density(26.3 kg m^(-3)) than those reared in high densities(36 and 45 kg m^(-3)). The results indicate that rainbow trout(114.44 g ± 6.21 g, 19.69 cm ± 0.31 cm) initially stocked in 6.6 or 8.6 kg m^(-3) should be lightened to less than 36 kg m^(-3) after an intensive rearing for 240 days.

关键词： Oncorhynchus Growth trout crude initially displayed varied length dissolved moisture

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Giant pattern evolution in third-harmonic generation of strained monolayer WS2 at two-photon excitonic resonance

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Nano Research 2020年第12期13卷 3235-3240页

作者： Jing Liang He Ma jinhuan wang Xu Zhou Wentao Yu Chaojie Ma Muhong Wu Peng Gao Kaihui Liu Dapeng Yu State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing100871China Academy for Advanced Interdisciplinary Studies Collaborative Innovation Center of Quantum MatterPeking UniversityBeijing100871China School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing100081China International Center for Quantum Materials Electron Microscopy LaboratorySchool of PhysicsPeking UniversityBeijing100871China Shenzhen Institute for Quantum Science and Engineering and Department of PhysicsSouthern University of Science and TechnologyShenzhen518055China

Strong geometrical confinement and reduced dielectric screening of two-dimensional(2D)materials leads to strong Coulomb interaction and eventually give rise to extraordinary excitonic effects,which dominates the optical and optoelectronic *** nonlinear 2D photonic or optoelectronic applications,excitonic effects have been proved effective to tune the light-matter interaction ***,the modulation of excitonic effects on the other aspect of nonlinear response,i.e.,polarization dependence,has not been fully explored *** we report the first systemic study on the modulation of excitonic effects on the polarization dependence of second and third harmonic generation(SHG and THG)in strained monolayer WS2 by varying excitation *** demonstrated that polarization-dependent THG patterns undergo a giant evolution near two-photon excitonic resonance,where the long-axis of the parallel component(originally parallel to the strain direction)has a 90°flip when the excitation wavelength *** striking contrast,no apparent variation of polarization-dependent SHG patterns occurs at either two-or three-photon excitonic resonance *** results open a new avenue to modulate the anisotropic nonlinear optical response of 2D materials through effective control of excitonic resonance states,and thus open opportunity for new designs and applications in nonlinear optoelectronic 2D devices.

关键词： two-dimensional materials nonlinear optics excitonic effects

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马齿苋中吲哚类生物碱的生物活性研究

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中国民族民间医药 2024年第5期33卷 20-24页

作者：兰秀娟郭胜男王金焕王呈玉英锡相辽宁中医药大学药学院辽宁大连116600

目的:研究马齿苋中分离所得吲哚类生物碱的抗胆碱酯酶活性及抗氧化活性。方法:采用改良的Ellman法测定各化合物的抗胆碱酯酶活性,通过测量吸光度值计算化合物的胆碱酯酶抑制率,并计算IC_(50)值;采用DPPH自由基清除法测定各化合物的抗氧... 详细信息

目的:研究马齿苋中分离所得吲哚类生物碱的抗胆碱酯酶活性及抗氧化活性。方法:采用改良的Ellman法测定各化合物的抗胆碱酯酶活性,通过测量吸光度值计算化合物的胆碱酯酶抑制率,并计算IC_(50)值;采用DPPH自由基清除法测定各化合物的抗氧化活性,通过测量吸光度值计算化合物的DPPH清除率,并计算IC_(50)值。结果:马齿苋中oleraindole A-oleraindole G均有抗胆碱酯酶活性,其中,oleraindole B抗胆碱酯酶作用的IC_(50)值为40.22μM,与阳性药毒扁豆碱(IC_(50)=37.92μM)的活性相当;oleraindole A、B、C、D和G均具有抗氧化活性,其中,oleraindole C和oleraindole A抗氧化作用的IC_(50)值分别为7.49μM和9.68μM,远远优于阳性药BHA的活性(IC_(50)=37.81μM)。结论:oleraindole B抗胆碱酯酶活性较强,oleraindole C和oleraindole A抗氧化活性较优,可为马齿苋生物碱的深入研究提供科学依据。

关键词：马齿苋吲哚类生物碱生物活性

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Finding Cut-Edges and the Minimum Spanning Tree via Semi-Tensor Product Approach

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Journal of Systems Science and Information 2018年第5期9卷 459-472页

作者： Xujiao FAN Yong XU Xue SU jinhuan wang School of Science Hebei University of Technology

Using the semi-tensor product of matrices, this paper investigates cycles of graphs with application to cut-edges and the minimum spanning tree, and presents a number of new results and algorithms. Firstly, by defining a characteristic logical vector and using the matrix expression of logical functions, an algebraic description is obtained for cycles of graph, based on which a new necessary and sufficient condition is established to find all cycles for any graph. Secondly, using the necessary and sufficient condition of cycles, two algorithms are established to find all cut-edges and the minimum spanning tree, respectively. Finally, the study of an illustrative example shows that the results/algorithms presented in this paper are effective.

关键词： semi-tensor product cycle cut-edge minimum spanning tree

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益气养血方治疗再生障碍性贫血的免疫学指标与血常规变化规律探析

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中国实验方剂学杂志 2024年第12期30卷 97-104页

作者：张耀尹张朝畅何嘉琪王文儒丁宇斌王金环徐瑞荣邸海侠万姜维刘奇峰王海霞孙岸弢唐旭东北京中医药大学研究生院北京100029 中国中医科学院研究生院北京100700 北京中医药大学东方医院北京100071 深圳市中医院广东深圳518000 黑龙江中医药大学附属第一医院哈尔滨150000 山东中医药大学附属医院济南250000 廊坊市中医医院河北廊坊065000 河南中医药大学第一附属医院郑州450000 吉林省人民医院长春130000 潍坊医学院附属医院山东潍坊261000 中国中医科学院广安门医院北京100032 中国中医科学院西苑医院北京100091

目的:探讨益气养血方联合西药治疗再生障碍性贫血(AA)血象升高患者的免疫学特征,以及免疫学指标对血象升高的预测作用,以期为疗效预测、治疗方案调整提供参考。方法:该研究为回顾性研究,选取2018年9月至2021年3月中国中医科学院西苑医院... 详细信息

目的:探讨益气养血方联合西药治疗再生障碍性贫血(AA)血象升高患者的免疫学特征,以及免疫学指标对血象升高的预测作用,以期为疗效预测、治疗方案调整提供参考。方法:该研究为回顾性研究,选取2018年9月至2021年3月中国中医科学院西苑医院等19个分中心接受益气养血方联合西药治疗6个月的77例AA患者,按治疗6个月时血象恢复程度[包括血红蛋白(HGB)、白细胞计数(WBC)、血小板计数(PLT)及中性粒细胞计数(ANC)],将患者分为2组,一组血象较基线值增长<50%,另一组较基线值增长≥50%,比较两组的临床特征及免疫学特征。结果:①与HGB上升<50%组比较,HGB上升≥50%组患者治疗前CD3^(+)人白细胞DR抗原(HLA-DR)^(+)更高,且治疗前辅助型T细胞2(Th2)<5%、CD8^(+)≥50%及CD3^(+)HLA-DR^(+)≥9%的患者占比更高(P<0.05,P<0.01);多因素Logistic回归分析显示治疗前CD8^(+)≥50%是HGB升高≥50%的独立影响因素[比值比(OR)=12.000,95%置信区间(95%CI)2.218,64.928,P<0.01]。②与WBC上升<50%组比较,WBC上升≥50%组治疗前CD3^(+)HLA-DR^(+)<6%及T-box转录因子(T-bet)≥200%的患者占比更高(P<0.05);多因素Logistic回归分析显示治疗前CD3^(+)HLA-DR^(+)<6%(OR=2.998,95%CI 1.036,8.680,P<0.05)、T-bet≥200%(OR=3.634,95%CI 1.076,12.273,P<0.05)均是WBC升高≥50%的独立影响因素;③与PLT上升<50%组比较,PLT上升≥50%组治疗前Th1、CD3^(+)HLA-DR^(+)更低,且Th1<12%、CD4^(+)≥6%、CD3^(+)HLA-DR^(+)<5%的患者占比更高(P<0.05,P<0.01);多因素Logistic回归分析显示治疗前CD3^(+)HLA-DR^(+)<5%是PLT升高≥50%的独立影响因素(OR=16.190,95%CI 3.430,76.434,P<0.01)。④与ANC上升<50%组比较,ANC上升≥50%组治疗前各指标差异均无统计学意义。结论:益气养血方联合西药治疗在HGB增长快的AA患者中,表现出Th2<5%、CD3^(+)HLA-DR^(+)≥9%,CD8^(+)≥50%的AA 患者中更为显著;在WBC 增长快的AA 患者中,表现出CD3^(+)HLA-DR^(+)<6%和T-bet≥200%;在PLT 增长快的AA 患者中,表现出Th1<12%、CD4^(+)≥6%,尤其是CD3^(+)HLA-DR^(+)<5%的AA 患者中更为显著。

关键词：再生障碍性贫血益气养血法血常规免疫预测

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Snyder希望理论+支持性照护综合护理方案在超声甲状腺结节患者中的应用效果

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中国医药导报 2024年第14期21卷 163-167页

作者：康杰康庆范姣王金环马琳张萱王颖周颖萍北京中医药大学东直门医院门诊超声科北京100700 北京中医药大学东直门医院放射科北京100700 北京中医药大学东直门医院护理部北京100700

目的探究Snyder希望理论+支持性照护综合护理方案在超声甲状腺结节患者中的应用效果。方法选择2023年4月至9月北京中医药大学东直门医院80例超声甲状腺结节患者,采用随机数字表法将其分成对照组和观察组,各40例。对照组采用常规护理干预... 详细信息

目的探究Snyder希望理论+支持性照护综合护理方案在超声甲状腺结节患者中的应用效果。方法选择2023年4月至9月北京中医药大学东直门医院80例超声甲状腺结节患者,采用随机数字表法将其分成对照组和观察组,各40例。对照组采用常规护理干预,观察组采用Snyder希望理论+支持性照护综合护理干预,干预时间为2周。比较两组干预前后中文版Herth希望量表(HHI)评分、家庭关怀度指数(APGAR)评分及自我管理能力评分。结果干预后,两组HHI评分高于干预前,且观察组高于对照组(P<0.05)。两组APGAR评分高于干预前,且观察组高于对照组(P<0.05)。两组自我管理能力评分高于干预前,且观察组高于对照组(P<0.05)。结论Snyder希望理论+支持性照护综合护理方案在超声甲状腺结节患者中的应用效果显著,可以提升患者希望水平、家庭功能与自我管理能力,值得在临床推广应用。

关键词： Snyder希望理论支持性照护护理方案超声甲状腺结节

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Visualizing grain boundaries in monolayer MoSe2 using mild H2O vapor etching

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Nano Research 2018年第8期11卷 4082-4089页

作者： jinhuan wang Xiaozhi Xu Ruixi Qiao Jing Liang Can Liu Bohao Zheng Lei Liu Peng Gao Qingze Jiao Dapeng Yu Yun Zhao Kaihui Liu School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 China State Key Laboratory for Mesoscopic Physics School of Physics Peking University 8eijing 100871 China Department of Materials Science and Engineering College of Engineering Peking University 8eijing 100871 China International Centre for Quantum Materials and Electron Microscopy Laboratory School of Physics Peking University Beijing 10087 I China Department of Physics South University of Science and Technology of China Shenzhen 518055 China Collaborative Innovation Centre of Quantum Matter Beijing 100871 China jinhuan wang Xiaozhi Xu and Ruixi Qiao contributed equally to this work.

Beyond graphene, two-dimensional （2D） transition metal dichalcogenides （TMDs） have attracted significant attention owing to their potential in next-generation nanoelectronics and optoelectronics. Nevertheless, grain boundaries are ubiquitous in large-area as-grown TMD materials and would significantly affect their band structure, electrical transport, and optical properties. Therefore, the characterization of grain boundaries is essential for engineering the properties and optimizing the growth in TMD materials. Although the existence of boundaries can be measured using scanning tunneling microscopy, transmission electron microscopy, or nonlinear optical microscop~ a universal, convenient, and accurate method to detect boundaries with a twist angle over a large scale is still lacking. Herein, we report a high-throughput method using mild hot H20 etching to visualize grain boundaries of TMDs under an optical microscope, while ensuring that the method is nearly noninvasive to grain domains. This technique utilizes the reactivity difference between stable grain domains and defective grain boundaries and the mild etching capacity of hot water vapor. As grain boundaries of two domains with twist angles have defective lines, this method enables to visualize all types of grain boundaries unambiguously. Moreover, the characterization is based on an optical microscope and therefore naturally of a large scale. We further demonstrate the successful application of this method to other TMD materials such as MoS2 and WSe2. Our technique facilitates the large-area characterization of grain boundaries and will accelerate the controllable growth of large single-crystal TMDs.

关键词： MoSez,grain boundar3 hot water vapor single crystal

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罗普司亭治疗再生障碍性贫血的机制与临床应用研究进展

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疑难病杂志 2024年第4期23卷 504-508页

作者：李洋洋高明洁田飞孙伟正(综述) 王金环(审校) 黑龙江中医药大学哈尔滨150040 黑龙江中医药大学附属第一医院血液病科

再生障碍性贫血(AA)是一种严重的造血系统疾病,临床上以全血细胞减少和骨髓造血功能受损为特征。罗普司亭作为一种Janus激酶抑制剂,近年来引起了广泛的关注。文章从多个角度对罗普司亭治疗AA的机制与临床应用展开了全面而深入的讨论,包... 详细信息

再生障碍性贫血(AA)是一种严重的造血系统疾病,临床上以全血细胞减少和骨髓造血功能受损为特征。罗普司亭作为一种Janus激酶抑制剂,近年来引起了广泛的关注。文章从多个角度对罗普司亭治疗AA的机制与临床应用展开了全面而深入的讨论,包括该药物在治疗过程中的作用机制、免疫调节作用以及潜在的不良反应和安全性考量。并展望个体化治疗策略的发展和新型治疗靶点的探索,为该领域的进一步研究提供有益的思路。

关键词：再生障碍性贫血罗普司亭 Janus激酶抑制剂治疗研究进展

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