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Anaerobic digestion in mesophilic and room temperature conditions: Digestion performance and soil-borne pathogen survival

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Journal of Environmental Sciences 2016年第5期28卷 224-233页

作者： Le Chen Shanshan Jian jinhua bi Yunlong Li Zhizhou Chang Jian He Xiaomei Ye Laboratory of Environmental Microbiology College of Life Sciences Nanjing Agricultural University Laboratory for Agricultural Wastes Treatment and Recycling Institute of Agricultural Resources and Environment Jiangsu Academy of Agricultural Science East China Scientific Observing and Experimental Station of Development and Utilization of Rural Renewable Energy Ministry of Agriculture

Tomato plant waste（TPW） was used as the feedstock of a batch anaerobic reactor to evaluate the effect of anaerobic digestion on Ralstonia solanacearum and Phytophthora capsici survival. Batch experiments were carried out for TS（total solid） concentrations of 2%, 4% and 6% respectively, at mesophilic（37 ± 1°C） and room（20–25°C） temperatures. Results showed that higher digestion performance was achieved under mesophilic digestion temperature and lower TS concentration conditions. The biogas production ranged from 71 to 416 L/kg VS（volatile solids）. The inactivation of anaerobic digestion tended to increase as digestion performance improved. The maximum log copies reduction of R. solanacearum and P. capsici detected by quantitative PCR（polymerase chain reaction） were 3.80 and 4.08 respectively in reactors with 4% TS concentration at mesophilic temperatures. However, both in mesophilic and room temperature conditions, the lowest reduction of R. solanacearum was found in the reactors with 6% TS concentration, which possessed the highest VFA（volatile fatty acid） concentration. These findings indicated that simple accumulation of VFAs failed to restrain R. solanacearum effectively, although the VFAs were considered poisonous. P. capsici was nearly completely dead under all conditions. Based on the digestion performance and the pathogen survival rate, a model was established to evaluate the digestate biosafety.

关键词： Anaerobic digestion Pathogen inactivation Digestion performance Fruit and vegetable wastes

Tildrakizumab for moderate-to-severe plaque psoriasis in Chinese patients: A 12-week randomized placebo-controlled phase III trial with long-term extension

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中华医学杂志(英文版) 2024年第10期137卷 2024 Jan 9页

作者： Yu Chen Geng Songmei Yang bin Deng Yunhua Li Fuqiu Kang Xiaojing bi Mingye Zhang Furen Zhao Yi Pan Weili Tian Zhongwei Xu jinhua Zhang Zhenghua Yu Nan Duan Xinsuo Guo Shuping Sun Qing Li Weiquan Tao Juan Liu Zhijun Yin Yuanyuan Wang Gang Shandong Academy of Medical Sciences Jinan Shandong China Department of Dermatology Beijing Tsinghua Changgung Hospital Beijing China Department of Dermatology Zhejiang Provincial People’s Hospital Hangzhou Zhejiang China Department of Dermatology The First Affiliated Hospital of Xinxiang Medical College Xinxiang Henan China Department of Dermatology Huashan Hospital Affiliated to Fudan University Shanghai China Department of Dermatology General Hospital of Ningxia Medical University Yinchuan Ningxia China Department of Dermatology Affiliated Hospital of Chengde Medical University Chengde Hebei China Department of Dermatology The First Hospital of Shanxi Medical University Taiyuan Shanxi China Department of Dermatology Qilu Hospital of Shandong University Jinan Shandong China Department of Dermatology Yuebei People’s Hospital Shaoguan Guangdong China Department of Dermatology Xijing Hospital The Fourth Military Medical University Xi’an Shaanxi China Department of Dermatology Union Hospital Tongji Medical Collage Huazhong University of Science and Technology Wuhan Hubei China Department of Dermatology and Venereal Diseases The First Affiliated Hospital of University of South China Hengyang Hunan China Shenzhen Kangzhe biotechnology Co. Ltd. Shenzhen Guangdong China Department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong University Xi’an Shaanxi China Department of Dermatology Dermatology Hospital of Southern Medical University Guangzhou Guangdong China Department of Dermatology Tongji Hospital Huazhong University of Science and Technology Wuhan Hubei China Department of Dermatology The Second Hospital of Jilin University Changchun Jilin China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous Region Urumqi Xinjiang China Department of Dermatology Wuxi People’s Hospital of Wuxi City Wuxi Jiangsu China Department of Dermatology Shandong Provincial Hospital for Skin Diseases &amp Shandong Provincia

Background: There is a need for effective and safe therapies for psoriasis that provide sustained benefits. The aim of this study was to assess the efficacy and safety of tildrakizumab, an anti-interleukin-23p19 monoclonal antibody, for treating moderate-to-severe plaque psoriasis in Chinese patients.Methods: In this multi-center, double-blind, phase III trial, patients with moderate-to-severe plaque psoriasis were enrolled and randomly assigned (1:1) to receive subcutaneous tildrakizumab 100 mg or placebo at weeks 0 and 4. Patients initially assigned to placebo were switched to receive tildrakizumab at weeks 12, 16, and every 12 weeks thereafter. Patients in the tildrakizumab group continued with tildrakizumab at week 16, and every 12 weeks until week 52. The primary endpoint was the Psoriasis Area and Severity Index (PASI 75) response rate at week 12.Results: At week 12, tildrakizumab demonstrated significantly higher PASI 75 response rates (66.4% [73/110]vs. 12.7% [14/110]; difference, 51.4% [95% confidence interval (CI), 40.72, 62.13];P <0.001) and Physician’s Global Assessment (60.9% [67/110]vs. 10.0% [11/110]; difference, 49.1% [95% CI, 38.64, 59.62];P <0.001) compared to placebo. PASI 75 response continued to improve over time in both tildrakizumab and placebo-switching to tildrakizumab groups, reaching maximal efficacy after 28 weeks (86.8% [92/106]vs. 82.4% [89/108]) and maintained up to 52 weeks (91.3% [95/104]vs. 87.4% [90/103]). Most treatment-emergent adverse events were mild and not related to tildrakizumab.Conclusion: Tildrakizumab demonstrated durable efficacy through week 52 and was well tolerated in Chinese patients with moderate-to-severe plaque psoriasis.Trial registration: ClinicalTrials.gov, NCT05108766.

关键词： Tildrakizumab Interleukin 23 Plaque psoriasis Chinese Randomized controlled trial

5月南极涛动对青藏高原西部夏季气温影响的诊断分析

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气象 2024年第3期50卷 344-356页

作者：张宇李清泉余锦华沈新勇毕淼吴清源南京信息工程大学气象灾害教育部重点实验室/气候与环境变化国际合作联合实验室/气象灾害预报预警与评估协同创新中心南京210044 中国气象局气候预测研究重点开放实验室国家气候中心北京100081 南方海洋科学与工程广东省实验室(珠海) 珠海519082 中国气象局气候资源经济转化重点开放实验室重庆市气象科学研究所重庆401147

青藏高原是全球气候变暖最敏感的地区之一,是北半球夏季最大的热源,其气候响应受到广泛关注。然而,有关南极涛动与青藏高原夏季气温的关系和机理知之甚少。为了研究南极涛动与青藏高原夏季气温的关系,基于1979—2020年英国东安哥拉大学... 详细信息

青藏高原是全球气候变暖最敏感的地区之一,是北半球夏季最大的热源,其气候响应受到广泛关注。然而,有关南极涛动与青藏高原夏季气温的关系和机理知之甚少。为了研究南极涛动与青藏高原夏季气温的关系,基于1979—2020年英国东安哥拉大学气候研究中心(CRU)的逐月气温、美国国家海洋和大气管理局(NOAA)的逐月海表面温度和大气环流再分析数据以及南极涛动指数等数据,采用相关、回归、合成分析等方法进行研究。结果表明,北半球夏季青藏高原西部气温与5月南极涛动存在显著负相关,即当5月南极涛动异常偏弱时,夏季青藏高原西部气温异常偏高。其影响过程为,南极涛动为正位相时,在南印度洋中高纬地区出现“负-正-负”的经向“三极子”海温模态,该模态可持续到夏季,在印度洋形成异常的纬向-垂直环流,相应在热带西印度洋和东印度洋-海洋性大陆之间的降水异常导致热带正“偶极子”降水模态,通过该降水模态在青藏高原西部引起异常反气旋环流和下沉运动,有利于高原西部气温偏高。研究结果显示,海洋的热惯性在“延长”南极涛动影响过程中起着重要的桥梁作用,可为青藏高原夏季气温预测提供科学依据。

关键词：南极涛动青藏高原印度洋气温

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贯叶金丝桃化学成分的分离与鉴定

沈阳药科大学学报 2024年第5期41卷 551-556页

作者：胡诗雨张梦雪方容杨金花雷亮宋红萍毕晓宾湖北中医药大学药学院湖北武汉430061 武汉市第四医院湖北武汉430033 华中科技大学药学院湖北武汉430030

目的研究藤黄科(Guttiferae)金丝桃属(Hypericum)贯叶金丝桃(Hypericum perforatum L.)的化学成分。方法采用正相硅胶色谱、反相ODS色谱、凝胶色谱及高效液相色谱等多种色谱方法对贯叶金丝桃体积分数95%乙醇提取物进行分离纯化。利用紫... 详细信息

目的研究藤黄科(Guttiferae)金丝桃属(Hypericum)贯叶金丝桃(Hypericum perforatum L.)的化学成分。方法采用正相硅胶色谱、反相ODS色谱、凝胶色谱及高效液相色谱等多种色谱方法对贯叶金丝桃体积分数95%乙醇提取物进行分离纯化。利用紫外、红外、核磁共振光谱,高分辨质谱及X-ray单晶衍射法对化合物的结构进行鉴定。结果从贯叶金丝桃中分离鉴定8个化合物,分别为perforxanthone A(1)、8-hydroxy-1,2,3-trimethoxyxanthone(2)、绵马酚D(3)、(S)-5-hydroxy-3,4-dimethyl-5-pentylfuran-2(5H)-one(4)、ent-4(15)-eudesmene-1β,6α-diol(5)、methyl-(E)-8-oxooctadec-9-enoate(6)、模绕酮酸(7)、白桦脂酸(8)。结论化合物1为新的氧杂蒽酮类化合物,化合物2-7为首次从该植物中分离得到。

关键词：贯叶金丝桃提取分离结构鉴定

血液灌流联合盐酸纳洛酮治疗急性重症镇静药物中毒患者的疗效分析

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疑难病杂志 2024年第2期23卷 192-195,201页

作者：段昱毕淑珍陈锦华刘强李卿山西省长治市人民医院急诊科 046000

目的观察血液灌流联合盐酸纳洛酮治疗急性重症镇静药物中毒患者的临床效果。方法选取2019年7月—2023年7月长治市人民医院急诊科治疗的急性重症镇静药物中毒患者120例为研究对象。按照随机数字表法分为对照组和研究组,各60例。对照组给... 详细信息

目的观察血液灌流联合盐酸纳洛酮治疗急性重症镇静药物中毒患者的临床效果。方法选取2019年7月—2023年7月长治市人民医院急诊科治疗的急性重症镇静药物中毒患者120例为研究对象。按照随机数字表法分为对照组和研究组,各60例。对照组给予盐酸纳洛酮静脉滴注,研究组在对照组基础上给予血液灌流治疗。比较2组临床疗效、意识清醒时间、中毒症状消失时间、住院时间、血气指标水平[pH、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、血清炎性因子水平[白介素-4(IL-4)、IL-6、肿瘤坏死因子-α(TNF-α)]及并发症发生率。结果研究组临床总有效率为93.33%,高于对照组的76.67%(χ^(2)/P=6.536/0.011);治疗后研究组患者意识清醒时间、中毒症状消失时间、住院时间短于对照组(t/P=6.675/<0.001、6.004/<0.001、7.174/<0.001);与治疗前比较,治疗后患者PaCO_(2)、IL-4、IL-6、TNF-α水平均下降,pH、PaO_(2)上升(P<0.05),且研究组降低/升高幅度大于对照组(t/P=6.745/<0.001、5.729/<0.001、6.922/<0.001、6.169/<0.001、2.419/0.017、4.291/<0.001);治疗后研究组并发症总发生率为3.33%,低于对照组的15.00%(χ^(2)/P=4.904/0.027)。结论血液灌流联合盐酸纳洛酮治疗急性重症镇静药物中毒患者,可有效改善血气状况,降低炎性反应,促进患者恢复。

关键词：急性重症镇静药物中毒血液灌流盐酸纳洛酮临床疗效炎性因子

三维大隔距机织间隔织物柔性复合材料的服役性能研究

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复合材料科学与工程 2024年第3期 73-78,112页

作者：许晓婷郝恩全邵慧奇邵光伟毕思伊陈南梁蒋金华东华大学产业用纺织品教育部工程研究中心上海201620 东华大学纺织学院上海201620 浙江明士达股份有限公司海宁314400

为了探究陆基充气天线用三维大隔距机织间隔织物柔性复合材料的服役性能影响因素,分别对裁剪拼接造成的拼接强力、在酸碱工作环境中的材料强力、经折叠-展开-再折叠的耐折叠性能三大方面进行了研究。结果表明:拼接宽度为30 mm,选用胶黏... 详细信息

为了探究陆基充气天线用三维大隔距机织间隔织物柔性复合材料的服役性能影响因素,分别对裁剪拼接造成的拼接强力、在酸碱工作环境中的材料强力、经折叠-展开-再折叠的耐折叠性能三大方面进行了研究。结果表明:拼接宽度为30 mm,选用胶黏剂聚氨酯A584,拼接方向夹网布经向,得到的拼接强力效果最佳,能达到反射面本体材料的断裂强力;在耐酸碱试验中,聚氨酯A584和TPU热熔胶膜均未脱胶,且表现出较好的耐腐蚀性能,表明构成反射面的各部分材料能适应天线的各种工作环境;充气反射面材料表现出较好的折叠性,其折叠性能与折叠次数、拼接宽度具有一定相关性,而与拼接用胶关系不大,拼接材料的宽度增加,折叠次数对其作用越小,折痕回复性能较好。

关键词：机织间隔织物拼接强力耐酸碱腐蚀折叠次数复合材料

Fluorescent immunosensor based on fluorescence resonance energy transfer between CdSe/ZnS quantum dots and Au nanorods for PRRSV detection

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Progress in Natural Science:Materials International 2022年第2期32卷 157-162页

作者： Xue Li jinhua Li Wentao Yang Dandan Han Na Yao Hongbin Zhao Xueying Chu Xuemei Liang Chunguang bi Chunfeng Wang Guilian Yang College of Information Technology Jilin Agricultural University Nanophotonics and biophotonics Key Laboratory of Jilin Province Changchun University of Science and Technology Jilin Provincial Engineering Research Center of Animal Probiotics Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding Jilin Agricultural University Changchun Huili biotech Co. Ltd. Engineering Research Center of the Chinese Ministry of Education for bioreactor and Pharmaceutical Development College of Life Sciences Jilin Agricultural University State Key Laboratory of Advanced Materials for Smart Sensing General Research Institute for Nonferrous Metals

An ultrasensitive and selective sandwich-type fluorescent immunosensor based on fluorescence resonance energy transfer(FRET) between CdSe/ZnS quantum dots(QDs) and Au nanorods(AuNRs) was developed for the rapid detection of porcine reproductive and respiratory syndrome virus(PRRSV).Modified CdSe/ZnS QDs and AuNRs were bioconjugated with primary antibodies M and GP5,respectively.When the target antigen was present,a well-known sandwich-type form CdSe/ZnS QDs-M antibody-antigen-GP5 antibody-AuNRs was produced,and thus reducing the distance between the QDs and NRs.As a result,FRET occurred and the fluorescence intensity of CdSe/ZnS QDs decreased,and this decrease was used to determine the antigen concentration.Ultrasensitive detection of PRRSV at low concentrations in swine serum was achieved with a limit of detection of 0.55 TCID50/mL and a linear detection range of 10~1-3.5 × 10~4 TCID50/mL.Therefore,the fluorescent immunosensor is selective and highly sensitive;specifically,it can detect PRRSV at low concentrations in swine serum over a large concentration range.This proposed detection method can facilitate the development of high-performance fluorescent immunosensors for the detection of PRRSV and other antigens.

关键词： Fluorescence resonance energy transfer Immunosensor CdSe/ZnS quantum Dots Au nanorods Porcine reproductive and respiratory syndrome virus

区域锁定型3D打印导航模板结合双向修正方案在胸腰椎骨折辅助置钉中的应用

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中华创伤骨科杂志 2024年第1期26卷 26-34页

作者：张文玺周金华朱华乔之军刘波江苏省溧阳市人民医院骨科常州213300

目的评价区域锁定型3D打印导航模板结合双向修正方案在胸腰椎骨折辅助置钉中的应用效果。方法回顾性分析2019年1月至2023年3月江苏省溧阳市人民医院骨科收治的52例胸腰椎骨折患者资料。男29例,女23例;年龄(58.2±13.3)岁。将患者按照置... 详细信息

目的评价区域锁定型3D打印导航模板结合双向修正方案在胸腰椎骨折辅助置钉中的应用效果。方法回顾性分析2019年1月至2023年3月江苏省溧阳市人民医院骨科收治的52例胸腰椎骨折患者资料。男29例,女23例;年龄(58.2±13.3)岁。将患者按照置钉方法不同分为导板组(25例,采用区域锁定型3D打印导航模板结合双向修正方案术中辅助椎弓根定位置钉)和徒手组(27例,依据影像资料及C型臂X线机透视徒手置钉)。比较两组患者的手术时间、术中透视次数、术中出血量、并发症发生率、置钉准确率,比较两组患者的术前、术后1周、末次随访时疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)、伤椎前缘高度比。结果两组患者术前一般资料比较差异均无统计学意义(P>0.05),具有可比性。所有患者术后随访(11.2±4.2)个月。两组患者间术中出血量、并发症发生率,术前、术后1周、末次随访时的疼痛VAS、ODI、伤椎前缘高度比比较差异均无统计学意义(P>0.05)。导板组患者的手术时间(80.1±18.5)min显著长于徒手组患者的(69.4±16.6)min,但术中透视次数2(2,3)次显著少于徒手组患者的3(3,4)次,置钉准确率98.4%(127/129)显著高于徒手组患者的91.8%(112/122),差异均有统计学意义(P<0.05)。所有患者术后1周的疼痛VAS、ODI、伤椎前缘高度比均较术前显著改善,且末次随访时以上指标较术后1周显著改善,差异均有统计学意义(P<0.05)。所有患者均未出现脊髓、神经根及血管损伤。结论区域锁定型3D打印导航模板结合双向修正方案在胸腰椎骨折辅助置钉的置钉准确率和透视次数方面均优于徒手置钉,但手术时间较徒手置钉长,两种方法疗效无明显差异。

关键词：外科手术,计算机辅助骨折固定术,内脊柱模板 3D打印

广州市市政供水浑浊度特征及其与pH值、耗氧量相关性

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医学动物防制 2024年第5期40卷 451-453,458页

作者：周金华姜燕婷时绍轩陈怡然钟嶷黎晓彤黄仁德孙丽丽王德东毕华王大虎广州市疾病预防控制中心消毒杀虫部广东广州510440 广州医科大学

目的研究广州市市政供水出厂水中浑浊度特征和变化趋势,初步探索浑浊度对pH值和耗氧量的影响,为饮用水水质管理提供科学依据。方法对2003—2018年广州市政供水厂的出厂水进行抽样和检测,整理分析480份监测样品的数据。不同季度和水期出... 详细信息

目的研究广州市市政供水出厂水中浑浊度特征和变化趋势,初步探索浑浊度对pH值和耗氧量的影响,为饮用水水质管理提供科学依据。方法对2003—2018年广州市政供水厂的出厂水进行抽样和检测,整理分析480份监测样品的数据。不同季度和水期出厂水的浑浊度水平采用均值±标准差表示,采用单因素方差分析比较不同季度和水期的监测值水平,采用Pearson相关性分析评估浑浊度与pH值和耗氧量之间的相关性。结果2003—2018年出厂水的浑浊度合格率为98.54%(473/480),浑浊度水平总体呈现下降趋势(r=-0.632,P<0.001),pH值总体呈上升趋势(r=0.791,P<0.001),耗氧量总体呈下降趋势(r=-0.833,P<0.001)。第一季度出厂水的浑浊度与pH值(r=-0.163,P=0.076)和耗氧量(r=0.173,P=0.134)无相关性。其余季度和不同水期的pH值与浑浊度呈负相关,其余季度和不同水期的耗氧量与浑浊度呈正相关。结论2003—2018年广州市市政供水出厂水的浑浊度水平总体呈下降趋势,浑浊度监测对pH值和耗氧量有一定的预示作用,为饮用水的监测提供参考。

关键词：浑浊度 pH值耗氧量相关性