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High-Content Screening and Analysis of Stem Cell-Derived Neural Interfaces Using a Combinatorial Nanotechnology and Machine Learning Approach

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研究(英文) 2023年第1期2022卷 153-167页

作者： Letao Yang Brian M.Conley jinho yoon Christopher Rathnam Thanapat Pongkulapa Brandon Conklin Yannan Hou Ki-Bum Lee Department of Chemistry and Chemical Biology Rutgers UniversityThe State University of New JerseyPiscatawayNJ 08854USA

A systematic investigation of stem cell-derived neural interfaces can facilitate the discovery of the molecular mechanisms behind cell behavior in neurological disorders and accelerate the development of stem cell-based ***,high-throughput investigation of the cell-type-specific biophysical cues associated with stem cell-derived neural interfaces continues to be a significant obstacle to *** this end,we developed a combinatorial nanoarray-based method for high-throughput investigation of neural interface micro-/nanostructures(physical cues comprising geometrical,topographical,and mechanical aspects)and the effects of these complex physical cues on stem cell fate ***,by applying a machine learning(ML)-based analytical approach to a large number of stem cell-derived neural interfaces,we comprehensively mapped stem cell adhesion,differentiation,and proliferation,which allowed for the cell-type-specific design of biomaterials for neural interfacing,including both adult and human-induced pluripotent stem cells(hiPSCs)with varying genetic *** short,we successfully demonstrated how an innovative combinatorial nanoarray and ML-based platform technology can aid with the rational design of stem cell-derived neural interfaces,potentially facilitating precision,and personalized tissue engineering applications.

关键词： overcome neural rational

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Multi-redox phenazine/non-oxidized graphene/cellulose nanohybrids as ultrathick cathodes for high-energy organic batteries

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Nano Research 2021年第5期14卷 1382-1389页

作者： Youngjin Ham Vitalii Ri Jin Kim Yeoheung yoon jinho Lee Kisuk Kang Ki-Seok An Chunjoong Kim Seokwoo Jeon Department of Materials Science and Engineering Advanced Battery CenterKorea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea Department of Materials Science and Engineering Chungnam National UniversityDaejeon34134Republic of Korea Thin Film Materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon34114Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea

Various redox-active organic molecules can serve as ideal electrode materials to realize sustainable energy storage systems. Yet, to be more appropriate for practical use, considerable architectural engineering of an ultrathick, high-loaded organic electrode with reliable electrochemical performance is of crucial importance. Here, by utilizing the synergetic effect of the non-covalent functionalization of highly conductive non-oxidized graphene flakes (NOGFs) and introduction of mechanically robust cellulose nanofiber (CNF)-intermingled structure, a very thick (≈ 1 mm), freestanding organic nanohybrid electrode which ensures the superiority in cycle stability and areal capacity is reported. The well-developed ion/electron pathways throughout the entire thickness and the enhanced kinetics of electrochemical reactions in the ultrathick 5,10-dihydro-5,10-dimethylphenazine/NOGF/CNF (DMPZ-NC) cathodes lead to the high areal energy of 9.4 mWh·cm−2 (= 864 Wh·kg−1 at 158 W·kg−1). This novel ultrathick electrode architecture provides a general platform for the development of the high-performance organic battery electrodes.

关键词： energy storage organic electrodes batteries graphene cellulose nanofibers

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