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Diagnostic accuracy of cystoscopic biopsy for tumour grade in outpatients with urothelial carcinoma of the bladder and the risk factors of upgrading

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Asian Journal of Urology 2023年第1期10卷 19-26页

作者： Junjie fan Hua Liang jinhai fan Lei Li Guanjun Zhang Xinqi Pei Tao Yang Dalin He Kaijie Wu Department of Urology First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anChina Department of Urology Baoji Center HospitalBaojiChina Department of Pathology First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anChina

Objective:To assess the concordance of tumour grade in specimens obtained from diagnostic cystoscopic biopsy and transurethral resection of bladder tumour(TURBT)and explore the risk factors of upgrading.Methods:The medical records of 205 outpatients who underwent diagnostic cystoscopic biopsy before initial TURBT were retrospectively reviewed.Comparative analysis of the tumour grade of biopsy and operation specimens was performed.Tumour grade changing from low-grade to high-grade with or without variant histology was defined as upgrading.Logistic regression an-alyses were performed to identify the risk factors of upgrading.Results:For the 205 patients,the concordance of tumour grade between specimens obtained from biopsy and operation was 0.639.The concordance for patients who were preoperatively diagnosed with low-grade and high-grade was 0.504 and 0.912,respectively.Univariate and multivariate logistic regression analyses showed that older age,tumour multifocality,high neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and low lymphocyte-to-monocyte ratio(LMR)were significantly associated with upgrading(odds ratio ranging from 0.412 to 4.364).The area under the curve of the different multivariate models was improved from 0.752 to 0.821,and decision curve analysis demonstrated a high net benefit when NLR,LMR,and PLR were added.Conclusion:Diagnostic cystoscopic biopsy may not accurately represent the true grade of primary bladder cancer,especially for outpatients with low-grade bladder cancer.Moreover,older age,tumour multifocality,high NLR,PLR,and low LMR are risk factors of upgrading,and systemic inflammatory markers improve the predictive ability.

关键词： Cystoscopic biopsy Bladder cancer Diagnostic accuracy Upgrading Systemic inflammatorymarkers

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Recent developments of droplets-based microfluidics for bacterial analysis

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Chinese Chemical Letters 2022年第5期33卷 2243-2252页

作者： Ruizhi Ning jinhai fan Liang Kong Xue Jiang Yun Qian Tao Du Guangjian Zhang Weiwei Wu Interdisciplinary Research Center of Smart Sensors Academy of Advanced Interdisciplinary ResearchXidian UniversityXi’an 710071China The First Affiliated Hospital of Xi’an Jiaotong University Xi’an 710061China State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial SurgerySchool of StomatologyAir Force Medical UniversityXi’an 710032China Stomatology Hospital School of StomatologyZhejiang University School of MedicineClinical Research Center for Oral Diseases of Zhejiang ProvinceKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310006China

Droplet-based microfluidics enables the generation of uniform microdroplets at picoliter or nanoliter scale with high frequency(∼kHz)under precise control.The droplets can function as bioreactors for versatile chemical/biological study and analysis.Taking advantage of the discrete compartment with a confined volume,(1)isolation and manipulation of a single cell,(2)improvement of in-droplet effective concen-trations,(3)elimination of heterogeneous population effects,(4)diminution of contamination risks can be achieved,making it a powerful tool for rapid,sensitive,and high-throughput detection and analysis of bacteria,even for rare or unculturable strains in conventional methods.This mini-review will focus on the generation and manipulation of micro-droplets and bacteria detection and analysis carried out by droplet-based microfluidics.Finally,applications with high potential of droplet-based bacteria analysis are briefly introduced.Due to the advantages of rapid,sensitive,high throughput,and compatibility with rare and unculturable bacteria in conventional methods,droplet-based microfluidics has tremendous potential of providing novel solutions for biological medicine,microbiological engineering,environmental ecology,etc.

关键词： Droplet microfluidics Droplet generation Droplet manipulation High throughput Bacteria analysis

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Multiplex ratiometric gold nanoprobes based on surface-enhanced Raman scattering enable accurate molecular detection and imaging of bladder cancer

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Nano Research 2022年第4期15卷 3487-3495页

作者： Xiao Liang Pu Zhang Minghai Ma Tao Yang Xiangwei Zhao Rui Zhang Minxuan Jing Rundong Song Lei Wang jinhai fan Department of Urology The First Affiliated HospitalXi’an Jiaotong UniversityXi’an 710061China Department of Thoracic Surgery Tangdu HospitalAir Force Medical UniversityXi’an 710038China Department of Urology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringNational Demonstration Center for Experimental Biomedical Engineering EducationSoutheast UniversityNanjing 210096China

Recently,surface-enhanced Raman scattering(SERS)has been successfully used in the non-invasive detection of bladder tumor(BCa).The internal standard method was considered as an effective ratiometric strategy for calibrating signal fluctuation originated from the interference of measurement conditions and samples.However,it is still difficult to detect the target mRNA quantitatively using the current ratiometric SERS nanosensors.In this study,we developed an internal reference based ratiometric SERS assay.Two kinds of molecular beacons(MB)carrying Raman reporter molecules were anchored on sea-urchinlike Au nanoclusters(AuNCs).Thymidine kinase1(TK1)MBs with hexachlorofluorescein(HEX)were used to capture tumor biomarker TK1 mRNA,and glyceraldehyde 3-phosphate dehydrogenase(GAPDH)MBs with 5(6)-carboxyfluorescein(FAM)were used to offer internal standard signals.The internal reference GAPDH MB can reflect the consistent content of the GAPDH mRNA in single cells.The ratiometric method(I745/I645)can more accurately reflect the content of target mRNA in single cells.The ratiometric nanoprobes had excellent stability(coefficient of variation:0.3%),high sensitivity(detection limit:3.4 pM),high specificity(capable of single-base mismatch recognition)and ribozyme-resistant stability.Notably,the nanoprobes can effectively distinguish BCa cells from normal cells,and it was easy to contour the single BCa cell using the ratiometric method.By combining asymmetric polymerase chain reaction(PCR)and ratiometric nanoprobes,it was easy to distinguish the SERS ratio(I_(745)/I_(645))as low concentration as 10-14 M.Further clinical detection in urine samples from patients with BCa confirmed its potential for early noninvasive diagnosis of BCa with the sensitivity of 80%and specificity of 100%,which is superior to the current urine cytological method.

关键词： surface-enhanced Raman scattering(SERS) internal reference bladder cancer non-invasive detection SERS imaging

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Erratum to:Detecting gravitational wave with an interferometric seismometer array on lunar nearside[Sci.China-Phys.Mech.Astron.66,109513(2023)]

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 182-183页

作者： Junlang Li fangfei Liu Yuan Pan Zijian Wang Mengdi Cao Mengyao Wang fan Zhang jinhai Zhang Zong-Hong Zhu Department of Astronomy Beijing Normal UniversityBeijing 100875China Advanced Institute of Natural Sciences Beijing Normal University at ZhuhaiZhuhai 519087China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

This paper"Detecting gravitational wave with an interferometric seismometer array on lunar nearside"[1]was published in SCIENCE CHINA Physics,Mechanics&Astronomy(66,109513(2023),doi:10.1007/s11433-023-2179-9).Due to an oversight on our part,some errors were made in the originally published paper.We apologize for these errors and offer the corresponding explanations and corrections for the readers.

关键词： gravitational seism wave

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基于三支因果力的邻域推荐算法

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山东大学学报（理学版） 2024年第5期59卷 12-22页

作者：范敏秦琴李金海昆明理工大学数据科学研究中心云南昆明650500 昆明理工大学理学院云南昆明650500

本文将三支决策思想、因果力理论与形式概念分析相结合,提出了三支因果力下的邻域推荐算法。考虑到极端用户评分对推荐精度的影响,根据宽松度和严苛度对用户进行分类,修正极端用户评分。基于修正评分矩阵计算节点之间的三支余弦相似度... 详细信息

本文将三支决策思想、因果力理论与形式概念分析相结合,提出了三支因果力下的邻域推荐算法。考虑到极端用户评分对推荐精度的影响,根据宽松度和严苛度对用户进行分类,修正极端用户评分。基于修正评分矩阵计算节点之间的三支余弦相似度和节点相似结构重要度,找出专家节点。在对象弱概念需要满足的目标函数和约束条件下进行聚类得到邻域,在邻域中根据属性密度识别关键的条件属性和决策属性并计算置信度,结合三支因果力提取推荐规则对社区成员进行邻域推荐。实验结果表明,本文算法的精确度、召回率、F1均优于其他传统的推荐算法。

关键词：形式概念分析三支决策因果力推荐算法网络形式背景

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轨道交通工程中消火栓系统设计关键技术探讨

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隧道建设（中英文） 2024年第1期44卷 139-147页

作者：周金忠张美琴范太兴杜金海中铁第六勘察设计院集团有限公司天津300308

为设计出更加安全可靠、经济合理的轨道交通工程,介绍南京—马鞍山城际铁路(简称宁马线)消火栓系统设计中的一些关键技术及其相对于常规传统设计的优点。首先,在对规范解读及工程经验分析的基础上,首次提出“轨道交通工程中,为了保证消... 详细信息

为设计出更加安全可靠、经济合理的轨道交通工程,介绍南京—马鞍山城际铁路(简称宁马线)消火栓系统设计中的一些关键技术及其相对于常规传统设计的优点。首先,在对规范解读及工程经验分析的基础上,首次提出“轨道交通工程中,为了保证消防安全,消防泵房保护距离尽量控制在2000 m以内”的原则。为了将此理念落实到具体设计中,在本工程中提出一种新的消防供水方案,即“消防供水多方案组合模式”,具体内容为:1)优先选用一站带左右各半个相邻区间的方案;2)当区间长度小于2000 m时,也可以采用一站带一相邻区间方案;3)当区间长度大于4000 m时,在一站带左右各半个相邻区间方案的基础上,在区间风井处设置独立的消防泵房,以保证所有消防泵房的保护距离控制在2000 m以内;4)将各消防泵房的供水单元完全独立。其次,在车站给水水压制式方面,提出2种单路水源高架站的消防供水方案及其适用范围,即:1)室外低压、室内临时高压系统,适用范围为“高架站布置在市政道路一侧,并且车站离市区较近、消防基础设施条件较好,能保证足量消防车及时赶到火灾现场”或“条件特别困难的既有高架车站改造”;2)室内外共用临时高压消防系统,适用范围为“高架站布置在市政道路中央”或“车站离市区较远、消防基础设施条件比较不利,不能保证足量消防车及时赶到火灾现场”。最后,在消防设施布置方面,提出“高架车站室外消防水池、扑救类室外消火栓”的布置原则,其中最重要的2条为:1)室外低压、室内临时高压系统中,当高架站超出消防水池150 m保护半径时,应增设相应的消防水池取水井;2)车站扑救面上布置室外消火栓时,应优先布置在每个高架站出入口附近。

关键词：轨道交通工程消火栓系统消火栓泵房保护距离消防供水多方案组合模式车站给水水压制式室外消防水池

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R11 peptides can promote the molecular imaging of spherical nucleic acids for bladder cancer margin identification

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Nano Research 2022年第3期15卷 2278-2287页

作者： Minghai Ma Pu Zhang Xiao Liang Daxiang Cui Qiuya Shao Haibao Zhang Mengzhao Zhang Tao Yang Lu Wang Nan Zhang Minxuan Jing Lu Zhang Weichao Dan Rundong Song Xi Liu Jiatao Hao Yuhang Chen Lijiang Gu Lei Wang jinhai fan Department of Urology The First Affiliated HospitalXi’an Jiaotong UniversityXi’an 710061China Department of Urology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014China Department of Thoracic Surgery Tangdu HospitalAir Force Medical UniversityXi’an 710038China Department of Bio-Nano-Science and Engineering National Key Laboratory of Nano/Micro Fabrication TechnologyInstitute of Micro-Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240China

One of the critical problems in bladder cancer(BC)management is the local recurrence of disease.However,achieving the accurate delineation of tumor margins intraoperatively remains extremely difficult due to the lack of effective tumor margin recognition technology.Herein,survivin molecular beacon(MB)and R11 peptide-linked spherical nucleic acids(SNAs)were synthesized as nanoprobes(AuNP-MB@R11)for sensitive detection of BC margins.Physicochemical properties proved that R11 peptides and survivin MB were successfully loaded onto the surface of SNAs.AuNP-MB@R11 had good stability against nuclease activity and high sensitivity and specificity to detect survivin single strand DNA(ssDNA)in vitro.According to cytology,R11 peptides could increase the BC targeting ability and membrane penetrability of SNAs.Notably,R11 peptides significantly promoted the disintegration of lysosomes and the release of SNAs to enhance fluorescence imaging quality.Further RNA sequencing proved that some genes and pathways related to endocytosis and lysosomes were significantly regulated,such as AGPAT5,GPD1L,and GRB2.In orthotopic BC models and a clinical sample from a patient with BC,AuNP-MB@R11 showed a more legible cancerous fluorescence margin and offered remarkably improved detection compared to those achieved by SNAs.R11 peptide-linked SNAs present promising potential to identify BC margin,which may help to improve the R0 resection rate in surgery and improve patients’quality of life.

关键词： R11 peptides molecular beacons spherical nucleic acids tumor targeting lysosome escape bladder cancer

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长径比与桩侧土体模量变化对灌注桩竖向承载特性影响分析

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市政技术 2024年第4期42卷 54-61,77页

作者：许白杨杨珂范金海施文辉吴悦四川省交通建设集团有限责任公司四川成都610047 重庆交通大学土木工程学院重庆400074 重庆市建筑科学研究院有限公司重庆400016 重庆建筑工程职业学院重庆400072

为研究桩基长径比与灌注桩成孔开挖过程引起的桩侧土体弹性模量弱化效应对桩基承载特性的影响,采用数值分析方法构建了15组竖向受荷单桩模型,以分析桩顶荷载-沉降曲线、桩身轴力变化曲线和桩端荷载-沉降曲线的变化特征。结果表明,在同... 详细信息

为研究桩基长径比与灌注桩成孔开挖过程引起的桩侧土体弹性模量弱化效应对桩基承载特性的影响,采用数值分析方法构建了15组竖向受荷单桩模型,以分析桩顶荷载-沉降曲线、桩身轴力变化曲线和桩端荷载-沉降曲线的变化特征。结果表明,在同一桩长和桩顶竖向荷载下,桩顶竖向位移随着桩径的增大而减小,而在同一桩顶竖向位移下,桩顶竖向荷载随着桩径的增大而增大;在同一桩径和桩顶竖向荷载下,桩顶竖向位移随着桩长的增大而减小,而在同一桩顶竖向位移下,桩顶竖向荷载随着桩长的增大而增大。存在一临界长径比,使得桩端阻力发挥比例和桩顶竖向位移变化率的影响达到最大。当桩侧土体弹性模量大于某一定值时,桩侧土体弹性模量变化对桩承载特性的影响可忽略;随着桩侧土体弹性模量减小且达到某一定值时,桩侧摩阻力开始不发挥的位置逐渐向上移动。

关键词：桩基承载特性长径比弹性模量荷载-沉降曲线数值模拟

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Detecting gravitational wave with an interferometric seismometer array on lunar nearside

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Science China(Physics,Mechanics & Astronomy) 2023年第10期66卷 203-223页

Our Moon is by far the easiest natural, extraterrestrial celestial object for us to reach, and many space agencies, in particular the China National Space Administration, have publicized plans for manned missions there. Such high-profile projects must yield commensurate scientific outputs to justify their cost to the taxpayers. An important criterion for the selection of candidate experiments is the extent to which the Moon plays an integral and irreplaceable role, as opposed to offering only marginal advantages over Earth-orbit, space-based alternatives. In this study, we propose an experiment that excels in this regard, which considers the Moon as part of the experimental apparatus. Specifically, the Moon acts as a Weber bar-style resonant mass that responds to deci-Hertz gravitational waves(GWs). GW-excited lunar vibrations can be picked up by an array of(prefabricated on Earth and easy to transport to the Moon) small laser interferometric seismometers yielding GW detection. Such a setup would plug a gap in the GW frequency range already covered by the existing or underdevelopment detectors, and it can inform us on important astrophysics topics, such as the progenitors of Type Ia supernovae(SNe Ia) or intermediate mass black holes. We provide the instrument design as well as its deployment strategy, and we also summarize relevant science cases according to the estimated viable sensitivity.

关键词： gravitational waves lunar antenna seismic motion

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Survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches

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Asian Journal of Urology 2020年第3期7卷 291-300页

作者： Weibin Xie Junming Bi Qiang Wei Ping Han Dongkui Song Lei Shi Dingwei Ye Yijun Shen Xin Gou Weiyang He Shaogang Wang Zheng Liu jinhai fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou Fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina Department of Urology West China HospitalSichuan UniversityChengduChina Department of Urology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Urology Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Urology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Urology First Affiliated Hospital of Army Medical UniversityUrology Institute of People Liberation ArmyChongqingChina Department of Urology The First Hospital of China Medical UniversityShenyangChina Department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhouChina Department of Urology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Urology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Urology General Hospital of Central Theater Command of the People’s Liberation ArmyWuhanChina

Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and ORC.The influence of surgical approaches on overall survival(OS)and cancer-specific survival(CSS)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank test.Multivariable Cox proportional hazard models were used to evaluate the association among OS,CSS and risk factors of interest.Results:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent ORC.No significant differences were noted in positive surgical margin rate and 90-day postoperative mortality rate.MIRC was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital stay.There was no significant difference in OS and CSS according to surgical approaches(pZ0.653,and 0.816,respectively).Subgroup analysis revealed that OS and CSS were not significantly different regardless of the status of extravesical involvement or LN involvement.Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of OS and CSS.Conclusions:Our study showed that MIRC was comparable to conventional ORC in terms of OS and CSS.

关键词： Bladder cancer Radical cystectomy Minimally invasive surgery Robotic surgery Laparoscopy

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