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翻转课堂+案例教学法对中医内科学临床带教质量的提升评价

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中国卫生产业 2024年第3期21卷 177-180页

作者：贾利华许京中日照市岚山区巨峰中心卫生院内科山东日照276812

目的评价翻转课堂+案例教学法(Case Based Learning,CBL)对中医内科学临床带教质量的提升效果。方法选取2022年1月—2023年10月日照市岚山区巨峰中心卫生院接收的100名中医实习生为研究对象,根据抽签法随机分为对照组(传统教学法)和干预... 详细信息

目的评价翻转课堂+案例教学法(Case Based Learning,CBL)对中医内科学临床带教质量的提升效果。方法选取2022年1月—2023年10月日照市岚山区巨峰中心卫生院接收的100名中医实习生为研究对象,根据抽签法随机分为对照组(传统教学法)和干预组(CBL+翻转课堂教学法),各50名。比较两组的考核成绩、教学成果与教学满意率。结果干预组各项考核成绩优于对照组,各项教学成果评分高于对照组,差异有统计学意义(P均<0.05)。干预组的教学总满意率为96.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。结论在翻转课堂教学基础上联合CBL带教中医内科学实习生能提升教学效果,能提高实习生成绩,培养其学习能力与临床思维能力,获得更高的满意率。

关键词：翻转课堂案例教学法中医内科学临床带教质量

Clinicopathological characterization of gastroenteropancreatic neu-roendocrine neoplasms： a retrospective study of 48 cases

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Oncology and Translational Medicine 2018年第4期4卷 163-170页

作者： Jianguo Sun Xiaodong Zhang Songjing Lei jingzhong xu Zhaoyang Qin Department of Endocrinae Rizhao Lanshan District People's Hospital Rizhao 276826 China Department of Laboratory The Centers for Disease Control and Prevention of Rizhao Rizhao 276826 China Department of Imaging Weihaiwei People's Hospital Weihai 264200 China Department of Internal medicine Rizhao Jufeng Central Hospital Rizhao 276826 China Department of General Surgery Rizhao People's Hospital Jining Medical University Rizhao 276826 China

Objective Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) constitute a rare and heterogeneous group of tumors with varied biology and still constitute a diagnostic and therapeutic challenge for physicians of all specialties. In the present study, we aimed to review and study the clinicopathological characteristics of GEP-NENs applying the World Health Organization(WHO) 2010 grading criterion.Methods A total of 48 patients were enrolled in the study. The study included patients diagnosed with GEP-NENs who were treated and followed up at our Hospital from January 2013 to December 2017. Data regarding clinicopathological features of the patients were retrospectively evaluated. The expression of neuroendocrine markers was measured using the immunohistochemical Ultra Sensitive^(TM) S-P method of staining in 48 cases of primary GEP-NENs; and serum levels of neuron-specific enolase, carbohydrate an-tigen 19-9, and carcinoembryonic antigen in 36 GEP-NEN patients were measured using the electrochemiluminescence method.Results The median age at presentation was 59.3(range 48–82) years, and 39 cases(81.3%) were seen between the 5 th and 6 th decades. There was a male predilection(male: female=3:1). In 79.2% cases(38/48), tumors were hormonally nonfunctional. The most common presentation was abdominal pain, and the most frequent primary site of the tumor was the rectum, followed by the stomach(n = 15, 31.3%), colon(n = 5, 10.4%), and so on. Of the 48 tumors, 16(33.3%) were G1, 6(12.5%) cases were G2, 16(33.3%) were neuroendocrine carcinoma(NEC), and 10(20.8%) were mixed adenoneuroendocrine carcinoma(MANEC). According to the AJCC/UICC classification, 45.8%(n = 22) were diagnosed at low stage(stage I or II) while 54.2%(n = 26) were diagnosed at high stage(stage III or IV)(the majority of NEC, G3, and MANEC). A male preponderance was noted for all tumors except for G2 neoplasms, which showed no gender predilection. Thirty-nine patients underwent endoscopic biopsy. The lesions in 18.8%(n = 9) of the patients were inden

关键词：盒子持续时间神经原组织学诊断肿瘤学习生物学

Methanol adsorption studies of electrified ACF by MD simulations

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Science China(Technological Sciences) 2004年第6期47卷 667-675页

作者： LIANG Shiqiang xu jingzhong Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100080China

In order to clarify whether static electricity can impose a control on physical adsorption of polar adsorbates, MD simulations were carried out to study the adsorption/desorption behavior of methanol in the nanopores of electrified activated carbon fiber (ACF). Some special phenomena were observed from the MD simulations for methanol adsorption in a mesopore of electrified ACF. For example it takes a shorter time for the adsorbates to reach the adsorption sites on the mesopore wall, the liquid-like methanol is highly condensed, the methanol molecules have a unique distribution of space orientation, and the total energy of equilibrium state dropped a lot. These phenomena indicate the static electricity reinforced the interaction between the polar methanol and the electrified ACF, so that the intensity, stability and regularity of adsorption were increased, and thus we predict that the adsorption capacity will be increased and the adsorption process will be accelerated. When adsorption equilibrium was reached at room temperature, eliminated the electric charges and heated the system, the desorption tendency was evidently observed from our simulations at 60℃ or so.

关键词： ACF 甲醇吸附 MD 静态的电

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复杂屋顶平面的RANSAC优化分割方法

武汉大学学报（信息科学版） 2023年第9期48卷 1531-1537页

作者：徐景中李均武汉大学遥感信息工程学院湖北武汉430079

针对传统随机采样一致性(random sample consensus,RANSAC)算法对复杂屋顶的分割缺陷,提出一种复杂屋顶平面的RANSAC优化分割方法。首先,在点云法向量估计的基础上,利用点法式方程优化种子点选取过程,提高初始平面选择的有效性;然后,采... 详细信息

针对传统随机采样一致性(random sample consensus,RANSAC)算法对复杂屋顶的分割缺陷,提出一种复杂屋顶平面的RANSAC优化分割方法。首先,在点云法向量估计的基础上,利用点法式方程优化种子点选取过程,提高初始平面选择的有效性;然后,采用距离与法向加权法抑制虚假平面生成,并利用加权函数进行平面内点的迭代修正,提高面片分割的准确性;最后,利用面片竞争方法优化分割结果,实现屋顶点云的分割处理。多组点云分割实验结果表明,该方法能有效抑制虚假平面,对复杂建筑物的屋顶平面分割结果的精确率、召回率和整体精度分别达到96.8%、98.2%和95.1%。相比传统方法,该方法在点云分割结果正确率及耗时方面均有明显优势。

关键词：激光雷达建筑物顶面点云分割随机采样一致性平面检测

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食管肉瘤样癌的临床病理分析(英文)

The Chinese-German Journal of Clinical Oncology 2014年第5期13卷 235-239页

作者： Changshan Li jingzhong xu Shenghua Tian Qingmin Meng Gangping Wang Department of Radiology Rizhao People's Hospital Department of Internal Medicine Rizhao Jufeng Hospital Department of Internal Medicine Rizhao Traditional Chinese Medicine Hospital Department of Radiology The Central Hospital of Tai'an Department of Clinical Pathology Rizhao People's Hospital

Objective: The purpose of this study was to study the clinical, imaging characters and pathological characteristics of esophageal sarcomatoid carcinoma. Methods: We reviewed 23 cases of esophageal sarcomatoid carcinoma from January 2006 to December 2013 in four hospitals. The data of patients who were esophageal sarcomatoid carcinoma operated were retrospectively analyzed. All cases had completed upper gastrointestinal barium images materials and 14 of these cases had completed CT images materials. Upper gastrointestinal barium images and CT imaging features include tumor location, size, shape, and strengthen, etc. The biological parameters of lesions including the express of cytokeratin AE1/AE3, 34βE12, p63, Vimentin, desmin, Actin, S-100 and Ki-67 detected by immunhistochemical UltraSensitiveTM S-P method(n = 23), and the patients' data of contrastographic picture(n = 23), imaging characters of CT scan(n = 14), and their relationship were studied. Results: Upper gastrointestinal barium images, CT imaging and gastrointestinal fiberscopy revealed lobulated intraluminal filling defect 0.4 cm to 5.7 cm × 3.5 cm × 1.3 cm(mean = 3. 7 cm) in the mid(n = 14), lower(n = 7) and upper(n = 2) intrathoracic esophagus. Among 23 cases of esophageal sarcomatoid carcinoma, 19 patients were of mushroom type, 2 patients was of ulcer type, and 2 patients were of medulla type; 19 patients were pedunculated, and 4 patients were no pedunculated(2 patients was of ulcer type). The tumor surface was relatively smooth and esophageal compliance was maintained. The pathological changes of esophagus such as lightly locked, rigid wall no-manifest partly, esophageal lumens expand partly, major filling sublobe defect could be shown through contrast medium. Normal esophagus was no unpack obviously over pathological changes. Enhanced computed tomography showed tumors in the intrathoracic esophagus and 8 lymph nodes metastases in 3 cases. Histologically, carcinomatous and sarcomatous components coexist. Microscopically, the tumor comprised poorly

关键词：食管癌肉瘤病理分析临床细胞角蛋白免疫组化染色食管肿瘤 CT图像

Neurotoxic mechanism of 1-methyl-4-phenyl-1,2,3,6-tetradropyridine

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Neural Regeneration Research 2006年第4期1卷 328-330页

作者： Xiulan Yang jingzhong Zhang Qunyuan xu Beijing Institute for Neuroscience Beijing Center for Neural Regeneration and RepairCapital Medical University Beijing 100054 China

BACKGROUND ： To summarize the metabolic pathway of 1-methyl-4-phenyl-1,2,3,6-tetradropyridine （MPTP） and its mechanism in inducing Parkinson disease. DATA SOURCES： A computer-based online search of Medline database was undertaken to identify articles about the metabolic pathway of MPTP and its mechanism in inducing Parkinson disease published in English between January 1996 and August 2004, the keywords were ＂MPTP, Parkinson disease＂. Meanwhile, Chinese relevant articles published between January 2000 and August 2004 were searched in Wanfang database with the keywords of ＂MPTP, Parkinson disease＂. STUDY SELECTION： More than 300 relevant literatures were retrieved, and the full-texts were further searched, those about the establishment of animal models, molecular mechanism of MPTP neurotoxicity and the metabolism were selected, and the obviously repetitive ones, case report and reviews were excluded, finally 18 of them were selected for summarization. DATA EXTRACTION： The 18 literatures were categorized according to MPTP induced animal models of Parkinson disease, mechanism of MPTP in inducing apoptosis in models of Parkinson disease, role of dopamine in the neurotoxic mechanism of MPTP, the role of reactive oxygen species and nitric oxide in the neurotoxicity of MPTP. DATA SYNTHESIS： Animal models of Parkinson disease induced by MPTP can not only produce the clinical characters of Parkinson disease, also duplicate the main biochemical and pathological changes of Parkinson disease. The metabolic pathway of MPTP and its mechanism in inducing Parkinson disease included producing free oxygen and nitric oxide, damaging mitochondrial respiratory chain, and inducing apoptosis, etc. which could all lead to the degeneration and loss of dopaminergic neurons. CONCLUSION ： Although some aspects of the models of Parkinson disease are different from that in human beings, we can still know the neurodegeneration of Parkinson disease through studying the molecular mechanism of MPTP.

关键词： MPTP Neurotoxic mechanism of 1-methyl-4-phenyl-1,2,3,6-tetradropyridine

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机载激光雷达波形数据横向高斯分解方法

武汉大学学报（信息科学版） 2018年第1期43卷 81-86,100页

作者：孟志立徐景中武汉大学遥感信息工程学院

针对机载激光雷达波形数据分解易受噪声影响,高斯组分个数及叠加波初始参数估计不精确等问题,提出了一种横向高斯波形分解方法。该方法首先对波形进行滤波平滑处理,剔除背景噪声后,将检测到的波峰划分为不同的类型,分别估计其初始参数;... 详细信息

针对机载激光雷达波形数据分解易受噪声影响,高斯组分个数及叠加波初始参数估计不精确等问题,提出了一种横向高斯波形分解方法。该方法首先对波形进行滤波平滑处理,剔除背景噪声后,将检测到的波峰划分为不同的类型,分别估计其初始参数;然后横向逐步迭代分解估计初始高斯分量,在去除无效的初始高斯分量后,利用列文伯格-马夸尔特（Levenberg-Marquardt）算法进一步优化参数;最后解算得到分解点云。实验结果表明,该方法能有效地检测各种类型的回波信号,对叠加波形具有良好的适应性,并能在一定程度上保护弱波。相比系统点云,本文方法解算的点云在数量和细节上更具有优势,反映了更加丰富的地物垂直结构信息以及在森林参数获取方面的应用潜力。

关键词：全波形数据高斯分解列文伯格-马夸尔特算法分解点云

增材制造孔隙结构生物医用钛合金力学及干摩擦行为有限元分析

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中国表面工程 2020年第6期33卷 37-46页

作者：徐敬忠吕晓仁李述军沈阳工业大学机械工程学院沈阳110870 中国科学研究院金属研究所沈阳110870

生物医用孔隙结构植入体的发展影响着人类的健康。当植入体与人体骨骼组织间出现体液缺失,即发生干滑动摩擦时,会出现肿胀、发炎等症状。为了减缓这种痛苦,有必要研究生物医用孔隙结构在干摩擦下的磨损行为。基于有限元方法建立了增材... 详细信息

生物医用孔隙结构植入体的发展影响着人类的健康。当植入体与人体骨骼组织间出现体液缺失,即发生干滑动摩擦时,会出现肿胀、发炎等症状。为了减缓这种痛苦,有必要研究生物医用孔隙结构在干摩擦下的磨损行为。基于有限元方法建立了增材制造孔隙结构Ti-6Al-4V干滑动摩擦计算模型,通过运动规律及模型转化计算所需的运动学和动力学边界条件。应用三角数学建模创建模型、利用微积分理论及曲线拟合综合推算磨损量,通过仿真得到的位移矢量和、旋转矢量和、摩擦力和摩擦热综合分析3种孔隙结构摩擦学性能的优劣,并对磨损量进行试验验证。结果表明:3种孔隙结构位移矢量和与旋转矢量和的排队顺序为三角形孔隙结构﹥无序孔隙结构﹥正方形孔隙结构。无序孔隙结构具有最优的摩擦学性能,三角形孔隙结构次之,正方形孔隙结构相对最差,孔隙结构越与人体原生骨组织接近其耐磨性能越优。研究结果将为生物医用植入体孔隙结构的选择提供参考,对实际应用有着重要意义。

关键词：增材制造 Ti-6Al-4V 摩擦有限元孔隙结构生物医用骨组织

基于结构特征的机载LiDAR数据与航空影像自动配准

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红外与激光工程 2013年第12期42卷 3502-3508页

作者：徐景中寇媛袁芳张伟武汉大学遥感信息工程学院湖北武汉430079 武汉大学测绘学院湖北武汉430079

针对现有机载LiDAR数据与航空影像配准方法对匹配特征具有较强的依赖性,易受数据等影响的问题,提出了一种基于结构特征的自动配准方法。该方法首先提取LiDAR距离图像与对应影像的结构特征,利用初始姿态参数将LiDAR结构特征投影至影像坐... 详细信息

针对现有机载LiDAR数据与航空影像配准方法对匹配特征具有较强的依赖性,易受数据等影响的问题,提出了一种基于结构特征的自动配准方法。该方法首先提取LiDAR距离图像与对应影像的结构特征,利用初始姿态参数将LiDAR结构特征投影至影像坐标系下,根据结构特征的几何约束条件获取初始匹配点集,完成粗匹配;接着利用粗匹配结果计算直接变换模型(DLT)参数,并以此为初值引入双点几何约束,采用循环迭代的匹配策略,不断剔除错误匹配,获得一组新的匹配点集,完成精匹配;最后根据精匹配结果,采用基于单位四元数的空间后方交会方法解算航空影像的姿态参数,实现机载LiDAR数据与航空影像的自动配准。实验证明,该方法受噪声影响小,能实现机载LiDAR数据与航空影像的自动配准。

关键词：自动配准航空影像机载LiDAR 结构特征