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Ethnopharmacology,phytochemistry,pharmacology and product application of Platycodon grandiflorum:A review

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Chinese Herbal Medicines 2024年第3期16卷 327-343页

作者： Lanying Zhang Xinrui Wang jingze Zhang Dailin liu Gang Bai Tianjin University of Traditional Chinese Medicine Tianjin 301617China Nankai University Tianjin 300353China Tianjin Modern Innovation Chinese Medicine Technology Co. Ltd.Tianjin 300380China

Platycodonis Radix(Jiegeng in Chinese)is a well-known traditional Chinese medicine used for both medicinal and culinary *** historical use as an antitussive and expectorant has been extensively ***,to date,have identified 219 chemical constituents in Platycodon grandiflorum(Jacq.)***,encompassing 89 saponins,11 flavonoids,21 polysaccharides,14 phenolic acids,six polyacetylenes,five sterols,34 fatty acids,17 amino acids,and 22 trace *** exhibits diverse pharmacological effects,including antitussive and anti-phlegm properties,anti-cancer activity,anti-inflammatory effects,immune regulation,antioxidant properties,anti-obesity,and antidiabetic ***,Jiegeng shows potential in protecting the heart and *** its medicinal benefits,Jiegeng is highly esteemed in culinary applications,and its global demand is on the *** utilization has expanded beyond medicine and food to encompass daily necessities,cosmetics,agricultural supplies,and other ***,there are 18272 patents related to *** comprehensive review summarizes the latest research published over the past 20 years,providing a robust foundation for further exploration of the medicinal and health benefits of ***.

关键词： application chemical constituents Jiegeng medicine and food homology Platycodon grandiflorum(Jacq.)A.DC

Chemical constituents and pharmacological activities of medicinal plants from Rosa genus

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Chinese Herbal Medicines 2022年第2期14卷 187-209页

作者： Yansheng Wang Yanmin Zhao Xinnan liu Jingyang Li jingze Zhang Dailin liu Tianjin University of Traditional Chinese Medicine Tianjin 301617China Tianjin Modern Innovation Chinese Medicine Technology Co. Ltd.Tianjin 300380China Logistics College of Chinese People’s Armed Police Forces Tianjin 300309China

The genus Rosa(Rosaceae family)includes about 200 species spread in the world,and this genus shows unique advantages in medicine and *** date,several scholars concentrated on compounds belonging to flavonoids,triterpenes,tannins,polysaccharide,phenolic acids,fatty acids,organic acids,carotenoids,and *** effects such as antineoplastic and anti-cancer properties,antiinflammatory,antioxidant,liver protection,regulate blood sugar,antimicrobial activity,antiviral activity,as well as nervous system protection and cardiovascular protection were wildly *** article reviews the chemical constituents,pharmacological effects,applications and safety evaluations of Rosa plants,which provides a reference for the comprehensive utilization of medicine and food resources and gives a scientific basis for the development of medicinal plants of the genus Rosa.

关键词： medicine and food homology pharmacological effect phytochemistry Rosa safety

Li-Ca Alloy Composite Anode with Ant-Nest-Like Lithiophilic Channels in Carbon Cloth Enabling High-Performance Li Metal Batteries

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Research 2022年第3期2022卷 343-353页

作者： Zihao Wang Yuchi liu Jianxiong Xing Zhicui Song Aijun Zhou Wei Zou Fu Zhou jingze Li School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China Research and Development Center Tianqi Lithium Co.Ltd.Chengdu 610093China

Constructing a three-dimensional(3D)multifunctional hosting architecture and subsequent thermal infusion of molten Li to produce advanced Li composite is an effective strategy for stable Li metal ***,the pure liquid Li is difficult to spread across the surface of various substrates due to its large surface tension and poor wettability,hindering the production and application of Li composite ***,heteroatomic Ca is doped into molten Li to generate Li-Ca alloy,which greatly regulates the surface tension of the molten alloy and improves the wettability against carbon cloth(CC).Moreover,a secondary network composed of CaLi2 intermetallic compound with interconnected ant-nest-like lithiophilic channels is in situ formed and across the primary scaffold of CC matrix by infiltrating molten Li-Ca alloy into CC and then cooling treatment(LCAC),which has a larger and lithiophilic surface to enable uniform Li deposition into interior space of the hybrid scaffold without Li ***,LCAC exhibits a long-term lifespan for 1100 h under a current density of 5 mA cm^(-2)with fixed areal capacity of 5 mAh cm^(-2).Remarkably,full cells paired with practical-level LiFePO4 cathode of 2.45 mAh cm^(-2)deliver superior performance.

关键词： alloy intermetallic composite

补阳还五汤抗动脉粥样硬化氧化应激的生信分析及实验研究

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湖南中医药大学学报 2023年第4期43卷 668-676页

作者：龙清吟傅馨莹李菀榆李俊熙刘竞泽李艳军谭维胡聪张伟湖南中医药大学中西医结合心脑疾病防治湖南省重点实验室湖南长沙410208

目的基于基因芯片数据库(GEO)、网络药理学,结合ox-LDL诱导的大鼠主动脉血管内皮细胞氧化损伤模型进行实验验证,探究补阳还五汤(Buyang Huanwu Decoction,BYHWD)干预动脉粥样硬化(atherosclerosis,AS)氧化应激的作用及相关机制。方法通... 详细信息

目的基于基因芯片数据库(GEO)、网络药理学,结合ox-LDL诱导的大鼠主动脉血管内皮细胞氧化损伤模型进行实验验证,探究补阳还五汤(Buyang Huanwu Decoction,BYHWD)干预动脉粥样硬化(atherosclerosis,AS)氧化应激的作用及相关机制。方法通过TCMSP、Herb数据库收集BYHWD中7味中药有效成分及靶点;从GEO数据库下载GSE19286、GSE2372数据集,鉴定AS差异表达基因(differentially expressed genes,DEGs);通过GeneCards数据库获取氧化应激靶点;取交集筛选出BYHWD、DEGs、氧化应激共同靶点,进行PPI、GO和KEGG通路富集分析;在GSE19286、GSE2372的表达矩阵中,采用独立样本t检验进行核心靶点验证。结合GEO数据库和网络药理学结果进行体外实验验证,检测药物对细胞活性氧表达及ALB、PLG、F2、GC、PLK1基因表达的影响。结果筛选出972个中药靶点、9438个氧化应激靶点、173个DEGs,其中103个DEGs在AS组织样本中高表达、70个DEGs在AS组织样本中低表达;综合中药作用靶点、AS DEGs和氧化应激靶点,得到24个“AS潜在靶点”,进行GO和KEGG富集分析,结果提示“AS潜在靶点”主要通过调控细胞周期信号通路,卵母细胞成熟信号通路和细胞减数分裂信号通路等信号通路发挥作用。根据Degree算法对“AS潜在靶点”进行拓扑分析,鉴定出前5位“AS核心靶点”,据统计分析提示BYHWD可能可以通过上调ALB、PLG、F2、GC的表达、下调PLK1的表达起到干预AS氧化应激的作用。体外实验结果显示,BYHWD能抑制ox-LDL引起的活性氧(reactive oxygen species,ROS)增高;qPCR结果显示,ox-LDL刺激后的大鼠主动脉内皮细胞ALB、PLG、F2、GC基因表达均下降,PLK1基因表达上升,BYHWD含药血清干预后可以上调ALB、PLG、F2、GC基因的表达(P<0.01;P<0.05),下调PLK1的表达(P<0.05)。结论BYHWD干预AS氧化应激具有多成分、多靶点、多途径的作用特点,其机制可能与减少ROS表达,上调ALB、PLG、F2、GC基因、下调PLK1基因表达相关。

关键词：补阳还五汤动脉粥样硬化氧化应激基因芯片网络药理学分子对接

Protective role of fruits of Rosa odorata var. gigantea against WIRSinduced gastric mucosal injury in rats by modulating pathway related to inflammation, oxidative stress and apoptosis

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Chinese Herbal Medicines 2024年第2期16卷 263-273页

作者： Xinnan liu Zhen Yuan Lifei Luo Teng Wang Feng Zhao jingze Zhang Dailin liu National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Modern Innovation Chinese Medicine Technology Co. Ltd.Tianjin 300380China School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug EvaluationMinistry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China

Objective: Rosa odorata var. gigantea is a popular medicinal plant. Some studies have demonstrated that ethanolic extract of the fruits of R. odorata var. gigantea(FOE) has gastroprotective properties. The aim of this study was to investigate the gastroprotective activity of FOE on water immersion restrained stress(WIRS)-induced gastric mucosal injury in a rat model and elucidate the possible molecular mechanisms ***: A rat stress ulcer model was established in this study using WIRS. After rats were treated with FOE orally for 7 d, the effect of FOE treatment was analyzed by hematoxylin and eosin(H&E) staining, and the changes of inflammatory factors, oxidative stress factors, and gastric-specific regulatory factors and pepsin in the blood and gastric tissues of rats were examined by ELISA assay. Molecular mechanism of FOE was investigated by immunohistochemical assay and Western ***: Compared with the WIRS group, FOE could diminish both the macroscopic and microscopic pathological morphology of gastric mucosa. FOE significantly preserved the antioxidants glutathione peroxidase(GSH-PX), superoxide dismutase(SOD) and catalase(CAT) contents;anti-inflammatory cytokines interleukin-10(IL-10) and prostaglandin E2(PGE2) levels as well as regulatory factors tumor necrosis factor-a(TGF-a) and somatostatin(SS) contents, while decreasing malondialdehyde(MDA), nitric oxide synthase(i NOS), tumor necrosis factor(TNF-a), interleukin-1β(IL-1β), interleukin-6(IL-6), gastrin(GAS)and endothelin(ET) levels. Moreover, FOE distinctly upregulated the expression of Nrf2, HO-1, Bcl2 and proliferating cell nuclear antigen(PCNA). In addition, FOE activated the expression of p-EGFR and downregulated the expression of NF-ΚB, Bax, Cleaved-caspase-3, Cyto-C and Cleaved-PARP1, thus promoting gastric mucosal cell ***: The current work demonstrated that FOE exerted a gastroprotective activity against gastric mucosal injury induced by WIRS. The underlying mecha

关键词： anti-apoptosis anti-inflammation anti-oxidation gastric mucosal injury Rosa odorata Sweet var.gigantea(Coll.et Hemsl.)Rehd.et Wils water immersion restrained stress

Ethnopharmacology,chemical composition and functions of Cymbopogon citratus

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Chinese Herbal Medicines 2024年第3期16卷 358-374页

作者： Xiqin Du Meng Zhang Shuping Wang Jingyang Li jingze Zhang Dailin liu Tianjin University of Traditional Chinese Medicine Tianjin 301617China Tianjin Modern Innovation Chinese Medicine Technology Co. Ltd.Tianjin 300380China Characteristic Medical Center of Chinese People’s Armed Police Force Tianjin 300300China Department of Pharmacy Logistics College of Chinese People’s Armed Police ForceTianjin 300309China

Cymbopogon citratus in the gramineous family,also known as lemongrass(LG),is a perennial ***,a drug and food homologous medicine,has a widely recorded medicinal value and food *** date,158 LG compounds have been reported,including terpenoids,flavonoids,phenolic *** and clinical studies have indicated that LG has antibacterial,neuroprotective,hypoglycemic,hypotensive,anti-inflammatory,and anti-tumor *** article reviews LG in ethnopharmacology,chemical composition,pharmacology,food,medicine,and daily chemical applications to provide a basis for the subsequent development of food and medicine.

关键词： chemical composition Cymbopogon citratus(DC.)Stapf drug and food homologous medicine ethnopharmacology lemongrass medicine and food applications

ZnF_(2)coated three dimensional Li-Ni composite anode for improved performance

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Journal of Materiomics 2019年第2期5卷 176-184页

作者： Weishang Jia Ying Wang Siji Qu Zeyu Yao Yuchi liu Chao Li Zhihong Wang jingze Li School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu610054China School of Mechanical and Automotive Engineering Shanghai University of Engineering Science333 Longteng RoadSongjiang DistrictShanghai201620China

Lithium metal is a promising anode material for high energy density batteries,which is restricted from practical application by the issues including lithium dendrite,parasitic reaction and volumetric ***,a strategy combing bulk and surface modification is proposed to address these *** bulk modification is to use Ni foam as three dimensional(3D)scaffold for direct infusion of molten Li resulting in the formation of Li-Ni composite anode,which reduces actual current density by increasing specific surface area and alleviates volumetric change in the process of Li stripping/*** the surface modification is to coat with ZnF_(2)film via sputtering,which is acted as artificial protective layer for controlling interfacial side *** symmetric cell consisting of ZnF_(2)coated Li-Ni composite electrodes exhibits low overpotential(about 45 mV)and stable cycling over 900 h at 1mA cm^(-2).Furthermore,the cell with LiCoO_(2)cathode delivers 110 mAh g^(-1)at 1 C rate after 500 cycles.

关键词： Lithium metal anode Composite lithium Nickel foam Lithium dendrite Surface modification Lithium battery

HID-1 is a peripheral membrane protein primarily associated with the medial-and transGolgi apparatus

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Protein & Cell 2011年第1期2卷 74-85页

作者： Lifen Wang Yi Zhan Eli Song Yong Yu Yaming Jiu Wen Du jingze Lu Pingsheng liu Pingyong Xu Tao Xu National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Graduate School of the Chinese Academy of Sciences Beijing 100864China College of Life Science and Technology Huazhong University of Science and TechnologyWuhan 430074China

Caenorhabditis elegans hid-1 gene was first identified in a screen for mutants with a high-temperature-induced dauer formation(Hid)*** the fact that the hid-1 gene encodes a novel protein(HID-1)which is highly conserved from Caenorhabditis elegans to mammals,the domain structure,subcellular localization,and exact function of HID-1 remain *** studies and various bioinformatic softwares predicted that HID-1 contained many transmembrane domains but no known functional *** this study,we revealed that mammalian HID-1 localized to the medial-and transGolgi apparatus as well as the cytosol,and the localization was sensitive to brefeldin A ***,we demonstrated that HID-1 was a peripheral membrane protein and dynamically shuttled between the Golgi apparatus and the ***,we verified that a conserved N-terminal myristoylation site was required for HID-1 binding to the Golgi *** propose that HID-1 is probably involved in the intracellular trafficking within the Golgi region.

关键词： HID-1 Golgi peripheral membrane protein fluorescent recovery after photobleaching N-myristoylation

Sulphur-doped ordered mesoporous carbon with enhanced electrocatalytic activity for the oxygen reduction reaction

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Journal of Energy Chemistry 2016年第4期25卷 566-570页

作者： Liping Wang Weishang Jia Xiaofeng liu jingze Li Maria Magdalena Titirici State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China School of Materials Science and Engineering Zhejiang University School of Materials Science and Engineering Queen Mary University of London Materials Research Institute Queen Mary University of London

Metal-free, heteroatom functionalized carbon-based catalysts have made remarkable progress in recent years in a wide range of applications related to energy storage and energy generation. In this study, high surface area mesoporous ordered sulphur doped carbon materials are obtained via one-pot hydrothermal synthesis of carbon/SBA-15 composite after removal of in-situ synthesized hard template SiO2. 2-thiophenecarboxy acid as sulphur source gives rise to sulphur doping level of 5.5 wt%. Comparing with pristine carbon, the sulphur doped mesoporous ordered carbon demonstrates improved electro-catalytic activity in the oxygen reduction reaction in alkaline solution. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. and Science Press. All rights reserved.

关键词： Mesoporous ordered carbon Oxygen reduction reaction Electrocatalyst Heteroatom doping In-situ synthesis